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Volumn 77, Issue , 2015, Pages 333-348

Blessings in disguise: Bio-functional benefits of grape seed extracts

Author keywords

Bioactivity; By product; Food industry; Grape seed extract; Polyphenol; Proanthocyanidin

Indexed keywords

BIOACTIVITY; BYPRODUCTS; DIETARY SUPPLEMENTS; FLAVONOIDS; FRUIT JUICES; ISOMERS; NUTRITION; PLANTS (BOTANY); POLYPHENOLIC COMPOUNDS;

EID: 84949104953     PISSN: 09639969     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodres.2015.08.026     Document Type: Review
Times cited : (63)

References (247)
  • 1
    • 7444220765 scopus 로고
    • Changes in polyphenols of red fruits during processing
    • Chipping Campden, Gloucestershire, England, The kinetics and mechanisms of anthocyanin degradation
    • Adams J.B. Changes in polyphenols of red fruits during processing. Campden Food Pres. Res. Assoc. Tech. Bull. 1972, Chipping Campden, Gloucestershire, England.
    • (1972) Campden Food Pres. Res. Assoc. Tech. Bull.
    • Adams, J.B.1
  • 3
    • 0036292835 scopus 로고    scopus 로고
    • Antioxidant properties of natural plant extracts containing polyphenolic compounds in cooked ground beef
    • Ahn J., Grun I.U., Fernando L.N. Antioxidant properties of natural plant extracts containing polyphenolic compounds in cooked ground beef. Journal of Food Science 2002, 67:1364-1369.
    • (2002) Journal of Food Science , vol.67 , pp. 1364-1369
    • Ahn, J.1    Grun, I.U.2    Fernando, L.N.3
  • 4
    • 0036847191 scopus 로고    scopus 로고
    • Antioxidative activity of persimmon and grape seed extract: In vitro and in vivo
    • Ahn H.S., Jeon T.I., Lee J.Y., Hwang S.G., Lim Y., Park D.K. Antioxidative activity of persimmon and grape seed extract: In vitro and in vivo. Nutrition Research 2002, 22:1265-1273.
    • (2002) Nutrition Research , vol.22 , pp. 1265-1273
    • Ahn, H.S.1    Jeon, T.I.2    Lee, J.Y.3    Hwang, S.G.4    Lim, Y.5    Park, D.K.6
  • 5
    • 0346965804 scopus 로고    scopus 로고
    • Antimicrobial and antioxidant activities of natural extracts in vitro and in ground beef
    • Ahn J., Grun I.U., Mustapha A. Antimicrobial and antioxidant activities of natural extracts in vitro and in ground beef. Journal of Food Protection 2004, 67:148-155.
    • (2004) Journal of Food Protection , vol.67 , pp. 148-155
    • Ahn, J.1    Grun, I.U.2    Mustapha, A.3
  • 6
    • 0033941122 scopus 로고    scopus 로고
    • A polyphenolic fraction from grape seeds causes irreversible growth inhibition of breast carcinoma MDA-MB468 cells by inhibiting mitogen-activated protein kinases activation and inducing G1 arrest and differentiation
    • Agarwal C., Sharma Y., Zhao J., Agarwal R. A polyphenolic fraction from grape seeds causes irreversible growth inhibition of breast carcinoma MDA-MB468 cells by inhibiting mitogen-activated protein kinases activation and inducing G1 arrest and differentiation. Clinical Cancer Research 2000, 6:2921-2930.
    • (2000) Clinical Cancer Research , vol.6 , pp. 2921-2930
    • Agarwal, C.1    Sharma, Y.2    Zhao, J.3    Agarwal, R.4
  • 7
    • 85029540659 scopus 로고    scopus 로고
    • Antioxidant and hepatoprotective activities of grape seeds and skin against Ehrlich solid tumor induced oxidative stress in mice
    • Ali D.A., Badr El-Din N.K., Abou-El-magd R.F. Antioxidant and hepatoprotective activities of grape seeds and skin against Ehrlich solid tumor induced oxidative stress in mice. Egyptian Journal of Basic and Applied Sciences 2015, xxx:1-12.
    • (2015) Egyptian Journal of Basic and Applied Sciences , vol.30 , pp. 1-12
    • Ali, D.A.1    Badr El-Din, N.K.2    Abou-El-magd, R.F.3
  • 9
    • 80054862809 scopus 로고    scopus 로고
    • Grape seed proanthocyanidin lowers brain oxidative stress in adult and middle-aged rats
    • Asha D.S., Sagar C.B., Manjula K.R., Ishii N. Grape seed proanthocyanidin lowers brain oxidative stress in adult and middle-aged rats. Experimental Gerontology 2011, 46:958-964.
    • (2011) Experimental Gerontology , vol.46 , pp. 958-964
    • Asha, D.S.1    Sagar, C.B.2    Manjula, K.R.3    Ishii, N.4
  • 10
    • 48449083346 scopus 로고    scopus 로고
    • Microbial metabolism of dietary phenolic compounds in the colon
    • Aura A.M. Microbial metabolism of dietary phenolic compounds in the colon. Phytochemistry Reviews 2008, 7:407-429.
    • (2008) Phytochemistry Reviews , vol.7 , pp. 407-429
    • Aura, A.M.1
  • 11
    • 84887312422 scopus 로고    scopus 로고
    • Co-administration of grape seed extract and exercise training improves endothelial dysfunction of coronary vascular bed of STZ-induced diabetic rats
    • Badavi M., Abedi H.A., Sarkaki A.R., Dianat M. Co-administration of grape seed extract and exercise training improves endothelial dysfunction of coronary vascular bed of STZ-induced diabetic rats. Iranian Red Crescent Medical Journal 2013, 15:e7624.
    • (2013) Iranian Red Crescent Medical Journal , vol.15 , pp. e7624
    • Badavi, M.1    Abedi, H.A.2    Sarkaki, A.R.3    Dianat, M.4
  • 12
    • 84922018035 scopus 로고    scopus 로고
    • Combination of grape seed extract and exercise training improves left ventricular dysfunction in STZ-induced diabetic rats
    • Badavi M., Abedi H.A., Dianat M., Sarkaki A.R. Combination of grape seed extract and exercise training improves left ventricular dysfunction in STZ-induced diabetic rats. International Cardiovascular Research Journal 2015, 9:22-27.
    • (2015) International Cardiovascular Research Journal , vol.9 , pp. 22-27
    • Badavi, M.1    Abedi, H.A.2    Dianat, M.3    Sarkaki, A.R.4
  • 14
    • 0345215163 scopus 로고    scopus 로고
    • Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice
    • Bagchi D., Garg A., Krohn R.L., Bagchi M., Balmoori J., Stohs S.J. Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice. General Pharmacology 1998, 30:771-776.
    • (1998) General Pharmacology , vol.30 , pp. 771-776
    • Bagchi, D.1    Garg, A.2    Krohn, R.L.3    Bagchi, M.4    Balmoori, J.5    Stohs, S.J.6
  • 16
    • 0033181107 scopus 로고    scopus 로고
    • Acute and chronic stress-induced oxidative gastrointestinal injury in rats, and the protective ability of a novel grape seed proanthocyanidin extract
    • Bagchi M., Milneses M., Williams C., Balmoori J., Ye X., Stohs S., et al. Acute and chronic stress-induced oxidative gastrointestinal injury in rats, and the protective ability of a novel grape seed proanthocyanidin extract. Nutrition Research 1999, 19:1189-1199.
    • (1999) Nutrition Research , vol.19 , pp. 1189-1199
    • Bagchi, M.1    Milneses, M.2    Williams, C.3    Balmoori, J.4    Ye, X.5    Stohs, S.6
  • 17
    • 0034617986 scopus 로고    scopus 로고
    • Free radicals and grape seed proanthocyanidin extract: Importance in human health and disease prevention
    • Bagchi D., Bagchi M., Stohs S.J., et al. Free radicals and grape seed proanthocyanidin extract: Importance in human health and disease prevention. Toxicology 2000, 148:187-197.
    • (2000) Toxicology , vol.148 , pp. 187-197
    • Bagchi, D.1    Bagchi, M.2    Stohs, S.J.3
  • 18
    • 84863733425 scopus 로고    scopus 로고
    • Method for preventing or reducing stress-induced gastric injury using grape seed proanthocyanidin extract
    • Bagchi, D., & Bagchi, S. J. S. (2001). Method for preventing or reducing stress-induced gastric injury using grape seed proanthocyanidin extract. US Patents, 6, 291, 517.
    • (2001)
    • Bagchi, D.1    Bagchi, S.J.S.2
  • 19
    • 0035108764 scopus 로고    scopus 로고
    • Protection against drug- and chemical induced multiorgan toxicity by a novel lH636 grape seed proanthocyanidin extract
    • Bagchi D., Ray S.D., Patel D., Bagchi M. Protection against drug- and chemical induced multiorgan toxicity by a novel lH636 grape seed proanthocyanidin extract. Drugs Under Experimental and Clinical Research 2001, 27:3-15.
    • (2001) Drugs Under Experimental and Clinical Research , vol.27 , pp. 3-15
    • Bagchi, D.1    Ray, S.D.2    Patel, D.3    Bagchi, M.4
  • 20
    • 14644446143 scopus 로고    scopus 로고
    • Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract
    • Bagchi D., Sen C.K., Ray S.D., Bagchi M., Preuss H.G., Vinson J.A. Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract. Mutation Research 2003, 523-524:87-97.
    • (2003) Mutation Research , pp. 87-97
    • Bagchi, D.1    Sen, C.K.2    Ray, S.D.3    Bagchi, M.4    Preuss, H.G.5    Vinson, J.A.6
  • 21
    • 84899467046 scopus 로고    scopus 로고
    • Free radical scavenging, antioxidant and cancer chemoprevention by grape seed proanthocyanidin: An overview
    • Bagchia D., Swaroop A., Preussc H.G., Bagchi M. Free radical scavenging, antioxidant and cancer chemoprevention by grape seed proanthocyanidin: An overview. Mutation Research 2014, 768:69-73.
    • (2014) Mutation Research , vol.768 , pp. 69-73
    • Bagchia, D.1    Swaroop, A.2    Preussc, H.G.3    Bagchi, M.4
  • 22
    • 84887468683 scopus 로고    scopus 로고
    • Anti-inflammatory effect of procyanidins from wild grape (Vitis amurensis) seeds in LPS-induced RAW 264.7 cells
    • 409321
    • Bak M.J., Truong V.L., Kang H.S., Jun M., Jeong W.S. Anti-inflammatory effect of procyanidins from wild grape (Vitis amurensis) seeds in LPS-induced RAW 264.7 cells. Oxidative Medicine and Cellular Longevity 2013, 409321.
    • (2013) Oxidative Medicine and Cellular Longevity
    • Bak, M.J.1    Truong, V.L.2    Kang, H.S.3    Jun, M.4    Jeong, W.S.5
  • 25
    • 1842453341 scopus 로고    scopus 로고
    • Total phenolic contents and antibacterial activities of grape (Vitis vinifera L.) extracts
    • Baydar N.G., Ozkan G., Sagdic O. Total phenolic contents and antibacterial activities of grape (Vitis vinifera L.) extracts. Food Control 2004, 15:335-339.
    • (2004) Food Control , vol.15 , pp. 335-339
    • Baydar, N.G.1    Ozkan, G.2    Sagdic, O.3
  • 26
    • 33746262973 scopus 로고    scopus 로고
    • Determination of antibacterial effects and total phenolic contents of grape (Vitis vinifera L.) seed extracts
    • Baydar N.G., Sagdic O., Ozkan G., Cetin S. Determination of antibacterial effects and total phenolic contents of grape (Vitis vinifera L.) seed extracts. International Journal of Food Science and Technology 2006, 41:799-804.
    • (2006) International Journal of Food Science and Technology , vol.41 , pp. 799-804
    • Baydar, N.G.1    Sagdic, O.2    Ozkan, G.3    Cetin, S.4
  • 27
    • 33847325373 scopus 로고    scopus 로고
    • Evaluation of antiradical and antioxidant potential of grape extracts
    • Baydar N.G., Ozkan G., Yasar S. Evaluation of antiradical and antioxidant potential of grape extracts. Food Control 2007, 18:1131-1136.
    • (2007) Food Control , vol.18 , pp. 1131-1136
    • Baydar, N.G.1    Ozkan, G.2    Yasar, S.3
  • 28
    • 84929725029 scopus 로고    scopus 로고
    • Effects of grape seed extract on oxidative stress and antioxidant defense markers in streptozotocin-induced diabetic rats
    • Belviranli M., Gökbel H., Okudan N., Büyükbaş S. Effects of grape seed extract on oxidative stress and antioxidant defense markers in streptozotocin-induced diabetic rats. Turkish Journal of Medical Sciences 2015, 45.
    • (2015) Turkish Journal of Medical Sciences , vol.45
    • Belviranli, M.1    Gökbel, H.2    Okudan, N.3    Büyükbaş, S.4
  • 29
    • 0036888160 scopus 로고    scopus 로고
    • Subchronic 3-month oral toxicity study of grape seed and grape skin extracts
    • Bentivegna S.S., Whitney K.M. Subchronic 3-month oral toxicity study of grape seed and grape skin extracts. Food and Chemical Toxicology 2002, 40:1731-1743.
    • (2002) Food and Chemical Toxicology , vol.40 , pp. 1731-1743
    • Bentivegna, S.S.1    Whitney, K.M.2
  • 30
    • 0032991077 scopus 로고    scopus 로고
    • Inhibition of TPA-induced tumor promotion in CD-1 mouse epidermis by a polyphenolic fraction from grape seeds
    • Bomser J., Singletary K., Wallig M.A., Smith M.A.L. Inhibition of TPA-induced tumor promotion in CD-1 mouse epidermis by a polyphenolic fraction from grape seeds. Cancer Letters 1999, 135:151-157.
    • (1999) Cancer Letters , vol.135 , pp. 151-157
    • Bomser, J.1    Singletary, K.2    Wallig, M.A.3    Smith, M.A.L.4
  • 31
    • 0034659120 scopus 로고    scopus 로고
    • Inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin ornithine decarboxylase and protein kinase C by polyphenolics from grapes
    • Bomser J., Singletary K., Meline B. Inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin ornithine decarboxylase and protein kinase C by polyphenolics from grapes. Chemico-Biological Interactions 2000, 127:45-59.
    • (2000) Chemico-Biological Interactions , vol.127 , pp. 45-59
    • Bomser, J.1    Singletary, K.2    Meline, B.3
  • 32
    • 0032953804 scopus 로고    scopus 로고
    • Extraction of phenolic compounds from red grape marc for use as food lipid antioxidants
    • Bonilla F., Mayen M., Merida J., Medina M. Extraction of phenolic compounds from red grape marc for use as food lipid antioxidants. Food Chemistry 1999, 66:209-215.
    • (1999) Food Chemistry , vol.66 , pp. 209-215
    • Bonilla, F.1    Mayen, M.2    Merida, J.3    Medina, M.4
  • 33
    • 0031884778 scopus 로고    scopus 로고
    • High protection by grape seed proanthocyanidins (GSPC) of polyunsaturated fatty acids against UV-C induced peroxidation
    • Bouhamidi R., Prevost V., Nouvelot A. High protection by grape seed proanthocyanidins (GSPC) of polyunsaturated fatty acids against UV-C induced peroxidation. Comptes Rendus de l'Académie des Sciences. Série III 1998, 321:31-38.
    • (1998) Comptes Rendus de l'Académie des Sciences. Série III , vol.321 , pp. 31-38
    • Bouhamidi, R.1    Prevost, V.2    Nouvelot, A.3
  • 34
    • 0034768975 scopus 로고    scopus 로고
    • Procyanidins from Vitis vinifera seeds inhibit the respiratory burst of activated human neutrophils and lysosomal enzyme release
    • Carini M., Stefani R., Aldini G., Orioli M., Maffei Facino R. Procyanidins from Vitis vinifera seeds inhibit the respiratory burst of activated human neutrophils and lysosomal enzyme release. Planta Medica 2001, 67:714-717.
    • (2001) Planta Medica , vol.67 , pp. 714-717
    • Carini, M.1    Stefani, R.2    Aldini, G.3    Orioli, M.4    Maffei Facino, R.5
  • 35
    • 62549100017 scopus 로고    scopus 로고
    • Grape seed extract protects IEC-6 cells from chemotherapy-induced cytotoxicity and improves parameters of small intestinal mucositis in rats with experimentally-induced mucositis
    • Cheah K.Y., Howarth G.S., Yazbeck R., et al. Grape seed extract protects IEC-6 cells from chemotherapy-induced cytotoxicity and improves parameters of small intestinal mucositis in rats with experimentally-induced mucositis. Cancer Biology & Therapy 2009, 8:382-390.
    • (2009) Cancer Biology & Therapy , vol.8 , pp. 382-390
    • Cheah, K.Y.1    Howarth, G.S.2    Yazbeck, R.3
  • 36
    • 84908086411 scopus 로고    scopus 로고
    • Grape seed extract dose-responsively decreases disease severity in a rat model of mucositis; concomitantly enhancing chemotherapeutic effectiveness in colon cancer cells
    • Cheah K.Y., Howarth G.S., Bastian S.E.P. Grape seed extract dose-responsively decreases disease severity in a rat model of mucositis; concomitantly enhancing chemotherapeutic effectiveness in colon cancer cells. PLoS ONE 2014, 9.
    • (2014) PLoS ONE , vol.9
    • Cheah, K.Y.1    Howarth, G.S.2    Bastian, S.E.P.3
  • 37
    • 84929379749 scopus 로고    scopus 로고
    • Grape seed proanthocyanidin extract ameliorates diabetic bladder dysfunction via the activation of the Nrf2 pathway
    • Chen S., Zhu Y., Liu Z., Gao Z., Li B., Zhang D., Zhang Z., et al. Grape seed proanthocyanidin extract ameliorates diabetic bladder dysfunction via the activation of the Nrf2 pathway. PloS One 2015, 10:e0126457.
    • (2015) PloS One , vol.10 , pp. e0126457
    • Chen, S.1    Zhu, Y.2    Liu, Z.3    Gao, Z.4    Li, B.5    Zhang, D.6    Zhang, Z.7
  • 38
    • 36348950244 scopus 로고    scopus 로고
    • Cardioprotective effects of grape seed proanthocyanidins extracts in streptozocin induced diabetic rats
    • Cheng M., Gao H.Q., Xu L., Li B.Y., Zhang H., Li X.H. Cardioprotective effects of grape seed proanthocyanidins extracts in streptozocin induced diabetic rats. Journal of Cardiovascular Pharmacology 2007, 50:503-509.
    • (2007) Journal of Cardiovascular Pharmacology , vol.50 , pp. 503-509
    • Cheng, M.1    Gao, H.Q.2    Xu, L.3    Li, B.Y.4    Zhang, H.5    Li, X.H.6
  • 39
    • 67349283330 scopus 로고    scopus 로고
    • Grape seed proanthocyanidin extract (GSPE) attenuates collagen-induced arthritis
    • Cho M.L., Heo Y.J., Park M.K., Oh H.J., Park J.S., Woo Y.J. Grape seed proanthocyanidin extract (GSPE) attenuates collagen-induced arthritis. Immunology Letters 2009, 124:102-110.
    • (2009) Immunology Letters , vol.124 , pp. 102-110
    • Cho, M.L.1    Heo, Y.J.2    Park, M.K.3    Oh, H.J.4    Park, J.S.5    Woo, Y.J.6
  • 40
    • 84964016859 scopus 로고    scopus 로고
    • Proanthocyanidin metabolism, a mini review
    • Choy Y.Y., Waterhouse A.L. Proanthocyanidin metabolism, a mini review. Nutrition and aging 2014, 2:111-116.
    • (2014) Nutrition and aging , vol.2 , pp. 111-116
    • Choy, Y.Y.1    Waterhouse, A.L.2
  • 41
    • 15244352723 scopus 로고    scopus 로고
    • Effect of grape seed extract and quercetin on cardiovascular and endothelial parameters in high-risk subjects
    • Clifton P.M. Effect of grape seed extract and quercetin on cardiovascular and endothelial parameters in high-risk subjects. Journal of Biomedicine and Biotechnology 2004, 2004:272-278.
    • (2004) Journal of Biomedicine and Biotechnology , vol.2004 , pp. 272-278
    • Clifton, P.M.1
  • 42
    • 84857498577 scopus 로고    scopus 로고
    • Clinical, biometric and ultrasound assessment of the effects of daily use of a nutraceutical composed of lycopene, acerola extract, grape seed extract and biomarine complex in photoaged human skin
    • Costa A., Lindmark L., Arruda L.H., Assumpção E.C., Ota F.S., Pereira Mde O., et al. Clinical, biometric and ultrasound assessment of the effects of daily use of a nutraceutical composed of lycopene, acerola extract, grape seed extract and biomarine complex in photoaged human skin. Anais Brasileiros de Dermatologia 2012, 87:52-61.
    • (2012) Anais Brasileiros de Dermatologia , vol.87 , pp. 52-61
    • Costa, A.1    Lindmark, L.2    Arruda, L.H.3    Assumpção, E.C.4    Ota, F.S.5    Pereira Mde, O.6
  • 44
    • 85028103931 scopus 로고    scopus 로고
    • Microwave-assisted aqueous two-phase extraction of phenolics from grape (Vitis vinifera) seed
    • Dang Y., Zhanga H., Xiua Z. Microwave-assisted aqueous two-phase extraction of phenolics from grape (Vitis vinifera) seed. Journal of Chemical Technology and Biotechnology 2014, 89:1576-1581.
    • (2014) Journal of Chemical Technology and Biotechnology , vol.89 , pp. 1576-1581
    • Dang, Y.1    Zhanga, H.2    Xiua, Z.3
  • 46
    • 67649126552 scopus 로고    scopus 로고
    • Chardonnay grape seed procyanidin extract supplementation prevents high-fat diet-induced obesity in hamsters by improving adipokine imbalance and oxidative stress markers
    • Decorde K., Teissedre P.L., Sutra T., Ventura E., Cristol J.P., Rouanet J.M. Chardonnay grape seed procyanidin extract supplementation prevents high-fat diet-induced obesity in hamsters by improving adipokine imbalance and oxidative stress markers. Molecular Nutrition & Food Research 2009, 53:659-666.
    • (2009) Molecular Nutrition & Food Research , vol.53 , pp. 659-666
    • Decorde, K.1    Teissedre, P.L.2    Sutra, T.3    Ventura, E.4    Cristol, J.P.5    Rouanet, J.M.6
  • 47
    • 0035663005 scopus 로고    scopus 로고
    • Transport of proanthocyanidin dimer, trimer, and polymer across monolayers of human intestinal epithelial Caco-2 cells
    • Deprez S., Mila I., Huneau J.F., Tome D., Scalbert A. Transport of proanthocyanidin dimer, trimer, and polymer across monolayers of human intestinal epithelial Caco-2 cells. Antioxidants & Redox Signaling 2001, 3:957-967.
    • (2001) Antioxidants & Redox Signaling , vol.3 , pp. 957-967
    • Deprez, S.1    Mila, I.2    Huneau, J.F.3    Tome, D.4    Scalbert, A.5
  • 48
    • 84901045742 scopus 로고    scopus 로고
    • Characterization of azoxymethane-induced colon tumor metastasis to lung in a mouse model relevant to human sporadic colorectal cancer and evaluation of grape seed extract efficacy
    • Derry M.M., Raina K., Agarwal R., Agarwal C. Characterization of azoxymethane-induced colon tumor metastasis to lung in a mouse model relevant to human sporadic colorectal cancer and evaluation of grape seed extract efficacy. Experimental and Toxicologic Pathology 2014, 66:235-242.
    • (2014) Experimental and Toxicologic Pathology , vol.66 , pp. 235-242
    • Derry, M.M.1    Raina, K.2    Agarwal, R.3    Agarwal, C.4
  • 49
    • 33645542656 scopus 로고    scopus 로고
    • Grape seed proanthocyanidin extract (GSPE) and antioxidant defense in the brain of adult rats
    • Devi S.A., Jolitha A.B., Ishii N. Grape seed proanthocyanidin extract (GSPE) and antioxidant defense in the brain of adult rats. Medical Science Monitor 2006, 12:124-129.
    • (2006) Medical Science Monitor , vol.12 , pp. 124-129
    • Devi, S.A.1    Jolitha, A.B.2    Ishii, N.3
  • 50
    • 77957255165 scopus 로고    scopus 로고
    • Apoptosis-inducing factor and caspase-dependent apoptotic pathways triggered by different grape seed extracts on human colon cancer cell line Caco-2
    • Dinicola S., Cucina A., Pasqualato A., Proietti S., D'Anselmi F., Pasqua G., Santamaria A.R., et al. Apoptosis-inducing factor and caspase-dependent apoptotic pathways triggered by different grape seed extracts on human colon cancer cell line Caco-2. British Journal of Nutrition 2010, 104:824-832.
    • (2010) British Journal of Nutrition , vol.104 , pp. 824-832
    • Dinicola, S.1    Cucina, A.2    Pasqualato, A.3    Proietti, S.4    D'Anselmi, F.5    Pasqua, G.6    Santamaria, A.R.7
  • 51
    • 84856296568 scopus 로고    scopus 로고
    • Antiproliferative and apoptotic effects triggered by grape seed extract (GSE) versus epigallocatechin and procyanidins on colon cancer cell lines
    • Dinicola S., Cucina A., Pasqualato A., D'Anselmi F., Proietti S., Lisi E., et al. Antiproliferative and apoptotic effects triggered by grape seed extract (GSE) versus epigallocatechin and procyanidins on colon cancer cell lines. International Journal of Molecular Sciences 2012, 13:651-664.
    • (2012) International Journal of Molecular Sciences , vol.13 , pp. 651-664
    • Dinicola, S.1    Cucina, A.2    Pasqualato, A.3    D'Anselmi, F.4    Proietti, S.5    Lisi, E.6
  • 53
    • 84872782870 scopus 로고    scopus 로고
    • Grape seed proanthocyanidin extracts alleviate oxidative stress and ER stress in skeletal muscle of low-dose streptozotocin- and high carbohydrate/high-fat diet-induced diabetic rats
    • Ding Y., Dai X., Jiang Y., Zhang Z., Bao L., Li Y., et al. Grape seed proanthocyanidin extracts alleviate oxidative stress and ER stress in skeletal muscle of low-dose streptozotocin- and high carbohydrate/high-fat diet-induced diabetic rats. Molecular Nutrition & Food Research 2013, 57:365-369.
    • (2013) Molecular Nutrition & Food Research , vol.57 , pp. 365-369
    • Ding, Y.1    Dai, X.2    Jiang, Y.3    Zhang, Z.4    Bao, L.5    Li, Y.6
  • 54
    • 84880335696 scopus 로고    scopus 로고
    • Grape seed proanthocyanidins ameliorate pancreatic β-cell dysfunction and death in low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats partially by regulating endoplasmic reticulum stress
    • Ding Y., Zhang Z., Dai X., Jiang Y., Bao L., Let Y., et al. Grape seed proanthocyanidins ameliorate pancreatic β-cell dysfunction and death in low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats partially by regulating endoplasmic reticulum stress. Nutrition and Metabolism 2013, 10:51.
    • (2013) Nutrition and Metabolism , vol.10 , pp. 51
    • Ding, Y.1    Zhang, Z.2    Dai, X.3    Jiang, Y.4    Bao, L.5    Let, Y.6
  • 55
    • 84855771864 scopus 로고    scopus 로고
    • Hepatoprotective and antioxidant activities of grape seeds against ethanol-induced oxidative stress in rats
    • Dogan A., Celik I. Hepatoprotective and antioxidant activities of grape seeds against ethanol-induced oxidative stress in rats. British Journal of Nutrition 2012, 107:45-51.
    • (2012) British Journal of Nutrition , vol.107 , pp. 45-51
    • Dogan, A.1    Celik, I.2
  • 56
    • 0036229187 scopus 로고    scopus 로고
    • Procyanidins are not bioavailable in rats fed a single meal containing a grape seed extract or the procyanidin dimer B3
    • Donovan J.L., Manach C., Rios L., Morand C., Scalbert A., Re'me'sy C. Procyanidins are not bioavailable in rats fed a single meal containing a grape seed extract or the procyanidin dimer B3. British Journal of Nutrition 2002, 87:299-306.
    • (2002) British Journal of Nutrition , vol.87 , pp. 299-306
    • Donovan, J.L.1    Manach, C.2    Rios, L.3    Morand, C.4    Scalbert, A.5    Re'me'sy, C.6
  • 57
    • 84921067099 scopus 로고    scopus 로고
    • Phenolic compounds, antioxidant activity and insulinotropic effect of extracts prepared from grape (Vitis vinifera L) byproducts
    • Doshi P., Adsule P., Banerjee K., Oulkar D. Phenolic compounds, antioxidant activity and insulinotropic effect of extracts prepared from grape (Vitis vinifera L) byproducts. Journal of Food Science and Technology 2015, 52:181-190.
    • (2015) Journal of Food Science and Technology , vol.52 , pp. 181-190
    • Doshi, P.1    Adsule, P.2    Banerjee, K.3    Oulkar, D.4
  • 58
    • 33947592661 scopus 로고    scopus 로고
    • Grape seed polyphenols protect cardiac cells from apoptosis via induction of endogenous antioxidant enzymes
    • Du Y., Guo H., Lou H. Grape seed polyphenols protect cardiac cells from apoptosis via induction of endogenous antioxidant enzymes. Journal of Agricultural and Food Chemistry 2007, 55:1695-1701.
    • (2007) Journal of Agricultural and Food Chemistry , vol.55 , pp. 1695-1701
    • Du, Y.1    Guo, H.2    Lou, H.3
  • 59
    • 84927537252 scopus 로고    scopus 로고
    • Extraction of polyphenols from grape skins and defatted grape seeds using subcritical water: Experiments and modeling
    • Duba K.S., Casazza A.A., Mohamed H., Perego P., Fiori L. Extraction of polyphenols from grape skins and defatted grape seeds using subcritical water: Experiments and modeling. Food and Bioproducts Processing 2015, 94:29-38.
    • (2015) Food and Bioproducts Processing , vol.94 , pp. 29-38
    • Duba, K.S.1    Casazza, A.A.2    Mohamed, H.3    Perego, P.4    Fiori, L.5
  • 62
    • 38949123212 scopus 로고    scopus 로고
    • Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract
    • Edirisinghe I., Burton-Freeman B., Tissa K.C. Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract. Clinical Science (London) 2008, 114:331-337.
    • (2008) Clinical Science (London) , vol.114 , pp. 331-337
    • Edirisinghe, I.1    Burton-Freeman, B.2    Tissa, K.C.3
  • 63
    • 84901985283 scopus 로고    scopus 로고
    • Combination of grape seed proanthocyanidin extract and docosahexaenoic acid-rich oil increases the hepatic detoxification by GST mediated GSH conjugation in a lipidic postprandial state
    • Fernández-Iglesias A., Quesada H., Díaz S., Pajuelo D., Bladé C., Arola L., Mulero M. Combination of grape seed proanthocyanidin extract and docosahexaenoic acid-rich oil increases the hepatic detoxification by GST mediated GSH conjugation in a lipidic postprandial state. Food Chemistry 2014, 165:14-20.
    • (2014) Food Chemistry , vol.165 , pp. 14-20
    • Fernández-Iglesias, A.1    Quesada, H.2    Díaz, S.3    Pajuelo, D.4    Bladé, C.5    Arola, L.6    Mulero, M.7
  • 64
    • 22144469767 scopus 로고    scopus 로고
    • Protective effect of red grape seeds proanthocyanidins against induction of diabetes by alloxan in rats
    • El-Alfy A.T., Ahmed A.A.E., Fatani A.J. Protective effect of red grape seeds proanthocyanidins against induction of diabetes by alloxan in rats. Pharmacological Research 2005, 52:264-270.
    • (2005) Pharmacological Research , vol.52 , pp. 264-270
    • El-Alfy, A.T.1    Ahmed, A.A.E.2    Fatani, A.J.3
  • 65
    • 34848842526 scopus 로고    scopus 로고
    • Effects of marjoram volatile oil and grape seed extract on ethanol toxicity in male rats
    • El-Ashmawy I.M., Saleh A., Salama O.M. Effects of marjoram volatile oil and grape seed extract on ethanol toxicity in male rats. Basic & Clinical Pharmacology & Toxicology 2007, 101:320-327.
    • (2007) Basic & Clinical Pharmacology & Toxicology , vol.101 , pp. 320-327
    • El-Ashmawy, I.M.1    Saleh, A.2    Salama, O.M.3
  • 66
    • 36549048357 scopus 로고    scopus 로고
    • Effect of grape seed extract on lipid peroxidation, antioxidant activity and peripheral blood lymphocytes in rats exposed to x-radiation
    • Enginar H., Cemek M., Karaca T., Unak P. Effect of grape seed extract on lipid peroxidation, antioxidant activity and peripheral blood lymphocytes in rats exposed to x-radiation. Phytotherapy Research 2007, 21:1029-1035.
    • (2007) Phytotherapy Research , vol.21 , pp. 1029-1035
    • Enginar, H.1    Cemek, M.2    Karaca, T.3    Unak, P.4
  • 68
    • 0042282804 scopus 로고    scopus 로고
    • Mass spectrometry in grape and wine chemistry. Part I: Polyphenols
    • Flamini R. Mass spectrometry in grape and wine chemistry. Part I: Polyphenols. Mass Spectrometry Reviews 2003, 22:218-250.
    • (2003) Mass Spectrometry Reviews , vol.22 , pp. 218-250
    • Flamini, R.1
  • 70
    • 0034052749 scopus 로고    scopus 로고
    • Oligomeric proanthocyanidin complexes: History, structure, and phytopharmaceutical applications
    • Fine A.M. Oligomeric proanthocyanidin complexes: History, structure, and phytopharmaceutical applications. Alternative Medicine Review 2000, 5:144-151.
    • (2000) Alternative Medicine Review , vol.5 , pp. 144-151
    • Fine, A.M.1
  • 71
    • 34247480425 scopus 로고    scopus 로고
    • FAOSTAT
    • Food and Agriculture Organization of the United Nations FAOSTAT database 2012, FAOSTAT, (Available from: ).
    • (2012) FAOSTAT database
  • 72
  • 73
    • 84903794240 scopus 로고    scopus 로고
    • Antibacterial, antiviral, and antifungal properties of wines and winery byproducts in relation to their flavonoid content
    • Friedman M. Antibacterial, antiviral, and antifungal properties of wines and winery byproducts in relation to their flavonoid content. Journal of Agricultural and Food Chemistry 2014, 62:6025-6042.
    • (2014) Journal of Agricultural and Food Chemistry , vol.62 , pp. 6025-6042
    • Friedman, M.1
  • 75
    • 0001033444 scopus 로고    scopus 로고
    • Catechin and procyanidin composition of seeds from grape cultivars grown in Ontario
    • Fuleki T., Ricardo-da-Silva J.M. Catechin and procyanidin composition of seeds from grape cultivars grown in Ontario. Journal of Agricultural and Food Chemistry 1997, 45:1156-1160.
    • (1997) Journal of Agricultural and Food Chemistry , vol.45 , pp. 1156-1160
    • Fuleki, T.1    Ricardo-da-Silva, J.M.2
  • 76
    • 55949097823 scopus 로고    scopus 로고
    • In vitro study of antioxidant capacity and antibacterial activity on oral anaerobes of a grape seed extract
    • Furiga A., Lonvaud-Funel A., Badet C. In vitro study of antioxidant capacity and antibacterial activity on oral anaerobes of a grape seed extract. Food Chemistry 2009, 113:1037-1040.
    • (2009) Food Chemistry , vol.113 , pp. 1037-1040
    • Furiga, A.1    Lonvaud-Funel, A.2    Badet, C.3
  • 77
    • 33645221101 scopus 로고    scopus 로고
    • Recovery of catechins and proanthocyanidins from winery byproducts using subcritical water extraction
    • Garcia-Marino M., Rivas-Gonzalo J., Ibanez E., Garcia-Moreno C. Recovery of catechins and proanthocyanidins from winery byproducts using subcritical water extraction. Analytica Chimica Acta 2006, 563:44-50.
    • (2006) Analytica Chimica Acta , vol.563 , pp. 44-50
    • Garcia-Marino, M.1    Rivas-Gonzalo, J.2    Ibanez, E.3    Garcia-Moreno, C.4
  • 78
    • 84892989486 scopus 로고    scopus 로고
    • Recent advances and uses of grape flavonoids as nutraceuticals
    • Georgiev V., Ananga A., Tsolova V. Recent advances and uses of grape flavonoids as nutraceuticals. Nutrients 2014, 6:391-415.
    • (2014) Nutrients , vol.6 , pp. 391-415
    • Georgiev, V.1    Ananga, A.2    Tsolova, V.3
  • 79
    • 84926363921 scopus 로고    scopus 로고
    • Vitis vinifera (Muscat variety) seed ethanolic extract preserves activity levels of enzymes and histology of the liver in adult male rats with diabetes
    • Giribabu N., Kumar K.E., Rekha S.S., Muniandy S., Salleh N. Vitis vinifera (Muscat variety) seed ethanolic extract preserves activity levels of enzymes and histology of the liver in adult male rats with diabetes. Evidence-based Complementary and Alternative Medicine 2014, 2015.
    • (2014) Evidence-based Complementary and Alternative Medicine , vol.2015
    • Giribabu, N.1    Kumar, K.E.2    Rekha, S.S.3    Muniandy, S.4    Salleh, N.5
  • 80
    • 33746920337 scopus 로고    scopus 로고
    • Advanced glycation end products: Sparking the development of diabetic vascular injury
    • Goldin A., Beckman J.A., Schmidt A.M., Creager M.A. Advanced glycation end products: Sparking the development of diabetic vascular injury. Circulation 2006, 114:597-605.
    • (2006) Circulation , vol.114 , pp. 597-605
    • Goldin, A.1    Beckman, J.A.2    Schmidt, A.M.3    Creager, M.A.4
  • 84
    • 84886866516 scopus 로고    scopus 로고
    • Hepatoprotective effect of red grape seed extracts against ethanol-induced cytotoxicity
    • Hassan H.M. Hepatoprotective effect of red grape seed extracts against ethanol-induced cytotoxicity. Global Journal of Biotechnology & Biochemistry 2012, 7:30-37.
    • (2012) Global Journal of Biotechnology & Biochemistry , vol.7 , pp. 30-37
    • Hassan, H.M.1
  • 85
    • 84881139270 scopus 로고    scopus 로고
    • Grape seeds proanthocyanidin extract as a hepatic-reno-protective agent against gibberellic acid induced oxidative stress and cellular alterations
    • Hassan H.A., Al-Rawi M.M. Grape seeds proanthocyanidin extract as a hepatic-reno-protective agent against gibberellic acid induced oxidative stress and cellular alterations. Cytotechnology 2013, 65:567-576.
    • (2013) Cytotechnology , vol.65 , pp. 567-576
    • Hassan, H.A.1    Al-Rawi, M.M.2
  • 86
    • 4143057071 scopus 로고    scopus 로고
    • Neuroprotective effects of grape seed extract on neuronal injury by inhibiting DNA damage in the gerbil hippocampus after transient forebrain ischemia
    • Hwang I.K., Yoo K.Y., Kim D.S., Jeong Y.K., Kim J.D., Shin H.K., et al. Neuroprotective effects of grape seed extract on neuronal injury by inhibiting DNA damage in the gerbil hippocampus after transient forebrain ischemia. Life Sciences 2004, 75:1989-2001.
    • (2004) Life Sciences , vol.75 , pp. 1989-2001
    • Hwang, I.K.1    Yoo, K.Y.2    Kim, D.S.3    Jeong, Y.K.4    Kim, J.D.5    Shin, H.K.6
  • 87
    • 84868555271 scopus 로고    scopus 로고
    • International Diabetes Federation Diabetes atlas 2013, (www.idf.org/diabetesatlas). 6th ed.
    • (2013) Diabetes atlas
  • 88
    • 84903757296 scopus 로고    scopus 로고
    • Comparative study of the enological potential of different winemaking byproducts: Implications in the antioxidant activity and color expression of red wine anthocyanins in a model solution
    • Jara-Palacios M.J., Gordillo B., González-Miret M.L., Hernanz D., Escudero-Gilete M.L., Heredia F.J. Comparative study of the enological potential of different winemaking byproducts: Implications in the antioxidant activity and color expression of red wine anthocyanins in a model solution. Journal of Agricultural and Food Chemistry 2014, 62:6975-6983.
    • (2014) Journal of Agricultural and Food Chemistry , vol.62 , pp. 6975-6983
    • Jara-Palacios, M.J.1    Gordillo, B.2    González-Miret, M.L.3    Hernanz, D.4    Escudero-Gilete, M.L.5    Heredia, F.J.6
  • 89
    • 0035029740 scopus 로고    scopus 로고
    • Antioxidant activity of grape seed (Vitis vinifera) extracts on peroxidation models in vitro
    • Jayaprakasha G.K., Singh R.P., Sakariah K.K. Antioxidant activity of grape seed (Vitis vinifera) extracts on peroxidation models in vitro. Food Chemistry 2001, 73:285-290.
    • (2001) Food Chemistry , vol.73 , pp. 285-290
    • Jayaprakasha, G.K.1    Singh, R.P.2    Sakariah, K.K.3
  • 90
    • 0038154529 scopus 로고    scopus 로고
    • Antibacterial and antioxidant activities of grape (Vitis vinifera) seed extracts
    • Jayaprakasha G.K., Selvi T., Sakariah K.K. Antibacterial and antioxidant activities of grape (Vitis vinifera) seed extracts. Food Research International 2003, 36:117-122.
    • (2003) Food Research International , vol.36 , pp. 117-122
    • Jayaprakasha, G.K.1    Selvi, T.2    Sakariah, K.K.3
  • 91
    • 11844277052 scopus 로고    scopus 로고
    • Biological properties of monomeric and polymeric catechins: Green tea catechins and procyanidins
    • Jeong W., Kong A.T. Biological properties of monomeric and polymeric catechins: Green tea catechins and procyanidins. Pharmaceutical Biology 2004, 42:84-93.
    • (2004) Pharmaceutical Biology , vol.42 , pp. 84-93
    • Jeong, W.1    Kong, A.T.2
  • 92
    • 79551696850 scopus 로고    scopus 로고
    • Grape seed proanthocyanidin extract protects human lens epithelial cells from oxidative stress via reducing NF-kB and MAPK protein expression
    • Jia Z., Song Z., Zhao Y., Wang X., Liu P. Grape seed proanthocyanidin extract protects human lens epithelial cells from oxidative stress via reducing NF-kB and MAPK protein expression. Molecular Vision 2011, 17:210-217.
    • (2011) Molecular Vision , vol.17 , pp. 210-217
    • Jia, Z.1    Song, Z.2    Zhao, Y.3    Wang, X.4    Liu, P.5
  • 93
    • 0034735888 scopus 로고    scopus 로고
    • Chemopreventive effects of grape seed proanthocyanidin extract on Chang liver cells
    • Joshi S.S., Kuszynski C.A., Bagchi M., Bagchi D. Chemopreventive effects of grape seed proanthocyanidin extract on Chang liver cells. Toxicology 2000, 155:83-90.
    • (2000) Toxicology , vol.155 , pp. 83-90
    • Joshi, S.S.1    Kuszynski, C.A.2    Bagchi, M.3    Bagchi, D.4
  • 95
    • 0036681974 scopus 로고    scopus 로고
    • Activin, a grape seed-derived proanthocyanidin extract, reduces plasma levels of oxidative stress and adhesion molecules (ICAM-1, VCAM-1 and E-selectin) in systemic sclerosis
    • Kalin R., Righi A., Del Rosso A., Bagchi D., Generini S., Cerinic M.M., Das D.K. Activin, a grape seed-derived proanthocyanidin extract, reduces plasma levels of oxidative stress and adhesion molecules (ICAM-1, VCAM-1 and E-selectin) in systemic sclerosis. Free Radical Research 2002, 36:819-825.
    • (2002) Free Radical Research , vol.36 , pp. 819-825
    • Kalin, R.1    Righi, A.2    Del Rosso, A.3    Bagchi, D.4    Generini, S.5    Cerinic, M.M.6    Das, D.K.7
  • 96
    • 65549143724 scopus 로고    scopus 로고
    • Effects of grape seed extract in type 2 diabetic subjects at high cardiovascular risk: A double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity
    • Kar P., Laight D., Rooprai H.K., Shaw K.M., Cummings M. Effects of grape seed extract in type 2 diabetic subjects at high cardiovascular risk: A double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabetic Medicine 2009, 26:526-531.
    • (2009) Diabetic Medicine , vol.26 , pp. 526-531
    • Kar, P.1    Laight, D.2    Rooprai, H.K.3    Shaw, K.M.4    Cummings, M.5
  • 97
    • 33750719426 scopus 로고    scopus 로고
    • Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells
    • Kaur M., Singh R.P., Gu M., Agarwal R., Agarwal C. Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells. Clinical Cancer Research 2006, 12:6194-6202.
    • (2006) Clinical Cancer Research , vol.12 , pp. 6194-6202
    • Kaur, M.1    Singh, R.P.2    Gu, M.3    Agarwal, R.4    Agarwal, C.5
  • 98
    • 69549109965 scopus 로고    scopus 로고
    • Anticancer and cancer chemopreventive potential of grape seed extract and other grape-based products
    • Kaur M., Agarwal C., Agarwal R. Anticancer and cancer chemopreventive potential of grape seed extract and other grape-based products. Journal of Nutrition 2009, 139:1806S-1812S.
    • (2009) Journal of Nutrition , vol.139 , pp. 1806S-1812S
    • Kaur, M.1    Agarwal, C.2    Agarwal, R.3
  • 100
    • 9744230005 scopus 로고    scopus 로고
    • Chemoprevention by grape seed extract and genistein in carcinogen-induced mammary cancer in rats is diet dependent
    • (Suppl.)
    • Kim H., Hall P., Smith M., Kirk M., Prasain J.K., Barnes S., et al. Chemoprevention by grape seed extract and genistein in carcinogen-induced mammary cancer in rats is diet dependent. Journal of Nutrition 2004, 134:3445S-3452S. (Suppl.).
    • (2004) Journal of Nutrition , vol.134 , pp. 3445S-3452S
    • Kim, H.1    Hall, P.2    Smith, M.3    Kirk, M.4    Prasain, J.K.5    Barnes, S.6
  • 101
    • 33644914727 scopus 로고    scopus 로고
    • Proteomics analysis of the actions of grape seed extract in rat brain: Technological and biological implications for the study of the actions of psychoactive compounds
    • Kim H., Deshane J., Barnes S., Meleth S. Proteomics analysis of the actions of grape seed extract in rat brain: Technological and biological implications for the study of the actions of psychoactive compounds. Life Sciences 2006, 78:2060-2065.
    • (2006) Life Sciences , vol.78 , pp. 2060-2065
    • Kim, H.1    Deshane, J.2    Barnes, S.3    Meleth, S.4
  • 102
    • 84922660823 scopus 로고    scopus 로고
    • Modulation of the intestinal microbiota is associated with lower plasma cholesterol and weight gain in hamsters fed chardonnay grape seed flour
    • Kim H., Kim D., Seo K., Chon J., Nah S., et al. Modulation of the intestinal microbiota is associated with lower plasma cholesterol and weight gain in hamsters fed chardonnay grape seed flour. Journal of Agricultural and Food Chemistry 2015, 63:1460-1467.
    • (2015) Journal of Agricultural and Food Chemistry , vol.63 , pp. 1460-1467
    • Kim, H.1    Kim, D.2    Seo, K.3    Chon, J.4    Nah, S.5
  • 103
    • 77953773615 scopus 로고    scopus 로고
    • The effect of grape seed extracts on serum paraoxonase activities in streptozotocin-induced diabetic rats
    • Kiyici A., Okudan N., Gokbel H., Belviranli M. The effect of grape seed extracts on serum paraoxonase activities in streptozotocin-induced diabetic rats. Journal of Medicinal Food 2010, 13:725-728.
    • (2010) Journal of Medicinal Food , vol.13 , pp. 725-728
    • Kiyici, A.1    Okudan, N.2    Gokbel, H.3    Belviranli, M.4
  • 104
    • 0035399661 scopus 로고    scopus 로고
    • Upregulation of oxidant-induced VEGF expression in cultured keratinocytes by a grape seed proanthocyanidin extract
    • Khanna S., Roy S., Bagchi D., Bagchi M., Ken C.K. Upregulation of oxidant-induced VEGF expression in cultured keratinocytes by a grape seed proanthocyanidin extract. Free Radical Biology and Medicine 2001, 31:38-42.
    • (2001) Free Radical Biology and Medicine , vol.31 , pp. 38-42
    • Khanna, S.1    Roy, S.2    Bagchi, D.3    Bagchi, M.4    Ken, C.K.5
  • 106
    • 84904289772 scopus 로고    scopus 로고
    • Value-adding to grape waste: Green synthesis of gold nanoparticles
    • Krishnaswamy K., Vali H., Orsat V. Value-adding to grape waste: Green synthesis of gold nanoparticles. Journal of Food Engineering 2014, 142:210-220.
    • (2014) Journal of Food Engineering , vol.142 , pp. 210-220
    • Krishnaswamy, K.1    Vali, H.2    Orsat, V.3
  • 108
    • 0037433581 scopus 로고    scopus 로고
    • Pre- and post-mortem use of grape seed extract in dark poultry meat to inhibit development of thiobarbituric acid reactive substances
    • Lau D.W., King J. Pre- and post-mortem use of grape seed extract in dark poultry meat to inhibit development of thiobarbituric acid reactive substances. Journal of Agricultural and Food Chemistry 2003, 51:1602-1607.
    • (2003) Journal of Agricultural and Food Chemistry , vol.51 , pp. 1602-1607
    • Lau, D.W.1    King, J.2
  • 109
    • 84927800264 scopus 로고    scopus 로고
    • Screening grape seeds recovered from winemaking by-products as sources of reducing agents and mammalian α-glucosidase and α-amylase inhibitors
    • Lavelli V., Sri Harsha P.S.C., Fiori L. Screening grape seeds recovered from winemaking by-products as sources of reducing agents and mammalian α-glucosidase and α-amylase inhibitors. International Journal of Food Science and Technology 2015, 50:1182-1189.
    • (2015) International Journal of Food Science and Technology , vol.50 , pp. 1182-1189
    • Lavelli, V.1    Sri Harsha, P.S.C.2    Fiori, L.3
  • 110
    • 59449099955 scopus 로고    scopus 로고
    • Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity
    • Leifert W.R., Abeywardena M.Y. Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity. Nutrition Research 2008, 28:842-850.
    • (2008) Nutrition Research , vol.28 , pp. 842-850
    • Leifert, W.R.1    Abeywardena, M.Y.2
  • 111
    • 0035213180 scopus 로고    scopus 로고
    • Anti-inflammatory effect and mechanism of proanthocyanidins from grape seeds
    • Li W.G., Zhang X.Y., Wu Y.J., Tian X. Anti-inflammatory effect and mechanism of proanthocyanidins from grape seeds. Acta Pharmacologica Sinica 2001, 22:1117-1120.
    • (2001) Acta Pharmacologica Sinica , vol.22 , pp. 1117-1120
    • Li, W.G.1    Zhang, X.Y.2    Wu, Y.J.3    Tian, X.4
  • 112
    • 57349140730 scopus 로고    scopus 로고
    • Therapeutic effect and mechanism of proanthocyanidins from grape seeds in rats with TNBS-induced ulcerative colitis
    • Li X.L., Cai Y.Q., Qin H., Wu Y.J. Therapeutic effect and mechanism of proanthocyanidins from grape seeds in rats with TNBS-induced ulcerative colitis. Canadian Journal of Physiology and Pharmacology 2008, 86:841-849.
    • (2008) Canadian Journal of Physiology and Pharmacology , vol.86 , pp. 841-849
    • Li, X.L.1    Cai, Y.Q.2    Qin, H.3    Wu, Y.J.4
  • 113
    • 43449114799 scopus 로고    scopus 로고
    • Back-regulation of six oxidative stress proteins with grape seed proanthocyanidin extracts in rat diabetic nephropathy
    • Li B.Y., Cheng M., Gao H.Q., Ma Y.B., Xu L., Li X.H., et al. Back-regulation of six oxidative stress proteins with grape seed proanthocyanidin extracts in rat diabetic nephropathy. Journal of Cellular Biochemistry 2008, 104:668-679.
    • (2008) Journal of Cellular Biochemistry , vol.104 , pp. 668-679
    • Li, B.Y.1    Cheng, M.2    Gao, H.Q.3    Ma, Y.B.4    Xu, L.5    Li, X.H.6
  • 114
    • 73649138248 scopus 로고    scopus 로고
    • Proteomics approach to study the mechanism of action of grape seed proanthocyanidin extracts on arterial remodeling in diabetic rats
    • Li X.L., Li B.Y., Gao H.Q., Cheng M., Xu L., Li X.H., et al. Proteomics approach to study the mechanism of action of grape seed proanthocyanidin extracts on arterial remodeling in diabetic rats. International Journal of Molecular Medicine 2009, 25:237-248.
    • (2009) International Journal of Molecular Medicine , vol.25 , pp. 237-248
    • Li, X.L.1    Li, B.Y.2    Gao, H.Q.3    Cheng, M.4    Xu, L.5    Li, X.H.6
  • 115
    • 58149340830 scopus 로고    scopus 로고
    • Grape seed proanthocyanidins ameliorate diabetic nephropathy via modulation of levels of AGE, RAGE and CTGF
    • Li X., Xiao Y., Gao H., Li B., Xu L., Cheng M., et al. Grape seed proanthocyanidins ameliorate diabetic nephropathy via modulation of levels of AGE, RAGE and CTGF. Nephron Experimental Nephrology 2009, 111:e31-e41.
    • (2009) Nephron Experimental Nephrology , vol.111 , pp. e31-e41
    • Li, X.1    Xiao, Y.2    Gao, H.3    Li, B.4    Xu, L.5    Cheng, M.6
  • 118
    • 84949100675 scopus 로고    scopus 로고
    • Optimization of subcritical water extraction of proanthocyanidins from grape seeds by response surface methodology
    • Li C., Zheng Y., Wang W., Wang N., Yang R. Optimization of subcritical water extraction of proanthocyanidins from grape seeds by response surface methodology. Shipin Kexue (Food Science) 2010, 31:6-10.
    • (2010) Shipin Kexue (Food Science) , vol.31 , pp. 6-10
    • Li, C.1    Zheng, Y.2    Wang, W.3    Wang, N.4    Yang, R.5
  • 120
    • 0344075992 scopus 로고    scopus 로고
    • The polyphenol constituents of grape pomace
    • Lu Y., Foo Y.L. The polyphenol constituents of grape pomace. Food Chemistry 1999, 65:1-8.
    • (1999) Food Chemistry , vol.65 , pp. 1-8
    • Lu, Y.1    Foo, Y.L.2
  • 121
    • 79955646921 scopus 로고    scopus 로고
    • Toxicology evaluation of a procyanidin-rich extract from grape skins and seeds
    • Lluis L., Munoz M., Nogues M.R., et al. Toxicology evaluation of a procyanidin-rich extract from grape skins and seeds. Food and Chemical Toxicology 2011, 49:1450-1454.
    • (2011) Food and Chemical Toxicology , vol.49 , pp. 1450-1454
    • Lluis, L.1    Munoz, M.2    Nogues, M.R.3
  • 122
    • 77954296915 scopus 로고    scopus 로고
    • Protective effects of grape seed proanthocyanidin extracts on cerebral cortex of streptozotocin-induced diabetic rats through modulating AGEs/RAGE/NF-kappaB pathway
    • Lu M., Xu L., Li B., Zhang W., Zhang C., Feng H., Gao H. Protective effects of grape seed proanthocyanidin extracts on cerebral cortex of streptozotocin-induced diabetic rats through modulating AGEs/RAGE/NF-kappaB pathway. Journal of Nutritional Science and Vitaminology 2010, 56:87-97.
    • (2010) Journal of Nutritional Science and Vitaminology , vol.56 , pp. 87-97
    • Lu, M.1    Xu, L.2    Li, B.3    Zhang, W.4    Zhang, C.5    Feng, H.6    Gao, H.7
  • 123
    • 34248570908 scopus 로고    scopus 로고
    • Inhibitory effect of chardonnay and black raspberry seed extracts on lipid oxidation in fish oil and their radical scavenging and antimicrobial properties
    • Luther M., Parry J., Moore J., Meng J., Zhang Y., Cheng Z., et al. Inhibitory effect of chardonnay and black raspberry seed extracts on lipid oxidation in fish oil and their radical scavenging and antimicrobial properties. Food Chemistry 2007, 104:1065-1073.
    • (2007) Food Chemistry , vol.104 , pp. 1065-1073
    • Luther, M.1    Parry, J.2    Moore, J.3    Meng, J.4    Zhang, Y.5    Cheng, Z.6
  • 124
    • 34249779224 scopus 로고    scopus 로고
    • Grape seed proanthocyanidin extracts inhibit vascular cell adhesion molecule expression induced by advanced glycation endproducts through activation of peroxisome proliferators-activated receptor gamma
    • Ma L., Gao H., Li B., Ma Y., You B., Zhang F. Grape seed proanthocyanidin extracts inhibit vascular cell adhesion molecule expression induced by advanced glycation endproducts through activation of peroxisome proliferators-activated receptor gamma. Cardiovascular Pharmacology 2007, 49:293-298.
    • (2007) Cardiovascular Pharmacology , vol.49 , pp. 293-298
    • Ma, L.1    Gao, H.2    Li, B.3    Ma, Y.4    You, B.5    Zhang, F.6
  • 125
    • 0344188829 scopus 로고    scopus 로고
    • Procyanidines from Vitis vinifera seeds protect rabbit heart from ischemia/reperfusion injury: Antioxidant intervention and/or iron and copper sequestering ability
    • Maffei Facino R., Carini M., Aldini G., Berti F., Rossoni G., Bombardelli E., et al. Procyanidines from Vitis vinifera seeds protect rabbit heart from ischemia/reperfusion injury: Antioxidant intervention and/or iron and copper sequestering ability. Planta Medica 1996, 62:495-502.
    • (1996) Planta Medica , vol.62 , pp. 495-502
    • Maffei Facino, R.1    Carini, M.2    Aldini, G.3    Berti, F.4    Rossoni, G.5    Bombardelli, E.6
  • 127
    • 84870704679 scopus 로고    scopus 로고
    • Grape seed extract neutralizes the effects of Cerastes cerastes cerastes post-synaptic neurotoxin in mouse diaphragm
    • Mahmoud Y.I. Grape seed extract neutralizes the effects of Cerastes cerastes cerastes post-synaptic neurotoxin in mouse diaphragm. Micron 2013, 44:298-302.
    • (2013) Micron , vol.44 , pp. 298-302
    • Mahmoud, Y.I.1
  • 128
    • 82555186525 scopus 로고    scopus 로고
    • Effects of grape seed proanthocyanidin extract on oxidative stress induced by diabetes in rat kidney
    • Mansouri E., Panahi M., Ghaffari M.A., Ghorbani A. Effects of grape seed proanthocyanidin extract on oxidative stress induced by diabetes in rat kidney. Iranian Biomedical Journal 2011, 15:100-106.
    • (2011) Iranian Biomedical Journal , vol.15 , pp. 100-106
    • Mansouri, E.1    Panahi, M.2    Ghaffari, M.A.3    Ghorbani, A.4
  • 130
    • 84905649151 scopus 로고    scopus 로고
    • A dose-response study of the bioavailability of grape seed proanthocyanidin in rat and lipid-lowering effects of generated metabolites in HepG2 cells
    • Margalef M., Guerreroa L., Pons Z., Bravo F.I., Arola L., Muguerza B., et al. A dose-response study of the bioavailability of grape seed proanthocyanidin in rat and lipid-lowering effects of generated metabolites in HepG2 cells. Food Research International 2014, 64:500-507.
    • (2014) Food Research International , vol.64 , pp. 500-507
    • Margalef, M.1    Guerreroa, L.2    Pons, Z.3    Bravo, F.I.4    Arola, L.5    Muguerza, B.6
  • 132
    • 0032773482 scopus 로고    scopus 로고
    • Inhibitory effect of procyanidin-rich extracts on LDL oxidation in vitro
    • Mazur A., Bayle D., Lab C., Rock E., Raysiguier Y. Inhibitory effect of procyanidin-rich extracts on LDL oxidation in vitro. Atherosclerosis 1999, 145:421-422.
    • (1999) Atherosclerosis , vol.145 , pp. 421-422
    • Mazur, A.1    Bayle, D.2    Lab, C.3    Rock, E.4    Raysiguier, Y.5
  • 133
    • 80054961809 scopus 로고    scopus 로고
    • Grape seed extract supplementation prevents high-fructose diet-induced insulin resistance in rats by improving insulin and adiponectin signaling pathways
    • Meeprom A., Sompong W., Suwannaphet W., Yibchokanun S., Adisakwattana S. Grape seed extract supplementation prevents high-fructose diet-induced insulin resistance in rats by improving insulin and adiponectin signaling pathways. British Journal of Nutrition 2011, 106:1173-1181.
    • (2011) British Journal of Nutrition , vol.106 , pp. 1173-1181
    • Meeprom, A.1    Sompong, W.2    Suwannaphet, W.3    Yibchokanun, S.4    Adisakwattana, S.5
  • 134
    • 0042889220 scopus 로고    scopus 로고
    • Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: Relationship to decreased fat and lipid peroxidation
    • Mittal A., Elmets C.A., Katiyar S.K. Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: Relationship to decreased fat and lipid peroxidation. Carcinogenesis 2003, 24:1379-1388.
    • (2003) Carcinogenesis , vol.24 , pp. 1379-1388
    • Mittal, A.1    Elmets, C.A.2    Katiyar, S.K.3
  • 135
    • 84949086061 scopus 로고    scopus 로고
    • Characterization of azoxymethane induced colon tumor metastasis to lung in a mouse model relevant to human sporadic colorectal cancer and evaluation of grape seed extract efficacy
    • Molly D., Komal R., Rajesh A., Aganwal C. Characterization of azoxymethane induced colon tumor metastasis to lung in a mouse model relevant to human sporadic colorectal cancer and evaluation of grape seed extract efficacy. Experimental and Toxicological Pathology 2014, 6:235-242.
    • (2014) Experimental and Toxicological Pathology , vol.6 , pp. 235-242
    • Molly, D.1    Komal, R.2    Rajesh, A.3    Aganwal, C.4
  • 136
    • 84922016736 scopus 로고    scopus 로고
    • Antimicrobial activity of grape seed extract on Alicyclobacillus acidoterrestris DSM 3922 vegetative cells and spores in apple juice
    • Molva C., Baysal A.H. Antimicrobial activity of grape seed extract on Alicyclobacillus acidoterrestris DSM 3922 vegetative cells and spores in apple juice. LWT - Food Science and Technology 2015, 60:238-245.
    • (2015) LWT - Food Science and Technology , vol.60 , pp. 238-245
    • Molva, C.1    Baysal, A.H.2
  • 137
    • 79951609639 scopus 로고    scopus 로고
    • Insights into the metabolism and microbial biotransformation of dietary flavan-3-ols and the bioactivity of their metabolites
    • Monagas M., Urpi-Sarda M., Sánchez-Patán F., Llorach R., Garrido I., Gómez- Cordovés C., et al. Insights into the metabolism and microbial biotransformation of dietary flavan-3-ols and the bioactivity of their metabolites. Food & Function 2010, 1:233-253.
    • (2010) Food & Function , vol.1 , pp. 233-253
    • Monagas, M.1    Urpi-Sarda, M.2    Sánchez-Patán, F.3    Llorach, R.4    Garrido, I.5    Gómez-Cordovés, C.6
  • 139
    • 77952879785 scopus 로고    scopus 로고
    • Oligomers of grape-seed procyanidin extract activate the insulin receptor and key targets of the pathway differently from insulin
    • Montagut G., Onnockx S., Vaque M., Bladé C., Blay M., Fernández-Larrea J., et al. Oligomers of grape-seed procyanidin extract activate the insulin receptor and key targets of the pathway differently from insulin. Journal of Nutritional Biochemistry 2010, 21:476-481.
    • (2010) Journal of Nutritional Biochemistry , vol.21 , pp. 476-481
    • Montagut, G.1    Onnockx, S.2    Vaque, M.3    Bladé, C.4    Blay, M.5    Fernández-Larrea, J.6
  • 140
    • 9144256952 scopus 로고    scopus 로고
    • Monomeric, oligomeric, and polymeric flavan-3-ol composition of wines and grapes from Vitis vinifera L. Cv. Graciano, Tempranillo, and Cabernet Sauvignon
    • Monagas M., Gomez-Cordoves C., Bartolome B., Laureano O., Ricardo da Silva J.M. Monomeric, oligomeric, and polymeric flavan-3-ol composition of wines and grapes from Vitis vinifera L. Cv. Graciano, Tempranillo, and Cabernet Sauvignon. Journal of Agricultural and Food Chemistry 2003, 51:6475-6481.
    • (2003) Journal of Agricultural and Food Chemistry , vol.51 , pp. 6475-6481
    • Monagas, M.1    Gomez-Cordoves, C.2    Bartolome, B.3    Laureano, O.4    Ricardo da Silva, J.M.5
  • 141
    • 0342431572 scopus 로고
    • Changes in the chromatographic profile of anthocyanins of red onion during extraction
    • Moore A.B., Francis F.J., Jason M.E. Changes in the chromatographic profile of anthocyanins of red onion during extraction. Journal of Food Protection 1982, 45:738-741.
    • (1982) Journal of Food Protection , vol.45 , pp. 738-741
    • Moore, A.B.1    Francis, F.J.2    Jason, M.E.3
  • 142
    • 0027492737 scopus 로고
    • Antioxidant and iron chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures
    • Morel I., Lescoat G., Cogrel P., Sergent O., Pasdeloup N., Brissot P., et al. Antioxidant and iron chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures. Biochemical Pharmacology 1993, 45:13-19.
    • (1993) Biochemical Pharmacology , vol.45 , pp. 13-19
    • Morel, I.1    Lescoat, G.2    Cogrel, P.3    Sergent, O.4    Pasdeloup, N.5    Brissot, P.6
  • 143
    • 37349091446 scopus 로고    scopus 로고
    • Effect of dietary fat-soluble vitamins A and E and proanthocyanidin-rich extract from grape seeds on oxidative DNA damage in rats
    • Morin B., Narbonne J.F., Ribera D., Badouard C., Ravanat J.L. Effect of dietary fat-soluble vitamins A and E and proanthocyanidin-rich extract from grape seeds on oxidative DNA damage in rats. Food and Chemical Toxicology 2008, 46:787-796.
    • (2008) Food and Chemical Toxicology , vol.46 , pp. 787-796
    • Morin, B.1    Narbonne, J.F.2    Ribera, D.3    Badouard, C.4    Ravanat, J.L.5
  • 144
    • 0033852165 scopus 로고    scopus 로고
    • Extraction of natural complex phenols and tannins from grape seeds by using supercritical mixtures of carbon dioxide and alcohol
    • Murga R., Ruiz R., Beltran S., Cabezas J.L. Extraction of natural complex phenols and tannins from grape seeds by using supercritical mixtures of carbon dioxide and alcohol. Journal of Agricultural and Food Chemistry 2000, 48:3408-3412.
    • (2000) Journal of Agricultural and Food Chemistry , vol.48 , pp. 3408-3412
    • Murga, R.1    Ruiz, R.2    Beltran, S.3    Cabezas, J.L.4
  • 145
    • 85015437464 scopus 로고    scopus 로고
    • Protective effect of grape seed extract and/or silymarin against thioacetamide-induced hepatic fibrosis in rats
    • Nada S.A., Gowifel A.M.H., El-Denshary E.E.S., Salama A.A., Khalil M.G., Ahmad K.A. Protective effect of grape seed extract and/or silymarin against thioacetamide-induced hepatic fibrosis in rats. Journal of Liver 2015, 4:178.
    • (2015) Journal of Liver , vol.4 , pp. 178
    • Nada, S.A.1    Gowifel, A.M.H.2    El-Denshary, E.E.S.3    Salama, A.A.4    Khalil, M.G.5    Ahmad, K.A.6
  • 146
    • 0242570130 scopus 로고    scopus 로고
    • Analysis of proanthocyanidins in grape seed extracts, health foods and grape seed oils
    • Nakamura Y., Tsuji S., Tonogai Y. Analysis of proanthocyanidins in grape seed extracts, health foods and grape seed oils. Journal of Health Science 2003, 49:45-54.
    • (2003) Journal of Health Science , vol.49 , pp. 45-54
    • Nakamura, Y.1    Tsuji, S.2    Tonogai, Y.3
  • 147
    • 51549102594 scopus 로고    scopus 로고
    • Multi-targeted prevention and therapy of cancer by proanthocyanidins
    • Nandakumar V., Singh T., Katiyar S.K. Multi-targeted prevention and therapy of cancer by proanthocyanidins. Cancer Letters 2008, 269:378-387.
    • (2008) Cancer Letters , vol.269 , pp. 378-387
    • Nandakumar, V.1    Singh, T.2    Katiyar, S.K.3
  • 149
    • 79551508556 scopus 로고    scopus 로고
    • Differential neuroprotective activity of two different grape seed extracts
    • Narita K., Hisamoto M., Okuda T., Takeda S. Differential neuroprotective activity of two different grape seed extracts. PloS One 2011, 6:1-10.
    • (2011) PloS One , vol.6 , pp. 1-10
    • Narita, K.1    Hisamoto, M.2    Okuda, T.3    Takeda, S.4
  • 150
    • 84949093299 scopus 로고    scopus 로고
    • Method for extraction of proanthocyanidins from plant material
    • Nasis-Moragher, K., Svanoe, T. T., & Seroy, W. A. (1999). Method for extraction of proanthocyanidins from plant material. US patent 5, 912,363.
    • (1999)
    • Nasis-Moragher, K.1    Svanoe, T.T.2    Seroy, W.A.3
  • 151
    • 69449092522 scopus 로고    scopus 로고
    • Review of the pharmacological effects of Vitis vinifera (grape) and its bioactive compounds
    • Nassiri-Asl M., Hosseinzadeh H. Review of the pharmacological effects of Vitis vinifera (grape) and its bioactive compounds. Phytotherapy Research 2009, 23:1197-1204.
    • (2009) Phytotherapy Research , vol.23 , pp. 1197-1204
    • Nassiri-Asl, M.1    Hosseinzadeh, H.2
  • 152
  • 153
    • 84934441530 scopus 로고    scopus 로고
    • The role of grape seed extract in the treatment of chemo/radiotherapy induced toxicity: A systematic review of preclinical studies
    • Olaku O.O., Ojukwu M.O., Zia F.Z., White J.D. The role of grape seed extract in the treatment of chemo/radiotherapy induced toxicity: A systematic review of preclinical studies. Nutrition and Cancer 2015, 67:730-740.
    • (2015) Nutrition and Cancer , vol.67 , pp. 730-740
    • Olaku, O.O.1    Ojukwu, M.O.2    Zia, F.Z.3    White, J.D.4
  • 155
    • 0033371674 scopus 로고    scopus 로고
    • Fractional extraction of compounds from grape seeds by supercritical fluid extraction and analysis for antimicrobial and agrochemical activities
    • Palma M., Taylor L.T. Fractional extraction of compounds from grape seeds by supercritical fluid extraction and analysis for antimicrobial and agrochemical activities. Journal of Agricultural and Food Chemistry 1999, 47:5044-5048.
    • (1999) Journal of Agricultural and Food Chemistry , vol.47 , pp. 5044-5048
    • Palma, M.1    Taylor, L.T.2
  • 156
    • 79952085774 scopus 로고    scopus 로고
    • Grape seed extract regulates androgen receptor-mediated transcription in prostate cancer cells through potent anti-histone acetyltransferase activity
    • Park S.Y., Lee Y.H., Choi K.C., Seong A.R., Choi H.K., Lee O.H., et al. Grape seed extract regulates androgen receptor-mediated transcription in prostate cancer cells through potent anti-histone acetyltransferase activity. Journal of Medicinal Food 2011, 14:9-16.
    • (2011) Journal of Medicinal Food , vol.14 , pp. 9-16
    • Park, S.Y.1    Lee, Y.H.2    Choi, K.C.3    Seong, A.R.4    Choi, H.K.5    Lee, O.H.6
  • 157
    • 0036228249 scopus 로고    scopus 로고
    • Grape seed proanthocyanidins improved cardiac recovery during reperfusion after ischemia in isolated rat hearts
    • Pataki T., Bak I., Kovacs P., Bagchi D., Das D.K., Tosaki A. Grape seed proanthocyanidins improved cardiac recovery during reperfusion after ischemia in isolated rat hearts. American Journal of Clinical Nutrition 2002, 75:894-899.
    • (2002) American Journal of Clinical Nutrition , vol.75 , pp. 894-899
    • Pataki, T.1    Bak, I.2    Kovacs, P.3    Bagchi, D.4    Das, D.K.5    Tosaki, A.6
  • 158
    • 61349177895 scopus 로고    scopus 로고
    • Interaction of astringent grape seed procyanidins with oral epithelial cells
    • Payne C., Bowyer P.K., Herderich M., Bastian S.E.P. Interaction of astringent grape seed procyanidins with oral epithelial cells. Food Chemistry 2009, 115:551-557.
    • (2009) Food Chemistry , vol.115 , pp. 551-557
    • Payne, C.1    Bowyer, P.K.2    Herderich, M.3    Bastian, S.E.P.4
  • 159
    • 0031948517 scopus 로고    scopus 로고
    • Study of the extraction of proanthocyanidins from grape seeds
    • Pekic B., Kovac V., Alonso E., Revilla E. Study of the extraction of proanthocyanidins from grape seeds. Food Chemistry 1998, 61:201-206.
    • (1998) Food Chemistry , vol.61 , pp. 201-206
    • Pekic, B.1    Kovac, V.2    Alonso, E.3    Revilla, E.4
  • 161
    • 69549138060 scopus 로고    scopus 로고
    • Grape consumption supports immunity in animals and humans
    • Percival S.S. Grape consumption supports immunity in animals and humans. Journal of Nutrition 2009, 139:1801S-1805S.
    • (2009) Journal of Nutrition , vol.139 , pp. 1801S-1805S
    • Percival, S.S.1
  • 162
    • 84921885413 scopus 로고    scopus 로고
    • A galloylated dimeric proanthocyanidin from grape seed exhibits dentin biomodification potential
    • Phansalkar R.S., Nam J., Chen S., McAlpine J.B., Napolitano J.G., et al. A galloylated dimeric proanthocyanidin from grape seed exhibits dentin biomodification potential. Fitoterapia 2015, 101:169-178.
    • (2015) Fitoterapia , vol.101 , pp. 169-178
    • Phansalkar, R.S.1    Nam, J.2    Chen, S.3    McAlpine, J.B.4    Napolitano, J.G.5
  • 163
    • 9244249143 scopus 로고    scopus 로고
    • Grape seed-derived procyanidins have an antihyperglycemic effect in streptozotoc-ininduced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines
    • Pinent M., Blay M., Blade M.C., Salvado M.J., Arola L., Ardevol A. Grape seed-derived procyanidins have an antihyperglycemic effect in streptozotoc-ininduced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines. Endocrinology 2004, 145:4985-4990.
    • (2004) Endocrinology , vol.145 , pp. 4985-4990
    • Pinent, M.1    Blay, M.2    Blade, M.C.3    Salvado, M.J.4    Arola, L.5    Ardevol, A.6
  • 164
    • 23744475472 scopus 로고    scopus 로고
    • Metabolic fate of glucose on 3T3-L1 adipocytes treated with grape seed-derived procyanidin extract (GSPE). Comparison with the effects of insulin
    • Pinent M., Bladea M.C., Salvadoa M.J., Arola L., Ardeavol A. Metabolic fate of glucose on 3T3-L1 adipocytes treated with grape seed-derived procyanidin extract (GSPE). Comparison with the effects of insulin. Journal of Agricultural and Food Chemistry 2005, 53:5932-5935.
    • (2005) Journal of Agricultural and Food Chemistry , vol.53 , pp. 5932-5935
    • Pinent, M.1    Bladea, M.C.2    Salvadoa, M.J.3    Arola, L.4    Ardeavol, A.5
  • 165
    • 84880071103 scopus 로고    scopus 로고
    • Grape seed proanthocyanidins inhibit migration potential of pancreatic cancer cells by promoting mesenchymal-to-epithelial transition and targeting NF-κB
    • Prasad R., Katiyar S.K. Grape seed proanthocyanidins inhibit migration potential of pancreatic cancer cells by promoting mesenchymal-to-epithelial transition and targeting NF-κB. Cancer Letters 2013, 2013(334):118-126.
    • (2013) Cancer Letters , vol.2013 , Issue.334 , pp. 118-126
    • Prasad, R.1    Katiyar, S.K.2
  • 166
  • 168
    • 34250827944 scopus 로고    scopus 로고
    • Oral grape seed extract inhibits prostate tumor growth and progression in TRAMP mice
    • Raina K., Singh R.P., Agarwal R., Agarwal C. Oral grape seed extract inhibits prostate tumor growth and progression in TRAMP mice. Cancer Research 2007, 67:5976-5982.
    • (2007) Cancer Research , vol.67 , pp. 5976-5982
    • Raina, K.1    Singh, R.P.2    Agarwal, R.3    Agarwal, C.4
  • 169
    • 0033198675 scopus 로고    scopus 로고
    • A novel proanthocyanidin IH636 grape seed extract increases in vivo Bcl-XL expression and prevents acetaminophen-induced programmed and unprogrammed cell death in mouse liver
    • Ray S.D., Kumar M.A., Bagchi D. A novel proanthocyanidin IH636 grape seed extract increases in vivo Bcl-XL expression and prevents acetaminophen-induced programmed and unprogrammed cell death in mouse liver. Archives of Biochemistry and Biophysics 1999, 369:42-58.
    • (1999) Archives of Biochemistry and Biophysics , vol.369 , pp. 42-58
    • Ray, S.D.1    Kumar, M.A.2    Bagchi, D.3
  • 174
    • 61449147954 scopus 로고    scopus 로고
    • Grape seed extract Vitis vinifera protects against radiation-induced oxidative damage and metabolic disorders in rats
    • Saada H.N., Said U.Z., Meky N.H., El A., Azime A.S. Grape seed extract Vitis vinifera protects against radiation-induced oxidative damage and metabolic disorders in rats. Phytotherapy Research 2009, 23:434-438.
    • (2009) Phytotherapy Research , vol.23 , pp. 434-438
    • Saada, H.N.1    Said, U.Z.2    Meky, N.H.3    El, A.4    Azime, A.S.5
  • 177
    • 9644255791 scopus 로고    scopus 로고
    • Anti-thrombotic effect of proanthocyanidin, a purified ingredient of grape seed
    • Sano T., Oda E., Yamashita T. Anti-thrombotic effect of proanthocyanidin, a purified ingredient of grape seed. Thrombosis Research 2005, 115:115-121.
    • (2005) Thrombosis Research , vol.115 , pp. 115-121
    • Sano, T.1    Oda, E.2    Yamashita, T.3
  • 178
    • 84873076983 scopus 로고    scopus 로고
    • Proanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sitting
    • Sano A., Tokutake S., Seo A. Proanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sitting. Journal of the Science of Food and Agriculture 2013, 93:457-462.
    • (2013) Journal of the Science of Food and Agriculture , vol.93 , pp. 457-462
    • Sano, A.1    Tokutake, S.2    Seo, A.3
  • 179
    • 0028903522 scopus 로고
    • Comparative flavan-3-ol composition of seeds from different grape varieties
    • Santos-Buelga C., Francia-Aricha E.M., Escribano-Bailon Comparative flavan-3-ol composition of seeds from different grape varieties. Food Chemistry 1995, 53:197-200.
    • (1995) Food Chemistry , vol.53 , pp. 197-200
    • Santos-Buelga, C.1    Francia-Aricha, E.M.2    Escribano-Bailon3
  • 180
    • 34548421180 scopus 로고    scopus 로고
    • The effect of grape seed extract (GSE) on spatial memory in aged male rats
    • Sarkaki A., Farbood Y., Badavi M. The effect of grape seed extract (GSE) on spatial memory in aged male rats. Pakistan Journal of Medical Sciences 2007, 23:561-565.
    • (2007) Pakistan Journal of Medical Sciences , vol.23 , pp. 561-565
    • Sarkaki, A.1    Farbood, Y.2    Badavi, M.3
  • 182
    • 0035884851 scopus 로고    scopus 로고
    • Grape seed proanthocyanidin reduces cardiomyocyte apoptosis by inhibiting ischemia/reperfusion-induced activation of JNK-1 and C-JUN
    • Sato M., Bagchi D., Tosaki A., Das D.K. Grape seed proanthocyanidin reduces cardiomyocyte apoptosis by inhibiting ischemia/reperfusion-induced activation of JNK-1 and C-JUN. Free Radical Biology and Medicine 2001, 31:729-737.
    • (2001) Free Radical Biology and Medicine , vol.31 , pp. 729-737
    • Sato, M.1    Bagchi, D.2    Tosaki, A.3    Das, D.K.4
  • 183
    • 84914175267 scopus 로고    scopus 로고
    • Influence of grape seed extract and zinc containing multivitamin-mineral nutritional food supplement on lipid profile in normal and diet-induced hypercholesterolemic rats
    • Satyam S.M., Bairy L.K., Pirasanthan R. Influence of grape seed extract and zinc containing multivitamin-mineral nutritional food supplement on lipid profile in normal and diet-induced hypercholesterolemic rats. Journal of Clinical and Diagnostic Research 2014, 8:HC12-HC15.
    • (2014) Journal of Clinical and Diagnostic Research , vol.8 , pp. HC12-HC15
    • Satyam, S.M.1    Bairy, L.K.2    Pirasanthan, R.3
  • 184
    • 77951209860 scopus 로고    scopus 로고
    • Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models
    • Serra A., Macià A., Romero M.P., Valls J., Bladé C., Arola L., et al. Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models. British Journal of Nutrition 2010, 103:944-952.
    • (2010) British Journal of Nutrition , vol.103 , pp. 944-952
    • Serra, A.1    Macià, A.2    Romero, M.P.3    Valls, J.4    Bladé, C.5    Arola, L.6
  • 185
    • 84879552495 scopus 로고    scopus 로고
    • Distribution of procyanidins and their metabolites in rat plasma and tissues in relation to ingestion of procyanidin-enriched or procyanidin-rich cocoa creams
    • Serra A., Macià A., Rubió L., Anglès N., Ortega N., Morelló J.R., et al. Distribution of procyanidins and their metabolites in rat plasma and tissues in relation to ingestion of procyanidin-enriched or procyanidin-rich cocoa creams. European Journal of Nutrition 2013, 52:1029-1038.
    • (2013) European Journal of Nutrition , vol.52 , pp. 1029-1038
    • Serra, A.1    Macià, A.2    Rubió, L.3    Anglès, N.4    Ortega, N.5    Morelló, J.R.6
  • 186
    • 67650064637 scopus 로고    scopus 로고
    • Grape seed proanthocyanidins protect cardiomyocytes from ischemia and reperfusion injury via Akt-NOS signaling
    • Shao Z.H., Wojcik K.R., Dossumbekova A., Hsu C., Mehendale S.R., Li C.Q., et al. Grape seed proanthocyanidins protect cardiomyocytes from ischemia and reperfusion injury via Akt-NOS signaling. Journal of Cellular Biochemistry 2009, 107:697-705.
    • (2009) Journal of Cellular Biochemistry , vol.107 , pp. 697-705
    • Shao, Z.H.1    Wojcik, K.R.2    Dossumbekova, A.3    Hsu, C.4    Mehendale, S.R.5    Li, C.Q.6
  • 187
    • 37749020102 scopus 로고    scopus 로고
    • Effects of grape seed extract consumption on platelet function in postmenopausal women
    • Shenoy S.F., Keen C.L., Kalgaonkar S., Polagruto J.A. Effects of grape seed extract consumption on platelet function in postmenopausal women. Thrombosis Research 2007, 121:431-432.
    • (2007) Thrombosis Research , vol.121 , pp. 431-432
    • Shenoy, S.F.1    Keen, C.L.2    Kalgaonkar, S.3    Polagruto, J.A.4
  • 188
    • 1642559404 scopus 로고    scopus 로고
    • Polyphenolics in grape seeds-biochemistry and functionality
    • Shi J., Yu J., Pohorly J.E., Kakuda Y. Polyphenolics in grape seeds-biochemistry and functionality. Journal of Medicinal Food 2003, 6:291-299.
    • (2003) Journal of Medicinal Food , vol.6 , pp. 291-299
    • Shi, J.1    Yu, J.2    Pohorly, J.E.3    Kakuda, Y.4
  • 189
    • 0033435711 scopus 로고    scopus 로고
    • Isolation and identification of an antibacterial compound from grape and its application to foods
    • Shoko T., Soichi T., Megumi M.M., Eri F., Jun K., Michiko W. Isolation and identification of an antibacterial compound from grape and its application to foods. Nippon Nogeikagaku Kaishi 1999, 73:125-128.
    • (1999) Nippon Nogeikagaku Kaishi , vol.73 , pp. 125-128
    • Shoko, T.1    Soichi, T.2    Megumi, M.M.3    Eri, F.4    Jun, K.5    Michiko, W.6
  • 190
    • 84859583241 scopus 로고    scopus 로고
    • Generation of reactive oxygen species by grape seed extract causes irreparable DNA damage leading to G2/M arrest and apoptosis selectively in head and neck squamous cell carcinoma cells
    • Shrotriya S., Deep G., Gu M., et al. Generation of reactive oxygen species by grape seed extract causes irreparable DNA damage leading to G2/M arrest and apoptosis selectively in head and neck squamous cell carcinoma cells. Carcinogenesis 2012, 33:848-858.
    • (2012) Carcinogenesis , vol.33 , pp. 848-858
    • Shrotriya, S.1    Deep, G.2    Gu, M.3
  • 191
    • 84949092920 scopus 로고    scopus 로고
    • Preparative isolation of monomer catechins and oligomer procyanidin fractions from grape seed extracts by high-speed counter-current chromatography
    • Shuting Z., Yan C., Baoshan S. Preparative isolation of monomer catechins and oligomer procyanidin fractions from grape seed extracts by high-speed counter-current chromatography. BIO Web of Conferences 2014, 3:02013.
    • (2014) BIO Web of Conferences , vol.3 , pp. 02013
    • Shuting, Z.1    Yan, C.2    Baoshan, S.3
  • 194
    • 0346024122 scopus 로고    scopus 로고
    • Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3
    • Singh R.P., Tyagi A.K., Dhanalakshmi S., Agarwal R., Agarwal C. Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3. International Journal of Cancer 2004, 108:733-740.
    • (2004) International Journal of Cancer , vol.108 , pp. 733-740
    • Singh, R.P.1    Tyagi, A.K.2    Dhanalakshmi, S.3    Agarwal, R.4    Agarwal, C.5
  • 195
    • 0035226734 scopus 로고    scopus 로고
    • Effect of grape seed proanthocyanidins on colon aberrant crypts and breast tumors in a rat dual-organ tumor model
    • Singletary K.W., Meline B. Effect of grape seed proanthocyanidins on colon aberrant crypts and breast tumors in a rat dual-organ tumor model. Nutrition and Cancer 2001, 39:252-258.
    • (2001) Nutrition and Cancer , vol.39 , pp. 252-258
    • Singletary, K.W.1    Meline, B.2
  • 198
    • 84869854052 scopus 로고    scopus 로고
    • Protective effect of grape seed proanthocyanidins against liver ischemic reperfusion injury: Particularly in diet-induced obese mice
    • Song X., Xu H., Feng Y., Li X., Lin M., Cao L. Protective effect of grape seed proanthocyanidins against liver ischemic reperfusion injury: Particularly in diet-induced obese mice. International Journal of Biological Sciences 2012, 8:1345-1362.
    • (2012) International Journal of Biological Sciences , vol.8 , pp. 1345-1362
    • Song, X.1    Xu, H.2    Feng, Y.3    Li, X.4    Lin, M.5    Cao, L.6
  • 199
    • 0034901818 scopus 로고    scopus 로고
    • Grape extract, resveratrol, and its analogs: A review
    • Sovak M. Grape extract, resveratrol, and its analogs: A review. Journal of Medicinal Food 2001, 4:93-105.
    • (2001) Journal of Medicinal Food , vol.4 , pp. 93-105
    • Sovak, M.1
  • 200
    • 0018416167 scopus 로고
    • Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine
    • St.Leger A.S., Cochrane A.L., Moore F. Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. Lancet 1979, 1:1017-1020.
    • (1979) Lancet , vol.1 , pp. 1017-1020
    • Leger St, A.S.1    Cochrane, A.L.2    Moore, F.3
  • 201
    • 77953545430 scopus 로고    scopus 로고
    • Preventive effect of grape seed extract against high-fructose diet-induced insulin resistance and oxidative stress in rats
    • Suwannaphet W., Meeprom A., Yibchok-Anun S., Adisakwattana S. Preventive effect of grape seed extract against high-fructose diet-induced insulin resistance and oxidative stress in rats. Food and Chemical Toxicology 2010, 48:1853-1857.
    • (2010) Food and Chemical Toxicology , vol.48 , pp. 1853-1857
    • Suwannaphet, W.1    Meeprom, A.2    Yibchok-Anun, S.3    Adisakwattana, S.4
  • 202
    • 0028577572 scopus 로고
    • Dietary grape seed tannins affect lipoproteins, lipoprotein lipases and tissue lipids in rats fed hypercholesterolemic diets
    • Tebib K., Besana P., Besanacon P., Rouanet J.M. Dietary grape seed tannins affect lipoproteins, lipoprotein lipases and tissue lipids in rats fed hypercholesterolemic diets. Journal of Nutrition 1994, 124:2452-2457.
    • (1994) Journal of Nutrition , vol.124 , pp. 2452-2457
    • Tebib, K.1    Besana, P.2    Besanacon, P.3    Rouanet, J.M.4
  • 203
    • 0031149851 scopus 로고    scopus 로고
    • Antioxidant effects of dietary polymeric grape seed tannins in tissues of rats fed a high cholesterol-vitamin E-deficient diet
    • Tebib K., Rouanet J.M., Besancon P. Antioxidant effects of dietary polymeric grape seed tannins in tissues of rats fed a high cholesterol-vitamin E-deficient diet. Food Chemistry 1997, 59:135-141.
    • (1997) Food Chemistry , vol.59 , pp. 135-141
    • Tebib, K.1    Rouanet, J.M.2    Besancon, P.3
  • 206
    • 34250626152 scopus 로고    scopus 로고
    • Grape-seed procyanidins act as anti-inflammatory agents in endotoxin-stimulated RAW 264.7 macrophages by inhibiting NFkB signaling pathway
    • Terra X., Valls J., Vitrac X., Mérrillon J.M., Arola L., Ardèvol A., et al. Grape-seed procyanidins act as anti-inflammatory agents in endotoxin-stimulated RAW 264.7 macrophages by inhibiting NFkB signaling pathway. Journal of Agricultural and Food Chemistry 2007, 55:4357-4365.
    • (2007) Journal of Agricultural and Food Chemistry , vol.55 , pp. 4357-4365
    • Terra, X.1    Valls, J.2    Vitrac, X.3    Mérrillon, J.M.4    Arola, L.5    Ardèvol, A.6
  • 207
    • 58749089503 scopus 로고    scopus 로고
    • Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet
    • Terra X., Montagut G., Bustos M., Llopiz N., Ardèvol A., Bladé C., et al. Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet. Journal of Nutritional Biochemistry 2009, 20:210-218.
    • (2009) Journal of Nutritional Biochemistry , vol.20 , pp. 210-218
    • Terra, X.1    Montagut, G.2    Bustos, M.3    Llopiz, N.4    Ardèvol, A.5    Bladé, C.6
  • 209
    • 33645375937 scopus 로고    scopus 로고
    • Inhibition of Listeria monocytogenes by nisin combined with grape seed extract or green tea extract in soy protein film coated on turkey frankfurters
    • Theivendran S., Hettiarachchy N.S., Johnson M.G. Inhibition of Listeria monocytogenes by nisin combined with grape seed extract or green tea extract in soy protein film coated on turkey frankfurters. Journal of Food Science 2006, 71:M39-M44.
    • (2006) Journal of Food Science , vol.71 , pp. M39-M44
    • Theivendran, S.1    Hettiarachchy, N.S.2    Johnson, M.G.3
  • 211
    • 0037422199 scopus 로고    scopus 로고
    • Grape seed extract inhibits EGF induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: Possible role in antiproliferation and apoptosis
    • Tyagi A., Agarwal R., Agarwal C. Grape seed extract inhibits EGF induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: Possible role in antiproliferation and apoptosis. Oncogene 2003, 22:1302-1316.
    • (2003) Oncogene , vol.22 , pp. 1302-1316
    • Tyagi, A.1    Agarwal, R.2    Agarwal, C.3
  • 212
    • 0023263456 scopus 로고
    • Condensed tannins scavenging active oxygen radicals
    • Uchida S. Condensed tannins scavenging active oxygen radicals. Medical Science Research 1980, 15:831-832.
    • (1980) Medical Science Research , vol.15 , pp. 831-832
    • Uchida, S.1
  • 213
    • 77955921029 scopus 로고    scopus 로고
    • NFκBdependent regulation of urokinase plasminogen activator by proanthocyanidin-rich grape seed extract: Effect on invasion by prostate cancer cells
    • Uchino R., Madhyastha R., Madhyastha H., et al. NFκBdependent regulation of urokinase plasminogen activator by proanthocyanidin-rich grape seed extract: Effect on invasion by prostate cancer cells. Blood Coagulation & Fibrinolysis 2010, 21:528-533.
    • (2010) Blood Coagulation & Fibrinolysis , vol.21 , pp. 528-533
    • Uchino, R.1    Madhyastha, R.2    Madhyastha, H.3
  • 215
  • 216
    • 79959620404 scopus 로고    scopus 로고
    • Grape seed proanthocyanidins inhibit melanoma cell invasiveness by reduction of PGE2 synthesis and reversal of epithelial-to-mesenchymal transition
    • Vaid M., Singh T., Katiyar S.K. Grape seed proanthocyanidins inhibit melanoma cell invasiveness by reduction of PGE2 synthesis and reversal of epithelial-to-mesenchymal transition. PloS One 2011, 6.
    • (2011) PloS One , vol.6
    • Vaid, M.1    Singh, T.2    Katiyar, S.K.3
  • 217
    • 0037153676 scopus 로고    scopus 로고
    • Nutrition and health-Favorable effect of wine and wine flavonoids on cardiovascular diseases
    • Van de Wiel A. Nutrition and health-Favorable effect of wine and wine flavonoids on cardiovascular diseases. Nederlands Tijdschrift voor Geneeskunde 2002, 146:2466-2469.
    • (2002) Nederlands Tijdschrift voor Geneeskunde , vol.146 , pp. 2466-2469
    • Van de Wiel, A.1
  • 219
    • 0036853770 scopus 로고    scopus 로고
    • Beneficial effects of a novel IH636 grape seed proanthocyanidin extract and a niacin-bound chromium in a hamster atherosclerosis model
    • Vinson J.A., Mandarano M.A., Shuta D.L., Bagchi M., Bagchi D. Beneficial effects of a novel IH636 grape seed proanthocyanidin extract and a niacin-bound chromium in a hamster atherosclerosis model. Molecular and Cellular Biochemistry 2002, 240:99-103.
    • (2002) Molecular and Cellular Biochemistry , vol.240 , pp. 99-103
    • Vinson, J.A.1    Mandarano, M.A.2    Shuta, D.L.3    Bagchi, M.4    Bagchi, D.5
  • 220
    • 33745610053 scopus 로고    scopus 로고
    • Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells
    • Veluri R., Singh R.P., Liu Z., Thompson J.A., Agarwal R., Agarwal C. Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Carcinogenesis 2006, 27:1445-1453.
    • (2006) Carcinogenesis , vol.27 , pp. 1445-1453
    • Veluri, R.1    Singh, R.P.2    Liu, Z.3    Thompson, J.A.4    Agarwal, R.5    Agarwal, C.6
  • 221
    • 0035026774 scopus 로고    scopus 로고
    • MegaNatural gold grapeseed extract: In vitro antioxidant and in vivo human supplementation studies
    • Vinson J.A., Proch J., Bose P. MegaNatural gold grapeseed extract: In vitro antioxidant and in vivo human supplementation studies. Journal of Medicinal Food 2001, 4:17-26.
    • (2001) Journal of Medicinal Food , vol.4 , pp. 17-26
    • Vinson, J.A.1    Proch, J.2    Bose, P.3
  • 222
    • 46749123053 scopus 로고    scopus 로고
    • Grape-derived polyphenolics prevent Aβ oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease
    • Wang J., Ho L., Zhao W., Ono K., Rosensweig C., Chen L., et al. Grape-derived polyphenolics prevent Aβ oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease. Journal of Neuroscience 2008, 28:6388-6392.
    • (2008) Journal of Neuroscience , vol.28 , pp. 6388-6392
    • Wang, J.1    Ho, L.2    Zhao, W.3    Ono, K.4    Rosensweig, C.5    Chen, L.6
  • 224
    • 78650816787 scopus 로고    scopus 로고
    • Inhibition of tau aggregation by grape derived polyphenols in a mouse model of Alzheimer's disease
    • Wang J., Santa-Maria I., Ho L., et al. Inhibition of tau aggregation by grape derived polyphenols in a mouse model of Alzheimer's disease. Journal of Alzheimer's Disease 2010, 22:653-661.
    • (2010) Journal of Alzheimer's Disease , vol.22 , pp. 653-661
    • Wang, J.1    Santa-Maria, I.2    Ho, L.3
  • 227
    • 77953162840 scopus 로고    scopus 로고
    • Grape seed proanthocyanidin extract chelates iron and attenuates the toxic effects of 6-hydroxydopamine: Implications for Parkinson's disease
    • Wu T.H., Liao J.H., Hsu F.L., et al. Grape seed proanthocyanidin extract chelates iron and attenuates the toxic effects of 6-hydroxydopamine: Implications for Parkinson's disease. Journal of Food Biochemistry 2010, 34:244-262.
    • (2010) Journal of Food Biochemistry , vol.34 , pp. 244-262
    • Wu, T.H.1    Liao, J.H.2    Hsu, F.L.3
  • 228
    • 0032890180 scopus 로고    scopus 로고
    • Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits
    • Yamakoshi J., Kataoka S., Koga T., Ariga T. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 1999, 142:139-149.
    • (1999) Atherosclerosis , vol.142 , pp. 139-149
    • Yamakoshi, J.1    Kataoka, S.2    Koga, T.3    Ariga, T.4
  • 229
    • 0037077393 scopus 로고    scopus 로고
    • Procyanidinrich extract from grape seeds prevents cataract formation in hereditary cataractous (ICR/f) rats
    • Yamakoshi J., Saito M., Kataoka S., Tokutake S. Procyanidinrich extract from grape seeds prevents cataract formation in hereditary cataractous (ICR/f) rats. Journal of Agricultural and Food Chemistry 2002, 50:4983-4988.
    • (2002) Journal of Agricultural and Food Chemistry , vol.50 , pp. 4983-4988
    • Yamakoshi, J.1    Saito, M.2    Kataoka, S.3    Tokutake, S.4
  • 231
    • 0345276519 scopus 로고    scopus 로고
    • Lightening effect on ultraviolet-induced pigmentation of guinea pig skin by oral administration of proanthocyanidin-rich extract from grape seeds
    • Yamakoshi J., Otsuka F., Sano A., Tokutake S., Saito M., Kikuchi M., et al. Lightening effect on ultraviolet-induced pigmentation of guinea pig skin by oral administration of proanthocyanidin-rich extract from grape seeds. Pigment Cell Research 2003, 16:629-638.
    • (2003) Pigment Cell Research , vol.16 , pp. 629-638
    • Yamakoshi, J.1    Otsuka, F.2    Sano, A.3    Tokutake, S.4    Saito, M.5    Kikuchi, M.6
  • 232
    • 11144233280 scopus 로고    scopus 로고
    • Oral intake of proanthocyanidin-rich extract from grape seeds improves chloasma
    • Yamakoshi J., Sano A., Tokutake S., et al. Oral intake of proanthocyanidin-rich extract from grape seeds improves chloasma. Phytotherapy Research 2004, 18:895-899.
    • (2004) Phytotherapy Research , vol.18 , pp. 895-899
    • Yamakoshi, J.1    Sano, A.2    Tokutake, S.3
  • 233
    • 0032797136 scopus 로고    scopus 로고
    • The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells
    • Ye X., Krohn R.L., Liu W., et al. The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells. Molecular and Cellular Biochemistry 1999, 196:99-108.
    • (1999) Molecular and Cellular Biochemistry , vol.196 , pp. 99-108
    • Ye, X.1    Krohn, R.L.2    Liu, W.3
  • 234
    • 84926685457 scopus 로고    scopus 로고
    • Concentration effects of grape seed extracts in anti-oral cancer cells involving differential apoptosis, oxidative stress, and DNA damage
    • Yen C.Y., Hou M.F., Yang Z.W., Tang J.Y., Li K.T., Huang H.W., et al. Concentration effects of grape seed extracts in anti-oral cancer cells involving differential apoptosis, oxidative stress, and DNA damage. BMC Complementary and Alternative Medicine 2015, 15:94.
    • (2015) BMC Complementary and Alternative Medicine , vol.15 , pp. 94
    • Yen, C.Y.1    Hou, M.F.2    Yang, Z.W.3    Tang, J.Y.4    Li, K.T.5    Huang, H.W.6
  • 235
    • 1542289825 scopus 로고    scopus 로고
    • Major flavonoids in grape seeds: Antioxidant capacity of catechin, epicatechin and gallic acid
    • Yilmaz Y., Toledo R.T. Major flavonoids in grape seeds: Antioxidant capacity of catechin, epicatechin and gallic acid. Journal of Agricultural and Food Chemistry 2004, 52:255-260.
    • (2004) Journal of Agricultural and Food Chemistry , vol.52 , pp. 255-260
    • Yilmaz, Y.1    Toledo, R.T.2
  • 236
    • 84920381317 scopus 로고    scopus 로고
    • Grape seed extract has superior beneficial effects than vitamin E on oxidative stress and apoptosis in the hippocampus of streptozotocin induced diabetic rats
    • Yonguc G.N., Dodurga Y., Adiguzel E., Gundogdu G., Kucukatay V., Ozbal S., Akdogan I. Grape seed extract has superior beneficial effects than vitamin E on oxidative stress and apoptosis in the hippocampus of streptozotocin induced diabetic rats. Gene 2015, 555:119-126.
    • (2015) Gene , vol.555 , pp. 119-126
    • Yonguc, G.N.1    Dodurga, Y.2    Adiguzel, E.3    Gundogdu, G.4    Kucukatay, V.5    Ozbal, S.6    Akdogan, I.7
  • 237
    • 0041660688 scopus 로고    scopus 로고
    • Study of anti-atherosclerosic effect of grape seed extract and its mechanism
    • Yu H., Wang S.E., Zhao C., Xu G. Study of anti-atherosclerosic effect of grape seed extract and its mechanism. Wei Sheng Yan Jiu 2002, 31:263-265.
    • (2002) Wei Sheng Yan Jiu , vol.31 , pp. 263-265
    • Yu, H.1    Wang, S.E.2    Zhao, C.3    Xu, G.4
  • 239
    • 33748491687 scopus 로고    scopus 로고
    • Selective inhibition by grape seed proanthocyanidin extracts of cell adhesion molecule expression induced by advanced glycation end products in endothelial cells
    • Zhang F.L., Gao H.Q., Wu J.M. Selective inhibition by grape seed proanthocyanidin extracts of cell adhesion molecule expression induced by advanced glycation end products in endothelial cells. Journal of Cardiovascular Pharmacology 2006, 48:47-53.
    • (2006) Journal of Cardiovascular Pharmacology , vol.48 , pp. 47-53
    • Zhang, F.L.1    Gao, H.Q.2    Wu, J.M.3
  • 240
    • 33645524328 scopus 로고    scopus 로고
    • Glycated proteins stimulate reactive oxygen species production in cardiac myocytes: Involvement of Nox2 (gp91phox)-containing NADPH oxidase
    • Zhang M., Kho A.L., Anilkumar N., Chibber R., Pagano P.J., Shah A.M., et al. Glycated proteins stimulate reactive oxygen species production in cardiac myocytes: Involvement of Nox2 (gp91phox)-containing NADPH oxidase. Circulation 2006, 113:1235-1243.70.
    • (2006) Circulation , vol.113 , pp. 1235-1243.70
    • Zhang, M.1    Kho, A.L.2    Anilkumar, N.3    Chibber, R.4    Pagano, P.J.5    Shah, A.M.6
  • 242
    • 84929164187 scopus 로고    scopus 로고
    • Preparative HSCCC isolation of phloroglucinolysis products from grape seed polymeric proanthocyanidins as new powerful antioxidants
    • Zhang S., Cui Y., Li L., Li Y., Zhou P., et al. Preparative HSCCC isolation of phloroglucinolysis products from grape seed polymeric proanthocyanidins as new powerful antioxidants. Food Chemistry 2015, 188:422-429.
    • (2015) Food Chemistry , vol.188 , pp. 422-429
    • Zhang, S.1    Cui, Y.2    Li, L.3    Li, Y.4    Zhou, P.5
  • 243
    • 0032821619 scopus 로고    scopus 로고
    • Anti-tumor-promoting activity of a polyphenolic fraction isolated from Grape Seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent
    • Zhao J., Wang J., Chen Y., Agarwal R. Anti-tumor-promoting activity of a polyphenolic fraction isolated from Grape Seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent. Carcinogenesis 1999, 20:1737-1745.
    • (1999) Carcinogenesis , vol.20 , pp. 1737-1745
    • Zhao, J.1    Wang, J.2    Chen, Y.3    Agarwal, R.4
  • 244
    • 34249827461 scopus 로고    scopus 로고
    • Experiment study on anti-nonenzyme glycosylation effect of grape seed proanthocyanidin extract in diabetic rats
    • Zhou Y., Ma Y.B., Gao H.Q., et al. Experiment study on anti-nonenzyme glycosylation effect of grape seed proanthocyanidin extract in diabetic rats. Chinese Journal of Geriatrics 2005, 24:49-52.
    • (2005) Chinese Journal of Geriatrics , vol.24 , pp. 49-52
    • Zhou, Y.1    Ma, Y.B.2    Gao, H.Q.3
  • 245
    • 84929521024 scopus 로고    scopus 로고
    • Advance on the bioactivity and potential applications of dietary fibre from grape pomace
    • Zhu F.M., Du B., Zheng L.H., Li J. Advance on the bioactivity and potential applications of dietary fibre from grape pomace. Food Chemistry 2014, 186:207-212.
    • (2014) Food Chemistry , vol.186 , pp. 207-212
    • Zhu, F.M.1    Du, B.2    Zheng, L.H.3    Li, J.4
  • 246
    • 84929857723 scopus 로고    scopus 로고
    • Recent advance on the antitumor and antioxidant activity of grape seed extracts
    • Zhu F., Du B., Li J. Recent advance on the antitumor and antioxidant activity of grape seed extracts. International Journal of Wine Research 2015, 7:63-67.
    • (2015) International Journal of Wine Research , vol.7 , pp. 63-67
    • Zhu, F.1    Du, B.2    Li, J.3
  • 247
    • 84913553843 scopus 로고    scopus 로고
    • Antimicrobial efficacy of grape seed extract against Escherichia coli O157:H7 growth, motility and Shiga toxin production
    • Zhu M.J., Olsen S.A., Sheng L., Xue Y., Yue W. Antimicrobial efficacy of grape seed extract against Escherichia coli O157:H7 growth, motility and Shiga toxin production. Food Control 2015, 51:177-182.
    • (2015) Food Control , vol.51 , pp. 177-182
    • Zhu, M.J.1    Olsen, S.A.2    Sheng, L.3    Xue, Y.4    Yue, W.5


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