Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice

Nature Medicine

Volumn 9, Issue 12, 2003, Pages 1477-1483

  Okazaki, Taku ^a   Tanaka, Yoshimasa ^a,b   Nishio, Ryosuke ^a,c   Mitsuiye, Tamotsu ^a   Mizoguchi, Akira ^d   Wang, Jian ^a   Ishida, Masayoshi ^a   Hiai, Hiroshi ^a   Matsumori, Akira ^a   Minato, Nagahiro ^a   Honjo, Tasuku ^a  

^a KYOTO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c KYOTO UNIVERSITY HOSPITAL   (Japan)

^d MIE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CALCIUM CHANNEL L TYPE; MONOCLONAL ANTIBODY; PROTEIN PD 1; RECEPTOR; TROPONIN I; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNE DISEASE; CALCIUM CURRENT; CALCIUM TRANSPORT; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; FAMILIAL HYPERTROPHIC CARDIOMYOPATHY; GENE MUTATION; HEART DILATATION; HEART DISEASE; HEART MUSCLE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, SURFACE; APOPTOSIS REGULATORY PROTEINS; AUTOANTIBODIES; BASE SEQUENCE; CALCIUM SIGNALING; CARDIOMYOPATHY, DILATED; DNA, COMPLEMENTARY; HUMANS; MICE; MICE, INBRED A; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, NUDE; MYOCYTES, CARDIAC; RATS; RATS, WISTAR; TROPONIN I;

ANIMALIA;

EID: 10744220884     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm955     Document Type: Article

References (38)

1. Richardson, P. et al. Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the definition and classification of cardiomyopathies. Circulation 93, 841-842 (1996).
2. Cohn, J.N. et al. Report of the National Heart, Lung, and Blood Institute Special Emphasis Panel on heart failure research. Circulation 95, 766-770 (1997).
3. Matsumori, A. et al. Epidemiologic and clinical characteristics of cardiomyopathies in Japan. Circ. J. 66, 323-236 (2002).
4. Herskowitz, A., Neumann, D.A. & Ansari, A.A. Concepts of autoimmunity applied to idiopathic dilated cardiomyopathy. J. Am. Coll. Cardiol. 22, 1385-1388 (1993).
5. Pankuweit, S. et al. Autoantibodies in sera of patients with myocarditis: characterization of the corresponding proteins by isoelectric focusing and N-terminal sequence analysis. J. Mol. Cell. Cardiol. 29, 77-84 (1997).
6. Schultheiss, H.P. et al. The ADP/ATP carrier as a mitochondrial auto-antigen-facts and perspectives. Ann. NY Acad. Sci. 488, 44-64 (1986).
7. Maisch, B. et al. Diagnostic relevance of humoral and cytotoxic immune reactions in primary and secondary dilated cardiomyopathy. Am. J. Cardiol. 52, 1072-1078 (1983).
8. Neumann, D.A. et al. Circulating heart-reactive antibodies in patients with myocarditis or cardiomyopathy. J. Am. Coll. Cardiol. 16, 839-846 (1990).
9. Staudt, A. et al. Immunohistological changes in dilated cardiomyopathy induced by immunoadsorption therapy and subsequent immunoglobulin substitution. Circulation 103, 2681-2686 (2001).
10. Matsumori, A. & Kawai, C. An experimental model for congestive heart failure after encephalomyocarditis virus myocarditis in mice. Circulation 65, 1230-1235 (1982).
11. Alvarez, F.L. et al. Heart-specific autoantibodies induced by coxsackievirus B3: identification of heart autoantigens. Clin. Immunol. Immunopathol. 43, 129-139 (1987).
12. Matsui, S. et al. Peptides derived from cardiovascular G-protein-coupled receptors induce morphological cardiomyopathic changes in immunized rabbits. J. Mol. Cell. Cardiol. 29, 641-655 (1997).
13. Neu, N. et al. Cardiac myosin induces myocarditis in genetically predisposed mice. J. Immunol. 139, 3630-3636 (1987).
14. Neu, N., Ploier, B. & Ofner, C. Cardiac myosin-induced myocarditis. Heart autoantibodies are not involved in the induction of the disease. J. Immunol. 145, 4094-4100 (1990).
15. Okazaki, T., Iwai Y., & Honjo, T. New regulatory co-receptors: inducible co-stimulator and PD-1. Curr. Opin. Immunol. 14, 779-782 (2002).
16. Nishimura, H. et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 291, 319-322 (2001).
17. Seidman, J. G. & Seidman, C. Cell 104, 557-567 (2001).
18. Kimura, A. et al. Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Nat. Genet. 16, 379-382 (1997).
19. Solaro, R.J. Troponin I, stunning, hypertrophy, and failure of the heart. Circ. Res. 84, 122-124 (1999).
20. Towbin, J.A. The role of cytoskeletal proteins in cardiomyopathies. Curr. Opin. Cell. Biol. 10, 131-139 (1998).
21. Kamisago, M. et al. Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy. N. Engl. J. Med. 343, 1688-1696 (2000).
22. Solaro, R.J. & Rarick, H.M. Troponin and tropomyosin: proteins that switch on and tune in the activity of cardiac myofilaments. Circ. Res. 83, 471-480 (1998).
23. Shou, W. et al. Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12. Nature 391, 489-492 (1998).
24. Molkentin, J.D. et al. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93, 215-228 (1998).
25. Knollmann, B.C. et al. Remodelling of ionic currents in hypertrophied and failing hearts of transgenic mice overexpressing calsequestrin. J. Physiol. 525, 483-498 (2000).
26. Schultheiss, H.P. et al. Antibody-mediated enhancement of calcium permeability in cardiac myocytes. J. Exp. Med. 168, 2105-2119 (1988).
27. 1-adrenoceptor antibodies induce positive inotropic response in isolated cardiomyocytes. Eur. J. Pharmacol. 423, 115-119 (2001).
28. Felix, S.B. et al. Removal of cardiodepressant antibodies in dilated cardiomyopathy by immunoadsorption. J. Am. Coll. Cardiol. 39, 646-652 (2002).
29. Murphy, A.M. et al. Transgenic mouse model of stunned myocardium. Science 287, 488-491 (2000).
30. Keffer, J.H. Myocardial markers of injury. Evolution and insights. Am. J. Clin. Pathol. 105, 305-320 (1996).
31. Schulze, K. et al. Disturbance of myocardial energy metabolism in experimental virus myocarditis by antibodies against the adenine nucleotide translocator. Cardiovasc. Res. 44, 91-100 (1999).
32. Kobuke, K. et al. ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is upregulated after vascular injury. J. Biol. Chem. 276, 34105-34114 (2001).
33. Mizoguchi, A. et al. Localization of rabphilin-3A on the synaptic vesicle. Biochem. Biophys. Res. Commun. 202, 1235-1243 (1994).
34. Nishio, R. et al. Left ventricular pressure-volume relationship in a murine model of congestive heart failure due to acute viral myocarditis. J. Am. Coll. Cardiol. 40, 1506-1514 (2002).
35. 2+ channel induced by cold acclimation of guinea pig. Am. J. Physiol. 274, R348-R356 (1998).
36. Isenberg, G. & Klockner, U. Calcium tolerant ventricular myocytes prepared by preincubation in a "KB medium." Pflugers. Arch. 395, 6-18 (1982).
37. Powell, T. et al. Electrical properties of individual cells isolated from adult rat ventricular myocardium J. Physiol. 302, 131-153 (1980).
38. Hamill, O.P. et al. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers. Arch. 391, 85-100 (1981).