Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis

Genes and Immunity

Volumn 8, Issue 8, 2007, Pages 634-645

  Liu, K ^a   Li, Q Z ^a   Yu, Y ^b   Liang, C ^a   Subramanian, S ^a   Zeng, Z ^a   Wang, H W ^c   Xie, C ^c   Zhou, X J ^c   Mohan, C ^a,c   Wakeland, E K ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; AUTOANTIBODY; AUTOANTIGEN; CD4 ANTIGEN; CELL NUCLEUS ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MAJOR HISTOCOMPATIBILITY ANTIGEN; SLE1 PROTEIN; SLE3 PROTEIN; SLE5 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONGENIC STRAIN; CONTROLLED STUDY; DISEASE SEVERITY; GLOMERULONEPHRITIS; GLOMERULUS; HETEROZYGOTE; IMMUNOGLOBULIN A NEPHROPATHY; LUPUS ERYTHEMATOSUS NEPHRITIS; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SPLENOMEGALY; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; AUTOANTIGENS; AUTOIMMUNITY; B-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHROMOSOMES; GENETIC SCREENING; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LUPUS NEPHRITIS; LYMPHOCYTE ACTIVATION; MICE; MICE, CONGENIC; PROTEIN ARRAY ANALYSIS; SPLENOMEGALY;

MUS;

EID: 36949001130     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/sj.gene.6364426     Document Type: Article

References (35)

1. Vyse TJ, Kotzin BL. Genetic susceptibility to systemic lupus erythematosus. Annu Rev Immunol 1998; 16: 261-292.
2. Wakeland EK, Liu K, Graham RR, Behrens TW. Delineating the genetic basis of systemic lupus erythematosus. Immunity 2001; 15: 397-408.
3. Hudgins CC, Steinberg RT, Klinman DM, Reeves MJ, Steinberg AD. Studies of consomic mice bearing the Y chromosome of the BXSB mouse. J Immunol 1985; 134: 3849-3854.
4. Liu K, Liang C, Liang Z, Tus K, Wakeland EK. Slelab mediates the aberrant activation of STAT3 and Ras-ERK signaling pathways in B lymphocytes. J Immunol 2005; 174: 1630-1637.
5. Mohan C, Alas E, Morel L, Yang P, Wakeland, EK. Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes. J Clin Invest 1998; 101: 1362-1372.
6. Mohan C, Morel L, Yang P, Wakeland EK. Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity. J Immunol 1997; 159: 454-465.
7. Mohan C, Morel L, Yang P, Watanabe H, Croker B, Gilkeson G et al. Genetic dissection of lupus pathogenesis: A recipe for nephrophilic autoantibodies. J Clin Invest 1999; 103: 1685-1695.
8. Mohan C, Yu Y, Morel L, Yang P, Wakeland EK. Genetic dissection of Sle pathogenesis: Sle3 on murine chromosome 7 impacts T cell activation, differentiation, and cell death. J Immunol 1999; 162: 6492-6502.
9. Morel L, Croker BP, Blenman KR, Mohan C, Huang G, Gilkeson G et al. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proc Natl Acad Sci USA 2000; 97: 6670-6675.
10. Rozzo SJ, Allard JD, Choubey D, Vyse TJ, Izui S, Peltz G et al. Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus. Immunity 2001; 15: 435-443.
11. Zhang D, Fujio K, Jiang Y, Zhao J, Tada N, Sudo K et al. Dissection of the role of MHC class II A and E genes in autoimmune susceptibility in murine lupus models with intragenic recombination. Proc Natl Acad Sci USA 2004; 101: 13838-13843.
12. Morel L, Mohan C, Yu Y, Croker BP, Tian N, Deng A et al. Functional dissection of systemic lupus erythematosus using congenic mouse strains. J Immunol 1997; 158: 6019-6028.
13. Morel L, Tian XH, Croker BP, Wakeland EK. Epistatic modifiers of autoimmunity in a murine model of lupus nephritis. Immunity 1999; 11: 131-139.
14. Morel L, Yu Y, Blenman KR, Caldwell RA, Wakeland EK. Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. Mamm Genome 1996; 7: 335-339.
15. Morel L, Rudofsky UH, Longmate JA, Schiffenbauer J, Wakeland EK. Polygenic control of susceptibility to murine systemic lupus erythematosus. Immunity 1994; 1: 219-229.
16. Shi X, Xie C, Kreska D, Richardson JA, Mohan C. Genetic dissection of SLE: SLE1 and FAS impact alternate pathways leading to lymphoproliferative autoimmunity. J Exp Med 2002; 196: 281-292.
17. Morel L, Mohan C, Yu Y, Schiffenbauer J., Rudofsky UH, Tian N et al. Multiplex inheritance of component phenotypes in a murine model of lupus. Mamm Genome 1999; 10: 176-181.
18. Sobel ES, Morel L, Baert R, Mohan C, Schiffenbauer J, Wakeland EK. Genetic dissection of systemic lupus erythematosus pathogenesis: evidence for functional expression of Sle3/5 by non-T cells. J Immunol 2002; 169: 4025-4032.
19. Bach JF, Koutouzov S, van Endert PM. Are there unique autoantigens, triggering autoimmune diseases? Immunol Rev 1998; 164: 139-155.
20. Hoffman RW, Greidinger EL. Epitope spreading in systemic lupus erythematosus: Comment on the article by Monneaux and Muller. Arthritis Rheum 2003; 48: 582-583.
21. James JA, Harley JB. B-cell epitope spreading in autoimmunity. Immunol Rev 1998; 164: 185-200.
22. McCluskey J, Farris AD, Keech CL, Purcell AW, Rischmueller M, Kinoshita G et al. Determinant spreading: Lessons from animal models and human disease. Immunol Rev 1998; 164: 209-229.
23. Monneaux F, Muller S. Epitope spreading in systemic lupus erythematosus: identification of triggering peptide sequences. Arthritis Rheum 2002; 46: 1430-1438.
24. Sawalha AH, Harley JB. Antinuclear autoantibodies in systemic lupus erythematosus. Curr Opin Rheumatol 2004; 16: 534-540.
25. Singh RR, Hahn BH. Reciprocal T-B determinant spreading develops spontaneously in murine lupus: Implications for pathogenesis. Immunol Rev 1998; 164: 201-208.
26. Kumar KR, Li L, Yan M, Bhaskarabhatla M, Mobley AB, Nguyen C et al. Regulation of B cell tolerance by the lupus susceptibiliiy gene Ly108. Science 2006; 312: 1665-1669.
27. Wandstrat AE, Nguyen C, Limaye N, Chan AY, Subramanian S, Tian XH et al. Association of extensive polymorphisms in the SLAM/CD2 gene duster with murine lupus. Immunity 2004; 21: 769-780.
28. Tokado H, Yumura W, Shiota J, Hirose S, Sato H, Shirai T. Lupus nephritis in autoimmune-prone NZB x NZW F1 mice and mechanisms of transition of the glomerular lesions. Acta Pathol Jpn 1991; 41 1-11.
29. Haraldsson MK, dela Paz NG, Kuan JG, Gilkeson GS, Theofilopoulos AN, Kono DH. Autoimmune alterations induced by the New Zealand Black Lbw2 locus in BWF1 mice. J Immunol 2005; 174: 5065-5073.
30. Mary C, Laporte C, Parzy D, Santiago ML, Stefani F, Lajaunias F et al. Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in Cd22a lupus-prone mice. J Immunol 2000; 165: 2987-2996.
31. Gripenberg M, Helve T. Anti-DNA antibodies of IgA class in patients with systemic lupus erythematosus. Rheumatol Int 1986; 6: 53-55.
32. Miltenburg AM, Roos A, Slegtenhorst L, Daha MR, Breedveld FC. IgA anti-dsDNA antibodies in systemic lupus erythematosus: Occurrence, incidence and association with clinical and laboratory variables of disease activity. J Rheumatol 1993; 20: 53-58.
33. Zhu J, Liu X, Xie C, Yan M, Yu Y, Sobel ES et al. T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells. J Clin Invest 2005; 115: 1869-1878.
34. Xie C, Zhou XJ, Liu X, Mohan C. Enhanced susceptibility to end-organ disease in the lupus-facilitating NZW mouse strain. Arthritis Rheum 2003; 48: 1080-1092.
35. Li QZ, Xie C, Wu T, Mackay M, Aranow C, Putterman C et al. Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays. J Clin Invest 2005; 115: 3428-3439.