Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in Cd22a lupus-prone mice

Journal of Immunology

Volumn 165, Issue 6, 2000, Pages 2987-2996

  Mary, C ^a   Laporte, C ^a   Parzy, D ^a   Santiago, M L ^a   Stefani, F ^a   Lajaunias, F ^a   Parkhouse, R M E ^a   O'Keefe, T L ^a   Neuberger, M S ^a   Izui, S ^a   Reininger, L ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD22 ANTIGEN; MEMBRANE PROTEIN; MESSENGER RNA;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE ACTIVATION; DISEASE PREDISPOSITION; DNA SEQUENCE; GENE EXPRESSION; GENE INSERTION; GENE MAPPING; GENE TARGETING; LUPUS ERYTHEMATOSUS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0034665505     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.6.2987     Document Type: Article

References (52)

1. Spontaneous murine lupus-like syndromes: Clinical and immunopathological manifestations in several strains
2. Increased spontaneous polyclonal activation of B lymphocytes in mice with spontaneous autoimmune disease
3. In vivo and in vitro production of anti-histone antibodies in NZB/NZW mice
4. The basis of autoimmunity. II. Genetic predisposition
5. Genetic dissection of lupus nephritis in murine models of SLE
6. Genetic susceptibility to systemic lupus erythematosus
7. Polygenic control of susceptibility to murine systemic lupus erythematosus
8. Lupus susceptibility loci in New Zealand mice
9. Functional dissection of systemic lupus erythematosus using congenic mouse strains
10. 1 mice
11. 1 male mice, but not in C57BL/6 male mice
12. CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling
13. Phosphotyrosine-dependent association between CD22 and protein tyrosine phosphatase 1C
14. CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-γ1 upon B cell activation
15. Hyperresponsive B cells in CD22-deficient mice
16. Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies
17. Lyb-8.2: A new B cell antigen defined and characterized with a monoclonal antibody
18. Identification and characterization of the mouse homologue of CD22, a B lymphocyte-restricted adhesion molecule
19. Organization of the murine Cd22 locus: Mapping to chromosome 7 and characterization of two alleles
20. Polymorphisms in the Cd22 gene in inbred mouse strains
21. B cell antigen receptor-evoked calcium influx is enhanced in CD22-deficient B cell lines
22. Increased autoantibody production by NZB/NZW B cells in response to IL-5
23. 1 mice
24. Algorithms and thermodynamics for RNA secondary structure prediction: A practical guide
25. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4, or 5 using modified cDNA expression vectors
26. Monoclonal antibodies reactive with the mouse interleukin 5 receptor
27. The autoantigen-binding B cell repertoires of normal and of chronically graft-versus-host-diseased mice
28. Structural features in eukaryotic mRNAs that modulate the initiation of translation
29. Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes
30. Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity
31. 1 mice: Relation to naturally occurring antibodies against murine leukemia virus-related cell surface antigens
32. The GIX antigen system: A cell surface allo-antigen associated with murine leukemia virus
33. Location of the second gene required for expression of the leukemia-associated mouse antigen G(IX)
34. Aberrant splicing caused by the insertion of the B2 sequence into an intron of the complement C4 gene is the basis for low C4 production in H-2(k) mice
35. Highly repeated DNA families in the genome of Mus Musculus
36. Structural organization of glycophorin A and B genes: Glycophorin B gene evolved by homologous recombination at Alu repeat sequences
37. DNA sequence of a class I pseudogene from the Tla region of the murine MHC: Recombination at a B2 alu repetitive sequence
38. Ig domains 1 and 2 of murine CD22 constitute the ligand-binding domain and bind multiple sialylated ligands expressed on B and T cells
39. CD22 regulates thymus-independent responses and the lifespan of B cells
40. CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: Altered signaling in CD22-deficient mice
41. CD22 is a negative regulator of B-cell receptor signalling
42. - bone marrow chimeric mice
43. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease
44. Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice
45. Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice
46. Identification of the tyrosine phosphatase PTP 1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signalling
47. Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection
48. CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity
49. CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes
50. Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection
51. Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain
52. Genetic dissection of Sle pathogenesis: Sle3 on murine chromosome 7 impacts T cell activation, differentiation, and cell death