Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: Possible role in antiproliferation and apoptosis

Oncogene

Volumn 22, Issue 9, 2003, Pages 1302-1316

  Tyagi, Alpana ^a   Agarwal, Rajesh ^a,b   Agarwal, Chapla ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO CANCER CENTER   (United States)

Author keywords

AP1; Apoptosis; Grape seed extract; MAPK; Prostate cancer

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANDROGEN; ANDROGEN RECEPTOR; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; FLAVONOID; GRAPE SEED EXTRACT; GROWTH FACTOR RECEPTOR; LIGAND; MEMBRANE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHOTRANSFERASE; PLANT EXTRACT; PROCYANIDIN; PROTEIN C JUN; PROTEIN SHC; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR ELK 1; TRANSFORMING GROWTH FACTOR ALPHA RECEPTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CANCER CELL CULTURE; CANCER GROWTH; CELL FREE SYSTEM; CELL PROLIFERATION; CELL STRAIN DU145; CELL VIABILITY; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA SYNTHESIS INHIBITION; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME INHIBITION; GENETICS; GROWTH INHIBITION; HUMAN; HUMAN CELL; MITOGENESIS; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; SERUM; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ADENOCARCINOMA; ANTHRACENES; APOPTOSIS; CELL DIVISION; CELL-FREE SYSTEM; CULTURE MEDIA, SERUM-FREE; DNA-BINDING PROTEINS; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; ETS-DOMAIN PROTEIN ELK-1; FLAVONOIDS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM PROTEINS; PHOSPHORYLATION; PLANT EXTRACTS; PROSTATIC NEOPLASMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SEEDS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; VITIS;

MUS MUSCULUS; VITIS SP.;

EID: 0037422199     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206265     Document Type: Article

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