Protection against drug- and chemical-induced multiorgan toxicity by a novel IH636 grape seed proanthocyanidin extract

Drugs under Experimental and Clinical Research

Volumn 27, Issue 1, 2001, Pages 3-15

  Bagchi, D ^a   Ray, S D ^a   Patel, D ^a   Bagchi, M ^a  

^a CREIGHTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; ALANINE AMINOTRANSFERASE; ALPHA TOCOPHEROL; AMIODARONE; ASCORBIC ACID; BETA CAROTENE; CADMIUM CHLORIDE; CREATINE KINASE; DIMETHYLNITROSAMINE; DOXORUBICIN; ETHOPROP; PARACETAMOL; PROANTHOCYANIDIN DERIVATIVE;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BRAIN PROTECTION; CARDIOTOXICITY; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG EXPOSURE; ENZYME BLOOD LEVEL; GRAPE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LIVER TOXICITY; LUNG TOXICITY; MACROPHAGE; MALE; MOUSE; MUCOSA CELL; NEPHROTOXICITY; NEUROTOXICITY; NONHUMAN; SPLEEN INJURY; SYMPTOMATOLOGY; UREA NITROGEN BLOOD LEVEL;

ALANINE TRANSAMINASE; ANIMALS; ANTIOXIDANTS; BIOLOGICAL AVAILABILITY; CARDIOVASCULAR DISEASES; DNA DAMAGE; DNA FRAGMENTATION; DRUG EVALUATION, PRECLINICAL; DRUG TOXICITY; FEMALE; FREE RADICAL SCAVENGERS; HUMANS; KIDNEY DISEASES; LIVER DISEASES; LUNG DISEASES; MALE; MICE; PLANT EXTRACTS; PROANTHOCYANIDINS; SPLEEN;

EID: 0035108764     PISSN: 03786501     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Chelating and free radical mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation
2. Activation and inhibition of benzo(a)pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occuring flavonoids
3. Moderate cytotoxicity of proanthocyanidins to human tumor cell lines
4. Radical scavenging by flavonoid antioxidants
5. Antioxidative activity of natural flavonoids is governed by number and location of their aromatic hydroxyl groups
6. On the occurrence of proanthocyanidins, leucoanthocyanidins and catechins in vegetables
7. Flavonoids and pycnogenols
8. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro
9. Cardioprotective effects of grape seed proanthocyanidin against ischemic reperfusion injury
10. Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice
11. Hydrogen peroxide-induced modulation of intracellular oxidized states in cultured macrophage J774A.1 and neuroactive PC-12 cells, and protection by a novel IH636 grape seed proanthocyanidin extract
12. The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells
13. Amelioration of cytotoxic effects of idarubicin and 4-hydroxyperoxycyclophosphamide on Chang liver cells by a novel grape seed proanthocyanidin extract
14. Smokeless tobacco, oxidative stress, apoptosis, and antioxidants in human oral keratinocytes
15. Acute and chronic stress-induced oxidative gastrointestinal injury in rats, and the protective ability of a novel grape seed proanthocyanidin extract
16. A novel proanthocyanidin IH636 grape seed extract increases in vivo Bcl-XL expression and prevents acetaminophen-induced programmed and unprogrammed cell death in mouse liver
17. Acute amiodarone-induced lung toxicity
18. Diagnostic usefulness of KL-6 measurements in patients with pulmonary complications after administration of amiodarone
19. Cardiotoxicity of doxorubicin and other anthracycline derivatives
20. Subclinical cardiotoxicity following adjuvant dose-escalated FEC, high-dose chemotherapy, or CMF in breast cancer
21. Oxidative mechanisms in the toxicity of metal ions
22. Cadmium-induced excretion of urinary lipid metabolites, DNA damage, glutathione depletion and hepatic lipid peroxidation in Sprague-Dawley rats
23. Role of metabolism in dimethylnitrosamine-induced immunosuppression: A review
24. Differential effects of coadministration of aminoacetonitrile on immunosuppression and hepatotoxicity produced by dimethylnitrosamine
25. Acute health effects from community exposure to N-propyl mercaptan from ethoprop (MOCAP)-treated potato field in Siskiyou County, California
26. Acute health effects from community exposure to N-propyl mercaptan from ethoprop (MOCAP)-treated potato field in Siskiyou County, California
27. Amiodarone inhibits the mitochondrial beta-oxidation of fatty acids and produces microvesicular steatosis of the liver in mice
28. Thyroid hormone alpha1 and beta1 receptor mRNA are downregulated by amiodarone in mouse myocardium
29. Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity
30. Thymoquinone protects against doxorubicin-induced cardiotoxicity without compromising its antitumor activity
31. Susceptibility of C57BL/6 mice to tumorigenicity induced by dimethylnitrosamine and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the neonatal bioassay
32. Mutational spectrum of dimethylnitrosamine in the liver of 3- and 6-week-old lacl transgenic mice
33. Effects of tetraethylthiuram disulfide on the toxicokinetics of cadmium in mice
34. Oxidation of pesticides by purified cytochrome P-450 isozymes from mouse liver
35. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment
36. Differential effects of IH636 grape seed proanthocyanidin extract and a DNA repair modulator 4-aminobenzamide on liver microsomal cytochrome P450 2E1-dependent aniline hydroxylation