Programmed death 1 ligand (PD-L) 1 and PD-L2 limit autoimmune kidney disease: Distinct roles

Journal of Immunology

Volumn 179, Issue 11, 2007, Pages 7466-7477

  Menke, Julia ^a   Lucas, Julie A ^a   Zeller, Geraldine C ^a   Keir, Mary E ^a   Huang, Xiao R ^b   Tsuboi, Naotake ^a   Mayadas, Tanya N ^a   Lan, Han Y ^b   Sharpe, Arlene H ^a   Kelley, Vicki Rubin ^a,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD68 ANTIGEN; IMMUNOGLOBULIN G; PROGRAMMED DEATH 1; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 2; UNCLASSIFIED DRUG; ANTISERUM; B7 ANTIGEN; MEMBRANE PROTEIN; MESSENGER RNA; PDCD1LG1 PROTEIN, MOUSE; PDCD1LG2 PROTEIN, MOUSE; PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW; C57BL 6 MOUSE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CONTROLLED STUDY; GLOMERULUS; HEMATOPOIETIC CELL; IMMUNE COMPLEX NEPHRITIS; IMMUNOGLOBULIN DEPOSITION; KIDNEY FUNCTION; LEUKOCYTE; MACROPHAGE; MOUSE; NONHUMAN; PARENCHYMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE; ANIMAL; APOPTOSIS; AUTOIMMUNE DISEASE; C57BL MOUSE; DOWN REGULATION; GENE EXPRESSION PROFILING; GENETICS; IMMUNOLOGY; KIDNEY DISEASE; MALE; MOUSE MUTANT; NEPHRITIS; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTIGENS, CD80; APOPTOSIS; AUTOIMMUNE DISEASES; DOWN-REGULATION; GENE EXPRESSION PROFILING; IMMUNE SERA; KIDNEY DISEASES; MACROPHAGES; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEPHRITIS; PEPTIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES;

EID: 38849127548     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.11.7466     Document Type: Article

References (50)

1. Tesch, G. H., A. Schwarting, K. Kinoshita, H. Y. Lan, B. J. Rollins, and V. R. Kelley. 1999. Monocyte chemoattractant protein-1 promotes macrophage-mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritis. J. Clin. Invest. 103: 73-80.
2. lpr kidneys are dependent on multiple T-cell subsets. Kidney Int. 59: 565-578.
3. Dean, E. G., G. R. Wilson, M. Li, K. L. Edgtton, K. M. O'Sullivan, B. G. Hudson, S. R. Holdsworth, and A. R. Kitching. 2005. Experimental autoimmune Goodpasture's disease: a pathogenetic role for both effector cells and antibody in injury. Kidney Int. 67: 566-575.
4. Sharpe, A. H., E. J. Wherry, R. Ahmed, and G. J. Freeman. 2007. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat. Immunol. 8: 239-245.
5. Greenwald, R. J., G. J. Freeman, and A. H. Sharpe. 2005. The B7 family revisited. Annu. Rev. Immunol. 23: 515-548.
6. Okazaki, T., and T. Honjo. 2006. The PD-1-PD-L pathway in immunological tolerance. Trends Immunol. 27: 195-201.
7. Chen, L. 2004. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat. Rev. Immunol. 4: 336-347.
8. Freeman, G. J., A. J. Long, Y. Iwai, K. Bourque, T. Chernova, H. Nishimura, L. J. Fitz, N. Malenkovich, T. Okazaki, M. C. Byrne, et al. 2000. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192: 1027-1034.
9. Ozkaynak, E., L. Wang, A. Goodearl, K. McDonald, S. Qin, T. O'Keefe, T. Duong, T. Smith, J. C. Gutierrez-Ramos, J. B. Rottman, et al. 2002. Programmed death-1 targeting can promote allograft survival. J. Immunol. 169: 6546-6553.
10. Tsuda, M., K. Matsumoto, H. Inoue, M. Matsumura, T. Nakano, A. Mori, M. Azuma, and Y. Nakanishi. 2005. Expression of B7-H1 and B7-DC on the airway epithelium is enhanced by double-stranded RNA. Biochem. Biophys. Res. Commun. 330: 263-270.
11. Eppihimer, M. J., J. Gunn, G. J. Freeman, E. A. Greenfield, T. Chernova, J. Erickson, and J. P. Leonard. 2002. Expression and regulation of the PD-L1 immunoinhibitory molecule on microvascular endothelial cells. Microcirculation 9: 133-145.
12. Ansari, M. J., A. D. Salama, T. Chitnis, R. N. Smith, H. Yagita, H. Akiba, T. Yamazaki, M. Azuma, H. Iwai, S. J. Khoury, et al. 2003. The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice. J. Exp. Med. 198: 63-69.
13. Liang, S. C., Y. E. Latchman, J. E. Buhlmann, M. F. Tomczak, B. H. Horwitz, G. J. Freeman, and A. H. Sharpe. 2003. Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses. Eur. J. Immunol. 33: 2706-2716.
14. Nakazawa, A., I. Dotan, J. Brimnes, M. Allez, L. Shao, F. Tsushima, M. Azuma, and L. Mayer. 2004. The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells. Gastroenterology 126: 1347-1357.
15. Salama, A. D., T. Chitnis, J. Imitola, M. J. Ansari, H. Akiba, F. Tushima, M. Azuma, H. Yagita, M. H. Sayegh, and S. J. Khoury. 2003. Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis. J. Exp. Med. 198: 71-78.
16. Schoop, R., P. Wahl, M. Le Hir, U. Heemann, M. Wang, and R. P. Wuthrich. 2004. Suppressed T-cell activation by IFN-γ-induced expression of PD-L1 on renal tubular epithelial cells. Nephrol. Dial. Transplant. 19: 2713-2720.
17. Yamazaki, T., H. Akiba, H. Iwai, H. Matsuda, M. Aoki, Y. Tanno, T. Shin, H. Tsuchiya, D. M. Pardoll, K. Okumura, et al. 2002. Expression of programmed death 1 ligands by murine T cells and APC. J. Immunol. 169: 5538-5545.
18. Latchman, Y. E., S. C. Liang, Y. Wu, T. Chernova, R. A. Sobel, M. Klemm, V. K. Kuchroo, G. J. Freeman, and A. H. Sharpe. 2004. PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc. Natl. Acad. Sci. USA 101: 10691-10696.
19. Keir, M. E., S. C. Liang, I. Guleria, Y. E. Latchman, A. Qipo, L. A. Albacker, M. Koulmanda, G. J. Freeman, M. H. Sayegh, and A. H. Sharpe. 2006. Tissue expression of PD-L1 mediates peripheral T cell tolerance. J. Exp. Med. 203: 883-895.
20. Carter, L. L., M. W. Leach, M. L. Azoitei, J. Cui, J. W. Pelker, J. Jussif, S. Benoit, G. Ireland, D. Luxenberg, G. R. Askew, et al. 2007. PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis. J. Neuroimmunol. 182: 124-134.
21. Zhu, B., I. Guleria, A. Khosroshahi, T. Chitnis, J. Imitola, M. Azuma, H. Yagita, M. H. Sayegh, and S. J. Khoury. 2006. Differential role of programmed death-ligand 1 [corrected] and programmed death-ligand 2 [corrected] in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitis. J. Immunol. 176: 3480-3489.
22. Nishimura, H., M. Nose, H. Hiai, N. Minato, and T. Honjo. 1999. Development of Lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11: 141-151.
23. -/- mice as an efficient animal model of type I diabetes. Proc. Natl. Acad. Sci. USA 102: 11823-11828.
24. Tipping, P. G., X. R. Huang, M. C. Berndt, and S. R. Holdsworth. 1994. A role for P selectin in complement-independent neutrophil-mediated glomerular injury. Kidney Int. 46: 79-88.
25. Vielhauer, V., G. Stavrakis, and T. N. Mayadas. 2005. Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis. J. Clin. Invest. 115: 1199-1209.
26. lpr mice delays nephritis and intrarenal IFN-γ expression, and diminishes systemic pathology. J. Immunol. 170: 3915-3925.
27. Doi, T., M. Hattori, L. Y. Agodoa, T. Sato, H. Yoshida, L. J. Striker, and G. E. Striker. 1990. Glomerular lesions in nonobese diabetic mouse: before and after the onset of hyperglycemia. Lab. Invest. 63: 204-212.
28. + T cell activation and cytolysis. Eur. J. Immunol. 33: 3117-3126.
29. Faraggiana, T., F. Malchiodi, A. Prado, and J. Churg. 1982. Lectin-peroxidase conjugate reactivity in normal human kidney. J. Histochem. Cytochem. 30: 451-458.
30. Swinford, A. E., J. Bernstein, H. V. Toriello, and J. V. Higgins. 1989. Renal tubular dysgenesis: delayed onset of oligohydramnios. Am. J. Med. Genet. 32: 127-132.
31. Kruger, T., D. Benke, F. Eitner, A. Lang, M. Wirtz, E. E. Hamilton-Williams, D. Engel, B. Giese, G. Muller-Newen, J. Floege, and C. Kurts. 2004. Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis. J. Am. Soc. Nephrol. 15: 613-621.
32. Moore, K. J., K. Yeh, T. Naito, and V. R. Kelley. 1996. TNF-α enhances colony-stimulating factor-1-induced macrophage accumulation in autoimmune renal disease. J. Immunol. 157: 427-432.
33. Topham, P. S., V. Csizmadia, D. Soler, D. Hines, C. J. Gerard, D. J. Salant, and W. W. Hancock. 1999. Lack of chemokine receptor CCR1 enhances Th1 responses and glomerular injury during nephrotoxic nephritis. J. Clin. Invest. 104: 1549-1557.
34. lpr mice. J. Immunol. 164: 6046-6056.
35. lpr mice. J. Immunol. 173: 4744-4754.
36. Wuthrich, R. P., L. H. Glimcher, M. A. Yui, A. M. Jevnikar, S. E. Dumas, and V. E. Kelley. 1990. MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells. Kidney Int. 37: 783-792.
37. Latchman, Y., C. R. Wood, T. Chernova, D. Chaudhary, M. Borde, I. Chernova, Y. Iwai, A. J. Long, J. A. Brown, R. Nunes, et al. 2001. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol. 2: 261-268.
38. Li, S., S. R. Holdsworth, and P. G. Tipping. 1997. Antibody independent crescentic glomerulonephritis in μ chain deficient mice. Kidney Int. 51: 672-678.
39. Rosenkranz, A. R., S. Knight, S. Sethi, S. I. Alexander, R. S. Cotran, and T. N. Mayadas. 2000. Regulatory interactions of αβ and γδ T cells in glomerulonephritis. Kidney Int. 58: 1055-1066.
40. Huang, X. R., P. G. Tipping, L. Shuo, and S. R. Holdsworth. 1997. Th1 responsiveness to nephritogenic antigens determines susceptibility to crescentic glomerulonephritis in mice. Kidney Int. 51: 94-103.
41. Kitching, A. R., S. R. Holdsworth, and P. G. Tipping. 1999. IFN-γ mediates crescent formation and cell-mediated immune injury in murine glomerulonephritis. J. Am. Soc. Nephrol. 10: 752-759.
42. Kitching, A. R., P. G. Tipping, and S. R. Holdsworth. 1999. IL-12 directs severe renal injury, crescent formation and Th1 responses in murine glomerulonephritis. Eur. J. Immunol. 29: 1-10.
43. + T cell tolerance to tissue antigens. J. Immunol. 177: 8291-8295.
44. + cytotoxic T cells. Nephrol. Dial. Transplant. 22: 1527-1536.
45. Reynolds, J., V. A. Norgan, U. Bhambra, J. Smith, H. T. Cook, and C. D. Pusey. 2002. Anti-CD8 monoclonal antibody therapy is effective in the prevention and treatment of experimental autoimmune glomerulonephritis. J. Am. Soc. Nephrol. 13: 359-369.
46. Liang, S. C., R. J. Greenwald, Y. E. Latchman, L. Rosas, A. Satoskar, G. J. Freeman, and A. H. Sharpe. 2006. PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis. Eur. J. Immunol. 36: 58-64.
47. Kelley, V. R., and G. G. Singer. 1993. The antigen presentation function of renal tubular epithelial cells. Exp. Nephrol. 1: 102-111.
48. Van Kooten, C., M. R. Daha, and L. A. van Es. 1999. Tubular epithelial cells: a critical cell type in the regulation of renal inflammatory processes. Exp. Nephrol. 7: 429-437.
49. Nguyen, L. T., S. Radhakrishnan, B. Ciric, K. Tamada, T. Shin, D. M. Pardoll, L. Chen, M. Rodriguez, and L. R. Pease. 2002. Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells. J. Exp. Med. 196: 1393-1398.
50. Radhakrishnan, S., L. T. Nguyen, B. Ciric, V. P. Van Keulen, and L. R. Pease. 2007. B7-DC/PD-L2 cross-linking induces NF-κB-dependent protection of dendritic cells from cell death. J. Immunol. 178: 1426-1432.