Generation of reactive oxygen species by grape seed extract causes irreparable DNA damage leading to G2/M arrest and apoptosis selectively in head and neck squamous cell carcinoma cells

Carcinogenesis

Volumn 33, Issue 4, 2012, Pages 848-858

  Shrotriya, Sangeeta ^a   Deep, Gagan ^a,b   Gu, Mallikarjuna ^a   Kaur, Manjinder ^a   Jain, Anil K ^a   Inturi, Swetha ^a   Agarwal, Rajesh ^a,b   Agarwal, Chapla ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ATM PROTEIN; ATR PROTEIN; BRCA1 PROTEIN; CASPASE 3; CASPASE 8; CASPASE 9; CELL DIVISION CYCLE 25C; CELL DNA; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CYCLIN B1; GRAPE SEED EXTRACT; HISTONE H2AX; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN TYROSINE PHOSPHATASE; RAD51 PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER INHIBITION; CARCINOMA CELL; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DRUG EFFICACY; GENE LOCUS; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; SQUAMOUS CELL CARCINOMA; TUMOR XENOGRAFT;

EID: 84859583241     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgs019     Document Type: Article

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