메뉴 건너뛰기




Volumn 67, Issue 5, 2015, Pages 730-740

The Role of Grape Seed Extract in the Treatment of Chemo/Radiotherapy Induced Toxicity: A Systematic Review of Preclinical Studies

Author keywords

[No Author keywords available]

Indexed keywords

GRAPE SEED EXTRACT; GRAPE SEED PROANTHOCYANIDINS; PROANTHOCYANIDIN;

EID: 84934441530     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2015.1029639     Document Type: Article
Times cited : (38)

References (96)
  • 1
    • 0042284013 scopus 로고    scopus 로고
    • Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk
    • Riboli E and Norat T: Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am J Clin Nutr 78, 559-569, 2003.
    • (2003) Am J Clin Nutr , vol.78 , pp. 559-569
    • Riboli, E.1    Norat, T.2
  • 4
    • 67649983234 scopus 로고    scopus 로고
    • Position of the American Dietetic Association: Vegetarian diets
    • Craig WJ and Mangels AR: Position of the American Dietetic Association: vegetarian diets. J Am Diet Assoc 109, 1266-1282, 2009.
    • (2009) J Am Diet Assoc , vol.109 , pp. 1266-1282
    • Craig, W.J.1    Mangels, A.R.2
  • 5
    • 0042889220 scopus 로고    scopus 로고
    • Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: Relationship to decreased fat and lipid peroxidation
    • Mittal A, Elmets CA, and Katiyar SK: Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: relationship to decreased fat and lipid peroxidation. Carcinogenesis 24, 1379-1388, 2003.
    • (2003) Carcinogenesis , vol.24 , pp. 1379-1388
    • Mittal, A.1    Elmets, C.A.2    Katiyar, S.K.3
  • 6
    • 62349122348 scopus 로고    scopus 로고
    • Dietary grape seed proanthocyanidins inhibit 12-O-tetradecanoyl phorbol-13-acetate-caused skin tumor promotion in 7,12-dimethylbenz(a)anthracene-initiated mouse skin, which is associated with the inhibition of inflammatory responses
    • Meeran SM, Vaid M, Punathil T, and Katiyar SK: Dietary grape seed proanthocyanidins inhibit 12-O-tetradecanoyl phorbol-13-acetate-caused skin tumor promotion in 7,12-dimethylbenz(a)anthracene-initiated mouse skin, which is associated with the inhibition of inflammatory responses. Carcinogenesis 30, 520-5287, 2009.
    • (2009) Carcinogenesis , vol.30 , pp. 520-5287
    • Meeran, S.M.1    Vaid, M.2    Punathil, T.3    Katiyar, S.K.4
  • 7
    • 51549102594 scopus 로고    scopus 로고
    • Multi-targeted prevention and therapy of cancer by proanthocyanidins
    • Nandakumar V, Singh T, and Katiyar SK: Multi-targeted prevention and therapy of cancer by proanthocyanidins. Cancer Lett 269, 378-387, 2008.
    • (2008) Cancer Lett , vol.269 , pp. 378-387
    • Nandakumar, V.1    Singh, T.2    Katiyar, S.K.3
  • 8
    • 31144473157 scopus 로고    scopus 로고
    • Polyphenol contents in grape seed extracts correlate with antipica effects in cisplatin-treated rats
    • Wang CZ, Fishbein A, Aung HH, Mehendale SR, Chang WT, et al.: Polyphenol contents in grape seed extracts correlate with antipica effects in cisplatin-treated rats. J Altern Complement Med 11, 1059-1065, 2005.
    • (2005) J Altern Complement Med , vol.11 , pp. 1059-1065
    • Wang, C.Z.1    Fishbein, A.2    Aung, H.H.3    Mehendale, S.R.4    Chang, W.T.5
  • 9
    • 32444441482 scopus 로고    scopus 로고
    • Caring for survivors of childhood cancers: The size of the problem
    • Curry HL, Parkes SE, Powell JE, and Mann JR: Caring for survivors of childhood cancers: the size of the problem. Eur J Cancer 2, 501-508, 2006.
    • (2006) Eur J Cancer , vol.2 , pp. 501-508
    • Curry, H.L.1    Parkes, S.E.2    Powell, J.E.3    Mann, J.R.4
  • 10
    • 2142686649 scopus 로고    scopus 로고
    • Oral and intestinal mucositis-causes and possible treatments
    • Duncan M and Grant G: Oral and intestinal mucositis-causes and possible treatments. Aliment Pharmacol Ther 18, 853-874, 2003.
    • (2003) Aliment Pharmacol Ther , vol.18 , pp. 853-874
    • Duncan, M.1    Grant, G.2
  • 12
    • 3042736846 scopus 로고    scopus 로고
    • Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: A unifying concept in stress response biology
    • Spitz DR, Azzam EI, Li JJ, and Guis D: Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology. Cancer Metastasis Rev 23, 311-322, 2004.
    • (2004) Cancer Metastasis Rev , vol.23 , pp. 311-322
    • Spitz, D.R.1    Azzam, E.I.2    Li, J.J.3    Guis, D.4
  • 13
    • 11244258947 scopus 로고    scopus 로고
    • Radioprotective effect of abana, a polyherbal drug following total body irradiation
    • Baliga MS, Jagetia GC, Venkatesh P, Reddy R, and Ulloor JN: Radioprotective effect of abana, a polyherbal drug following total body irradiation. Br J Radiol 77, 1027-1035, 2004.
    • (2004) Br J Radiol , vol.77 , pp. 1027-1035
    • Baliga, M.S.1    Jagetia, G.C.2    Venkatesh, P.3    Reddy, R.4    Ulloor, J.N.5
  • 14
    • 1542299579 scopus 로고    scopus 로고
    • Radiation protection in humans: Extending the concept of as low as reasonably achievable (ALARA) from dose to biological damage
    • Prasad KN, Cole WC, and Haase GM: Radiation protection in humans: extending the concept of as low as reasonably achievable (ALARA) from dose to biological damage. Br J Radiol 77, 97-99, 2004.
    • (2004) Br J Radiol , vol.77 , pp. 97-99
    • Prasad, K.N.1    Cole, W.C.2    Haase, G.M.3
  • 15
    • 68549101842 scopus 로고    scopus 로고
    • The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: Explanation and elaboration
    • Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche, PC, et al.: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339, b2700, 2009.
    • (2009) BMJ , vol.339 , pp. b2700
    • Liberati, A.1    Altman, D.G.2    Tetzlaff, J.3    Mulrow, C.4    Gøtzsche, P.C.5
  • 16
    • 77649170234 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: The PRISMA Statement
    • Moher D, Liberati A, Tetzlaff J, Altman DG, and The PRISMA Group: Preferred reporting items for systematic reviews and meta-analyses: The PRISMA Statement. Open Med 3, e123-e130, 2009.
    • (2009) Open Med , vol.3 , pp. e123-e130
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.G.4
  • 18
    • 84873909442 scopus 로고    scopus 로고
    • Cardioprotective effect of grape-seed proanthocyanidins on doxorubicin-induced cardiac toxicity in rats
    • El Ammar SM, Said SA, El-Damarawy SL, and Suddek GM: Cardioprotective effect of grape-seed proanthocyanidins on doxorubicin-induced cardiac toxicity in rats. Pharm Biol 51, 339-344, 2013.
    • (2013) Pharm Biol , vol.51 , pp. 339-344
    • El Ammar, S.M.1    Said, S.A.2    El-Damarawy, S.L.3    Suddek, G.M.4
  • 19
    • 84878688864 scopus 로고    scopus 로고
    • Antioxidant and antiapoptotic effects of proanthocyanidin and ginkgo biloba extract against doxorubicin-induced cardiac injury in rats
    • El Boghdady NA: Antioxidant and antiapoptotic effects of proanthocyanidin and ginkgo biloba extract against doxorubicin-induced cardiac injury in rats. Cell Biochem Funct 31, 344-351, 2012.
    • (2012) Cell Biochem Funct , vol.31 , pp. 344-351
    • El Boghdady, N.A.1
  • 20
    • 84864706152 scopus 로고    scopus 로고
    • Grape seed and skin extract protects against acute chemotherapy toxicity induced by doxorubicin in rat heart
    • Mokni M, Hamlaoui-Guesmi S, Amri M, Marzouki L, Limam F, et al.: Grape seed and skin extract protects against acute chemotherapy toxicity induced by doxorubicin in rat heart. Cardiovasc Toxicol 12, 158-165, 2012.
    • (2012) Cardiovasc Toxicol , vol.12 , pp. 158-165
    • Mokni, M.1    Hamlaoui-Guesmi, S.2    Amri, M.3    Marzouki, L.4    Limam, F.5
  • 21
    • 84973399449 scopus 로고    scopus 로고
    • Assessment of cardiac toxicity of doxorubicin on the rat electrocardiogram and its prevention by drugs
    • Ammar EM, Said SA, Suddek GM, and El-Damaraw SL: Assessment of cardiac toxicity of doxorubicin on the rat electrocardiogram and its prevention by drugs. Altex 28, 32, 2011.
    • (2011) Altex , vol.28 , pp. 32
    • Ammar, E.M.1    Said, S.A.2    Suddek, G.M.3    El-Damaraw, S.L.4
  • 22
    • 77953549260 scopus 로고    scopus 로고
    • Grape seed proanthocyanidins ameliorate doxorubicin-induced cardiotoxicity
    • Li J, Liu H, Ramachandran S, Waypa GB, Yin JJ, et al.: Grape seed proanthocyanidins ameliorate doxorubicin-induced cardiotoxicity. Am J Chin Med 38, 569-584, 2010.
    • (2010) Am J Chin Med , vol.38 , pp. 569-584
    • Li, J.1    Liu, H.2    Ramachandran, S.3    Waypa, G.B.4    Yin, J.J.5
  • 23
    • 77955197109 scopus 로고    scopus 로고
    • Protective role of grape seed extract against doxorubicin-induced cardiotoxicity and genotoxicity in albino mice
    • Yalcin E, Oruc E, Cavusoglu K, and Yapar K: Protective role of grape seed extract against doxorubicin-induced cardiotoxicity and genotoxicity in albino mice. J Med Food 13, 917-925, 2010.
    • (2010) J Med Food , vol.13 , pp. 917-925
    • Yalcin, E.1    Oruc, E.2    Cavusoglu, K.3    Yapar, K.4
  • 24
    • 84973399450 scopus 로고    scopus 로고
    • The effects of proanthocyanidins on cardiotoxic and antitumour activity of doxorubicin
    • Bogdanovic G, Andric N, Stanic B, Canadanovic-Brunet J, Spasic M, et al.: The effects of proanthocyanidins on cardiotoxic and antitumour activity of doxorubicin. Eur J Cancer 8(Suppl.), 62-63, 2010.
    • (2010) Eur J Cancer , vol.8 , pp. 62-63
    • Bogdanovic, G.1    Andric, N.2    Stanic, B.3    Canadanovic-Brunet, J.4    Spasic, M.5
  • 25
    • 70349154670 scopus 로고    scopus 로고
    • Cardioprotective roles of aged garlic extract, grape seed proanthocyanidin, and hazelnut on doxorubicin-induced cardiotoxicity
    • Demirkaya E A, Kesik V, Karslioglu Y, Oztas E, et al.: Cardioprotective roles of aged garlic extract, grape seed proanthocyanidin, and hazelnut on doxorubicin-induced cardiotoxicity. Can J Physiol Pharmacol 87,633-640, 2009.
    • (2009) Can J Physiol Pharmacol , vol.87 , pp. 633-640
    • Demirkaya, E.A.1    Avci, A.2    Kesik, V.3    Karslioglu, Y.4    Oztas, E.5
  • 26
    • 60349096342 scopus 로고    scopus 로고
    • Procyanidins produce significant attenuation of doxorubicin-induced cardiotoxicity via suppression of oxidative stress
    • Li W, Xu B, Xu J, and Wu XL: Procyanidins produce significant attenuation of doxorubicin-induced cardiotoxicity via suppression of oxidative stress. Basic and Clinical Pharmacology and Toxicology 104, 192-197, 2009.
    • (2009) Basic and Clinical Pharmacology and Toxicology , vol.104 , pp. 192-197
    • Li, W.1    Xu, B.2    Xu, J.3    Wu, X.L.4
  • 27
    • 48749108187 scopus 로고    scopus 로고
    • Catechin and proanthocyanidin B4 from grape seeds prevent doxorubicin-induced toxicity in cardiomyocytes
    • Du Y and Lou H: Catechin and proanthocyanidin B4 from grape seeds prevent doxorubicin-induced toxicity in cardiomyocytes. Eur J Pharmacol 4, 96-101, 2008.
    • (2008) Eur J Pharmacol , vol.4 , pp. 96-101
    • Du, Y.1    Lou, H.2
  • 28
    • 22844445800 scopus 로고    scopus 로고
    • Amelioration of doxorubicininduced myocardial oxidative stress and immunosuppression by grape seed proanthocyanidins in tumour-bearing mice
    • Zhang XY, Li WG, Wu YJ, and Gao MT: Amelioration of doxorubicininduced myocardial oxidative stress and immunosuppression by grape seed proanthocyanidins in tumour-bearing mice. Journal of Pharmacy and Pharmacology 57, 1043-1051, 2005.
    • (2005) Journal of Pharmacy and Pharmacology , vol.57 , pp. 1043-1051
    • Zhang, X.Y.1    Li, W.G.2    Wu, Y.J.3    Gao, M.T.4
  • 29
    • 0035108764 scopus 로고    scopus 로고
    • Protection against drug-and chemical-induced multiorgan toxicity by a novel IH636 grape seed proanthocyanidin extract
    • Bagchi D, Ray SD, Patel D, and Bagchi M: Protection against drug-and chemical-induced multiorgan toxicity by a novel IH636 grape seed proanthocyanidin extract. Drugs Exptl Clin Res 27, 3-15, 2001.
    • (2001) Drugs Exptl Clin Res , vol.27 , pp. 3-15
    • Bagchi, D.1    Ray, S.D.2    Patel, D.3    Bagchi, M.4
  • 30
    • 0034461838 scopus 로고    scopus 로고
    • Unique organoprotective properties of a novel IH636 grape seed proanthocyanidin extract on cadmium chloride-induced nephrotoxicity, dimethylnitrosamine (DMN)-induced splenotoxicity and mocap-induced neurotoxicity in mice
    • Ray SD, Wong V, Rinkovsky A, Bagchi M, Raje RR, et al.: Unique organoprotective properties of a novel IH636 grape seed proanthocyanidin extract on cadmium chloride-induced nephrotoxicity, dimethylnitrosamine (DMN)-induced splenotoxicity and mocap-induced neurotoxicity in mice. Research Communications in Molecular Pathology and Pharmacology 107, 105-128, 2000.
    • (2000) Research Communications in Molecular Pathology and Pharmacology , vol.107 , pp. 105-128
    • Ray, S.D.1    Wong, V.2    Rinkovsky, A.3    Bagchi, M.4    Raje, R.R.5
  • 31
    • 0036278141 scopus 로고    scopus 로고
    • Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract
    • Bagchi D, Ray SD, Bagchi M, Preuss HG, and Stohs SJ: Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract. Indian J Exp Biol 40, 717-726, 2004.
    • (2004) Indian J Exp Biol , vol.40 , pp. 717-726
    • Bagchi, D.1    Ray, S.D.2    Bagchi, M.3    Preuss, H.G.4    Stohs, S.J.5
  • 32
    • 84863804511 scopus 로고    scopus 로고
    • Grape seed and skin extract protects against acute chemotherapy toxicity induced by doxorubicin in rat red blood cells and plasma
    • Hamlaoui S, Mokni M, Limam N, Carrier A, Limam F, et al.: Grape seed and skin extract protects against acute chemotherapy toxicity induced by doxorubicin in rat red blood cells and plasma. Bangladesh Journal of Pharmacology 7, 54-62, 2012.
    • (2012) Bangladesh Journal of Pharmacology , vol.7 , pp. 54-62
    • Hamlaoui, S.1    Mokni, M.2    Limam, N.3    Carrier, A.4    Limam, F.5
  • 33
    • 67349090609 scopus 로고    scopus 로고
    • Protective effects of proanthocyanidins of grape (Vitis vinifera L.) seeds on DNA damage induced by Doxorubicin in somatic cells of Drosophila melanogaster
    • De Rezende AA, Graf U, Guterres ZD, Kerr WE, and Spano MA: Protective effects of proanthocyanidins of grape (Vitis vinifera L.) seeds on DNA damage induced by Doxorubicin in somatic cells of Drosophila melanogaster. Food Chem Toxicol 47, 1466-1472, 2009.
    • (2009) Food Chem Toxicol , vol.47 , pp. 1466-1472
    • De Rezende, A.A.1    Graf, U.2    Guterres, Z.D.3    Kerr, W.E.4    Spano, M.A.5
  • 34
    • 33746761553 scopus 로고    scopus 로고
    • Defatted milled grape seed protects adriamycin-treated hepatocytes against oxidative damage
    • Valls-Belles V, Torres MC, Muniz P, Beltran S, Martinez-Alvarez JR, et al.: Defatted milled grape seed protects adriamycin-treated hepatocytes against oxidative damage. Euro J Nutr 45, 251-258, 2006.
    • (2006) Euro J Nutr , vol.45 , pp. 251-258
    • Valls-Belles, V.1    Torres, M.C.2    Muniz, P.3    Beltran, S.4    Martinez-Alvarez, J.R.5
  • 35
    • 79951538779 scopus 로고    scopus 로고
    • Proanthocyanidins produce significant attenuation of doxorubicin-induced mutagenicity via suppression of oxidative stress
    • Attia SM, Al-Bakheet SA, and Al-Rasheed NM: Proanthocyanidins produce significant attenuation of doxorubicin-induced mutagenicity via suppression of oxidative stress. Oxid Med Cell Longev 3, 404-413, 2010.
    • (2010) Oxid Med Cell Longev , vol.3 , pp. 404-413
    • Attia, S.M.1    Al-Bakheet, S.A.2    Al-Rasheed, N.M.3
  • 36
    • 84864068420 scopus 로고    scopus 로고
    • Modulation of doxorubicin-induced oxidative stress by a grape (Vitis vinifera L.) seed extract in normal and tumor cells
    • Postescu ID, Chereches G, Tatomir C, Daicoviciu D, and Filip GA: Modulation of doxorubicin-induced oxidative stress by a grape (Vitis vinifera L.) seed extract in normal and tumor cells. J Med Food 15, 639-645, 2012.
    • (2012) J Med Food , vol.15 , pp. 639-645
    • Postescu, I.D.1    Chereches, G.2    Tatomir, C.3    Daicoviciu, D.4    Filip, G.A.5
  • 37
    • 73449101842 scopus 로고    scopus 로고
    • Proanthocyanidin protects against cisplatin-induced nephrotoxicity
    • Sayed AAR: Proanthocyanidin protects against cisplatin-induced nephrotoxicity. Phyto Res 23, 1738-1741, 2009.
    • (2009) Phyto Res , vol.23 , pp. 1738-1741
    • Sayed, A.A.R.1
  • 38
    • 67349269500 scopus 로고    scopus 로고
    • Cisplatin induced damage in kidney genomic DNA and nephrotoxicity in male rats: The protective effect of grape seed proanthocyanidin extract
    • Saad AA, Youssef MI, and El-Shennawy LK: Cisplatin induced damage in kidney genomic DNA and nephrotoxicity in male rats: The protective effect of grape seed proanthocyanidin extract. Food Chem Toxicol 47, 1499-1506, 2009.
    • (2009) Food Chem Toxicol , vol.47 , pp. 1499-1506
    • Saad, A.A.1    Youssef, M.I.2    El-Shennawy, L.K.3
  • 39
    • 67349207859 scopus 로고    scopus 로고
    • Protective effect of grape seed proanthocyanidin extract against oxidative stress induced by cisplatin in rats
    • Yousef MI, Saad AA, and El-Shennawy LK: Protective effect of grape seed proanthocyanidin extract against oxidative stress induced by cisplatin in rats. Food Chem Toxicol 47, 1176-1183, 2009.
    • (2009) Food Chem Toxicol , vol.47 , pp. 1176-1183
    • Yousef, M.I.1    Saad, A.A.2    El-Shennawy, L.K.3
  • 42
    • 79954567499 scopus 로고    scopus 로고
    • Effect of proanthocyanidin, arginine and glutamine supplementation on methotrexate-induced gastrointestinal toxicity in rats
    • Gulgun M, Karaoglu A, Kesik V, Kurt B, Erdem O, et al.: Effect of proanthocyanidin, arginine and glutamine supplementation on methotrexate-induced gastrointestinal toxicity in rats. Experimental and Clinical Pharmacology 32, 657-661, 2010.
    • (2010) Experimental and Clinical Pharmacology , vol.32 , pp. 657-661
    • Gulgun, M.1    Karaoglu, A.2    Kesik, V.3    Kurt, B.4    Erdem, O.5
  • 43
    • 75949102985 scopus 로고    scopus 로고
    • Proanthocyanidin prevents methotrexate-induced intestinal damage and oxidative stress
    • Gulgun M, Erdem O, Oztas E, Kesik V, Balamtekin N, et al.: Proanthocyanidin prevents methotrexate-induced intestinal damage and oxidative stress. Exptl Toxicol Path 62, 109-115, 2010.
    • (2010) Exptl Toxicol Path , vol.62 , pp. 109-115
    • Gulgun, M.1    Erdem, O.2    Oztas, E.3    Kesik, V.4    Balamtekin, N.5
  • 44
    • 74049128932 scopus 로고    scopus 로고
    • Decrease of adenosine deaminase activity and increase of the lipid peroxidation after acute methotrexate treatment in young rats: Protective effects of grape seed extract
    • Pinheiro FV, Pimentel VC, De Bona KS, Scola G, Salvador M, et al.: Decrease of adenosine deaminase activity and increase of the lipid peroxidation after acute methotrexate treatment in young rats: protective effects of grape seed extract. Cell Biochem Funct 28, 89-94, 2010.
    • (2010) Cell Biochem Funct , vol.28 , pp. 89-94
    • Pinheiro, F.V.1    Pimentel, V.C.2    De Bona, K.S.3    Scola, G.4    Salvador, M.5
  • 45
    • 57349194210 scopus 로고    scopus 로고
    • Role of grape seed extract on methotrexate induced oxidative stress in rat Liver
    • Cetin A, Kaynar L, Kocyigit I, Hacioglu SK, Saraymen R, et al.: Role of grape seed extract on methotrexate induced oxidative stress in rat Liver. Am J Chin Med 36, 861-872, 2008.
    • (2008) Am J Chin Med , vol.36 , pp. 861-872
    • Cetin, A.1    Kaynar, L.2    Kocyigit, I.3    Hacioglu, S.K.4    Saraymen, R.5
  • 46
    • 84973326427 scopus 로고    scopus 로고
    • Grape seed extract: Effects on chemotherapy-induced mucositis and inflammatory bowel disease in rats
    • Cheah KY, Bastian S, Acott T, and Howarth G: Grape seed extract: Effects on chemotherapy-induced mucositis and inflammatory bowel disease in rats. Supportive Care in Cancer 17, 905-906, 2009.
    • (2009) Supportive Care in Cancer , vol.17 , pp. 905-906
    • Cheah, K.Y.1    Bastian, S.2    Acott, T.3    Howarth, G.4
  • 47
    • 62549100017 scopus 로고    scopus 로고
    • Grape seed extract protects IEC-6 cells from chemotherapy-induced cytotoxicity and improves parameters of small intestinal mucositis in rats with experimentally-induced mucositis
    • Cheah KY, Howarth GS, Yazbeck R, Wright TH, Whitford EJ, et al.: Grape seed extract protects IEC-6 cells from chemotherapy-induced cytotoxicity and improves parameters of small intestinal mucositis in rats with experimentally-induced mucositis. Cancer Biology and Therapy 8, 382-390, 2009.
    • (2009) Cancer Biology and Therapy , vol.8 , pp. 382-390
    • Cheah, K.Y.1    Howarth, G.S.2    Yazbeck, R.3    Wright, T.H.4    Whitford, E.J.5
  • 48
    • 0035005704 scopus 로고    scopus 로고
    • The cellular and molecular basis of health benefits of grape seed proanthocyanidin extract
    • Joshi SS, Kuszynski CA, and Bagchi D: The cellular and molecular basis of health benefits of grape seed proanthocyanidin extract. Current Pharmaceutical Biotechnology 2, 187-200, 2001.
    • (2001) Current Pharmaceutical Biotechnology , vol.2 , pp. 187-200
    • Joshi, S.S.1    Kuszynski, C.A.2    Bagchi, D.3
  • 49
    • 0033301352 scopus 로고    scopus 로고
    • Amelioration of the cytotoxic effects of chemotherapeutic agents by grape seed proanthocyanidin extract
    • Joshi SS, Kuszynski CA, Benner EJ, Bagchi M, and Bagchi D: Amelioration of the cytotoxic effects of chemotherapeutic agents by grape seed proanthocyanidin extract. Antioxid Redox Signal 1, 563-570, 1999.
    • (1999) Antioxid Redox Signal , vol.1 , pp. 563-570
    • Joshi, S.S.1    Kuszynski, C.A.2    Benner, E.J.3    Bagchi, M.4    Bagchi, D.5
  • 52
    • 61449147954 scopus 로고    scopus 로고
    • Grape seed extract Vitis vinifera protects against radiation-induced oxidativedamage and metabolic disorders in rats
    • Saada HN, Said UZ, Meky NH, and Abd El Azime AS: Grape seed extract Vitis vinifera protects against radiation-induced oxidativedamage and metabolic disorders in rats. Phytother Res 23, 434-438, 2009.
    • (2009) Phytother Res , vol.23 , pp. 434-438
    • Saada, H.N.1    Said, U.Z.2    Meky, N.H.3    Abd El Azime, A.S.4
  • 53
    • 33747372824 scopus 로고    scopus 로고
    • Protective effect of grape seed proanthocyanidin and casein peptide on intestinal mucosal barrier in rats with radiation injury
    • Jiang BQ and Chang H: Protective effect of grape seed proanthocyanidin and casein peptide on intestinal mucosal barrier in rats with radiation injury. Chin J Clin Rehab 10, 121-123, 2006.
    • (2006) Chin J Clin Rehab , vol.10 , pp. 121-123
    • Jiang, B.Q.1    Chang, H.2
  • 54
    • 20544475006 scopus 로고    scopus 로고
    • Protective action of grape seed proanthocyanidins combined with casein on radiation damage of rats
    • Chang H and Jiang BQ: Protective action of grape seed proanthocyanidins combined with casein on radiation damage of rats. Chin Jo Clin Rehab 9, 210-211, 2005.
    • (2005) Chin Jo Clin Rehab , vol.9 , pp. 210-211
    • Chang, H.1    Jiang, B.Q.2
  • 56
    • 36549048357 scopus 로고    scopus 로고
    • Effect of grape seed extract on lipid peroxidation, antioxidant activity and peripheral blood lymphocytes in rats exposed to x-radiation
    • Enginar H, Cemek M, Karaca T, and Unak P: Effect of grape seed extract on lipid peroxidation, antioxidant activity and peripheral blood lymphocytes in rats exposed to x-radiation. Phytother Res 21, 1029-1035, 2007.
    • (2007) Phytother Res , vol.21 , pp. 1029-1035
    • Enginar, H.1    Cemek, M.2    Karaca, T.3    Unak, P.4
  • 57
    • 84867635954 scopus 로고    scopus 로고
    • Inhibitory effect of grape procyanidin on the cell apoptosis induced by radiation
    • Liu HZ and Zhong JY: Inhibitory effect of grape procyanidin on the cell apoptosis induced by radiation. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 22, 448-451, 2004.
    • (2004) Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi , vol.22 , pp. 448-451
    • Liu, H.Z.1    Zhong, J.Y.2
  • 58
    • 0034115582 scopus 로고    scopus 로고
    • Antioxidant activity and radioprotective effects against chromosomal damage induced in vivo by X-rays of flavan-3-ols (Procyanidins) from grape seeds (Vitis vinifera): Comparative study versus other phenolic and organic compounds
    • Castillo J, Benavente-Garc-?a O, Lorente J, Alcaraz M, Redondo A, et al.: Antioxidant activity and radioprotective effects against chromosomal damage induced in vivo by X-rays of flavan-3-ols (Procyanidins) from grape seeds (Vitis vinifera): comparative study versus other phenolic and organic compounds. J Agric Food Chem 48, 1738-1745, 2000.
    • (2000) J Agric Food Chem , vol.48 , pp. 1738-1745
    • Castillo, J.1    Benavente-Garca, O.2    Lorente, J.3    Alcaraz, M.4    Redondo, A.5
  • 59
    • 0036968160 scopus 로고    scopus 로고
    • Secondary leukemia after advanced bladder cancer with methotrexate, vinblastine, doxorubicin and cisplatin chemotherapy and radiotherapy
    • Theodore C, Bayle C, Bernheim A, and Wibault P: Secondary leukemia after advanced bladder cancer with methotrexate, vinblastine, doxorubicin and cisplatin chemotherapy and radiotherapy. BJU Int 90, 470-471, 2002.
    • (2002) BJU Int , vol.90 , pp. 470-471
    • Theodore, C.1    Bayle, C.2    Bernheim, A.3    Wibault, P.4
  • 60
    • 0348162303 scopus 로고    scopus 로고
    • Risk for the development of treatment related acute myelocytic leukemia and myelodysplastic syndrome among patients with breast cancer: Review of the literature and the National Surgical Adjunct Breast and Bowel Project experience
    • Smith RE: Risk for the development of treatment related acute myelocytic leukemia and myelodysplastic syndrome among patients with breast cancer: review of the literature and the National Surgical Adjunct Breast and Bowel Project experience. Clin Breast Cancer 4, 273-279, 2003.
    • (2003) Clin Breast Cancer , vol.4 , pp. 273-279
    • Smith, R.E.1
  • 61
    • 20144388623 scopus 로고    scopus 로고
    • DNA topoisomerase II therapy related acute promyelocytic leukemia
    • Mistry AR, Felix CA, Whitmarsh RJ, Mason A, Reiter A, et al.: DNA topoisomerase II therapy related acute promyelocytic leukemia. N Engl J Med 352, 1529-1538, 2005.
    • (2005) N Engl J Med , vol.352 , pp. 1529-1538
    • Mistry, A.R.1    Felix, C.A.2    Whitmarsh, R.J.3    Mason, A.4    Reiter, A.5
  • 64
    • 1542286856 scopus 로고    scopus 로고
    • Concentrations of proanthocyanidins in common foods and estimations of normal consumption
    • Gu L, Kelm MA, Hammerstone JF, Beecher G, Holden J, et al.: Concentrations of proanthocyanidins in common foods and estimations of normal consumption. J Nutr 134, 613-617, 2004.
    • (2004) J Nutr , vol.134 , pp. 613-617
    • Gu, L.1    Kelm, M.A.2    Hammerstone, J.F.3    Beecher, G.4    Holden, J.5
  • 65
    • 16444383794 scopus 로고    scopus 로고
    • The antioxidative function, preventive action on disease and utilization of proanthocyanidins
    • Ariga T: The antioxidative function, preventive action on disease and utilization of proanthocyanidins. Biofactors 21, 197-201, 2004.
    • (2004) Biofactors , vol.21 , pp. 197-201
    • Ariga, T.1
  • 66
    • 70350068120 scopus 로고    scopus 로고
    • Bioavailability and activity of phytosome complexes from botanical polyphenols: The silymarin, curcumin, green tea, and grape seed extracts
    • Kidd PM: Bioavailability and activity of phytosome complexes from botanical polyphenols: the silymarin, curcumin, green tea, and grape seed extracts. Altern Med Rev 14, 226-246, 2009.
    • (2009) Altern Med Rev , vol.14 , pp. 226-246
    • Kidd, P.M.1
  • 68
    • 0346995279 scopus 로고    scopus 로고
    • Suppression of estrogen biosynthesis by procyanidin dimmers in red wine and grape seeds
    • Eng ET, Ye J, Williams D, Phung S, Moore RE, et al.: Suppression of estrogen biosynthesis by procyanidin dimmers in red wine and grape seeds. Cancer Res 63, 8516-8522, 2003.
    • (2003) Cancer Res , vol.63 , pp. 8516-8522
    • Eng, E.T.1    Ye, J.2    Williams, D.3    Phung, S.4    Moore, R.E.5
  • 69
    • 16344367235 scopus 로고    scopus 로고
    • Effects of grape cell culture extracts on human topoisomerase II catalytic activity and characterization of active fractions
    • Jo JY, Gonzalez de Mejia E, and Lila MA: Effects of grape cell culture extracts on human topoisomerase II catalytic activity and characterization of active fractions. J Agric Food Chem 53, 2489-2498, 2005.
    • (2005) J Agric Food Chem , vol.53 , pp. 2489-2498
    • Jo, J.Y.1    Gonzalez De Mejia, E.2    Lila, M.A.3
  • 70
    • 0034032282 scopus 로고    scopus 로고
    • Animal definition: A necessity for the validity of animal experiments?
    • Obrink KJ and Rehbinder C: Animal definition: a necessity for the validity of animal experiments? Laboratory Animals 34, 121-130, 2000.
    • (2000) Laboratory Animals , vol.34 , pp. 121-130
    • Obrink, K.J.1    Rehbinder, C.2
  • 71
    • 0021959525 scopus 로고    scopus 로고
    • Guidelines for specification of animals and husbandry methods when reporting the results of animal experiments
    • Working Committee for the Biological Characterization of Laboratory Animals/GV-Solas
    • Working Committee for the Biological Characterization of Laboratory Animals/GV-Solas: Guidelines for specification of animals and husbandry methods when reporting the results of animal experiments. Laboratory Animals 19, 106-108, 2005.
    • (2005) Laboratory Animals , vol.19 , pp. 106-108
  • 72
    • 26844446362 scopus 로고    scopus 로고
    • Specification of laboratory animal use in scientific articles: Current low detail in the journal's instructions for authors and some proposals
    • Alfaro V: Specification of laboratory animal use in scientific articles: current low detail in the journal's instructions for authors and some proposals. Experimental and Clinical Pharmacology 27, 495-502, 2005.
    • (2005) Experimental and Clinical Pharmacology , vol.27 , pp. 495-502
    • Alfaro, V.1
  • 73
    • 0035822324 scopus 로고    scopus 로고
    • Systematic reviews in health care: Assessing the quality of controlled clinical trials
    • Juni P, Altman DG, and Egger M: Systematic reviews in health care: Assessing the quality of controlled clinical trials. BMJ 323, 42-46, 2001.
    • (2001) BMJ , vol.323 , pp. 42-46
    • Juni, P.1    Altman, D.G.2    Egger, M.3
  • 74
    • 0035901579 scopus 로고    scopus 로고
    • The revised CONSORT statement for reporting randomized trials: Explanation and elaboration
    • Altman DG, Schulz KF, Moher D, Egger M, Davidoff F, et al.: The revised CONSORT statement for reporting randomized trials: explanation and elaboration. Ann Intern Med 134, 663-694, 2001.
    • (2001) Ann Intern Med , vol.134 , pp. 663-694
    • Altman, D.G.1    Schulz, K.F.2    Moher, D.3    Egger, M.4    Davidoff, F.5
  • 75
    • 0036374477 scopus 로고    scopus 로고
    • Guidelines for the design and statistical analysis of experiments using laboratory animals
    • Festing MF and Altman DG: Guidelines for the design and statistical analysis of experiments using laboratory animals. ILAR Journal 43930, 244-258, 2002.
    • (2002) ILAR Journal , pp. 244-258
    • Festing, M.F.1    Altman, D.G.2
  • 77
    • 0038616401 scopus 로고    scopus 로고
    • Emergency medicine animal research: Does use of randomization and blinding affect the results?
    • Berbata V, Luyten D, and Heard K: Emergency medicine animal research: does use of randomization and blinding affect the results? Academic Emergency Medicine 10, 684-687, 2003.
    • (2003) Academic Emergency Medicine , vol.10 , pp. 684-687
    • Berbata, V.1    Luyten, D.2    Heard, K.3
  • 78
    • 54049103993 scopus 로고    scopus 로고
    • Evidence for the efficacy of NXY-059 in experimental focal cerebral ischemia is confounded by study quality
    • Macleod MR, van der Worp HB, Sena ES, Howells DW, Dirnagl U, et al.: Evidence for the efficacy of NXY-059 in experimental focal cerebral ischemia is confounded by study quality. Stroke 39, 2824-2829, 2008.
    • (2008) Stroke , vol.39 , pp. 2824-2829
    • Macleod, M.R.1    Van Der Worp, H.B.2    Sena, E.S.3    Howells, D.W.4    Dirnagl, U.5
  • 79
    • 76849104977 scopus 로고    scopus 로고
    • Survey of the quality of experimental design, statistical analysis and reporting of research using animals
    • Kilkenny C, Parsons N, Kadyszewski E, Festing MFW, Cuthill IC, et al.: Survey of the quality of experimental design, statistical analysis and reporting of research using animals. PloS ONE 4(11), e7824, 2009. doi:10.1371/journal.pone.0007824
    • (2009) PloS ONE , vol.4 , Issue.11 , pp. e7824
    • Kilkenny, C.1    Parsons, N.2    Kadyszewski, E.3    Festing, M.F.W.4    Cuthill, I.C.5
  • 81
    • 33644806519 scopus 로고    scopus 로고
    • Protecting against anthracycline induced myocardial damage: A review of the most promising strategies
    • Wouters KA, Kremer LC, Miller TL, Herman EH, and Lipshuttz SC: Protecting against anthracycline induced myocardial damage: A review of the most promising strategies. Br J Haematol 13, 561-578, 2005.
    • (2005) Br J Haematol , vol.13 , pp. 561-578
    • Wouters, K.A.1    Kremer, L.C.2    Miller, T.L.3    Herman, E.H.4    Lipshuttz, S.C.5
  • 82
    • 0033813886 scopus 로고    scopus 로고
    • Molecular basis of anthracycline induced cardiotoxicity and its prevention
    • Horenstein MS, Vander Heide RS, and L'Ecuyer TJ: Molecular basis of anthracycline induced cardiotoxicity and its prevention. Mol Genet Metab 71, 436-444, 2000.
    • (2000) Mol Genet Metab , vol.71 , pp. 436-444
    • Horenstein, M.S.1    Vander Heide, R.S.2    L'ecuyer, T.J.3
  • 83
    • 0018915753 scopus 로고
    • Enzymatic defenses of the mouse heart against reactive oxygen metabolites: Alterations produced by doxorubicin
    • Doroshow JH, Locker GY, and Myers CE: Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin. J Clin Invest 65, 128-135, 1980.
    • (1980) J Clin Invest , vol.65 , pp. 128-135
    • Doroshow, J.H.1    Locker, G.Y.2    Myers, C.E.3
  • 85
    • 0141788133 scopus 로고    scopus 로고
    • Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses
    • Leonard SS, Xia C, Jiang BH, Stinefelt B, Klandorf H, et al.: Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses. Biochem Biophys Res Commun 309, 1017-1026, 2003.
    • (2003) Biochem Biophys Res Commun , vol.309 , pp. 1017-1026
    • Leonard, S.S.1    Xia, C.2    Jiang, B.H.3    Stinefelt, B.4    Klandorf, H.5
  • 86
    • 0031562410 scopus 로고    scopus 로고
    • Generation of free radicals during lipid hydroperoxide-triggered apoptosis in PC12h cells
    • Aoshima H, Satoh T, and Sakai N: Generation of free radicals during lipid hydroperoxide-triggered apoptosis in PC12h cells. Biochim Biophys Acta 1345, 35-42, 1997.
    • (1997) Biochim Biophys Acta , vol.1345 , pp. 35-42
    • Aoshima, H.1    Satoh, T.2    Sakai, N.3
  • 87
    • 0029014788 scopus 로고
    • Peroxynitrite-induced apoptosis in HL-60 cells
    • Lin KT, Xue JY, Nomen M, Spur B, and Wong PY. Peroxynitrite-induced apoptosis in HL-60 cells. J Biol Chem 270, 16487-16490, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 16487-16490
    • Lin, K.T.1    Xue, J.Y.2    Nomen, M.3    Spur, B.4    Wong, P.Y.5
  • 88
    • 27744456655 scopus 로고    scopus 로고
    • Involvement of peroxiredoxin i in protecting cells from radiation-induced death
    • Zhang B, Su Y, Ai G, Wang Y, Wang T, et al.: Involvement of peroxiredoxin I in protecting cells from radiation-induced death. J Radiat Res 46, 305-312, 2005.
    • (2005) J Radiat Res , vol.46 , pp. 305-312
    • Zhang, B.1    Su, Y.2    Ai, G.3    Wang, Y.4    Wang, T.5
  • 90
    • 0019304979 scopus 로고
    • The role of WR-2721 in radiotherapy and/or chemotherapy
    • Yuhas, JM, Spellman JM, and Culo F: The role of WR-2721 in radiotherapy and/or chemotherapy. Cancer Clin Trials 3, 211-216, 1980.
    • (1980) Cancer Clin Trials , vol.3 , pp. 211-216
    • Yuhas, J.M.1    Spellman, J.M.2    Culo, F.3
  • 91
    • 84872474162 scopus 로고    scopus 로고
    • An initiative to facilitate well informed decision making in laboratory animal research: Report of the first international symposium on systematic reviews in laboratory animal science
    • Hooijmans CR, Rovers M, de Vries RB, Leenaars M, and Ritskes-Hoitinga M: An initiative to facilitate well informed decision making in laboratory animal research: report of the first international symposium on systematic reviews in laboratory animal science. Lab Anim 46, 356, 2012.
    • (2012) Lab Anim , vol.46 , pp. 356
    • Hooijmans, C.R.1    Rovers, M.2    De Vries, R.B.3    Leenaars, M.4    Ritskes-Hoitinga, M.5
  • 92
    • 77950572352 scopus 로고    scopus 로고
    • Publication bias in reports of animal stroke studies leads to major overstatement of efficacy
    • Sena ES, van der Worp HB, Bath PM, Howells DW, and Macleod MR: Publication bias in reports of animal stroke studies leads to major overstatement of efficacy. PLoS Biol 8(3), e1000344, 2010. doi:10.1371/journal. pbio.1000344
    • (2010) PLoS Biol , vol.8 , Issue.3 , pp. e1000344
    • Sena, E.S.1    Van Der Worp, H.B.2    Bath, P.M.3    Howells, D.W.4    Macleod, M.R.5
  • 93
    • 84934448575 scopus 로고    scopus 로고
    • Clinical Trials.gov: Search for studies 2014. Available from http:clinicaltrials
    • Clinical Trials.gov: Search for studies 2014. Available from http:clinicaltrials. gov/ct2/results?termD%22grapeCseedCextract%22CANDC%22Cancer. . .
  • 94
    • 33646190012 scopus 로고    scopus 로고
    • Double blind, placebo-controlled randomized phase II tiral of IH636 grape seed proanthocyanidin extract (GSPE) in patients with radiation-induced breast induration
    • Brooker S, Martin S, Pearson A, Bagchi D, Earl J, et al.: Double blind, placebo-controlled randomized phase II tiral of IH636 grape seed proanthocyanidin extract (GSPE) in patients with radiation-induced breast induration. Radiother Oncol 79, 45-51, 2006.
    • (2006) Radiother Oncol , vol.79 , pp. 45-51
    • Brooker, S.1    Martin, S.2    Pearson, A.3    Bagchi, D.4    Earl, J.5
  • 95
    • 84900475546 scopus 로고    scopus 로고
    • The effect of complementary and alternative medicines on CYP3A4 mediated metabolism of three different substrates: 7-benzyloxy-4-trifluoromethyl-coumarin, midazolam and docetaxel
    • Mooiman KD, Maas-Bakker RF, Hendrix JJ, Bank PC, Rosing H, et al.: The effect of complementary and alternative medicines on CYP3A4 mediated metabolism of three different substrates: 7-benzyloxy-4-trifluoromethyl-coumarin, midazolam and docetaxel. J Pharm Pharmacol 66, 865-874, 2014. doi:10.1111/jphp. 12208
    • (2014) J Pharm Pharmacol , vol.66 , pp. 865-874
    • Mooiman, K.D.1    Maas-Bakker, R.F.2    Hendrix, J.J.3    Bank, P.C.4    Rosing, H.5
  • 96
    • 63449126034 scopus 로고    scopus 로고
    • Variable inhibitory effect of different brands of commercial herbal supplements on human cytochrome P-450 CYP3A4
    • Wanwimolruk S,Wong K, and Wanwimolruk P: Variable inhibitory effect of different brands of commercial herbal supplements on human cytochrome P-450 CYP3A4. Drug Metabol Drug Interact 24, 17-35, 2009.
    • (2009) Drug Metabol Drug Interact , vol.24 , pp. 17-35
    • Wanwimolruk, S.1    Wong, K.2    Wanwimolruk, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.