Wine contamination with ochratoxins: A review

Beverages

Volumn 4, Issue 1, 2018, Pages

  Gil Serna, Jessica ^a   Vázquez, Covadonga ^a   González Jaén, María Teresa ^a   Patiño, Belén ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

D0toxification; Grapes; Legislation; Ochratoxins; Wine

Indexed keywords

EID: 85044590122     PISSN: None     EISSN: 23065710     Source Type: Journal    
DOI: 10.3390/beverages4010006     Document Type: Review

References (150)

1. Gil-Serna, J.; Vázquez, C.; Sardiñas, N.; González-Jaén, M.T.; Patiño, B. Revision of ochratoxin A production capacity by the main species of Aspergillus section Circumdati. Aspergillus steynii revealed as the main risk of OTA contamination. Food Control 2011, 22, 343-345.
2. El Khoury, A.; Atoui, A. Ochratoxin A: General overview and actual molecular status. Toxins 2010, 2, 461-493.
3. Palumbo, J.D.; O’Keeffe, T.L. Detection and discrimination of four Aspergillus section Nigri species by PCR. Lett. Appl. Microbiol. 2015, 60, 188-195.
4. Gil-Serna, J.; Vázquez, C.; González-Jaén, M.T.; Patiño, B. Mycotoxins: Toxicology. In Encyclopedia of Food Microbiology, 2nd ed.; Batt, C., Tortorello, M.L., Eds.; Elsevier Ltd. Academic Press: Amsterdam, The Netherlands, 2014; pp. 887-892. ISBN 978-0-12-384733-1.
5. International Agency for Research on Cancer (IARC). Some naturally occurring substances: Food items and constituents, heterocyclic aromatic amines and mycotoxins. IARC Monogr. Eval. Carcinog. Risks Hum. 1993, 56, 245-395.
6. Zimmerli, B.; Dick, R. Ochratoxin A in table wine and grape juice: Occurrence and risk assessment. Food Addit. Contam. 1996, 13, 655-668.
7. Blesa, J.; Soriano, J.M.; Moltó, J.C.; Mañes, J. Factors affecting the presence of ochratoxin A in wines. Crit. Rev. Food Sci. 2006, 46, 473-478.
8. European Commission. Commission Regulation EC No 1881/2006 setting maximum levels for certain contaminants in foodstuffs. Off. J. Eur. Union 2006, 364, 5-24.
9. Anli, R.E.; Bayram, M. Ochratoxin A in wines. Food Rev. Int. 2009, 25, 214-232.
10. Cabañes, F.J.; Accensi, F.; Bragulat, M.R.; Abarca, M.L.; Castellá, G.; Minguez, S.; Pons, A. What is the source of ochratoxin A in wine? Int. J. Food Microbiol. 2002, 79, 213-215.
11. Varga, J.; Kozakiewicz, Z. Ochratoxin A in grapes and grape derived products. Trends Food Sci. Technol. 2006, 17, 72-81.
12. Bau, M.; Bragulat, M.R.; Abarca, M.L.; Minguez, S.; Cabañes, F.J. Ochratoxigenic species from Spanish wine grapes. Int. J. Food Microbiol. 2005, 98, 125-130.
13. Bellí, N.; Bau, M.; Marín, S.; Abarca, M.L.; Ramos, A.J.; Bragulat, R. Mycobiota and ochratoxin A producing fungi from Spanish wine grapes. Int. J. Food Microbiol. 2006, 111, S40-S45.
14. García-Cela, E.; Crespo-Sempere, A.; Gil-Serna, J.; Porqueres, A.; Marín, S. Fungal diversity, incidence and mycotoxin contamination in grapes from two agro-climatic Spanish regions with emphasis on Aspergillus species. J. Sci. Food Agric. 2014, 95, 1716-1729.
15. Serra, R.; Abrunhosa, L.; Kozakiewicz, Z.; Venancio, A. Black Aspergillus species as ochratoxin A producers in Portuguese wine grapes. Int. J. Food Microbiol. 2003, 88, 63-68.
16. Serra, R.; Mendoça, C.; Venancio, A. Ochratoxin A occurrence and formation in Portuguese wine grapes at various stages of maturation. Int. J. Food Microbiol. 2006, 111, S35-S39.[Green Version]
17. Bejaoui, H.; Mathieu, F.; Taillandier, P.; Lebrihi, A. Black Aspergilli and ochratoxin A production in French vineyards. Int. J. Food Microbiol. 2006, 111, S46-S52.[Green Version]
18. Dachoupakan, C.; Ratomahenina, R.; Martinez, V.; Guiraud, J.P.; Baccou, J.C.; Schorr-Galindo, S. Study of the phenotypic and genotypic biodiversity of potentially ochratoxigenic black aspergilli isolated from grapes. Int. J. Food Microbiol. 2009, 132, 14-23.
19. Battilani, P.; Pietri, A.; Bertuzzi, T.; Languasco, L.; Giorni, P.; Kozakiewicz, Z. Occurrence of ochratoxin A—Producing fungi in grapes grown in Italy. J. Food Prot. 2003, 66, 633-636.
20. Battilani, P.; Giorni, P.; Bertuzzi, T.; Formenti, S.; Pietri, A. Black Aspergilli and ochratoxin A in grapes in Italy. Int. J. Food Microbiol. 2006, 111, S53-S60.
21. Tjamos, S.E.; Antoniou, P.P.; Tjamos, E.C. Aspergillus spp., distribution, population composition and ochratoxin A production in wine producing vineyards in Greece. Int. J. Food Microbiol. 2006, 111, S61-S66.
22. Lasram, S.; Oueslati, S.; Mliki, A.; Ghorbel, A.; Silar, P.; Chebil, S. Ochratoxin A and ochratoxigenic black Aspergillus species in Tunisian grapes cultivated in different geographic areas. Food Control 2012, 25, 75-80.
23. Fredj, S.M.; Chebil, S.; Mliki, A. Isolation and characterization of ochratoxin A and aflatoxin B1 producing fungi infecting grapevines cultivated in Tunisia. Afr. J. Microbiol. Res. 2009, 3, 523-527.
24. El Khoury, A.; Rizk, T.; Lteif, R.; Azouri, H.; Delia, M.L.; Lebrihi, A. Fungal contamination and aflatoxin B1 and ochratoxin A in Lebanese wine-grapes and musts. Food Chem. Toxicol. 2008, 46, 2244-2250.
25. Chulze, S.N.; Magnoli, C.E.; Dalcero, A.M. Occurrence of ochratoxin A in wine and ochratoxigenic mycoflora in grapes and dried vine fruits in South America. Int. J. Food Microbiol. 2006, 111, S5-S9.
26. Leong, S.L.; Hocking, A.D.; Pitt, J.I.; Kazi, B.A.; Emmett, R.W.; Scott, E.S. Australian research on ochratoxigenic fungi and ochratoxin A. Int. J. Food Microbiol. 2006, 111, S10-S17.
27. Da Rocha, C.A.; Palacios, V.; Combina, M.; Fraga, M.E.; De Oliveira, A.; Magnoli, C.E.; Dalcero, A.M. Potential ochratoxin A producers from wine grapes in Argentina and Brazil. Food Addit. Contam. 2002, 19, 408-414.
28. Magnoli, C.; Violante, M.; Combina, M.; Palacio, G.; Dalcero, A. Mycoflora and ochratoxin-producing strains of Aspergillus section Nigri in wine grapes in Argentina. Lett. Appl. Microbiol. 2003, 37, 179-184.
29. Chiotta, M.L.; Ponsone, M.L.; Combina, M.; Torres, A.M.; Chulze, S.N. Aspergillus section Nigri species isolated from different wine-grape growing regions in Argentina. Int. J. Food Microbiol. 2009, 136, 137-141.
30. Pantelides, I.S.; Aristeidou, E.; Lazari, M.; Tsolakidou, M.D.; Tsaltas, D.; Christofidou, M.; Kafouris, D.; Christou, E.; Ioannou, N. Biodiversity and ochratoxin A profile of Aspergillus section Nigri populations isolated from wine grapes in Cyprus vineyards. Food Microbiol. 2017, 67, 106-115.
31. Medina, A.; Mateo, R.; López-Ocaña, L.; Valle-Algarra, F.M.; Jiménez, M. Study of Spanish grape mycobiota and ochratoxin A production by isolates of Aspergillus tubingensis and other members of Aspergillus section Nigri. Appl. Environ. Microbiol. 2006, 71, 4696-4702.
32. Garmendia, G.; Vero, S. Occurrence and biodiversity of Aspergillus section Nigri on ‘Tannat’ grapes in Uruguay. Int. J. Food Microbiol. 2016, 216, 31-39.
33. Qi, T.F.; Renaud, J.B.; McDowell, T.; Seifert, K.A.; Yeung, K.K.C.; Sumarah, M.W. Diversity of Mycotoxin-Producing Black Aspergilli in Canadian Vineyards. J. Agric. Food Chem. 2016, 64, 1583-1589.
34. Perrone, G.; Varga, J.; Susca, A.; Frisvad, J.C.; Stea, G.; Kocsube, S.; Kozakiewicz, Z.; Samson, R.A. Aspergillus uvarum sp. nov., an uniseriate black Aspergillus species isolated from grapes in Europe. Int. J. Syst. Evol. Microbiol. 2007, 58, 1032-1039.
35. Hocking, A.D.; Leong, S.L.; Kazi, B.A.; Emmett, R.W.; Scott, E.S. Fungi and mycotoxins in vineyards and grape products. Int. J. Food Microbiol. 2007, 119, 84-88.
36. Valero, A.; Begum, M.; Leong, S.L.; Hocking, A.D.; Ramos, A.J.; Sanchis, V.; Marín, S. Effect of germicidal UVC light on fungi isolated from grapes and raisins. Lett. Appl. Microbiol. 2007, 45, 238-243.
37. Bellí, N.; Marín, S.; Sanchis, V.; Ramos, A.J. Influence of water activity and temperature on growth of isolates of Aspergillus section Nigri obtained from grapes. Int. J. Food Microbiol. 2004, 96, 19-27.
38. Mitchell, D.; Parra, R.; Aldred, D.; Magan, N. Water and temperature relations of growth and ochratoxin A production by Aspergillus carbonarius strains from grapes in Europe and Israel. J. Appl. Microbiol. 2004, 97, 439-445.
39. Leong, S.L.; Hocking, A.D.; Scott, E.S. Effect of temperature and water activity on growth and ochratoxin A production by Australian Aspergillus carbonarius and A. niger isolates on a simulated grape juice medium. Int. J. Food Microbiol. 2006, 110, 209-216.
40. Marín, S.; Bellí, N.; Lasram, S.; Chebil, S.; Ramos, A.J.; Ghorbel, A.; Sanchis, V. Kinetics of ochratoxin A production and accumulation by Aspergillus carbonarius on synthetic grape medium at different temperature levels. J. Food Sci. 2006, 71, M196-M200.
41. Lucchetta, G.; Bazzo, I.; Dal Cortivo, G.; Stringher, L.; Bellotto, D.; Borgo, M.; Angelini, E. Occurrence of black Aspergilli and ochratoxin A on grapes in Italy. Toxins 2010, 2, 840-855.
42. Ponsone, M.L.; Chiotta, M.L.; Combina, M.; Torres, A.; Knass, P.; Dalcero, A.; Chulze, S.N. Natural occurrence of ochratoxin A in musts, wines and grape vine fruits from grapes harvested in Argentina. Toxins 2010, 2, 1984-1996.
43. Hocking, A.D.; Varelis, P.; Pitt, J.I.; Cameron, S.F.; Leong, S.L. Occurrence of ochratoxin A in Australian wine. Aust. J. Grape Wine Res. 2003, 9, 72-78.
44. Ng, W.; Mankotia, M.; Pantazopoulos, P.; Neil, R.J.; Scott, P.M. Ochratoxin A in wine and grape juice sold in Canada. Food Addit. Contam. 2004, 21, 971-981.
45. Vega, M.; Ríos, G.; Baer, D.; Mardones, C.; Tessini, C.; Herlitz, E.; Saelzer, R.; Ruiz, M.A. Ochratoxin A occurrence in wines produced in Chile. Food Control 2012, 28, 147-150.
46. Wu, J.; Tan, Y.; Wang, Y.; Xu, R. Occurrence of ochratoxin A in wine and beer samples from China. Food Addit. Contam. B 2011, 4, 52-56.
47. Zhang, X.; Chen, L.; Li, J.; Zhu, B.; Ma, L. Occurrence of ochratoxin A in Chinese wines: Influence of local meteorological parameters. Eur. Food Res. Technol. 2013, 236, 277-283.
48. Mikulikova, R.; Belakova, S.; Benesoba, K.; Svoboda, Z. Study of ochratoxin A content in South Moravian and foreign wines by the UPLC method with fluorescence detection. Food Chem. 2012, 133, 55-59.
49. Burdaspal, P.; Legarda, T. Occurrence of ochratoxin A in sweet wines produced in Spain and other countries. Food Addit. Contam. 2007, 24, 976-986.
50. Stefanaki, I.; Foufa, E.; Tsatsou-Dritsa, A.; Dais, P. Ochratoxin A concentrations in Greek domestic wines and dried vine fruits. Food Addit. Contam. 2003, 20, 74-83.
51. Soufleros, E.H.; Tricard, C.; Bouloumpasi, E.C. Occurrence of ochratoxin A in Greek wines. J. Sci. Food Agric. 2003, 83, 173-179.
52. Labrinea, E.P.; Natskoulis, P.I.; Spiropoulos, A.E.; Magan, N.; Tassou, C.C. A survey of ochratoxin A occurrence in Greek wines. Food Addit. Contam. B 2011, 4, 61-66.
53. Varga, J.; Kiss, R.; Mátrai, T.; Mátrai, T.; Téren, J. Detection of ochratoxin A in Hungarian wines and beers. Acta Aliment. 2005, 34, 381-392.
54. Pietri, A.; Bertuzzi, T.; Pallaroni, L.; Piva, G. Occurrence of ochratoxin A in Italian wines. Food Addit. Contam. 2001, 18, 647-654.
55. Spadaro, D.; Lorè, A.; Garibaldi, A.; Gullino, M.L. Occurrence of ochratoxin A before bottling in DOC and DOCG wines produced in Piedmont (Northern Italy). Food Control 2010, 21, 1294-1297.
56. Visconti, A.; Pascale, M.; Centonze, G. Determination of ochratoxin A in wine by means of immunoaffinity column clean-up and high-performance liquid chromatography. J. Chromatogr. A 1999, 864, 89-101.
57. Brera, C.; Debegnach, F.; Minardi, V.; Prantera, E.; Pannunzi, E.; Faleo, S.; De Santis, B.; Miraglia, M. Ochratoxin A contamination in Italian wine samples and evaluation of the exposure in the Italian population. J. Agric. Food Chem. 2008, 56, 10611-10618.
58. Di Stefano, V.; Pitonzo, R.; Avellone, G.; Di Fiore, A.; Monte, L.; Ogorka, A.Z. Determination of aflatoxins and ochratoxins in Sicilian Sweet Wines by High-Performance Liquid Chromatography with Fluorometric Detection and Immunoaffinity Cleanup. Food Anal. Method 2015, 8, 569-577.
59. Rotaru, S.; Israel-Roming, F.; Campeanu, G.; Deciu, G. Correlation of ochratoxin A level in wine with vine environment. Rom. Biotechnol. Lett. 2011, 16, 126-130.
60. Bellí, N.; Marín, S.; Duaigües, A.; Ramos, A.J.; Sanchis, V. Ochratoxin A in wines, musts and grape juices from Spain. J. Sci. Food Agric. 2004, 84, 591-594.
61. Quintela, S.; Villarán, M.C.; López de Armentia, I.; Elejalde, E. Occurrence of ochratoxin A in Rioja Alavesa wines. Food Chem. 2011, 126, 302-305.
62. Murillo-Arbizu, M.T.; Amézqueta, S.; González-Peñas, E.; López de Cerain, A. Occurrence of Ochratoxin A in Southern Spanish Generous Wines under the Denomination of Origin “Jerez-Xérès-Sherry and Manzanilla Sanlúcar de Barrameda”. Toxins 2010, 2, 1054-1064.
63. Shepard, G.S.; Fabiani, A.; Stockenstro, S.; Mschicileli, N.; Sewram, V. Quantitation of ochratoxin A in South African wines. J. Agric. Food Chem. 2003, 51, 1102-1106.
64. Stander, M.A.; Steyn, P.S. Survey of ochratoxin A in South African wines. S. Afr. J. Enol. Vitic. 2002, 23, 9-13.
65. Var, I.; Kabak, B. Occurrence of ochratoxin A in Turkish wines. Microchem. J. 2007, 86, 241-247.
66. Grazioli, B.; Fumi, M.D.; Silva, A. The role of processing on ochratoxin A content in Italian must and wine: A study on naturally contaminated grapes. Int. J. Food Microbiol. 2006, 111, S93-S96.
67. Miraglia, M.; Brera, C. Task 3.2.7. Assessment of Dietary Intake of Ochratoxin A by the Population of EU Member States. 2002. Available online: Https://ec.europa.eu/food/sites/food/files/safety/docs/cs_contaminants_catalogue_ochratoxin_task_3-2-7_en.pdf (accessed on 25 October 2017).
68. Otteneder, H.; Majerus, P. Occurrence of ochratoxin A (OTA) in wines: Influence of the type of wine and its geographical origin. Food Addit. Contam. 2000, 17, 793-798.
69. Remiro, R.; Irigoyen, A.; González-Peñas, E.; Lizarraga, E.; López de Cerain, A. Levels of ochratoxin in Mediterranean red wines. Food Control 2013, 32, 63-68.
70. Cozzi, G.; Pascale, M.; Perrone, G.; Visconti, A.; Logrieco, A. Effect of Lobesia botrana damages on black aspergilli rot and ochratoxin A content in grapes. Int. J. Food Microbiol. 2006, 111, S88-S92.
71. Covarelli, L.; Beccari, G.; Marini, A.; Tosi, L. A review on the occurrence and control of ochratoxigenic fungal species and ochratoxin A in dehydrated grapes, non-fortified dessert wines and dried vine fruit in the Mediterranean area. Food Control 2012, 26, 347-356.
72. Cozzi, G.; Haidukowski, M.; Perrone, G.; Visconti, A.; Logrieco, A. Influence of Lobesia botrana field control on black aspergilli rot and ochratoxin A contamination in grapes. J. Food Prot. 2009, 72, 894-897.
73. Cozzi, G.; Somma, S.; Haidukowski, M.; Logrieco, A. Ochratoxin A management in vineyards by Lobesia botrana biocontrol. Toxins 2013, 5, 49-59.
74. The Joint FAO/WHO Expert Committee on Food Additives (JECFA). Safety Evaluation of Certain Food Additives and Contaminants. Ochratoxin A. WHO Food Additives Series 2008, No. 59. Available online: Http://apps.who.int/iris/bitstream/ 10665/43823/1/9789241660594_eng.pdf (accessed on 25 October 2017).
75. López de Cerain, A.; González-Peñas, E.; Jiménez, A.M.; Bello, J. Contribution to the study of ochratoxin A in Spanish wines. Food Addit. Contam. 2002, 19, 1058-1064.
76. Clouvel, P.; Bonvarlet, L.; Martínez, A.; Lagouarde, P.; Dieng, I.; Martin, P. Wine contamination by ochratoxin A in relation to vine environment. Int. J. Food Microbiol. 2008, 123, 74-80.
77. Paterson, M.; Venancio, A.; Lima, N.; Guilloux-Bénatier, M.; Rousseaux, S. Predominant mycotoxins, mycotoxigenic fungi and climate change related to wine. Food Res. Int. 2017, in press.
78. Gambuti, A.; Strollo, D.; Genovese, A.; Ugliano, M.; Ritieni, A.; Moio, L. Influence of enological practices on ochratoxin A concentration in wine. Am. J. Enol. Vitic. 2005, 56, 155-162.
79. Food and Agriculture Organization (FAO). Manual on the Application of the HACCP System in Mycotoxin Prevention and Control; FAO Food and Nutrition Paper; Food and Agriculture Organization: Roma, Italy, 2001; Volume 73, pp. 1-124. Available online: Http://www.fao.org/3/a-y1390e.pdf (accessed on 25 October 2017).
80. International Organization of Vine and Wine (OIV). Resolution VITI/OENO 1/2005. Code of Sound Vitivinicultural Practices in Order to Minimise Levels of Ochratoxin A in Vine-Based Products. 2005. Available online: Http://www.oiv.int/public/medias/2771/viti-oeno-1-2005-en.pdf (accessed on 25 October 2017).
81. Chiodini, A.M.; Scherpenisse, P.; Bergwerff, A.A. Ochratoxin A contents in wine: Comparison of organically and conventionally produced products. J. Agric. Food Chem. 2006, 54, 7399-7404.
82. Lasram, S.; Mani, A.; Zaied, C.; Chebil, S.; Abid, S.; Bacha, H.; Mliki, A.; Ghorbel, A. Evolution of ochratoxin A content during red and rose vinification. J. Sci. Food Agric. 2008, 88, 1696-1703.
83. Bellver, J.; Fernández-Franzón, M.; Ruiz, M.J.; Juan-García, A. Presence of ochratoxin A (OTA) mycotoxin in alcoholic drinks from Southern European countries: Wine and beer. J. Agric. Food Chem. 2014, 62, 7643-7651.
84. Battilani, P.; Pietri, A. Ochratoxin A in grapes and wine. Eur. J. Plant Pathol. 2002, 108, 639-643.
85. Battilani, P.; Magan, N.; Logrieco, A. European research on ochratoxin A in grapes and wine. Int. J. Food Microbiol. 2006, 11, S2-S4.
86. Leong, S.L.; Hocking, A.D.; Varelis, P.; Giannikopoulos, G.; Scott, E.S. Fate of ochratoxin A during vinification of Semillon and Shiraz grapes. J. Agric. Food Chem. 2006, 54, 6460-6464.
87. Dachery, B.; Fonseca, F.; Dal Magro, L.; Manfroi, V.; Welke, J.E. Exposure risk assessment to ochratoxin A through consumption of juice and wine considering the effect of steam extraction time and vinification stages. Food Chem. Toxicol. 2017, 109, 237-244.
88. Csutorás, C.; Rácz, L.; Rácz, K.; Futo, P.; Forgó, P.; Kiss, A. Monitoring ochratoxin A during fermentation of different wines by applying high toxin concentrations. Microchem. J. 2013, 107, 182-184.
89. Fernandes, A.; Ratola, N.; Cerdeira, A.; Alves, A.; Venancio, A. Changes in ochratoxin A concentration during winemaking. Am. J. Enol. Vitic. 2007, 58, 92-96.
90. Esti, M.; Benucci, I.; Liburdi, K.; Acciaro, G. Monitoring of ochratoxin A fate during alcoholic fermentation of wine-must. Food Control 2012, 27, 53-56.
91. Caridi, A.; Galvano, F.; Tafuri, A.; Ritieni, A. Ochratoxin A removal during winemaking. Enzyme Microb. Technol. 2006, 40, 122-126.
92. Cecchini, F.; Morassut, M.; García-Moruno, E.; Di Stefano, R. Influence of yeast strain on ochratoxin A content during fermentation of white and red must. Food Microbiol. 2006, 23, 411-417.
93. Meca, G.; Blaiotta, G.; Ritieni, A. Reduction of ochratoxin A during the fermentation of Italian red wine Moscato. Food Control 2010, 21, 579-583.
94. Del Prete, V.; Rodríguez, H.; Carrascosa, A.V.; De las Rivas, B.; García-Moruno, E.; Muñoz, R. In vitro removal of ochratoxin A by wine lactic acid bacteria. J. Food Prot. 2007, 70, 2155-2160.
95. Mateo, E.M.; Medina, A.; Mateo, F.; Valle-Algarra, F.M.; Pardo, I.; Jiménez, M. Ochratoxin A removal in synthetic media by living and heat-inactivated cells of Oenococcus oeni isolated from wines. Food Control 2010, 21, 23-28.[Green Version]
96. Abrunhosa, L.; Ines, A.; Rodrigues, A.I.; Guimaraes, A.; Pereira, V.L.; Parpot, P.; Mendes-Faia, A.; Venancio, A. Biodegradation of ochratoxin A by Pediococcus parvulus isolated from Douro wines. Int. J. Food Microbiol. 2014, 188, 45-52.[Green Version]
97. Leong, S.L.; Hocking, A.D.; Scott, E.S. The effect of juice clarification, static or rotary fermentation and fining on ochratoxin A in wine. Aust. J. Grape Wine Res. 2006, 12, 245-251.
98. García-Moruno, E.; Sanlorenzo, C.; Boccaccino, B.; Di Stefano, R. Treatment with yeast to reduce the concentration of ochratoxin A in red wine. Am. J. Enol. Vitic. 2005, 56, 73-76.
99. Castellari, M.; Versari, A.; Fabiani, A.; Parpinello, G.P.; Galassi, S. Removal of ochratoxin A in red wines by means of adsorption treatments with commercial fining agents. J. Agric. Food Chem. 2001, 49, 3917-3921.
100. Var, I.; Kabak, B.; Erginkaya, Z. Reduction in ochratoxin A levels in white wine, following treatment with activated carbon and sodium bentonite. Food Control 2008, 19, 592-598.
101. Anli, R.E.; Vural, N.; Bayram, M. Removal of ochratoxin A (OTA) from naturally contaminated wines during the vinification process. J. Inst. Brew. 2011, 117, 456-461.
102. Quintela, S.; Villarán, M.C.; López de Armentia, I.; Elejalde, E. Ochratoxin A removal from red wine by several oenological fining agents: Bentonite, egg albumin, allergen-free adsorbents, chitin and chitosan. Food Addit. Contam. A 2012, 29, 1168-1174.
103. Sun, X.; Niu, Y.; Ma, T.; Xu, P.; Huang, W.; Zhan, J. Determination, content analysis and removal efficiency of fining agents on ochratoxin A in Chinese wines. Food Control 2017, 73, 382-392.
104. Bornet, A.; Teissedre, P.L. Chitosan, chitin-glucan and chitin effects on minerals (iron, lead, cadmium) and organic (ochratoxin A) contaminants in wines. Eur. Food Res. Technol. 2008, 226, 681-689.
105. Kurtbay, H.M.; Bekçi, Z.; Merdivan, M.; Yurdakoç, K. Reduction of ochratoxin A levels in red wine by bentonite, modified bentonites and chitosan. J. Agric. Food Chem. 2008, 56, 2541-2545.
106. Quintela, S.; Villarán, M.C.; López de Armentia, I.; Elejalde, E. Ochratoxin A removal in wine: A review. Food Control 2013, 30, 439-445.
107. Varga, J.; Kocsubé, S.; Péteri, Z.; Vágvölgyi, C.; Tóth, B. Chemical, physical and biological approaches to prevent ochratoxin induced toxicoses in humans and animals. Toxins 2010, 2, 1718-1750.
108. European Council. Council Regulation EC No 1493/1999 on the common organization of the market in wine. Off. J. Eur. Communities 1999, 179, 1-84.
109. International Organization of Vine and Wine (OIV). Resolution OIV/OENO 338A/2009. Wines-Treatment Using Chitosan. 2009. Available online: Http://www.oiv.int/public/medias/3551/f-code-ii-3416.pdf (accessed on 25 October 2017).
110. International Organization of Vine and Wine (OIV). Resolution OIV/OENO 338B/2009. Wines-Treatment Using Chitin Glucane. 2009. Available online: Http://www.oiv.int/public/medias/3553/f-code-ii-3417.pdf (accessed on 25 October 2017).
111. The Joint FAO/WHO Expert Committee on Food Additives (JECFA). Safety Evaluation of Certain Mycotoxins in Food. WHO Food Additives Series 2001, No. 47. Available online: Http://www.fao.org/3/a-bc528e.pdf (accessed on 25 October 2017).
112. European Commission. Commission Regulation EC No 401/2006 laying down the methods of sampling and analysis for the official control of the levels of mycotoxins in foodstuffs. Off. J. Eur. Union 2006, 70, 12-70.
113. European Food Safety Authority (EFSA). Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to ochratoxin A in food. EFSA J. 2006, 365, 1-56.
114. VICAM. Global Mycotoxin Regulations. Available online: Https://play.google.com/store/apps/details?id=com.vicam.Regulations (accessed on 25 October 2017).
115. National Health and Family Planning Commission (NHFPC). Maximum Levels of Mycotoxins in Food (GB 2761-2017). 2017. Available online: Http://www.nhfpc.gov.cn/sps/s7891/201704/b83ad058ff544ee39dea811264878981.shtml (accessed on 25 October 2017).
116. Bellí, N.; Marín, S.; Sanchis, V.; Ramos, A.J. Impact of fungicides on Aspergillus carbonarius growth and ochratoxin A production on synthetic grape-like medium and on grapes. Food Addit. Contam. 2006, 23, 1021-1029.
117. Medina, A.; Mateo, R.; Valle-Algarra, F.; Mateo, E.M.; Jiménez, M. Effect of carbendazim and physicochemical factors on the growth and ochratoxin A production of Aspergillus carbonarius isolated from grapes. Int. J. Food Microbiol. 2007, 119, 230-235.
118. Tjamos, S.E.; Antoniou, P.P.; Kazantzidou, A.; Antonopoulos, D.F.; Papageorgiou, I.; Tjamos, E.C. Aspergillus niger and Aspergillus carbonarius in Corinth raisin and wine-producing vineyards in Greece: Population composition, ochratoxin A production and chemical control. J. Phytopathol. 2004, 152, 250-255.
119. Bellí, N.; Marín, S.; Argilés, E.; Ramos, A.J.; Sanchis, V. Effect of chemical treatments on ochratoxigenic fungi and common mycobiota of grapes (Vitis vinifera). J. Food Prot. 2007, 70, 157-163.
120. Medina, A.; Jiménez, M.; Mateo, R.; Magan, N. Efficacy of natamycin for control of growth and ochratoxin A production by Aspergillus carbonarius strains under different environmental conditions. J. Appl. Microbiol. 2007, 103, 2234-2239.
121. Tian, J.; Wang, Y.; Zeng, H.; Li, Z.; Zhang, P.; Tessema, A.; Peng, X. Efficacy and possible mechanisms of perillaldehyde in control of Aspergillus niger causing grape decay. Int. J. Food Microbiol. 2015, 202, 27-34.
122. Favilla, M.; Pascale, M.; Ricelli, A.; Evidente, A.; Amalfitano, C.; Altomare, C. Inhibition of species of the Aspergillus section Nigri and ochratoxin production in grapes by fusapyrone. Appl. Environ. Microbiol. 2008, 74, 2248-2253.
123. Zhang, H.; Apaliya, M.T.; Mahunu, G.K.; Chen, L.; Li, W. Control of ochratoxin A-producing fungi in grape berry by microbial antagonists: A review. Trends Food Sci. Technol. 2016, 51, 88-97.
124. Bleve, G.; Grieco, F.; Cozzi, G.; Logrieco, A.; Visconti, A. Isolation of epiphytic yeast with potential biocontrol of Aspergillus carbonarius and A. niger on grape. Int. J. Food Microbiol. 2006, 108, 204-209.
125. Ponsone, M.L.; Chiotta, M.L.; Combina, M.; Dalcero, A.; Chulze, S. Biocontrol as a strategy to reduce the impact of ochratoxin A and Aspergillus section Nigri in grapes. Int. J. Food Microbiol. 2011, 151, 70-77.
126. Fiori, S.; Urgeghe, P.P.; Hammami, W.; Razzu, S.; Jaoua, S.; Migueli, Q. Biocontrol activity of four non- and low-fermenting yeast strains against Aspergillus carbonarius and their ability to remove ochratoxin A from grape juice. Int. J. Food Microbiol. 2014, 189, 45-50.
127. Pantelides, I.S.; Christou, O.; Tsolakidou, D.; Tsaltas, D.; Ioannou, N. Isolation, identification and in vitro screening of grapevine yeast for the control of black Aspergilli on grapes. Biol. Control 2015, 88, 46-53.
128. Dimakopoulou, M.; Tjamos, S.E.; Antoniou, P.P.; Pietri, A.; Battilani, P.; Avramidis, N.; Markakis, E.A.; Tjamos, E.C. Phyllosphere grapevine yeast Aureobasidium pullulans reduce Aspergillus carbonarius (sour rot) incidence in wine-producing vineyards in Greece. Biol. Control 2008, 46, 158-165.
129. Ponsone, M.L.; Nally, M.C.; Chiotta, M.L.; Combina, M.; Köhl, J.; Chulze, S.N. Evaluation of the effectiveness of potential biocontrol yeasts against black sour rot and ochratoxin A occurring under greenhouse and field grape production conditions. Biol. Control 2016, 103, 78-85.
130. De Curtis, F.; de Felice, D.V.; Ianiri, G.; De Cicco, V.; Castoria, R. Environmental factors affect the activity of biocontrol agents against ochratoxigenic Aspergillus carbonarius on wine grape. Int. J. Food Microbiol. 2012, 159, 17-24.
131. Solfrizzo, M.; Avantaggiato, G.; Panzarini, G.; Visconti, A. Removal of ochratoxin A from contaminated red wines by repassage over grape pomaces. J. Agric. Food Chem. 2010, 58, 317-323.
132. Farbo, M.G.; Urgeghe, P.P.; Fiori, S.; Marceddu, S.; Jaoua, S.; Migueli, Q. Adsorption of ochratoxin A from grape juice by yeast cells immobilised in calcium alginate beads. Int. J. Food Microbiol. 2015, 217, 29-34.
133. Bejaoui, H.; Mathieu, F.; Taillandier, P.; Lebrihi, A. Ochratoxin A removal in synthetic and natural grape juices by selected oenological Saccharomyces strains. J. Appl. Microbiol. 2004, 97, 1038-1044.
134. Petruzzi, L.; Baiano, A.; De Gianni, A.; Sinigaglia, M.; Corbo, M.R.; Bevilacqua, A. Differential adsorption of ochratoxin A and anthocyanins by inactivated yeasts and yeast cell walls during simulation of wine aging. Toxins 2015, 7, 4350-4365.
135. European Committee for Standardization. CSN EN 14133—Foodstuffs—Determination of Ochratoxin A in Wine and Beer—HPLC with Immunoaffinity Column Clean-Up; Czech Office for Standards, Metrology and Testing: Praha, Czech Republic, 2009.
136. Brera, C.; Grossi, S.; De Santis, B.; Miraglia, M. Automated HPLC method for the determination of ochratoxin A in wine samples. J. Liq. Chromatogr. Relat. Technol. 2003, 26, 119-133.
137. Giraudi, G.; Ferrero, V.E.V.; Anfossi, L.; Baggiani, C.; Giovannoli, C.; Tozzi, C. Solid-phase extraction of ochratoxin A from wine based on a binding hexapeptide prepared by combinatorial synthesis. J. Chromatogr. 2007, 1175, 174-180.
138. Cao, J.; Kong, W.; Zhou, S.; Yin, L.; Wan, L.; Yang, M. Molecularly imprinted polymer-based solid phase clean-up for analysis of ochratoxin A in beer, red wine, and grape juice. J. Sep. Sci. 2013, 36, 1291-1297.
139. Hernández, M.J.; García-Moreno, M.V.; Durán, E.; Guillén, D.; Barroso, G. Validation of two analytical methods for the determination of ochratoxin A by reversed-phased high-performance liquid chromatography coupled to fluorescence detection in must and sweet wines from Andalusia. Anal. Chim. Acta 2006, 566, 117-121.
140. Longobardi, F.; Iacovelli, V.; Catucci, L.; Panzarini, G.; Pascale, M.; Visconti, A.; Agostiano, A. Determination of ochratoxin A in wine by means of immunoaffinity and aminopropyl solid-phase column cleanup and fluorometric detection. J. Agric. Food Chem. 2013, 61, 1604-1608.
141. Dall’Asta, C.; Galaverna, G.; Dossena, A.; Marchelli, R. Reversed-phase liquid chromatographic method for the determination of ochratoxin A in wine. J. Chromatogr. A 2004, 1024, 275-279.
142. García-Fonseca, S.; Ballesteros-Gómez, A.; Rubio, S.; Pérez-Bendito, D. Coacervate extraction of ochratoxin A in wines prior to liquid chromatography/fluorescence determination. Anal. Chim. Acta 2008, 617, 3-10.
143. Vidal, J.C.; Bonel, L.; Ezquerra, A.; Duato, P.; Castillo, J.R. An electrochemical immunosensor for ochratoxin A determination in wines based on a monoclonal antibody and paramagnetic microbeads. Anal. Bioanal. Chem. 2012, 403, 1585-1593.
144. Fernandes, P.J.; Barros, N.; Camara, J.S. A survey of the occurrence of ochratoxin A in Madeira wines based on a modified QuEChERS extraction procedure combined with liquid chromatography-triple quadrupole tandem mass spectrometry. Food Res. Int. 2013, 54, 293-301.
145. Zezza, F.; Longobardi, F.; Pascale, M.; Eremin, S.A.; Visconti, A. Fluorescence polarization immunoassay for rapid screening of ochratoxin A in red wine. Anal. Bioanal. Chem. 2009, 395, 1317-1323.
146. Arroyo-Manzanares, N.; Gámiz-Gracia, L.; García-Campaña, A.M. Determination of ochratoxin A in wines by capillary liquid chromatography with laser induced fluorescence detection using dispersive liquid-liquid microextraction. Food Chem. 2012, 135, 368-372.
147. Barthelmebs, L.; Jonca, J.; Hayat, A.; Prieto-Simon, B.; Marty, J.L. Enzyme-Linked Aptamer Assays (ELAAs), based on a competition format for a rapid and sensitive detection of ochratoxin A in wine. Food Control 2011, 22, 737-743.
148. Yin, X.; Wang, S.; Liu, X.; He, C.; Tang, Y.; Li, Q.; Liu, Q.; Su, H.; Tan, T.; Dong, Y. Aptamer-based colorimetric biosensing of ochratoxin A in fortified white grape wine sample using unmodified gold nanoparticles. Anal. Sci. 2017, 33, 659-664.
149. Remiro, R.; González-Peñas, E.; Lizarraga, E.; López de Cerain, A. Quantification of ochratoxin A and five analogs in Navarra red wines. Food Control 2012, 27, 139-145.
150. Di Stefano, V.; Avellone, G.; Pitonzo, R.; Capocchiano, V.G.; Mazza, A.; Cicero, N.; Dugo, G. Natural co-occurrence of ochratoxin A, ochratoxin B and aflatoxins in Sicilian red wines. Food Addit. Contam. Part A 2015, 32, 1343-1351.