Grape seed proanthocyanidins inhibit migration potential of pancreatic cancer cells by promoting mesenchymal-to-epithelial transition and targeting NF-κB

Cancer Letters

Volumn 334, Issue 1, 2013, Pages 118-126

  Prasad, Ram ^a   Katiyar, Santosh K ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

Cancer cell migration; Epithelial to mesenchymal transition; Grape seed proanthocyanidins; NF B; Pancreatic cancer cells

Indexed keywords

CAFFEIC ACID; DESMOGLEIN 2; FIBRONECTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NERVE CELL ADHESION MOLECULE; PROANTHOCYANIDIN DERIVATIVE; TRANSCRIPTION FACTOR RELA; UO 126; UVOMORULIN; VIMENTIN; 1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; GRAPE SEED EXTRACT; GRAPE SEED PROANTHOCYANIDINS; MAPK1 PROTEIN, HUMAN; NITRILE; PROANTHOCYANIDIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG TARGETING; ENZYME PHOSPHORYLATION; EPITHELIAL MESENCHYMAL TRANSITION; GRAPE; HUMAN; HUMAN CELL; MIGRATION INHIBITION; PANCREAS CANCER; PLANT SEED; PRIORITY JOURNAL; UPREGULATION; CELL MOTION; DRUG EFFECTS; METABOLISM; PANCREATIC NEOPLASMS; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

VITACEAE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BUTADIENES; CELL LINE, TUMOR; CELL MOVEMENT; ENZYME INHIBITORS; EPITHELIAL-MESENCHYMAL TRANSITION; GRAPE SEED EXTRACT; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-KAPPA B; NITRILES; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PROANTHOCYANIDINS;

EID: 84880071103     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2012.08.003     Document Type: Article

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