Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway

Journal of Experimental Medicine

Volumn 206, Issue 8, 2009, Pages 1661-1671

  Espinosa, Alexander ^a   Dardalhon, Valerie ^b   Brauner, Susanna ^a   Ambrosi, Aurelie ^a   Higgs, Rowan ^c   Quintana, Fransisco J ^b   Sjöstrand, Maria ^a   Eloranta, Maija Leena ^d   Gabhann, Joan Ní ^c   Winqvist, Ola ^a   Sundelin, Birgitta ^a   Jefferies, Caroline A ^c   Rozell, Björn ^a   Kuchroo, Vijay K ^b   Wahren Herlenius, Marie ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^d UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; DNA ANTIBODY; INTERFERON REGULATORY FACTOR; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 6; PROTEIN; PROTEIN RO52; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DERMATITIS; FEMALE; GENE DELETION; HYPERGAMMAGLOBULINEMIA; IMMUNOPATHOGENESIS; INFLAMMATION; KIDNEY DISEASE; MALE; MOUSE; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; PROTEINURIA; SYSTEMIC LUPUS ERYTHEMATOSUS; TH17 CELL;

ANIMALS; AUTOIMMUNE DISEASES; BASE SEQUENCE; CYTOKINES; DISEASE MODELS, ANIMAL; DNA PRIMERS; FEEDBACK, BIOCHEMICAL; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERFERONS; INTERLEUKIN-23; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; RIBONUCLEOPROTEINS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 68149179247     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20090585     Document Type: Article

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