Grape-derived polyphenolics prevent Aβ oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease

Journal of Neuroscience

Volumn 28, Issue 25, 2008, Pages 6388-6392

  Wang, Jun ^a   Ho, Lap ^a,c   Zhao, Wei ^a   Ono, Kenjiro ^b   Rosensweig, Clark ^b   Chen, Linghong ^a   Humala, Nelson ^a   Teplow, David B ^b   Pasinetti, Giulio M ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

A peptide; Alzheimer's disease; Amyloid ; Cognitive; Dementia; Morris water maze; Spatial memory

Indexed keywords

AMYLOID BETA PROTEIN; GRAPE SEED EXTRACT; OLIGOMER; POLYPHENOL DERIVATIVE; FLAVONOID; PHENOL DERIVATIVE; PLANT EXTRACT; POLYPHENOLS;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; ANIMAL; COMPARATIVE STUDY; DISEASE MODEL; DRUG ANTAGONISM; GRAPE; ISOLATION AND PURIFICATION; METABOLISM; PATHOLOGY; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; FEMALE; FLAVONOIDS; MALE; MICE; MICE, TRANSGENIC; PHENOLS; PLANT EXTRACTS; VITIS;

EID: 46749123053     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0364-08.2008     Document Type: Article

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