Advances in food allergen analysis

Food Safety: Innovative Analytical Tools for Safety Assessment

Volumn , Issue , 2016, Pages 305-360

  Costa, Joana ^a   Fernandes, Telmo J R ^a   Villa, Caterina ^a   Oliveira, M Beatriz P P ^a   Mafra, Isabel ^a  

^a UNIVERSITY OF PORTO   (Portugal)

Author keywords

Allergen detection; Biosensors; ELISA; Food allergens; LC MS MS; Real time PCR

Indexed keywords

BINARY ALLOYS; BIOSENSORS; CONTAMINATION; POLYMERASE CHAIN REACTION; THORIUM ALLOYS;

ALLERGEN DETECTION; ELISA; FOOD ALLERGEN; LC-MS/MS; REAL-TIME PCR;

ALLERGENS;

EID: 85014771367     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781119160588.ch9     Document Type: Chapter

References (167)

1. Muraro, A., Werfel, T., Hoff mann-Sommergruber, K., Roberts, G., Beyer, K., Bindslev-Jensen, C., Cardona, V., Dubois, A., duToit, G., Eigenmann, P., Fernandez Rivas, M., Halken, S., Hickstein, L., Høst, A., Knol, E., Lack, G., Marchisotto, M.J., Niggemann, B., Nwaru, B.I., Papadopoulos, N.G., Poulsen, L.K., Santos, A.F., Skypala, I., Schoepfer, A., Van Ree, R., Venter, C., Worm, M., Vlieg-Boerstra, B., Panesar, S., de Silva, D., Soares-Weiser, K., Sheikh, A., Ballmer-Weber, B.K., Nilsson, C., de Jong, N.W., and Akdis, C.A. on behalf of the EAACI Food Allergy and Anaphylaxis Guidelines Group, EAACI food allergy and anaphylaxis guidelines: Diagnosis and management of food allergy. Allergy, 69, 1008-1025, 2014.
2. Taylor, S.L. and Baumert, J.L., Worlwide food allergy labeling and detection of allergens in processed foods, in: Food Allergy: Molecular Basis and Clinical Practice. Chemical Immunology and Allergy, M. Ebisawa, B.K. Ballmer-Weber, S. Vieths, R.A. Wood (Eds), vol. 101, pp. 227-234, Basel, Karger, 2015.
3. Argyri, A.A., Zoumpopoulou, G., Karatzas, K.-A.G., Tsakalidou, E., Nychas, G.-J.E., Panagou, E.Z., and Tassou, C.C., Selection of potential probiotic lactic acid bacteria from fermented olives by in vitro tests. Food Microbiol., 33, 282-291, 2013.
4. Gomaa, A. and Boye, J., Simultaneous detection of multi-allergens in an incurred food matrix using ELISA, multiplex flflow cytometry and liquid chromatography mass spectrometry (LC-MS). Food Chem., 175, 585-592, 2015.
5. Johnson, P.E., Sancho, A.I., Crevel, R.W.R., and Mills, E.N.C., Detection of allergens in foods, in: Food Allergens: Analysis Instrumentation and Methods, A.J. Hengel and L.M.L. Nollet (Eds), pp. 13-27, Taylor and Francis Group, LLC, USA, 2011.
6. Lee, P-W. and Taylor, S.L., Fish, crustaceans, and mollusks, in: Food Allergens: Analysis Instrumentation and Methods, A.J. Hengel and L.M.L. Nollet (Eds), pp. 117-205, Taylor and Francis Group, LLC, USA, 2011.
7. Costa, J., Carrapatoso, I., Oliveira, M.B.P.P., and Mafra, I., Walnut allergens: Molecular characterization, detection and clinical relevance. Clin. Exp. Allergy, 44, 319-341, 2014.
8. Rencova, E., Kostelnikova, D., and Tremlova, B., Detection of allergenic parvalbumin of Atlantic and Pacififi c herrings in fifi sh products by PCR. Food Addit. Contam. Part A Chem. Anal. Control, Expo. Risk Assess., 30, 1679-1683, 2013.
9. Directive 2006/142/EC of 22 December 2006 amending Annex IIIa of Directive 2000/13/EC of the European Parliament and of the Council listing the ingredients which must under all circumstances appear on the labelling of foodstuff s. Off J. Eur. Union, L368, 110-111, 2006.
10. Directive 2007/68/EC of 27 November 2007 amending Annex IIIa to Directive 2000/13/EC regarding certain food ingredients. Off J. Eur. Union, L310, 11-4, 2007.
11. Regulation (EU) No 1169/2011 of 25 October 2011 on the provision of food information to consumers, amending Regulations (EC) No 1924/2006 and (EC) No 1925/2006 of the European Parliament and of the Council, and repealing Commission Directive 87/250/EEC, Council Directive 90/496/EEC, Commission Directive 1999/10/EC, Directive 2000/13/EC of the European Parliament and of the Council, Commission Directives 2002/67/EC and 2008/5/EC and Commission Regulation (EC) No 608/2004. Off J. Eur. Union, L304, 18-63, 2011.
12. Köppel, R., van Velsen-Zimmerli, F., and Bucher, T., Two quantitative hexaplex real-time PCR systems for the detection and quantifification of DNA from twelve allergens in food. Eur. Food Res. Technol., 235, 843-852, 2012.
13. Poms, R.E., Klein, C.L., and Anklam, E., Methods for allergen analysis in food: A review. Food Addit. Contam., 21, 1-31, 2004.
14. Alves, R.C., Barroso, M.F., González-García, M.B., Oliveira, M.B.P.P., and Delerue-Matos, M.C., New trends in food allergens detection: Towards biosensing strategies. Crit. Rev. Food Sci. Nutr., 56, 2304-2319, 2016.
15. Monaci, L. and Visconti, A., Immunochemical and DNA-based methods in food allergen analysis and quality assurance perspectives. Trends Food Sci. Technol., 21, 272-283, 2010.
16. Pilolli, R., Monaci, L., and Visconti, A., Advances in biosensor development based on integrating nanotechnology and applied to food-allergen management. TrAC-Trend. Anal. Chem., 47, 12-26, 2013.
17. Prado, M., Ortea, I., Vial, S., Rivas, J., Calo-Mata, P., and Barros-Velázquez, J., Advanced DNA- and protein-based methods for the detection and investigation of food allergens. Crit. Rev. Food Sci. Nutr., 56, 2511-2542, 2016.
18. Costa, J.S.B., Development and application of molecular-based methods for the detection of tree nut allergens: The cases of almond, hazelnut and walnut. PhD thesis, Faculty of Pharmacy, University of Porto, Porto, Portugal, 2013.
19. Johnson, P.E., Baumgartner, S., Aldick, T., Bessant, C., Giosafatto, V., and Heick, J., Current perspectives and recommendations for the development of mass spectrometry methods for the determination of allergens in foods. J. AOAC Int., 94, 1026-1033, 2011.
20. Mills, E.N.C., Sancho, A.I., Rigby, N.M., Jenkins, J.A., and Mackie, A.R., Impact of food processing on the structural and allergenic properties of food allergens. Mol. Nutr. Food Res., 53, 963-969, 2009.
21. Paschke, A., Aspects of food processing and its eff ect on allergen structure. Mol. Nutr. Food Res., 53, 959-962, 2009.
22. Sathe, S.K. and Sharma, G.M., Eff ects of ffff food processing on food allergens. Mol. Nutr. Food Res., 53, 970-978, 2009.
23. Monaci, L. and Visconti, A., Mass spectrometry-based proteomics methods for analysis of food allergens. TrAC-Trend. Anal. Chem., 28, 581-591, 2009.
24. Diaz Amigo, C. and Popping, B., Detection of food allergens, in: Molecular Biological and Immunological Techniques and Applications for Food Chemists, B. Popping, C. Diaz-Amigo, K. Hoenicke (Eds.), pp. 175-198, New Jersey: John Wiley & Sons, Inc., 2010.
25. Chen, Y.T. and Hsieh, Y.H.P., A sandwich ELISA for the detection of fifish and fifish products. Food Control, 40, 265-273, 2014.
26. Costa, J., Ansari, P., Mafra, I., Oliveira, M.B.P.P., and Baumgartner, S., Development of a sandwich ELISA-type system for the detection and quantifification of hazelnut in model chocolates. Food Chem., 173, 257-265, 2015.
27. Deckwart, M., Carstens, C., Webber-Witt, M., Schäfer, V., Eichhorn, L., Kang, S., Fischer, M., Brockow, K., Christmann, M., and Paschke-Kratzin, A., Development of a sensitive ELISA for the detection of casein-containing fifi ning agents in red and white wines. J. Agric. Food Chem., 62, 6803-6812, 2014.
28. de la Cruz, S., Cubillos-Zapata, C., López-Calleja, I.M., Ghosh, S., Alcocer, M., González, I., Martín, R., and García, T., Isolation of recombinant antibody fragments (scFv) by phage display technology for detection of almond allergens in food products. Food Control, 54, 322-330, 2015.
29. Jiang, D., Zhu, P., Jiang, H., Ji, J., Sun, X., Gu, W., and Zhang, G., Fluorescent magnetic bead-based mast cell biosensor for electrochemical detection of allergens in foodstuffs. Biosens. Bioelectron., 70, 482-490, 2015.
30. Polenta, G., Godefroy-Benrejeb, S., Delahaut, P., Weber, D., and Abbott, M., Development of a competitive ELISA for the detection of pecan (Carya illinoinensis (Wangenh.) K. Koch) traces in food. Food Anal. Method., 3, 375-381, 2010.
31. Wang, H., Li, G., Wu, Y., Yuan, F., and Chen, Y., Development of an indirect competitive immunoassay for walnut protein component in food. Food Chem., 147, 106-110, 2014.
32. Garber, E. and Perry, J., Detection of hazelnuts and almonds using commercial ELISA test kits. Anal. Bioanal. Chem., 396, 1939-1945, 2010.
33. Sakai, S., Adachi, R., Akiyama, H., Teshima, R., Doi, H., Shibata, H., and Urisu, A., Determination of walnut protein in processed foods by enzymelinked immunosorbent assay: Inter laboratory study. J. AOAC Int., 93, 1255-1261, 2010.
34. Scharf, A., Kasel, U., Wichmann, G., and Besler, M., Performance of ELISA and PCR methods for the determination of allergens in food: An evaluation of six years of profificiency testing for soy (Glycine max L.) and wheat gluten (Triticum aestivum L.). J. Agric. Food Chem., 61, 10261-10272, 2013.
35. Cucu, T., Devreese, B., Trashin, S., Kerkaert, B., Rogge, M., and De Meulenaer, B., Detection of hazelnut in foods using ELISA: challenges related to the detectability in processed foodstuffs. J. AOAC Int., 95, 149-156, 2012.
36. Khuda, S.E., Jackson, L.S., Fu, T.-J., and Williams, K.M., Eff ects of processing on the recovery of food allergens from a model dark chocolate matrix. Food Chem., 168, 580-587, 2015.
37. Bugyi, Z., Török, K., Hajas, L., Adonyi, Z., Popping, B., and Tömösközi, S., Comparative study of commercially available gluten ELISA kits using an incurred reference material. Qual. Assur. Saf. Crop., 5, 79-87, 2013.
38. Sharma, G.M., Khuda, S.E., Pereira, M., Slate, A., Jackson, L.S., Pardo, C., Williams, K.M., and Whitaker, T.B., Development of an incurred cornbread model for gluten detection by immunoassays. J. Agric. Food Chem., 61, 12146-12154, 2013.
39. Schubert-Ullrich, P., Rudolf, J., Ansari, P., Galler, B., Führer, M., Molinelli, A., and Baumgartner, S., Commercialized rapid immunoanalytical tests for determination of allergenic food proteins: An overview. Anal. Bioanal. Chem., 395, 69-81, 2009.
40. Billakanti, J.M., Fee, C.J., Lane, F.R., Kash, A.S., and Fredericks, R., Simultaneous, quantitative detection of fififi ve whey proteins in multiple samples by surface plasmon resonance. Int. Dairy J., 20, 96-105, 2010.
41. Godoy-Navajas, J., Aguilar Caballos, M.P., and Gómez-Hens, A., Heterogeneous immunoassay for soy protein determination using nile bluedoped silica nanoparticles as labels and front-surface long-wavelength flfluorimetry. Anal. Chim. Acta, 701, 194-199, 2011.
42. Hiep, H.M., Endo, T., Kerman, K., Chikae, M., Kim, D.-K., Yamamura, S., Takamura, Y., and Tamiya, E., A localized surface plasmon resonance based immunosensor for the detection of casein in milk. Sci. Tech. Adv. Mater., 8, 331-338, 2007.
43. Indyk, H.E., Development and application of an optical biosensor immunoassay for a-lactalbumin in bovine milk. Int. Dairy J., 19, 36-42, 2009.
44. Lu, Y., Ohshima, T., and Ushio, H., Rapid detection of fifi sh major allergen parvalbumin by surface plasmon resonance biosensor. J. Food Sci., 69, 652-658, 2004.
45. Mohammed, I., Mullett, W.M., Lai, E.P.C., and Yeung, J.M., Is biosensor a viable method for food allergen detection?. Anal. Chim. Acta, 444, 97-102, 2001.
46. Pilolli, R., Visconti, A., and Monaci, L., Rapid and label-free detection of egg allergen traces in wines by surface plasmon resonance biosensor. Anal. Bioanal. Chem., 407, 3787-3797, 2015.
47. Pollet, J., Delport, F., Janssen, K.P.F., Tran, D.T., Wouters, J., Verbiest, T., and Lammertyn, J., Fast and accurate peanut allergen detection with nanobead enhanced optical fifiber SPR biosensor. Talanta, 83, 1436-1441, 2011.
48. Rebe Raz, S., Liu, H., Norde, W., and Bremer, M.G.E.G., Food allergens profifi ling with an imaging surface plasmon resonance-based biosensor. Anal. Chem., 82, 8485-8491, 2010.
49. Hohensinner, V., Maier, I., and Pittner, F., A 'gold cluster-linked immunosorbent assay': Optical near-fi eld biosensor chip for the detection of allergenic ß-lactoglobulin in processed milk matrices. J. Biotechnol., 130, 385-388, 2007.
50. Maier, I., Lindner, W., and Pittner, F., Antigenicity of heat-treated and trypsin- digested milk samples studied by an optical immunochip biosensor. Monatsh. Chem., 140, 921-929, 2009.
51. Alves, R., Pimentel, F., Nouws, H.A., Correr, W., González-García, M., Oliveira, M.B.P., and Delerue-Matos, C., Detection of the peanut allergen Ara h 6 in foodstuff s using a voltammetric biosensing approach. Anal. Bioanal. Chem., 407, 7157-7163, 2015.
52. Alves, R.C., Pimentel, F.B., Nouws, H.P.A., Marques, R.C.B., González- García, M.B., Oliveira, M.B.P.P., and Delerue-Matos, C., Detection of Ara h 1 (a major peanut allergen) in food using an electrochemical gold nanoparticle- coated screen-printed immunosensor. Biosens. Bioelectron., 64, 19-24, 2015.
53. Cadková, M., Metelka, R., Holubová, L., Horák, D., Dvoráková, V., Bílková, Z., and Korecká, L., Magnetic beads-based electrochemical immunosensor for monitoring allergenic food proteins. Anal. Biochem., 484, 4-8, 2015.
54. Eissa, S., L'Hocine, L., Siaj, M., and Zourob, M., A graphene-based label-free voltammetric immunosensor for sensitive detection of the egg allergen ovalbumin. Analyst, 138, 4378-4384, 2013.
55. Jiang, D., Ji, J., An, L., Sun, X., Zhang, Y., Zhang, G., and Tang, L., Mast cellbased electrochemical biosensor for quantifification of the major shrimp allergen Pen a 1 (tropomyosin). Biosens. Bioelectron., 50, 150-156, 2013.
56. Montiel, V.R.-V., Campuzano, S., Conzuelo, F., Torrente-Rodríguez, R.M., Gamella, M., Reviejo, A.J., and Pingarrón, J.M., Electrochemical magnetoimmunosensing platform for determination of the milk allergen ß-lactoglobulin. Talanta, 131, 156-162, 2015.
57. Montiel, V.R.-V., Campuzano, S., Pellicanò, A., Torrente-Rodríguez, R.M., Reviejo, A.J., Cosio, M.S., and Pingarrón, J.M., Sensitive and selective magnetoimmunosensing platform for determination of the food allergen Arah Anal. Chim. Acta, 880, 52-59, 2015.
58. Trashin, S.A., Cucu, T., Devreese, B., Adriaens, A., and De Meulenaer, B., Development of a highly sensitive and robust Cor a 9 specififi c enzyme-linked immunosorbent assay for the detection of hazelnut traces. Anal. Chim. Acta, 708, 116-122, 2011.
59. Sun, X., Zhang, Y., Shao, J., Shen, L., Qian, H., and Zhu, W., A quartz crystal microbalance-based immunosensor for shrimp allergen determination in food. Eur. Food Res. Technol., 231, 563-570, 2010.
60. Fæste, C.K., Rønning, H.T., Christians, U., and Granum, P.E., Liquid chromatography and mass spectrometry in food allergen detection. J. Food Prot., 74, 316-345, 2011.
61. Mari, A., Rasi, C., Palazzo, P., and Scala, E., Allergen databases: current status and perspectives. Curr. Allergy Asthma Rep., 9, 376-383, 2009.
62. Koeberl, M., Clarke, D., and Lopata, A.L., Next generation of food allergen quantififi cation using mass spectrometric systems. J. Proteome Res., 13, 3499-3509, 2014.
63. Kitteringham, N.R., Jenkins, R.E., Lane, C.S., Elliott, V.L., and Park, B.K., Multiple reaction monitoring for quantitative biomarker analysis in proteomics and metabolomics. J. Chromatogr. B, 877, 1229-1239, 2009.
64. Picariello, G., Mamone, G., Addeo, F., and Ferranti, P., The frontiers of mass spectrometry-based techniques in food allergenomics. J. Chromatogr. A, 1218, 7386-7398, 2011.
65. Bignardi, C., Mattarozzi, M., Penna, A., Sidoli, S., Elviri, L., Careri, M., and Mangia, A., A rapid size-exclusion solid-phase extraction step for enhanced sensitivity in multi-allergen determination in dark chocolate and biscuits by liquid chromatography-tandem mass spectrometry. Food Anal. Method., 6, 1144-1152, 2013.
66. Careri, M., Elviri, L., Lagos, J.B., Mangia, A., Speroni, F., and Terenghi, M., Selective and rapid immunomagnetic bead-based sample treatment for the liquid chromatography-electrospray ion-trap mass spectrometry detection of Ara h3/4 peanut protein in foods. J. Chromatogr. A, 1206, 89-94, 2008.
67. Costa, J., Ansari, P., Mafra, I., Oliveira, M.B.P., and Baumgartner, S., Assessing hazelnut allergens by protein- and DNA-based approaches: LC-MS/MS, ELISA and real-time PCR. Anal. Bioanal. Chem., 406, 2581-2590, 2014.
68. Heick, J., Fischer, M., and Pöpping, B., First screening method for the simultaneous detection of seven allergens by liquid chromatography mass spectrometry. J. Chromatogr. A, 1218, 938-943, 2011.
69. Lutter, P., Parisod, V., and Weymuth, H., Development and validation of a method for the quantifification of milk proteins in food products based on liquid chromatography with mass spectrometric detection. J. AOAC Int., 94, 1043-1059, 2011.
70. Monaci, L., Losito, I., De Angelis, E., Pilolli, R., and Visconti, A., Multiallergen quantifification of fifi ning-related egg and milk proteins in white wines by high-resolution mass spectrometry. Rapid Commun. Mass Spectrom., 27, 2009-2018, 2013.
71. Azarnia, S., Boye, J.I., Mongeon, V., and Sabik, H., Detection of ovalbumin in egg white, whole egg and incurred pasta using LC-ESI-MS/MS and ELISA. Food Res. Int., 52, 526-534, 2013.
72. Chassaigne, H., Nørgaard, J.V., and van Hengel, A.J., Proteomics-based approach to detect and identify major allergens in processed peanuts by capillary LC-Q-TOF (MS/MS). J. Agric. Food Chem., 55, 4461-4473, 2007.
73. Heick, J., Fischer, M., Kerbach, S., Tamm, U., and Popping, B., Application of a liquid chromatography tandem mass spectrometry method for the simultaneous detection of seven allergenic foods in flflour and bread and comparison of the method with commercially available ELISA test kits. J. AOAC Int., 94, 1060-1068, 2011.
74. Bignardi, C., Elviri, L., Penna, A., Careri, M., and Mangia, A., Particle-packed column versus silica-based monolithic column for liquid chromatographyelectrospray- linear ion trap-tandem mass spectrometry multiallergen trace analysis in foods. J. Chromatogr. A, 1217, 7579-7585, 2010.
75. Sealey-Voyksner, J., Zweigenbaum, J., and Voyksner, R., Discovery of highly conserved unique peanut and tree nut peptides by LC-MS/MS for multiallergen detection. Food Chem., 194, 201-211, 2016.
76. Mafra, I., Ferreira, I.M.P.L.V.O., and Oliveira, M.B.P.P., Food authentication by PCR-based methods. Eur. Food Res. Technol., 227, 649-665, 2008.
77. van Hengel, A., Food allergen detection methods and the challenge to protect food-allergic consumers. Anal. Bioanal. Chem., 389, 111-118, 2007.
78. Druml, B. and Cichna-Markl, M., High resolution melting (HRM) analysis of DNA - Its role and potential in food analysis. Food Chem., 158, 245-254, 2014.
79. Madesis, P., Ganopoulos, I., Anagnostis, A., and Tsaftft aris, A., The application of Bar-HRM (Barcode DNA-High Resolution Melting) analysis for authenticity testing and quantitative detection of bean crops (Leguminosae) without prior DNA purifification. Food Control, 25, 576-582, 2012.
80. Madesis, P., Ganopoulos, I., Bosmali, I., and Tsaftftaris, A., Barcode high resolution melting analysis for forensic uses in nuts: A case study on allergenic hazelnuts (Corylus avellana). Food Res. Int., 50, 351-360, 2013.
81. Costa, J., Mafra, I., and Oliveira, M.B.P.P., High resolution melting analysis as a new approach to detect almond DNA encoding for Pru du 5 allergen in foods. Food Chem., 133, 1062-1069, 2012.
82. Fitzcharles, E.M., Rapid discrimination between four Antarctic fifish species, genus Macrourus, using HRM analysis. Fisheries Res., 127-128, 166-170, 2012.
83. Jaakola, L., Suokas, M., and Häggman, H., Novel approaches based on DNA barcoding and high-resolution melting of amplicons for authenticity analyses of berry species. Food Chem., 123, 494-500, 2010.
84. Mackay, J., Wright, C., and Bonfifiglioli, R., A new approach to varietal identifification in plants by microsatellite high resolution melting analysis: Application to the verifification of grapevine and olive cultivars. Plant Methods, 4, 8, 2008.
85. Sakaridis, I., Ganopoulos, I., Argiriou, A., and Tsaftftaris, A., High resolution melting analysis for quantitative detection of bovine milk in pure water buffalo mozzarella and other buffalo dairy products. Int. Dairy J., 28, 32-35, 2013.
86. Jin, Y., Li, Q., Kong, L., Yu, H., and Zhong, X., High-resolution melting (HRM) analysis: A highly sensitive alternative for the identifification of commercially important Crassostrea oysters. J. Mollus. Stud., 81, 167-170, 2015.
87. Bergerová, E., Brežná, B., and Kuchta, T., A novel method with improved sensitivity for the detection of peanuts based upon single-tube nested real-time polymerase chain reaction. Eur. Food Res. Technol., 232, 1087-109, 2011.
88. Costa, J., Mafra, I., Kuchta, T., and Oliveira, M.B.P.P., Single-tube nested realtime PCR as a new highly sensitive approach to trace hazelnut. J. Agric. Food Chem., 60, 8103-8110, 2012.
89. Costa, J., Oliveira, M.B.P.P., and Mafra, I., Novel approach based on singletube nested real-time PCR to detect almond allergens in foods. Food Res. Int., 5, 228-235, 2013.
90. Costa, J., Oliveira, M.B.P.P., and Mafra, I., Eff ect of thermal processing on the performance of the novel single-tube nested real-time PCR for the detection of walnut allergens in sponge cakes. Food Res. Int., 54, 1722-1729, 2013.
91. Unterberger, C., Luber, F., Demmel, A., Grünwald, K., Huber, I., Engel, K.-H., and Busch, U., Simultaneous detection of allergenic fifish, cephalopods and shellfifish in food by multiplex ligation-dependent probe amplifification. Eur. Food Res. Technol., 239, 559-566, 2014.
92. Ehlert, A., Demmel, A., Hupfer, C., Busch, U., and Engel, K.-H., Simultaneous detection of DNA from 10 food allergens by ligation-dependent probe amplififi cation. Food Addit. Contam. A, 26, 409-418, 2009.
93. Mustorp, S.L., Drømtorp, S.M., and Holck, A.L., Multiplex, quantitative, ligation- dependent probe amplififi cation for determination of allergens in food. J. Agric. Food Chem., 59, 5231-5239, 2011.
94. Rossi, S., Scaravelli, E., Germini, A., Corradini, R., Fogher, C., and Marchelli, R., A PNA-array platform for the detection of hidden allergens in foodstuffs. Eur. Food Res. Technol., 223, 1-6, 2006.
95. Bettazzi, F., Lucarelli, F., Palchetti, I., Berti, F., Marrazza, G., and Mascini, M., Disposable electrochemical DNA-array for PCR amplifified detection of hazelnut allergens in foodstuffs. Anal. Chim. Acta, 614, 93-102, 2008.
96. Wang, W., Han, J., Wu, Y., Yuan, F., Chen, Y., and Ge, Y., Simultaneous detection of eight food allergens using optical thin-fifilm biosensor chips. J. Agric. Food Chem., 59, 6889-6894, 2011.
97. Wang, W., Li, Y., Zhao, F., Chen, Y., and Ge, Y., Optical thin-fifilm biochips for multiplex detection of eight allergens in food. Food Res. Int., 44, 3229-3234, 2011.
98. Sun, X., Jia, M., Guan, L., Ji, J., Zhang, Y., Tang, L., and Li, Z., Multilayer graphene-gold nanocomposite modifified stem-loop DNA biosensor for peanut allergen-Ara h1 detection. Food Chem., 172, 335-342, 2015.
99. Martín-Fernández, B., Miranda-Ordieres, A.J., Lobo-Castañón, M.J., Frutos- Cabanillas, G., de-los-Santos-álvarez, N., and López-Ruiz, B., Strongly structured DNA sequences as targets for genosensing: Sensing phase design and coupling to PCR amplififi cation for a highly specifific 33-mer gliadin DNA fragment. Biosens. Bioelectron., 60, 244-251, 2014.
100. Martín-Fernández, B., de-los-Santos-álvarez, N., Lobo-Castañón, M.J., and López-Ruiz, B., Hairpin-based DNA electrochemical sensor for selective detection of a repetitive and structured target codifying a gliadin fragment. Anal. Bioanal. Chem., 407, 3481-3488, 2015.
101. Martín-Fernández, B., de-los-Santos-álvarez, N., Martín-Clemente, J.P., Lobo-Castañón, M.J., and López-Ruiz, B., Challenging genosensors in food samples: Th e case o f gluten determination in highly processed samples. Talanta, 146, 490-495, 2016.
102. Amaya-González, S., de-los-Santos-álvarez, N., Miranda-Ordieres, A., and Lobo-Castañón, M., Aptamer-based analysis: A promising alternative for food safety control. Sensors, 13, 16292, 2013.
103. Acquah, C., Danquah, M.K., Yon, J.L.S., Sidhu, A., and Ongkudon, C.M., A review on immobilised aptamers for high throughput biomolecular detection and screening. Anal. Chim. Acta, 888, 10-18, 2015.
104. Tran, D.T., Knez, K., Janssen, K.P., Pollet, J., Spasic, D., and Lammertyn, J., Selection of aptamers against Ara h 1 protein for FO-SPR biosensing of peanut allergens in food matrices. Biosens. Bioelectron., 43, 245-251, 2013.
105. Khuda, S., Slate, A., Pereira, M., Al-Taher, F., Jackson, L., Diaz-Amigo, C., Bigley, E. C., Whitaker, T., and Williams, K.M., Eff ect of processing on recovery and variability associated with immunochemical analytical methods for multiple allergens in a single matrix: sugar cookies. J. Agric. Food Chem., 60, 4195-4203, 2012.
106. Montserrat, M., Sanz, D., Juan, T., Herrero, A., Sánchez, L., Calvo, M., and Pérez, M.D., Detection of peanut (Arachis hypogaea) allergens in processed foods by immunoassay: Inflfluence of selected target protein and ELISA format applied. Food Control, 54, 300-307, 2015.
107. Khuda, S., Slate, A., Pereira, M., Al-Taher, F., Jackson, L., Diaz-Amigo, C., Bigley, E.C., Whitaker, T., and Williams, K., Effect of processing on recovery and variability associated with immunochemical analytical methods for multiple allergens in a single matrix: dark chocolate. J. Agric. Food Chem., 60, 4204-4211, 2012.
108. Jablonski, J.E., Fu, T.-J., Jackson, L.S., and Gendel, S.M., Determination of protein levels in soy and peanut oils by colorimetric assay and ELISA. J. AOAC Int., 93, 213-220, 2010.
109. Peng, J., Song, S., Liu, L., Kuang, H., and Xu, C., Development of sandwich ELISA and immunochromatographic strip for the detection of peanut allergen Ara h 2. Food Anal. Method., 8, 2605-2611, 2015.
110. Su, M., Venkatachalam, M., Liu, C., Zhang, Y., Roux, K.H., and Sathe, S.K., A murine monoclonal antibody based enzyme-linked immunosorbent assay for almond (Prunus dulcis L.) detection. J. Agric. Food Chem., 61, 10823-10833, 2013.
111. Röder, M., Vieths, S., and Holzhauser, T., Sensitive and specifific detection of potentially allergenic almond (Prunus dulcis) in complex food matrices by Taqman real-time polymerase chain reaction in comparison to commercially available protein-based enzyme-linked immunosorbent assay. Anal. Chim. Acta, 685, 74-83, 2011.
112. Gaskin, F.E. and Taylor, S.L., Sandwich enzyme-linked immunosorbent assay (ELISA) for detection of cashew nut in foods. J. Food Sci., 76, 218-226, 2011.
113. Ghorbani, M. and Morgan, M.R.A., Protein characterisation and immunochemical measurements of residual macadamia nut proteins in foodstuffs. Food Agric. Immunol., 21, 347-360, 2010.
114. Kerkaert, B., Mestdagh, F., and De Meulenaer, B., Detection of hen's egg white lysozyme in food: Comparison between a sensitive HPLC and a commercial ELISA method. Food Chem., 120, 580-584, 2010.
115. Gomaa, A. and Boye, J., Impact of irradiation and thermal processing on the immunochemical detection of milk and egg allergens in foods. Food Res. Int., 74, 275-283, 2015.
116. Decastelli, L., Gallina, S., Manila Bianchi, D., Fragassi, S., and Restani, P., Undeclared allergenic ingredients in foods from animal origin: Survey of an Italian region's food market, 2007-2009. Food Addit. Contam. B, 5, 160-164, 2012.
117. Török, K., Horváth, V., Horváth, á., Hajas, L., Bugyi, Z., and Tömösközi, S., Investigation of incurred single- and multi-component model food matrices for determination of food proteins triggering allergy and coeliac disease. Eur. Food Res. Technol., 239, 923-932, 2014.
118. Carstens, C., Deckwart, M., Webber-Witt, M., Schäfer, V., Eichhorn, L., Brockow, K., Fischer, M., Christmann, M., and Paschke-Kratzin, A., Evaluation of the effiffi ciency of enological procedures on lysozyme depletion in wine by an indirect ELISA method. J. Agric. Food Chem., 62, 6247-6253, 2014.
119. Johnson, P.E., Rigby, N.M., Dainty, J.R., Mackie, A.R., Immer, U.U., Rogers, A., Titchener, P., Shoji, M., Ryan, A., Mata, L., Brown, H., Holzhauser, T., Dumont, V., Wykes, J.A., Walker, M., Griffiffi n, J., White, J., Taylor, G., Popping, B., Crevel, R., Miguel, S., Lutter, P., Gaskin, F., Koerner, T.B., Clarke, D., Sherlock, R., Flanagan, A., Chan, C.-H., and Mills, E.N.C., A multi-laboratory evaluation of a clinically-validated incurred quality control material for analysis of allergens in food. Food Chem., 148, 30-36, 2014.
120. Jiang, T.-L., Cai, Q.-F., Shen, J.-D., Huang, M.-J., Zhang, L.-J., Liu, G.-M., and Cao, M.-J., Establishment of immunological methods for the detection of soybean proteins in surimi products. LWT-Food Sci. Technol., 64, 344-349, 2015.
121. Hei, W., Li, Z., Ma, X., and He, P., Determination of beta-conglycinin in soybean and soybean products using a sandwich enzyme-linked immunosorbent assay. Anal. Chim. Acta, 734, 62-68, 2012.
122. Morishita, N., Matsumoto, T., Morimatsu, F., and Toyoda, M., Detection of soybean proteins in fermented soybean products by using heating extraction. J. Food Sci., 79, 1049-1054, 2014.
123. Cressey, P., Grounds, P., Jones, S., Ashmore, S., and Saunders, D., Gluten residues in gluten-free foods sold in Christchurch, New Zealand: Comparison of LC-MS and ELISA methods. Qual. Assur. Saf. Crop., 5, 207-213, 2013.
124. Lukášková, Z.R., Tremlová, B., Pospiech, M., Rencová, E., Randulová, Z., Steinhauser, L., Reichová, A., and Bednár, J., Comparison of immunohistochemical, histochemical and immunochemical methods for the detection of wheat protein allergens in meat samples and cooked, dry, raw and fermented sausage samples. Food Addit. Contam. Part A, 28, 817-825, 2011.
125. Shibahara, Y., Uesaka, Y., Wang, J., Yamada, S., and Shiomi, K., A sensitive enzyme-linked immunosorbent assay for the determination of fifish protein in processed foods. Food Chem., 136, 675-681, 2013.
126. Cai, Q.-F., Wang, X.-C., Liu, G.-M., Zhang, L., Ruan, M.-M., Liu, Y., and Cao, M.-J., Development of a monoclonal antibody-based competitive enzyme linked-immunosorbent assay (c-ELISA) for quantifification of silver carp parvalbumin. Food Control, 29, 241-247, 2013.
127. Zhang, H., Lu, Y., Ushio, H., and Shiomi, K., Development of sandwich ELISA for detection and quantifification of invertebrate major allergen tropomyosin by a monoclonal antibody. Food Chem., 150, 151-157, 2014.
128. Bremer, M., Smits, N., and Haasnoot, W., Biosensor immunoassay for traces of hazelnut protein in olive oil. Anal. Bioanal. Chem., 395, 119-126, 2009.
129. He, L., Haynes, C.L., Diez-Gonzalez, F., and Labuza, T.P., Rapid detection of a foreign protein in milk using IMS-SERS. J. Raman Spectrosc., 42, 1428-1434, 2011.
130. Maier, I., Morgan, M.R.A., Lindner, W., and Pittner, F., Optical resonanceenhanced absorption-based near-fifield immunochip biosensor for allergen detection. Anal. Chem., 80, 2694-2703, 2008.
131. Jiang, D., Jiang, H., Ji, J., Sun, X., Qian, H., Zhang, G., and Tang, L., Mastcell- based flfluorescence biosensor for rapid detection of major fifi sh allergen parvalbumin. J. Agric. Food Chem., 62, 6473-6480, 2014.
132. Monaci, L., De Angelis, E., Bavaro, S.L., and Pilolli, R., High-resolution Orbitrap -based mass spectrometry for rapid detection of peanuts in nuts. Food Addit. Contam. Part A, 32, 1607-1616, 2015.
133. Pedreschi, R., Nørgaard, J., and Maquet, A., Current challenges in detecting food allergens by shotgun and targeted proteomic approaches: a case study on traces of peanut allergens in baked cookies. Nutrients, 4, 132-150, 2012.
134. Careri, M., Elviri, L., Maffiffi ni, M., Mangia, A., Mucchino, C., and Terenghi, M., Determination of peanut allergens in cereal-chocolate-based snacks: metal-tag inductively coupled plasma mass spectrometry immunoassay versus liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun. Mass Spectrom., 22, 807-811, 2008.
135. Shefcheck, K.J., Callahan, J.H., and Musser, S.M., Confifi rmation of peanut protein using peptide markers in dark chocolate using liquid chromatography- tandem mass spectrometry (LC-MS/MS). J. Agric. Food Chem., 54, 7953-7959, 2006.
136. Shefcheck, K.J. and Musser, S.M., Confifi rmation of the allergenic peanut protein, Ara h 1, in a model food matrix using liquid chromatography/tandem mass spectrometry (LC/MS/MS). J. Agric. Food Chem., 52, 2785-2790, 2004.
137. Ansari, P., Stoppacher, N., and Baumgartner, S., Marker peptide selection for the determination of hazelnut by LC-MS/MS and occurrence in other nuts. Anal. Bioanal. Chem., 402, 2607-2615, 2012.
138. Cucu, T., De Meulenaer, B., and Devreese, B., MALDI-based identifification of stable hazelnut protein derived tryptic marker peptides. Food Addit. Contam. Part A, 29, 1821-1831, 2012.
139. Pilolli, R., De Angelis, E., Godula, M., Visconti, A., and Monaci, L., Orbitrap monostage MS versus hybrid linear ion trap MS: Application to multi-allergen screening in wine. J. Mass Spectrom., 49, 1254-1263, 2014.
140. Mattarozzi, M., Milioli, M., Bignardi, C., Elviri, L., Corradini, C., and Careri, M., Investigation of different sample pre-treatment routes for liquid chromatography- tandem mass spectrometry detection of caseins and ovalbumin in fortifified red wine. Food Control, 38, 82-87, 2014.
141. Monaci, L., Pilolli, R., De Angelis, E., Godula, M., and Visconti, A., Multiallergen detection in food by micro high-performance liquid chromatography coupled to a dual cell linear ion trap mass spectrometry. J. Chromatogr. A, 1358, 136-144, 2014.
142. Monaci, L., Norgaard, J.V., and van Hengel, A.J., Feasibility of a capillary LC/ ESI-Q-TOF MS method for the detection of milk allergens in an incurred model food matrix. Anal. Methods, 2, 967-972, 2010.
143. Monaci, L., Losito, I., Palmisano, F., and Visconti, A., Reliable detection of milk allergens in food using a high-resolution, stand-alone mass spectrometer. J. AOAC Int., 94, 1034-1042, 2011.
144. Monaci, L., Losito, I., Palmisano, F., and Visconti, A., Identifification of allergenic milk proteins markers in fifi ned white wines by capillary liquid chromatography- electrospray ionization-tandem mass spectrometry. J. Chromatogr. A, 1217, 4300-4305, 2010.
145. Monaci, L. and van Hengel, A.J., Development of a method for the quantififi cation of whey allergen traces in mixed-fruit juices based on liquid chromatography with mass spectrometric detection. J. Chromatogr. A, 1192, 113-120, 2008.
146. Chen, Q., Zhang, J., Ke, X., Lai, S., Tao, B., Yang, J., Mo, W., and Ren, Y., Quantifification of bovine ß-casein allergen in baked foodstuffs based on ultra-performance liquid chromatography with tandem mass spectrometry. Food Addit. Contam. Part A, Chem. Anal. Control, Expo. Risk Assess., 32, 25-34, 2015.
147. Cucu, T., De Meulenaer, B., Kerkaert, B., Vandenberghe, I., and Devreese, B., MALDI based identififi cation of whey protein derived tryptic marker peptides that resist protein glycation. Food Res. Int., 47, 23-30, 2012.
148. Weber, D., Raymond, P., Ben-Rejeb, S., and Lau, B., Development of a liquid chromatography-tandem mass spectrometry method using capillary liquid chromatography and nanoelectrospray ionization-quadrupole time-of-flflight hybrid mass spectrometer for the detection of milk allergens. J. Agric. Food Chem., 54, 1604-1610, 2006.
149. Ansari, P., Stoppacher, N., Rudolf, J., Schuhmacher, R., and Baumgartner, S., Selection of possible marker peptides for the detection of major ruminant milk proteins in food by liquid chromatography-tandem mass spectrometry. Anal. Bioanal. Chem., 399, 1105-1115, 2011.
150. Newsome, G.A. and Scholl, P.F., Quantififi cation of allergenic bovine milk aS1-casein in baked goods using an intact 15N-labeled protein internal standard. J. Agric. Food Chem., 61, 5659-5668, 2013.
151. Cucu, T., De Meulenaer, B., and Devreese, B., MALDI based identifification of soybean protein markers - Possible analytical targets for allergen detection in processed foods. Peptides, 33, 187-196, 2012.
152. Julka, S., Kuppannan, K., Karnoup, A., Dielman, D., Schafer, B., and Young, S.A., Quantifification of Gly m 4 protein, a major soybean allergen, by two-dimensional liquid chromatography with ultraviolet and mass spectrometry detection. Anal. Chem., 84, 10019-10030, 2012.
153. Manfredi, A., Mattarozzi, M., Giannetto, M., and Careri, M., Multiplex liquid chromatography-tandem mass spectrometry for the detection of wheat, oat, barley and rye prolamins towards the assessment of gluten-free product safety. Anal. Chim. Acta, 895, 62-70, 2015.
154. Carrera, M., Cañas, B., and Gallardo, J.M., Rapid direct detection of the major fifish allergen, parvalbumin, by selected MS/MS ion monitoring mass spectrometry. J. Proteomics, 75, 3211-3220, 2012.
155. Sun, X., Guan, L., Shan, X., Zhang, Y., and Li, Z., Electrochemical detection of peanut allergen Ara h 1 using a sensitive DNA biosensor based on stem- loop probe. J. Agric. Food Chem., 60, 10979-10984, 2012.
156. López, M.S.-P., Cabanillas, G.F., Castañón, M.J.L., and López-Ruiz, B., Development of a genosensor for peanut allergen ARA h 2 detection and its optimization by surface response methodology. Biosens. Bioelectron., 62, 350-356, 2014.
157. Peeters, M., van Grinsven, B., Cleij, T.J., Jiménez-Monroy, K.L., Cornelis, P., Pérez-Ruiz, E., Wackers, G., ThTh oelen, R., De Ceuninck, W., Lammertyn, J., and Wagner, P., Label-free protein detection based on the heat-transfer method-A case study with the peanut allergen Ara h 1 and aptamer-based synthetic receptors. ACS Appl. Mater. Interfaces, 7, 10316-10323, 2015.
158. Trashin, S., de Jong, M., Breugelmans, T., Pilehvar, S., and De Wael, K., Labelfree impedance aptasensor for major peanut allergen Ara h 1. Electroanal., 27, 32-37, 2015.
159. Tran, D.T., Janssen, K.P., Pollet, J., Lammertyn, E., Anne, J., Van Schepdael, A., and Lammertyn, J., Selection and characterization of DNA aptamers for egg white lysozyme. Molecules, 15, 1127-1140, 2010.
160. Mihai, I., Vezeanu, A., Polonschii, C., Albu, C., Radu, G.-L., and Vasilescu, A., Label-free detection of lysozyme in wines using an aptamer based biosensor and SPR detection. Sensor. Actuat. B: Chem., 206, 198-204, 2015.
161. Amaya-González, S., de-los-Santos-álvarez, N., Miranda-Ordieres, A.J., and Lobo-Castañón, M.J., Aptamer binding to celiac disease-triggering hydrophobic proteins: A sensitive gluten detection approach. Anal. Chem., 86, 2733-2739, 2014.
162. Amaya-González, S., López-López, L., Miranda-Castro, R., de-los-Santosálvarez, N., Miranda-Ordieres, A.J., & Lobo-Castañón, M.J., Affiffi nity of aptamers binding 33-mer gliadin peptide and gluten proteins: Inflfluence of immobilization and labeling tags. Anal. Chim. Acta, 873, 63-70, 2015.
163. Amaya-González, S., de-los-Santos-álvarez, N., Miranda-Ordieres, A., and Lobo-Castañón, M., Sensitive gluten determination in gluten-free foods by an electrochemical aptamer-based assay. Anal. Bioanal. Chem., 407, 6021-6029, 2015.
164. Nadal, P., Pinto, A., Svobodova, M., Canela, N., and O'Sullivan, C.K., DNA aptamers against the Lup an 1 food allergen. PLoS ONE, 7, e35253, 2012.
165. Mairal, T., Nadal, P., Svobodova, M., and O'Sullivan, C.K., FRET-based dimeric aptamer probe for selective and sensitive Lup an 1 allergen detection. Biosens. Bioelectron., 54, 207-210, 2014.
166. Svobodova, M., Mairal, T., Nadal, P., Bermudo, M.C., and O'Sullivan, C.K., Ultrasensitive aptamer based detection of ß-conglutin food allergen. Food Chem., 165, 419-423, 2014.
167. Pinto, A., Polo, P., Henry, O., Redondo, M.C., Svobodova, M., and O'Sullivan, C., Label-free detection of gliadin food allergen mediated by real-time apta- PCR. Anal. Bioanal. Chem., 406, 515-524, 2014.