Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice

Science

Volumn 304, Issue 5674, 2004, Pages 1147-1150

  Hanayama, Rikinari ^a   Tanaka, Masato ^a,b   Miyasaka, Kay ^a,c   Aozasa, Katsuyuki ^a   Koike, Masato ^a   Uchiyama, Yasuo ^a   Nagata, Shigekazu ^a,c,d  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b RIKEN YOKOHAMA INSTITUTE   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; GROWTH KINETICS; IMMUNOLOGY; OILS AND FATS; PATIENT MONITORING; PROTEINS;

AUTOIMMUNE DISEASES; EPIDERMAL GROWTH FACTOR (EGF);

CELLS;

AUTOANTIBODY; CD68 ANTIGEN; EPIDERMAL GROWTH FACTOR; MESSENGER RNA; MILK FAT GLOBULE EPIDERMAL GROWTH FACTOR 8; PHOSPHATIDYLSERINE; PHOSPHOLIPID; PROTEIN; UNCLASSIFIED DRUG;

MEDICINE;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; GENE TARGETING; IMMUNE SYSTEM; LYMPH NODE; MACROPHAGE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; ANTIGENS, SURFACE; APOPTOSIS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; B-LYMPHOCYTES; BLOTTING, NORTHERN; FEMALE; GENE TARGETING; GERMINAL CENTER; GLOMERULONEPHRITIS; IN SITU NICK-END LABELING; MACROPHAGE ACTIVATION; MACROPHAGES; MACROPHAGES, PERITONEAL; MEMBRANE GLYCOPROTEINS; MICE; MILK PROTEINS; PHAGOCYTOSIS; PHOSPHATIDYLSERINES; PROTEIN BINDING; SPLEEN; SPLENOMEGALY; T-LYMPHOCYTES;

ANIMALIA;

EID: 2442665179     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1094359     Document Type: Article

References (27)

1. M. D. Jacobson, M. Weil, M. C. Raff, Cell 88, 347 (1997).
2. J. Savill, V. Fadok, Nature 407, 784 (2000).
3. J. Savill, I. Dransfield, C. Gregory, C. Haslett, Nature Rev. Immunol. 2, 965 (2002).
4. M. O. Hengartner, Cell 104, 325 (2001).
5. V. A. Fadok et al., J. Immunol. 148, 2207 (1992).
6. R. Hanayama et al., Nature 417, 182 (2002).
7. J. D. Stubbs et al., Proc. Natl. Acad. Sci. U.S.A. 87, 8417 (1990).
8. K. Oshima et al., Biochem. Biophys. Res. Commun. 254, 522 (1999).
9. Materials and methods are available as supporting materials on Science Online.
10. S. S. Rabinotz, S. Gordon, J. Exp. Med. 174, 827 (1991).
11. R. Hanayama, S. Nagata, unpublished data.
12. P. C. Leijh, T. L. van Zwet, M. N. ter Kuile, R. van Furth, Infect. Immun. 46, 448 (1984).
13. K. Kawane et al., Nature Immunol. 4, 138 (2003).
14. G. Kraal, M. Janse, Immunology 58, 665 (1986).
15. J. P. Smith, A. M. Lister, J. G. Tew, A. K. Szakal, Anat. Rec. 229, 511 (1991).
16. A. J. McKnight, S. Gordon, Adv. Immunol. 68, 271 (1998).
17. D. Mevorach, J. L. Zhou, X. Song, K. B. Elkon, J. Exp. Med. 188, 387 (1998).
18. V. J. Gauthier, C. K. Abrass, Semin. Nephrol. 12, 379 (1992).
19. C. D. Surh, J. Sprent, Nature 372, 100 (1994).
20. G. Kelsoe, Immunity 4, 107 (1996).
21. P. R. Hoffmann et al., J. Cell Biol. 155, 649 (2001).
22. K. Miyasaka, R. Hanayama, M. Tanaka, S. Nagata, Eur. J. Immunol. 34, 1414 (2004).
23. N. Platt, H. Suzuki, T. Kodama, S. Gordon, J. Immunol. 164, 4861 (2000).
24. R. S. Scott et al., Nature 411, 207 (2001).
25. R. Hanayama, M. Tanaka, K. Miwa, S. Nagata, J. Immunol. 172, 3876 (2004).
26. I. Baumann et al., Arthritis Rheum. 46, 191 (2002).
27. We thank M. Fujii and M. Harayama for secretarial assistance. This work was supported in part by Grants-in-Aid from the Ministry of Education, Science, Sports, and Culture in Japan. R.H. is supported by a research fellowship from the Japan Society for the Promotion of Science, and M.T. is a recipient of a research grant from the Uehara Foundation.