Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice

Journal of Biological Chemistry

Volumn 283, Issue 20, 2008, Pages 13825-13833

  Lu, Xiangdong ^a,b   Kovalev, Grigoriy I ^b   Chang, Hua ^c   Kallin, Eric ^a,b   Knudsen, Geoffrey ^b   Xia, Li ^a,b   Mishra, Nilamadhab ^d   Ruiz, Phillip ^e   Li, En ^c   Su, Lishan ^a,b   Zhang, Yi ^a,b,f  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; CHROMOSOMES; GENE EXPRESSION; PATHOLOGY; SKIN; TRANSCRIPTION;

ACTIVATION CONDITIONS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; BIOLOGICAL FUNCTIONS; BONE MARROW CELLS; CHROMATIN STRUCTURES; COVALENT MODIFICATIONS; DYNAMIC CHANGES; EMBRYONIC LETHALITIES; HISTONE DEACETYLASE; HISTONE DEACETYLASE ACTIVITIES; IMMUNE RESPONSES; KNOCK OUTS; MOUSE MODELS; NUCLEOSOME REMODELING; SKIN LESIONS; T CELLS; T LYMPHOCYTES; TARGET GENES; TRANSCRIPTION REGULATIONS;

ELECTRIC LOAD MANAGEMENT;

AUTOANTIBODY; GAMMA INTERFERON; GENE PRODUCT; HISTONE DEACETYLASE; INTERLEUKIN 2; INTERLEUKIN 4; MULTIPROTEIN COMPLEX; PROTEIN MTA2; PROTEIN NURD; UNCLASSIFIED DRUG; CARRIER PROTEIN; MTA2 PROTEIN, MOUSE; NURD COMPLEX; REPRESSOR PROTEIN; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; EMBRYO DEATH; GLOMERULONEPHRITIS; HEPATITIS; IMMUNOMODULATION; LETHALITY; LUPUS LIKE SYNDROME; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; SKIN DEFECT; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; WEIGHT REDUCTION; ALLELE; ANIMAL; BIOLOGICAL MODEL; DISEASE MODEL; GENETICS; IMMUNOLOGY; INFLAMMATION; LYMPHOCYTE ACTIVATION; METABOLISM; PHYSIOLOGY; SKIN LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; TRANSGENIC MOUSE;

MUS;

ALLELES; ANIMALS; CARRIER PROTEINS; DISEASE MODELS, ANIMAL; HISTONE DEACETYLASES; INFLAMMATION; INTERFERON TYPE II; LUPUS ERYTHEMATOSUS, CUTANEOUS; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MODELS, GENETIC; REPRESSOR PROTEINS; T-LYMPHOCYTES; TRANS-ACTIVATORS;

EID: 46649086595     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801275200     Document Type: Article

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