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Volumn 50, Issue 4, 2003, Pages 320-346

Candidate genes and late-onset type 2 diabetes mellitus: Susceptibility genes or common polymorphisms?

Author keywords

[No Author keywords available]

Indexed keywords

AMYLIN; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; BRAIN PROTEIN; CALPAIN; CALPAIN 10; FRATAXIN; GLUCAGON RECEPTOR; GLUCOKINASE; GLYCOGEN SYNTHASE; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; NUCLEAR FACTOR 1ALPHA; NUCLEAR FACTOR 1BETA; NUCLEAR FACTOR I; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P85; PROTEIN SUBUNIT; SOMATOMEDIN; STAT4 PROTEIN; SULFONYLUREA RECEPTOR; SULFONYLUREA RECEPTOR 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX4; TRANSCRIPTION FACTOR PAX6; UNCLASSIFIED DRUG;

EID: 0345134160     PISSN: 09078916     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (20)

References (383)
  • 1
    • 0028903027 scopus 로고
    • Molecular defects of the insulin receptor gene
    • Accili D: Molecular defects of the insulin receptor gene. Diabetes Metab Reviews 11: 47-62, 1995.
    • (1995) Diabetes Metab Reviews , vol.11 , pp. 47-62
    • Accili, D.1
  • 4
    • 0031020002 scopus 로고    scopus 로고
    • Independent requirement for ISL1 in formation of mesenchyme and islet cells
    • Ahlgren U, Pfaff SL, Jessel TM, Edlund T, Edlund H: Independent requirement for ISL1 in formation of mesenchyme and islet cells. Nature 385: 257-60, 1997.
    • (1997) Nature , vol.385 , pp. 257-260
    • Ahlgren, U.1    Pfaff, S.L.2    Jessel, T.M.3    Edlund, T.4    Edlund, H.5
  • 5
    • 0032525981 scopus 로고    scopus 로고
    • Beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes
    • Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H: beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev 12: 1763-1768, 1998.
    • (1998) Genes Dev , vol.12 , pp. 1763-1768
    • Ahlgren, U.1    Jonsson, J.2    Jonsson, L.3    Simu, K.4    Edlund, H.5
  • 6
    • 0027233603 scopus 로고
    • Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme
    • Alessi DR, Street AJ, Cohen PTW: Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme. Eur. J. Biochem 213: 1055-1066, 1993.
    • (1993) Eur J Biochem , vol.213 , pp. 1055-1066
    • Alessi, D.R.1    Street, A.J.2    Cohen, P.T.W.3
  • 8
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha
    • Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P: Characterization of a phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha. Curr. Biol. 7: 261-269, 1997a.
    • (1997) Curr Biol , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3    Holmes, A.B.4    Gaffney, P.R.5    Reese, C.B.6    Cohen, P.7
  • 10
    • 0027367546 scopus 로고
    • Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin dependent diabetes mellitus
    • Almind K, Bjørbæk C, Vestergaard H, Hansen T, Echwald S, Pedersen O: Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin dependent diabetes mellitus. Lancet 342: 828-832, 1993.
    • (1993) Lancet , vol.342 , pp. 828-832
    • Almind, K.1    Bjørbæk, C.2    Vestergaard, H.3    Hansen, T.4    Echwald, S.5    Pedersen, O.6
  • 11
    • 0029893417 scopus 로고    scopus 로고
    • A common amino acid polymorphism in the insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies
    • Almind K, Inoue G, Pedersen O, Kahn CR: A common amino acid polymorphism in the insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies. J. Clin. Invest. 97: 2569-2575, 1996.
    • (1996) J Clin Invest , vol.97 , pp. 2569-2575
    • Almind, K.1    Inoue, G.2    Pedersen, O.3    Kahn, C.R.4
  • 12
    • 0033237647 scopus 로고    scopus 로고
    • Discovery of a Met300Val variant in Shc and studies of its relationship to birth weight and length, impaired insulin secretion, insulin resistance, and type 2 diabetes mellitus
    • Almind K, Ahlgren MG, Hansen T, Urhammer SA, Clausen JO, Pedersen O: Discovery of a Met300Val variant in Shc and studies of its relationship to birth weight and length, impaired insulin secretion, insulin resistance, and type 2 diabetes mellitus. J Clin Endocrinol Metab 84: 2241-44, 1999a.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 2241-2244
    • Almind, K.1    Ahlgren, M.G.2    Hansen, T.3    Urhammer, S.A.4    Clausen, J.O.5    Pedersen, O.6
  • 13
    • 0032822218 scopus 로고    scopus 로고
    • Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: Evaluation of their relation with alterations in insulin secretion and insulin sensitivity
    • Almind K, Frederiksen SK, Bernal D, Hansen T, Ambye L, Urhammer S, Ekstrøm CT, Berglund L, reneland R, Lithell H, White MF, Van Obberghen E, Pedersen O: Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity. Diabetologia 42: 1244-49, 1999b.
    • (1999) Diabetologia , vol.42 , pp. 1244-1249
    • Almind, K.1    Frederiksen, S.K.2    Bernal, D.3    Hansen, T.4    Ambye, L.5    Urhammer, S.6    Ekstrøm, C.T.7    Berglund, L.8    Reneland, R.9    Lithell, H.10    White, M.F.11    Van Obberghen, E.12    Pedersen, O.13
  • 15
    • 0029064102 scopus 로고    scopus 로고
    • Catalytic activities of glycogenin additional to autocatalytic self-glucosylation
    • Alonso MD, Lomako J, Lomako WM, Whelan WJ: Catalytic activities of glycogenin additional to autocatalytic self-glucosylation. J Biol Chem 270: 15315-19, 1996.
    • (1996) J Biol Chem , vol.270 , pp. 15315-15319
    • Alonso, M.D.1    Lomako, J.2    Lomako, W.M.3    Whelan, W.J.4
  • 18
    • 0033043389 scopus 로고    scopus 로고
    • Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase
    • Andjelkovic M, Maira SM, Cron P, Parker PJ, Hemmings BA: Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase. Mol Cell Biol 19: 5061-72, 1999.
    • (1999) Mol Cell Biol , vol.19 , pp. 5061-5072
    • Andjelkovic, M.1    Maira, S.M.2    Cron, P.3    Parker, P.J.4    Hemmings, B.A.5
  • 21
    • 0032856044 scopus 로고    scopus 로고
    • Insulin sensitivity, glucose effectiveness, and insulin secretion in nondiabetic offspring of patients with non-insulin dependent diabetes mellitus: A cross-sectional study
    • Araujo-Vilar D, Garcia-Estevez DA, Cabezas-Cerrato J: Insulin sensitivity, glucose effectiveness, and insulin secretion in nondiabetic offspring of patients with non-insulin dependent diabetes mellitus: a cross-sectional study. Metabolism 48: 978-83, 1999.
    • (1999) Metabolism , vol.48 , pp. 978-983
    • Araujo-Vilar, D.1    Garcia-Estevez, D.A.2    Cabezas-Cerrato, J.3
  • 22
    • 0023240110 scopus 로고
    • Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and type 2 diabetes (non-insulin-dependent) diabetes mellitus
    • Arner P, pollare T, Lithell H, Livingston JN: Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and type 2 diabetes (non-insulin-dependent) diabetes mellitus. Diabetologia 30: 437-40, 1987.
    • (1987) Diabetologia , vol.30 , pp. 437-440
    • Arner, P.1    Pollare, T.2    Lithell, H.3    Livingston, J.N.4
  • 25
    • 0031803108 scopus 로고    scopus 로고
    • Variant in the regulatory subunit of phosphatidylinositol 3-kinase (p85α): Preliminary evidence indicates a potential role of this variant in the acute insulin response and type 2 diabetes in Pima Women
    • Baier LJ, Wiedrich C, Hanson RL, Bogardus C: Variant in the regulatory subunit of phosphatidylinositol 3-kinase (p85α): Preliminary evidence indicates a potential role of this variant in the acute insulin response and type 2 diabetes in Pima Women. Diabetes 47: 973-975, 1998.
    • (1998) Diabetes , vol.47 , pp. 973-975
    • Baier, L.J.1    Wiedrich, C.2    Hanson, R.L.3    Bogardus, C.4
  • 28
    • 0025324634 scopus 로고
    • Localization of the gene encoding a type 1 protein phosphatase catalytic subunit to human chromosome band 11q13
    • Barker HM, Jones TA, da Cruz e Silva EF, Spurr NK, Sheer D, Cohen PTW: Localization of the gene encoding a type 1 protein phosphatase catalytic subunit to human chromosome band 11q13. Genomics 7: 159-166, 1990.
    • (1990) Genomics , vol.7 , pp. 159-166
    • Barker, H.M.1    Jones, T.A.2    Da Cruz E Silva, E.F.3    Spurr, N.K.4    Sheer, D.5    Cohen, P.T.W.6
  • 29
    • 0027171705 scopus 로고
    • Sequence of protein serine/threonine phosphatase 1 gamma and localization of the gene (PP1CC) encoding it to chromosome bands 12q24.1-q24.2
    • Barker HM, Craig SP, Spurr NK, Cohen PTW: Sequence of protein serine/threonine phosphatase 1 gamma and localization of the gene (PP1CC) encoding it to chromosome bands 12q24. 1-q24.2. Biochem Biophis Acta 1178: 228-233, 1993.
    • (1993) Biochem Biophis Acta , vol.1178 , pp. 228-233
    • Barker, H.M.1    Craig, S.P.2    Spurr, N.K.3    Cohen, P.T.W.4
  • 30
    • 0028097766 scopus 로고
    • Three genes for protein phosphatase 1 map to different human chromosomes: Sequence, expression and gene localization of protein serine/threonine phosphatase 1 beta (PP1CB)
    • Barker HM, Brewis ND, Street AJ, Spurr NK, Cohen PTW: Three genes for protein phosphatase 1 map to different human chromosomes: Sequence, expression and gene localization of protein serine/threonine phosphatase 1 beta (PP1CB). Biochem Biophis Acta 1220: 212-218, 1994.
    • (1994) Biochem Biophis Acta , vol.1220 , pp. 212-218
    • Barker, H.M.1    Brewis, N.D.2    Street, A.J.3    Spurr, N.K.4    Cohen, P.T.W.5
  • 35
    • 0031667127 scopus 로고    scopus 로고
    • Association of the Pro12Ala variant in the peroxisome proliferator-activator receptor-2γ gene with obesity in two Caucasian populations
    • Beamer BA, Yen CJ, Andersen RE, Muller D, Elahi D, Cheskin LJ, Andres R, Roth J, Shuldiner AR: Association of the Pro12Ala variant in the peroxisome proliferator-activator receptor-2γ gene with obesity in two Caucasian populations. Diabetes 47: 1806-8, 1998.
    • (1998) Diabetes , vol.47 , pp. 1806-1808
    • Beamer, B.A.1    Yen, C.J.2    Andersen, R.E.3    Muller, D.4    Elahi, D.5    Cheskin, L.J.6    Andres, R.7    Roth, J.8    Shuldiner, A.R.9
  • 36
    • 0028091753 scopus 로고
    • Metabolic and genetic characterization of prediabetic states - Sequence of events leading to non-insulin-dependent diabetes-mellitus
    • Beck-Nielsen H, Groop LC (1994) Metabolic and genetic characterization of prediabetic states - sequence of events leading to non-insulin-dependent diabetes-mellitus. J Clin Inv; 94(5): 1714-1721.
    • (1994) J Clin Inv , vol.94 , Issue.5 , pp. 1714-1721
    • Beck-Nielsen, H.1    Groop, L.C.2
  • 38
    • 0033048456 scopus 로고    scopus 로고
    • Exclusion of insulin receptor substrate-2 (IRS-2) as a major locus for early-onset autosomal dominant type 2 diabetes
    • Bektas A, Warram JH, White MF, Krolewski AS, Doria A: Exclusion of insulin receptor substrate-2 (IRS-2) as a major locus for early-onset autosomal dominant type 2 diabetes. Diabetes 48: 640-42, 1999.
    • (1999) Diabetes , vol.48 , pp. 640-642
    • Bektas, A.1    Warram, J.H.2    White, M.F.3    Krolewski, A.S.4    Doria, A.5
  • 39
    • 0026032055 scopus 로고
    • Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q
    • Bell GI, Xiang KS, Newman MV, Wu SH, Wright LG, Fajans SS, Spielman RS, Cox NJ: Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q. Proc Natl Acad Sci USA 88: 1484-1488, 1991.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 1484-1488
    • Bell, G.I.1    Xiang, K.S.2    Newman, M.V.3    Wu, S.H.4    Wright, L.G.5    Fajans, S.S.6    Spielman, R.S.7    Cox, N.J.8
  • 41
    • 0344044252 scopus 로고    scopus 로고
    • Overexpression of protein targeting to glycogen (PTG) in rat hepatocytes causes profound activation of glycogen synthesis independent of normal hormone- and substrate-mediated regulatory mechanisms
    • Bergman HK, O'Doherty RM, Anderson P, Newgaard CB: Overexpression of protein targeting to glycogen (PTG) in rat hepatocytes causes profound activation of glycogen synthesis independent of normal hormone- and substrate-mediated regulatory mechanisms. J Biol Chem 279: 264221-5, 1998.
    • (1998) J Biol Chem , vol.279 , pp. 264221-264225
    • Bergman, H.K.1    O'Doherty, R.M.2    Anderson, P.3    Newgaard, C.B.4
  • 42
    • 0031803329 scopus 로고    scopus 로고
    • Insulin receptor substrate-2 amino acid polymorphyisms are not associated with random tye 2 diabetes among Caucasians
    • Bernal D, Almind K, Yenush L, Ayoub M, Zhang Y, Rosshani L, Larsson C, Pedersen O, White MF: Insulin receptor substrate-2 amino acid polymorphyisms are not associated with random tye 2 diabetes among Caucasians. Diabetes 47: 976-79, 1998.
    • (1998) Diabetes , vol.47 , pp. 976-979
    • Bernal, D.1    Almind, K.2    Yenush, L.3    Ayoub, M.4    Zhang, Y.5    Rosshani, L.6    Larsson, C.7    Pedersen, O.8    White, M.F.9
  • 43
    • 0032768284 scopus 로고    scopus 로고
    • Glucose metabolism and beta-cell mass in adult offspring of rats protein and/or energy restricted during the last week of pregnancy
    • Bertin E, Gangnerau MN, Bailbe D, Portha B: Glucose metabolism and beta-cell mass in adult offspring of rats protein and/or energy restricted during the last week of pregnancy. Am J Physiol 277: E11-17, 1999.
    • (1999) Am J Physiol , vol.277
    • Bertin, E.1    Gangnerau, M.N.2    Bailbe, D.3    Portha, B.4
  • 44
    • 0031057526 scopus 로고    scopus 로고
    • Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation
    • Bjornholm M, Kawano Y, Lehtihet M, Zierath JR: Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation. Diabetes 46: 524-27, 1997.
    • (1997) Diabetes , vol.46 , pp. 524-527
    • Bjornholm, M.1    Kawano, Y.2    Lehtihet, M.3    Zierath, J.R.4
  • 45
    • 0027930399 scopus 로고
    • Genetic variants in the promoters and coding regions of muscle glycogen synthase and the inulin-responsive GLUT4 genes in NIDDM
    • Bjørbæk C, Echwald SM, Hubricht P et al.: Genetic variants in the promoters and coding regions of muscle glycogen synthase and the inulin-responsive GLUT4 genes in NIDDM. Diabetes 43: 976-983, 1994.
    • (1994) Diabetes , vol.43 , pp. 976-983
    • Bjørbæk, C.1    Echwald, S.M.2    Hubricht, P.3
  • 46
    • 0028804624 scopus 로고
    • Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients
    • Bjørbæk C, Vik TA, Echwald SM et al.: Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients. Diabetes 44: 90-97, 1995.
    • (1995) Diabetes , vol.44 , pp. 90-97
    • Bjørbæk, C.1    Vik, T.A.2    Echwald, S.M.3
  • 47
    • 0035119823 scopus 로고    scopus 로고
    • Mutations in the coding region of the neurogenin 3 gene (NEUROG3) are not a common cause of maturity-onset diabetes of the young in Japanese subjects
    • del Bosque-Plata L, Lin J, Horikawa Y, Schwarz PE, Cox NJ, Iwasaki N, Ogata M, Iwamoto Y, German MS, Bell GI: Mutations in the coding region of the neurogenin 3 gene (NEUROG3) are not a common cause of maturity-onset diabetes of the young in Japanese subjects. Diabetes 50: 694-696, 2001.
    • (2001) Diabetes , vol.50 , pp. 694-696
    • Del Bosque-Plata, L.1    Lin, J.2    Horikawa, Y.3    Schwarz, P.E.4    Cox, N.J.5    Iwasaki, N.6    Ogata, M.7    Iwamoto, Y.8    German, M.S.9    Bell, G.I.10
  • 48
    • 0030721534 scopus 로고    scopus 로고
    • The regulation of glycogen synthase by protein phosphatase 1 in 3T3-L1 adipocytes
    • Brady MJ, Nairn AC, Saltiel AR: The regulation of glycogen synthase by protein phosphatase 1 in 3T3-L1 adipocytes. J. Biol. Chem. 272: 29698-29703, 1997a.
    • (1997) J Biol Chem , vol.272 , pp. 29698-29703
    • Brady, M.J.1    Nairn, A.C.2    Saltiel, A.R.3
  • 49
    • 0030806934 scopus 로고    scopus 로고
    • Role of protein targeting to glycogen (PTG) in the regulation of protein phosphatase-1 activity
    • Brady MJ, Printen JA, Mastick CC, Saltiel AR: Role of protein targeting to glycogen (PTG) in the regulation of protein phosphatase-1 activity. J. Biol. Chem. 272: 20198-20204, 1997b.
    • (1997) J Biol Chem , vol.272 , pp. 20198-20204
    • Brady, M.J.1    Printen, J.A.2    Mastick, C.C.3    Saltiel, A.R.4
  • 50
    • 0035800763 scopus 로고    scopus 로고
    • Two splice variants of PKBgamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site Ser472 in the C-terminal hydrophobic domain
    • May 31
    • Brodbeck D, Hill MM, Hemmings BA: Two splice variants of PKBgamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site Ser472 in the C-terminal hydrophobic domain. J Biol Chem May 31, 2001.
    • (2001) J Biol Chem
    • Brodbeck, D.1    Hill, M.M.2    Hemmings, B.A.3
  • 51
    • 0038155702 scopus 로고    scopus 로고
    • Development of a novel polygenic model of NIDDM in mice heterozygous for 1R and IRS-1 null alleles
    • Brüning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR: Development of a novel polygenic model of NIDDM in mice heterozygous for 1R and IRS-1 null alleles. Cell 88: 561-572, 1997.
    • (1997) Cell , vol.88 , pp. 561-572
    • Brüning, J.C.1    Winnay, J.2    Bonner-Weir, S.3    Taylor, S.I.4    Accili, D.5    Kahn, C.R.6
  • 52
    • 0032214652 scopus 로고    scopus 로고
    • A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
    • Brüning JC, Michael MD, Winnay JN, Hayashi T, Horsch D, Accili D, Goodyear LJ, Kahn CR: A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Moll Cell 2: 559-69, 1998.
    • (1998) Moll Cell , vol.2 , pp. 559-569
    • Brüning, J.C.1    Michael, M.D.2    Winnay, J.N.3    Hayashi, T.4    Horsch, D.5    Accili, D.6    Goodyear, L.J.7    Kahn, C.R.8
  • 57
    • 0032881288 scopus 로고    scopus 로고
    • AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide dependent phosphorylation
    • Chan OT, Rittenhause SE, Tsichlis PN: AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide dependent phosphorylation. Ann. Rev. Biochem. 68: 965-1014, 1999.
    • (1999) Ann Rev Biochem , vol.68 , pp. 965-1014
    • Chan, O.T.1    Rittenhause, S.E.2    Tsichlis, P.N.3
  • 58
    • 0028904053 scopus 로고
    • Insulin action and the insulin signaling network
    • Cheatham B, Kahn CR: Insulin action and the insulin signaling network. Endocrine Reviews 16; 2: 117-142, 1995.
    • (1995) Endocrine Reviews , vol.16 , Issue.2 , pp. 117-142
    • Cheatham, B.1    Kahn, C.R.2
  • 59
    • 0028039132 scopus 로고
    • Sequence of the Human Glycogen-Associated Regulatory Subunit of Type 1 Protein Phosphatase and Analysis of its Coding Region and mRNA Level in Muscle from Patients with Non-Insulin-Dependent Diabetes Mellitus
    • Chen YH, Hansen L, Chen MW, Bjørbæk C, Vestergaard H, Hansen T, Cohen PTW, Pedersen O: Sequence of the Human Glycogen-Associated Regulatory Subunit of Type 1 Protein Phosphatase and Analysis of its Coding Region and mRNA Level in Muscle from Patients with Non-Insulin-Dependent Diabetes Mellitus. Diabetes 43: 1234-1241, 1994.
    • (1994) Diabetes , vol.43 , pp. 1234-1241
    • Chen, Y.H.1    Hansen, L.2    Chen, M.W.3    Bjørbæk, C.4    Vestergaard, H.5    Hansen, T.6    Cohen, P.T.W.7    Pedersen, O.8
  • 60
  • 62
    • 0029882911 scopus 로고    scopus 로고
    • Promotor variation in the liver glucokinase is a risk for non-insulin-dependent diabetes mellitus
    • Chiu KC, McCarthy JE: Promotor variation in the liver glucokinase is a risk for non-insulin-dependent diabetes mellitus. Biochem Biophys Res Commun 221: 614-18, 1996.
    • (1996) Biochem Biophys Res Commun , vol.221 , pp. 614-618
    • Chiu, K.C.1    McCarthy, J.E.2
  • 63
    • 0030828826 scopus 로고    scopus 로고
    • Preliminary data on a genome search in NIDDM siblings: The NIDDM1 locus on chromosome 2 is not linked to NIDDM in the Sardinian population
    • Study group for the genetics of diabetes in Sardenia
    • Ciccarese M, Tonolo G, Delin I, Wong FK, Holm P, Atzeni MM, Lichtenstein P, Kockum I, Maioli M, Luthman H: Preliminary data on a genome search in NIDDM siblings: the NIDDM1 locus on chromosome 2 is not linked to NIDDM in the Sardinian population. Study group for the genetics of diabetes in Sardenia. Diabetologia 40: 1366-67, 1997.
    • (1997) Diabetologia , vol.40 , pp. 1366-1367
    • Ciccarese, M.1    Tonolo, G.2    Delin, I.3    Wong, F.K.4    Holm, P.5    Atzeni, M.M.6    Lichtenstein, P.7    Kockum, I.8    Maioli, M.9    Luthman, H.10
  • 65
    • 0029775612 scopus 로고    scopus 로고
    • Insulin sensitivity index, acute insulin response and glucose effectiveness in a population-based sample of 380 young healthy caucasians
    • Clausen JO, Borch-Johnsen K, Ibsen H, Bergman RN, Hougaard P, Winther K, Pedersen O Insulin sensitivity index, acute insulin response and glucose effectiveness in a population-based sample of 380 young healthy caucasians. J Clin Invest 98: 1195-1209, 1996.
    • (1996) J Clin Invest , vol.98 , pp. 1195-1209
    • Clausen, J.O.1    Borch-Johnsen, K.2    Ibsen, H.3    Bergman, R.N.4    Hougaard, P.5    Winther, K.6    Pedersen, O.7
  • 67
    • 0344019486 scopus 로고    scopus 로고
    • A sib-pair analysis study of 15 candidate genes in French families with morbid obesity: Indication for linkage with islet 1 locus on chromosome 5q
    • Clement K, Dina C, Basdevant A, Chastang N, Pellouc V, Lahlou N, Berlan M, Langin D, Guy-Grand B, Froguel P: A sib-pair analysis study of 15 candidate genes in French families with morbid obesity: indication for linkage with islet 1 locus on chromosome 5q. Diabetes 48: 398-402, 1999.
    • (1999) Diabetes , vol.48 , pp. 398-402
    • Clement, K.1    Dina, C.2    Basdevant, A.3    Chastang, N.4    Pellouc, V.5    Lahlou, N.6    Berlan, M.7    Langin, D.8    Guy-Grand, B.9    Froguel, P.10
  • 69
    • 77956911584 scopus 로고
    • Muscle glycogen synthase
    • Cohen P: Muscle glycogen synthase. The Enzymes. vol. XVII: 461-497,1986
    • (1986) The Enzymes , vol.17 , pp. 461-497
    • Cohen, P.1
  • 70
    • 0030841793 scopus 로고    scopus 로고
    • PDK1, one of the missing links in insulin signal transduction?
    • Cohen P, Alesssi DR, Cross DA: PDK1, one of the missing links in insulin signal transduction? FEBS Lett. 410: 3-10, 1997.
    • (1997) FEBS Lett , vol.410 , pp. 3-10
    • Cohen, P.1    Alesssi, D.R.2    Cross, D.A.3
  • 72
    • 0030734345 scopus 로고    scopus 로고
    • Physiological role of Akt in insulin-stimulated translocation of Glut4 in transfected rat adipose cells
    • Cong L, Chen H, Zhou L, McGibbon MA, Taylot SI, Qoun MJ: Physiological role of Akt in insulin-stimulated translocation of Glut4 in transfected rat adipose cells. Mol. Endcrinol. 11: 1881-1890, 1997.
    • (1997) Mol Endcrinol , vol.11 , pp. 1881-1890
    • Cong, L.1    Chen, H.2    Zhou, L.3    McGibbon, M.A.4    Taylot, S.I.5    Qoun, M.J.6
  • 73
    • 0027476081 scopus 로고
    • Association of low birth weight with β-cell function in the adult first degree relaitves of non-insulin-dependent diabetes subject
    • Cook JTE, Levy JC, Page RCL, Shaw JAG, Hattersley AT, Turner RC: Association of low birth weight with β-cell function in the adult first degree relaitves of non-insulin-dependent diabetes subject. BMJ 306: 302-6, 1993.
    • (1993) BMJ , vol.306 , pp. 302-306
    • Cook, J.T.E.1    Levy, J.C.2    Page, R.C.L.3    Shaw, J.A.G.4    Hattersley, A.T.5    Turner, R.C.6
  • 74
    • 0032928542 scopus 로고    scopus 로고
    • Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans
    • Cox NJ, Frigge M, Nicolae DL, Concannon P, Hanis CL, Bell GI, Kong A: Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nature Gen. 21: 213-215, 1999.
    • (1999) Nature Gen , vol.21 , pp. 213-215
    • Cox, N.J.1    Frigge, M.2    Nicolae, D.L.3    Concannon, P.4    Hanis, C.L.5    Bell, G.I.6    Kong, A.7
  • 76
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross DAE, Alessi DR, Cohen P, Andjelkovich M, Hemmings B: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-789, 1995.
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.E.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.5
  • 77
    • 0033054726 scopus 로고    scopus 로고
    • Intermediate expansions of a GAA repeat in the frataxin gene are nor associated with type 2 diabetes or altered glucose-induced beta-cell function in Danish Caucasians
    • Dalgaard LT, Hansen T, Urhammer SA, Clausen JO, Eiberg H, Pedersen O: Intermediate expansions of a GAA repeat in the frataxin gene are nor associated with type 2 diabetes or altered glucose-induced beta-cell function in Danish Caucasians. Diabetes 48: 914-917, 1999.
    • (1999) Diabetes , vol.48 , pp. 914-917
    • Dalgaard, L.T.1    Hansen, T.2    Urhammer, S.A.3    Clausen, J.O.4    Eiberg, H.5    Pedersen, O.6
  • 78
    • 0025860114 scopus 로고
    • Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus
    • Damsbo P, Vaag A, Hother-Nielsen O, Beck-Nielsen H: Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 34: 239-45, 1991.
    • (1991) Diabetologia , vol.34 , pp. 239-245
    • Damsbo, P.1    Vaag, A.2    Hother-Nielsen, O.3    Beck-Nielsen, H.4
  • 79
    • 0031595923 scopus 로고    scopus 로고
    • A Pro12Ala substitution in PPAR-2γ associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
    • Deeb SS, Fajas L, Nemoto M, Pihlajamaki J, Mykkanen L, kuusisto J, Laakso M, Fujimoto W, Auwerx J: A Pro12Ala substitution in PPAR-2γ associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 20: 284-87, 1998.
    • (1998) Nat Genet , vol.20 , pp. 284-287
    • Deeb, S.S.1    Fajas, L.2    Nemoto, M.3    Pihlajamaki, J.4    Mykkanen, L.5    Kuusisto, J.6    Laakso, M.7    Fujimoto, W.8    Auwerx, J.9
  • 80
    • 0018520840 scopus 로고
    • Glucose clamp technique: A method for quantifying insulin secretion and resistance
    • DeFronzo RA, Tobin JD, Andres R: Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237: E214-E223, 1979.
    • (1979) Am J Physiol , vol.237
    • DeFronzo, R.A.1    Tobin, J.D.2    Andres, R.3
  • 81
    • 0025522071 scopus 로고
    • The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle
    • Dent P, Lavoinnne A, Nakielny S, Caudwell FB, Watt P, Cohen P: The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle. Nature 348: 302-308, 1990.
    • (1990) Nature , vol.348 , pp. 302-308
    • Dent, P.1    Lavoinnne, A.2    Nakielny, S.3    Caudwell, F.B.4    Watt, P.5    Cohen, P.6
  • 83
    • 0030590869 scopus 로고    scopus 로고
    • Amino acid sequence of a novel protein phophatase 1 binding protein (R5) which is related to the liver- and muscle-specific glycogen binding subunits of protein phophatase 1
    • Doherty M, Young PR, Cohen PTW: Amino acid sequence of a novel protein phophatase 1 binding protein (R5) which is related to the liver- and muscle-specific glycogen binding subunits of protein phophatase 1. FEBS Lett. 399: 339-343, 1996.
    • (1996) FEBS Lett , vol.399 , pp. 339-343
    • Doherty, M.1    Young, P.R.2    Cohen, P.T.W.3
  • 84
    • 0035029812 scopus 로고    scopus 로고
    • Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes
    • Ducluzeau PH, Perretti N, Laville M, Andreelli F, Vega N, Riou JP, Vidal H: Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes. Diabetes 50: 1134-42, 2001.
    • (2001) Diabetes , vol.50 , pp. 1134-1142
    • Ducluzeau, P.H.1    Perretti, N.2    Laville, M.3    Andreelli, F.4    Vega, N.5    Riou, J.P.6    Vidal, H.7
  • 86
    • 0033051861 scopus 로고    scopus 로고
    • No evidence of linkage or diabetes-associated mutations in the transcription factors Beta2/NeuroD1 and Pax4 in type 2 diabetes in France
    • Dupont S, Vionnet N, Chevre JC, Gallina S, Dina C, Seino Y, Yamada Y, Froguel P: No evidence of linkage or diabetes-associated mutations in the transcription factors Beta2/NeuroD1 and Pax4 in type 2 diabetes in France. Diabetologia 42: 480-484, 1999.
    • (1999) Diabetologia , vol.42 , pp. 480-484
    • Dupont, S.1    Vionnet, N.2    Chevre, J.C.3    Gallina, S.4    Dina, C.5    Seino, Y.6    Yamada, Y.7    Froguel, P.8
  • 87
    • 0033431661 scopus 로고    scopus 로고
    • Absence of replication in the French population of the association between beta 2/NEUROD-A 45T polymorphism and type 1 diabetes
    • Dupont S, Dina C, Hani EH, Froguel P: Absence of replication in the French population of the association between beta 2/NEUROD-A45T polymorphism and type 1 diabetes. Diabetes Metab 25: 516-17, 1999.
    • (1999) Diabetes Metab , vol.25 , pp. 516-517
    • Dupont, S.1    Dina, C.2    Hani, E.H.3    Froguel, P.4
  • 88
    • 0028962835 scopus 로고
    • Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness and insulin sensitivity
    • Echwald SM, Bjoerbaek C, Hansen T, Clausen JO, Vestergaard H, Zierath JR, Printz RL, Granner DK, Pedersen O: Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness and insulin sensitivity. Diabetes 44: 347-353, 1995.
    • (1995) Diabetes , vol.44 , pp. 347-353
    • Echwald, S.M.1    Bjoerbaek, C.2    Hansen, T.3    Clausen, J.O.4    Vestergaard, H.5    Zierath, J.R.6    Printz, R.L.7    Granner, D.K.8    Pedersen, O.9
  • 89
    • 0033553415 scopus 로고    scopus 로고
    • Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance
    • Egawa K, Sharma PM, Nakashima N, Huang Y, Huver E, Boss GR, Olefsky JM: Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance. J Biol Chem 274: 14306-14, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 14306-14314
    • Egawa, K.1    Sharma, P.M.2    Nakashima, N.3    Huang, Y.4    Huver, E.5    Boss, G.R.6    Olefsky, J.M.7
  • 91
    • 0032781890 scopus 로고    scopus 로고
    • Homozygosity of the Pro12Ala variant of the peroxisome proliferation-activated activated receptor-g2 (PPAR-g2): Divergent modulating effects on body mass index in obese and lean Caucasian men
    • Ek J, Urhammer SA, Sorensen TI, Andersen T, Auwerx J, Pedersen O: Homozygosity of the Pro12Ala variant of the peroxisome proliferation-activated activated receptor-g2 (PPAR-g2): divergent modulating effects on body mass index in obese and lean Caucasian men. Diabetologia 42: 892-95, 1999.
    • (1999) Diabetologia , vol.42 , pp. 892-895
    • Ek, J.1    Urhammer, S.A.2    Sorensen, T.I.3    Andersen, T.4    Auwerx, J.5    Pedersen, O.6
  • 92
    • 0026664599 scopus 로고
    • Linkage analysis of insulin-receptor gene in familial NIDDM
    • Elbein SC, Sorensen LK, Taylor M: Linkage analysis of insulin-receptor gene in familial NIDDM. Diabetes 41: 648-56, 1992.
    • (1992) Diabetes , vol.41 , pp. 648-656
    • Elbein, S.C.1    Sorensen, L.K.2    Taylor, M.3
  • 93
    • 0027446952 scopus 로고
    • Methionine for valine substitution in exon 17 of the insulin receptor gene in a pedigree with familial NIDDM
    • Elbein SC, Sorensen LK, Schumacher MC Methionine for valine substitution in exon 17 of the insulin receptor gene in a pedigree with familial NIDDM. Diabetes 42: 429-434, 1993.
    • (1993) Diabetes , vol.42 , pp. 429-434
    • Elbein, S.C.1    Sorensen, L.K.2    Schumacher, M.C.3
  • 94
    • 0029976297 scopus 로고    scopus 로고
    • Role of mitochondrial DNA tRNA leucine nd glucagon receptor missense muations in Utah white diabetic patients
    • Elbein SC, Hoffman MD: Role of mitochondrial DNA tRNA leucine nd glucagon receptor missense muations in Utah white diabetic patients. Diabetes Care 19: 507-8, 1996.
    • (1996) Diabetes Care , vol.19 , pp. 507-508
    • Elbein, S.C.1    Hoffman, M.D.2
  • 95
    • 0033312608 scopus 로고    scopus 로고
    • Heritability of pancdraetic β-cell function among nondiabetic members of Caucasian familial type 2 diabetic kindreds
    • Elbein SC, Hasstedt SJ, Wegner K, Kahn SE: Heritability of pancdraetic β-cell function among nondiabetic members of Caucasian familial type 2 diabetic kindreds. J Clin Endocrinol Metab 84: 1398-403, 1999.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 1398-1403
    • Elbein, S.C.1    Hasstedt, S.J.2    Wegner, K.3    Kahn, S.E.4
  • 96
    • 0032910599 scopus 로고    scopus 로고
    • A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians
    • Elbein SC, Hoffman MD, Teng K, Leppert MF, Hasstedt SJ: A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians. Diabetes 48: 1175-82, 1999.
    • (1999) Diabetes , vol.48 , pp. 1175-1182
    • Elbein, S.C.1    Hoffman, M.D.2    Teng, K.3    Leppert, M.F.4    Hasstedt, S.J.5
  • 97
    • 0029811140 scopus 로고    scopus 로고
    • Expression of glycogen synthase kinase-3 mutants in cells and their effects on glycogen synthase activity in intact cells
    • Eldar-Finkelman H, Argast GM, Foord O, Fisher E, Krebs EG: Expression of glycogen synthase kinase-3 mutants in cells and their effects on glycogen synthase activity in intact cells. Proc. Natl. Acad. Sci. USA. 93: 10228-10233, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10228-10233
    • Eldar-Finkelman, H.1    Argast, G.M.2    Foord, O.3    Fisher, E.4    Krebs, E.G.5
  • 98
    • 0029870187 scopus 로고    scopus 로고
    • Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase inhibitor
    • Endo S, Zhou X, Connor J, Wang B, Shenolikar S: Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase inhibitor. Biochemistry 35: 5220-5228, 1996.
    • (1996) Biochemistry , vol.35 , pp. 5220-5228
    • Endo, S.1    Zhou, X.2    Connor, J.3    Wang, B.4    Shenolikar, S.5
  • 104
    • 0030991386 scopus 로고    scopus 로고
    • High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity
    • Frech M, Andjelkovic M, Ingley E, Reddy KK, Falck JR, Hemmings BA: High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity. J Biol Chem 272: 8374-81, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 8374-8381
    • Frech, M.1    Andjelkovic, M.2    Ingley, E.3    Reddy, K.K.4    Falck, J.R.5    Hemmings, B.A.6
  • 107
  • 108
    • 0031874185 scopus 로고    scopus 로고
    • Mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese
    • Furuta H, Horikawa Y, Iwasaki N et al. Mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese. Diabetes 47: 1356-1358, 1998.
    • (1998) Diabetes , vol.47 , pp. 1356-1358
    • Furuta, H.1    Horikawa, Y.2    Iwasaki, N.3
  • 110
    • 0033506255 scopus 로고    scopus 로고
    • Pathophysiological and genetic characterization of the major diabetes locus in GK rats
    • Galli J, Fakhrai-Rad H, Kamel A, Marcus C, Norgren S, Luthman H: Pathophysiological and genetic characterization of the major diabetes locus in GK rats. Diabetes 48: 2463-70, 1999.
    • (1999) Diabetes , vol.48 , pp. 2463-2470
    • Galli, J.1    Fakhrai-Rad, H.2    Kamel, A.3    Marcus, C.4    Norgren, S.5    Luthman, H.6
  • 115
    • 0035043009 scopus 로고    scopus 로고
    • Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53)
    • Gloyn L, Hashim Y, Ashcroft SJ, Ashfield R, Wiltshire S, Turner RC: Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53). Diabetic Medicine 18: 206-10, 2001.
    • (2001) Diabetic Medicine , vol.18 , pp. 206-210
    • Gloyn, L.1    Hashim, Y.2    Ashcroft, S.J.3    Ashfield, R.4    Wiltshire, S.5    Turner, R.C.6
  • 116
    • 0028903232 scopus 로고
    • Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects
    • Goodyear LJ, Giorgino F, Sherman LA, Carey J, Smith RJ, Dohm GL: Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J Clin Invest 95: 2195-204, 1995.
    • (1995) J Clin Invest , vol.95 , pp. 2195-2204
    • Goodyear, L.J.1    Giorgino, F.2    Sherman, L.A.3    Carey, J.4    Smith, R.J.5    Dohm, G.L.6
  • 117
    • 0034652287 scopus 로고    scopus 로고
    • Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    • Gradwohl G, Dierich A, Lemeur M, Guillemot F: Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc. Natl. Acad. Sci. U.S.A. 97: 1607-1611, 2000.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1607-1611
    • Gradwohl, G.1    Dierich, A.2    Lemeur, M.3    Guillemot, F.4
  • 119
    • 0033863689 scopus 로고    scopus 로고
    • Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis
    • Gu HF, Almgren P, Lindholm E, Frittitta L, Trischitta V, Groop LC: Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis. Diabetes: 49: 1601-3, 2000.
    • (2000) Diabetes , vol.49 , pp. 1601-1603
    • Gu, H.F.1    Almgren, P.2    Lindholm, E.3    Frittitta, L.4    Trischitta, V.5    Groop, L.C.6
  • 122
    • 0026969347 scopus 로고
    • Genetic and enviromental determinants of non-insulin dependent diabetes mellitus (NIDDM)
    • Hamman RF: Genetic and enviromental determinants of non-insulin dependent diabetes mellitus (NIDDM). Diabetes Metab Rev 8: 287-338, 1992.
    • (1992) Diabetes Metab Rev , vol.8 , pp. 287-338
    • Hamman, R.F.1
  • 124
    • 0030925094 scopus 로고    scopus 로고
    • Mapping NIDDM susceptibility loci in French families: Studies with markers in the region of NIDDM1 on chromosome 2q
    • Hani EH, Hager J, Philippi A, Demenais F, Froguel P, Vionnet N: Mapping NIDDM susceptibility loci in French families: studies with markers in the region of NIDDM1 on chromosome 2q. Diabetes 46: 1225-26, 1997b.
    • (1997) Diabetes , vol.46 , pp. 1225-1226
    • Hani, E.H.1    Hager, J.2    Philippi, A.3    Demenais, F.4    Froguel, P.5    Vionnet, N.6
  • 125
    • 0031773333 scopus 로고    scopus 로고
    • + channel gene (KIR6.2/BIR): A meta-analysis suggests a role in the polygenic basis of type II diabetes mellitus in Caucasians
    • + channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of type II diabetes mellitus in Caucasians. Diabotologia 41: 1511-5, 1998.
    • (1998) Diabotologia , vol.41 , pp. 1511-1515
    • Hani, E.H.1    Boutin, P.2    Durand, E.3    Inoue, H.4    Permutt, M.A.5    Velho, G.6    Froguel, P.7
  • 127
    • 9044243415 scopus 로고    scopus 로고
    • A geneome-wide search for Non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2
    • Hanis CL, Boerwinkel E, Chakraborty R et al.: A geneome-wide search for Non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nature Gen. 13; 2: 161-166, 1996.
    • (1996) Nature Gen , vol.13 , Issue.2 , pp. 161-166
    • Hanis, C.L.1    Boerwinkel, E.2    Chakraborty, R.3
  • 128
    • 0029126604 scopus 로고
    • A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin
    • Hansen L, Hansen T, Vestergaard H, Bjørbæk C, Echwald SM, Clausen JO, Chen YH, Chen MX, Cohen PTW, Pedersen O: A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin. Hum. Mol. Genet. 4; 8: 1313-1320, 1995.
    • (1995) Hum Mol Genet , vol.4 , Issue.8 , pp. 1313-1320
    • Hansen, L.1    Hansen, T.2    Vestergaard, H.3    Bjørbæk, C.4    Echwald, S.M.5    Clausen, J.O.6    Chen, Y.H.7    Chen, M.X.8    Cohen, P.T.W.9    Pedersen, O.10
  • 130
    • 0031051534 scopus 로고    scopus 로고
    • Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir 6.2 and their relationsships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM
    • Hansen L, Echwald SM, Hansen T, Urhammer SA, Clausen JO, Pedersen O: Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir 6.2 and their relationsships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM. Diabetes 46: 508-512, 1997b.
    • (1997) Diabetes , vol.46 , pp. 508-512
    • Hansen, L.1    Echwald, S.M.2    Hansen, T.3    Urhammer, S.A.4    Clausen, J.O.5    Pedersen, O.6
  • 131
    • 0030923338 scopus 로고    scopus 로고
    • The Val985Met insulin-receptor variant in the Danish Caucasian population: Lack of associations with non-insulin-dependent diabetes mellitus or insulin resistance
    • Hansen L, Hansen T, Clausen JO, Echwald SM, Urhammer SA, Rasmussen SK, Pedersen O: The Val985Met insulin-receptor variant in the Danish Caucasian population: lack of associations with non-insulin-dependent diabetes mellitus or insulin resistance. Am J Hum Genet 60: 1532-5, 1997c.
    • (1997) Am J Hum Genet , vol.60 , pp. 1532-1535
    • Hansen, L.1    Hansen, T.2    Clausen, J.O.3    Echwald, S.M.4    Urhammer, S.A.5    Rasmussen, S.K.6    Pedersen, O.7
  • 133
    • 0032896978 scopus 로고    scopus 로고
    • Mutational Analysis of the Coding Regions of the Genes Encoding Protein Kinase B α and β, Phosphoinositide Dependent Protein Kinase-1
    • Hansen L, Fjordvang H, Rasmussen SK, Vestergaard H, Echwald SM, Hansen T, Alessi D, Shenolikar S, Saltiel AR, Barbetti F, Pedersen O: Mutational Analysis of the Coding Regions of the Genes Encoding Protein Kinase B α and β, Phosphoinositide Dependent Protein Kinase-1, Phosphatase Targeting to Glycogen, Protein Phosphatase Inhibitor-1, and Glycogenin: Lessons from a search for genetic variability of the Insulin Stimulated Glycogen Synthesis Pathway of Skeletal Muscle in NIDDM Patients. Diabetes 48: 403-408, 1999.
    • (1999) Diabetes , vol.48 , pp. 403-408
    • Hansen, L.1    Fjordvang, H.2    Rasmussen, S.K.3    Vestergaard, H.4    Echwald, S.M.5    Hansen, T.6    Alessi, D.7    Shenolikar, S.8    Saltiel, A.R.9    Barbetti, F.10    Pedersen, O.11
  • 134
    • 0033956880 scopus 로고    scopus 로고
    • Polymorphism in glycogen associated regulatory subunit of type-1 protein phosphatase (PPP1R3) gene and insulin sensitivity
    • Hansen L, Reneland R, Berglund L, Rasmussen SK, Hansen T, Lithell H, Pedersen O: Polymorphism in glycogen associated regulatory subunit of type-1 protein phosphatase (PPP1R3) gene and insulin sensitivity. Diabetes 49: 298-301, 2000a.
    • (2000) Diabetes , vol.49 , pp. 298-301
    • Hansen, L.1    Reneland, R.2    Berglund, L.3    Rasmussen, S.K.4    Hansen, T.5    Lithell, H.6    Pedersen, O.7
  • 135
    • 0034454416 scopus 로고    scopus 로고
    • Missense mutations in insulin promoter factor-1 (IPF-1) gene and their relation to maturity onset diabetes of the young and late onset type 2 diabetes mellitus in Caucasians
    • Hansen L, Urioste S, Petersen HV, Jensen JN, Eiberg H, Barbetti F, Serup P, Hansen T, Pedersen P: Missense mutations in insulin promoter factor-1 (IPF-1) gene and their relation to maturity onset diabetes of the young and late onset type 2 diabetes mellitus in Caucasians. J. Clin. Endocrin. & Metab., 85: 1323-1326, 2000b.
    • (2000) J Clin Endocrin & Metab , vol.85 , pp. 1323-1326
    • Hansen, L.1    Urioste, S.2    Petersen, H.V.3    Jensen, J.N.4    Eiberg, H.5    Barbetti, F.6    Serup, P.7    Hansen, T.8    Pedersen, P.9
  • 136
    • 0034033618 scopus 로고    scopus 로고
    • NeuroD/BETA2 gene variability and diabetes mellitus: No associations to late-onset type 2 diabetes mellitus but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes
    • Hansen L, Jensen JN, Urioste S, Petersen HV, Pociot F, Eiberg H, Kristiansen OP, Hansen T, Serup P, Nerup J, DSGD, DIEGG, Pedersen O: NeuroD/BETA2 gene variability and diabetes mellitus: No associations to late-onset type 2 diabetes mellitus but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Diabetes 49: 876-878, 2000c.
    • (2000) Diabetes , vol.49 , pp. 876-878
    • Hansen, L.1    Jensen, J.N.2    Urioste, S.3    Petersen, H.V.4    Pociot, F.5    Eiberg, H.6    Kristiansen, O.P.7    Hansen, T.8    Serup, P.9    Nerup, J.10    Pedersen, O.11
  • 137
    • 0035095168 scopus 로고    scopus 로고
    • In vitro and in vivo studies of a naturally occurring variant of the p85α regulatory subunit of the phosphoinositide-3 kinase: Inhibition of protein kinase B, prediction of type 2 diabetes and relationships with insulin secretion, glucose disappearance constant, and insulin sensitivity
    • Hansen L, Zethelius B, Berglund L, Reneland R, Hansen T, Berne C, Lithell H, Hemmings BA, Pedersen O: In vitro and in vivo studies of a naturally occurring variant of the p85α regulatory subunit of the phosphoinositide-3 kinase: inhibition of protein kinase B, prediction of type 2 diabetes and relationships with insulin secretion, glucose disappearance constant, and insulin sensitivity. Diabetes 50: 690-93, 2001a.
    • (2001) Diabetes , vol.50 , pp. 690-693
    • Hansen, L.1    Zethelius, B.2    Berglund, L.3    Reneland, R.4    Hansen, T.5    Berne, C.6    Lithell, H.7    Hemmings, B.A.8    Pedersen, O.9
  • 143
    • 0032860478 scopus 로고    scopus 로고
    • Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice
    • Harrison KA, Thaler J, Pfaff SL, Gu H, Kehrl JH: Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. Nature Genetics 23: 71-75, 1999.
    • (1999) Nature Genetics , vol.23 , pp. 71-75
    • Harrison, K.A.1    Thaler, J.2    Pfaff, S.L.3    Gu, H.4    Kehrl, J.H.5
  • 144
    • 0034649608 scopus 로고    scopus 로고
    • Attenuation of FGF signalling in mouse beta-cells leads to diabetes
    • Hart AW, Baeza N, Apelqvist A, Edlund H: Attenuation of FGF signalling in mouse beta-cells leads to diabetes. Nature 408: 864-868, 2000.
    • (2000) Nature , vol.408 , pp. 864-868
    • Hart, A.W.1    Baeza, N.2    Apelqvist, A.3    Edlund, H.4
  • 145
    • 0029907562 scopus 로고    scopus 로고
    • Association of the insulin receptor variant Met-985 with hyperglycemia and non-insulin dependent diabetes mellitus in the Netherlands: A population-based study
    • t'Hart LM, Stolk RP, Heine RJ, Groebbee DE, van der Does FEE, Maassen JA: Association of the insulin receptor variant Met-985 with hyperglycemia and non-insulin dependent diabetes mellitus in the Netherlands: A population-based study. Am J Hum Genet 59: 1119-1125, 1996.
    • (1996) Am J Hum Genet , vol.59 , pp. 1119-1125
    • T'Hart, L.M.1    Stolk, R.P.2    Heine, R.J.3    Groebbee, D.E.4    Van Der Does, F.E.E.5    Maassen, J.A.6
  • 147
    • 0033863689 scopus 로고    scopus 로고
    • Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis
    • Harvest FG, Almgren P, Lindholm E, Frititta L, Pizzuti A, Trischitta V, Groop LC: Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis. Diabetes 49: 1601-3, 2000.
    • (2000) Diabetes , vol.49 , pp. 1601-1603
    • Harvest, F.G.1    Almgren, P.2    Lindholm, E.3    Frititta, L.4    Pizzuti, A.5    Trischitta, V.6    Groop, L.C.7
  • 148
    • 0030846804 scopus 로고    scopus 로고
    • Recessive inheritance of obesity in familial non-insulin dependent diabetes mellitus, and lack of linkage to nine candidate genes
    • Hasstedt SJ, Hoffman M, Leppert MF, Elbein SC: Recessive inheritance of obesity in familial non-insulin dependent diabetes mellitus, and lack of linkage to nine candidate genes. Am J Hum Genet 61: 668-77, 1997.
    • (1997) Am J Hum Genet , vol.61 , pp. 668-677
    • Hasstedt, S.J.1    Hoffman, M.2    Leppert, M.F.3    Elbein, S.C.4
  • 152
    • 0033857978 scopus 로고    scopus 로고
    • Heterozygous expansion of the GAA tract of the X25/frataxin gene is associated with insulin resistance in humans
    • Hebinck J, Hardt C, Schols L, Vorgerd M, Briedigkeit L, kahn CR, Ristow M: Heterozygous expansion of the GAA tract of the X25/frataxin gene is associated with insulin resistance in humans. Diabetes 49: 1604.1607, 2000.
    • (2000) Diabetes , vol.49 , pp. 1604-1607
    • Hebinck, J.1    Hardt, C.2    Schols, L.3    Vorgerd, M.4    Briedigkeit, L.5    Kahn, C.R.6    Ristow, M.7
  • 153
    • 0016777296 scopus 로고
    • A study of middle-aged men with particular reference to risk factors for cardiovascular disease
    • Hedstrand H: A study of middle-aged men with particular reference to risk factors for cardiovascular disease. Upsala J Med Sci 80 (Suppl.19):161,1975.
    • (1975) Upsala J Med Sci , vol.80 , Issue.SUPPL. 19 , pp. 161
    • Hedstrand, H.1
  • 154
    • 0031763878 scopus 로고    scopus 로고
    • Variation in the AU(AT)-rich element within the 3′-untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadians
    • Hegele RA, Harris SB, Zinman B, Wang J, Cao H, Hanley AJ, Tsui LC, Scherer SW: Variation in the AU(AT)-rich element within the 3′ -untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadians. J Clin Endocrinol Metab 83: 3980-83, 1998.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 3980-3983
    • Hegele, R.A.1    Harris, S.B.2    Zinman, B.3    Wang, J.4    Cao, H.5    Hanley, A.J.6    Tsui, L.C.7    Scherer, S.W.8
  • 157
    • 0034612636 scopus 로고    scopus 로고
    • Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation
    • Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR: Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature 406: 86-90, 2000.
    • (2000) Nature , vol.406 , pp. 86-90
    • Hoeflich, K.P.1    Luo, J.2    Rubie, E.A.3    Tsao, M.S.4    Jin, O.5    Woodgett, J.R.6
  • 161
    • 0034351407 scopus 로고    scopus 로고
    • The Gly→Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells
    • Hribal ML, Federici M, Porzio O, Lauro D, Borboni P, Accili D, Lauro R, Sesti G: The Gly→Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells. J Clin Endocrinol Metab 85: 2004-13, 2000.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 2004-2013
    • Hribal, M.L.1    Federici, M.2    Porzio, O.3    Lauro, D.4    Borboni, P.5    Accili, D.6    Lauro, R.7    Sesti, G.8
  • 162
    • 0033996527 scopus 로고    scopus 로고
    • Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3
    • Huang HP, Liu M, El-Hodiri HM, Chu K, Jamrich M, Tsai MJ: Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3. Mol Cell Biol 20: 3297-307, 2000.
    • (2000) Mol Cell Biol , vol.20 , pp. 3297-3307
    • Huang, H.P.1    Liu, M.2    El-Hodiri, H.M.3    Chu, K.4    Jamrich, M.5    Tsai, M.J.6
  • 163
    • 0029051799 scopus 로고
    • Lack of association between the Gly40Ser polymorphism in the glucagon receptor gene and NIDDM in Finland
    • Huang X, Orho M, Lehto M, Groop L: Lack of association between the Gly40Ser polymorphism In the glucagon receptor gene and NIDDM in Finland. Diabetologia 38: 1246-48, 1995.
    • (1995) Diabetologia , vol.38 , pp. 1246-1248
    • Huang, X.1    Orho, M.2    Lehto, M.3    Groop, L.4
  • 164
    • 0027277098 scopus 로고
    • On target with a new mechanism for the regulation of protein phosphatase
    • Hubbard MJ, Cohen P: On target with a new mechanism for the regulation of protein phosphatase. TIBS 18: 172-177, 1993.
    • (1993) TIBS , vol.18 , pp. 172-177
    • Hubbard, M.J.1    Cohen, P.2
  • 165
    • 0027475421 scopus 로고
    • Modulation of glycogen synthase kinase-3 family by tyrosine phosphorylation
    • Hughes K, Nikolakaki E, Plyte SE, Totty NF, Woodgett JR: Modulation of glycogen synthase kinase-3 family by tyrosine phosphorylation. EMBO J. 12; 2: 803-808, 1993.
    • (1993) EMBO J , vol.12 , Issue.2 , pp. 803-808
    • Hughes, K.1    Nikolakaki, E.2    Plyte, S.E.3    Totty, N.F.4    Woodgett, J.R.5
  • 167
    • 0033959416 scopus 로고    scopus 로고
    • Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles
    • Huxtable SJ, Saker PJ, Haddad L, Walker M, Frayling TM, Levy JC, Hitman GA, O'Rahilly S, Hattersley AT, McCarthy MI: Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles. Diabetes 49: 126-30, 2000.
    • (2000) Diabetes , vol.49 , pp. 126-130
    • Huxtable, S.J.1    Saker, P.J.2    Haddad, L.3    Walker, M.4    Frayling, T.M.5    Levy, J.C.6    Hitman, G.A.7    O'Rahilly, S.8    Hattersley, A.T.9    McCarthy, M.I.10
  • 172
    • 0030615068 scopus 로고    scopus 로고
    • p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin
    • Inukai K, Funaki M, Ogihara T, Katagiri H, Kanda A, Anai M, Fukushima Y, Hosaka T, Suzuki M, Shin BC, Takata K, Yazaki Y, Kikuchi M, Oka Y, Asano T: p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin. J Biol Chem 212: 7873-82, 1997.
    • (1997) J Biol Chem , vol.212 , pp. 7873-7882
    • Inukai, K.1    Funaki, M.2    Ogihara, T.3    Katagiri, H.4    Kanda, A.5    Anai, M.6    Fukushima, Y.7    Hosaka, T.8    Suzuki, M.9    Shin, B.C.10    Takata, K.11    Yazaki, Y.12    Kikuchi, M.13    Oka, Y.14    Asano, T.15
  • 176
    • 0032731961 scopus 로고    scopus 로고
    • Effect of intrauterine growth restriction on blood pressure, glucose tolerance and sympathetic nervous system activity in the rat at 3-4 months of age
    • Jansson T, Lambert GW: Effect of intrauterine growth restriction on blood pressure, glucose tolerance and sympathetic nervous system activity in the rat at 3-4 months of age. J Hypertens 17: 1239-1248, 1999.
    • (1999) J Hypertens , vol.17 , pp. 1239-1248
    • Jansson, T.1    Lambert, G.W.2
  • 177
    • 0033578776 scopus 로고    scopus 로고
    • 90 kDa ribosomal S6 kinase (RSK) is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1 (PDK1)
    • Jensen CJ, Buch M-B, Krag TO, Hemmings BA, Gammeltoft S, Frödin M: 90 kDa ribosomal S6 kinase (RSK) is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1 (PDK1). J Biol Chem 274: 27168-27176, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 27168-27176
    • Jensen, C.J.1    Buch, M.-B.2    Krag, T.O.3    Hemmings, B.A.4    Gammeltoft, S.5    Frödin, M.6
  • 179
    • 0033984886 scopus 로고    scopus 로고
    • Independent development of pancreatic alpha-and beta-cells from neurogenin3-expressing precursors: A role for the notch pathway in repression of premature differentiation
    • Jensen J, Heller RS, Funder-Nielsen T, Pedersen EE, Lindsell C, Weinmaster G, Madsen OD, Serup P: Independent development of pancreatic alpha-and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes 49: 163-76, 2000.
    • (2000) Diabetes , vol.49 , pp. 163-176
    • Jensen, J.1    Heller, R.S.2    Funder-Nielsen, T.3    Pedersen, E.E.4    Lindsell, C.5    Weinmaster, G.6    Madsen, O.D.7    Serup, P.8
  • 180
    • 0035124665 scopus 로고    scopus 로고
    • Polymorphisms in the human neurogenin 3 gene and their relationships to altered insulin secretion and diabetes in the Danish population
    • Jensen JN, Hansen L, Ekstrøm CT, Pociot F, Nerup J, Hansen T, Pedersen O: Polymorphisms in the human neurogenin 3 gene and their relationships to altered insulin secretion and diabetes in the Danish population. Diabetologia 44: 123-26, 2001.
    • (2001) Diabetologia , vol.44 , pp. 123-126
    • Jensen, J.N.1    Hansen, L.2    Ekstrøm, C.T.3    Pociot, F.4    Nerup, J.5    Hansen, T.6    Pedersen, O.7
  • 181
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • Jonsson J, Carlsson L, Edlund T, Edlund H: Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371: 606-609, 1994.
    • (1994) Nature , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 184
    • 0031157826 scopus 로고    scopus 로고
    • Prevalence of a polymorphism of the phosphatidylinositol 3-kinase p85α regulatory subunit (codon 326 Met→Ile) in Japanese NIDDM patients
    • Kawanishi M, Tamori Y, Masugi J, Mori H, Ito C, Hansen T, Andersen CB, Pedersen O, Kasuga M: Prevalence of a polymorphism of the phosphatidylinositol 3-kinase p85α regulatory subunit (codon 326 Met→Ile) in Japanese NIDDM patients. Diabetes Care 20; 6: 1043, 1997.
    • (1997) Diabetes Care , vol.20 , Issue.6 , pp. 1043
    • Kawanishi, M.1    Tamori, Y.2    Masugi, J.3    Mori, H.4    Ito, C.5    Hansen, T.6    Andersen, C.B.7    Pedersen, O.8    Kasuga, M.9
  • 185
    • 0028881617 scopus 로고
    • The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription
    • Kennedy GC, German MS, Rutter WJ: The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription. Nature Genetics 9: 293-298, 1995.
    • (1995) Nature Genetics , vol.9 , pp. 293-298
    • Kennedy, G.C.1    German, M.S.2    Rutter, W.J.3
  • 186
    • 0025117502 scopus 로고
    • Insulin resistance is associated with reduced fasting and insulin-stimulated glycogen synthase phosphatase activity in human skeletal muscle
    • Kida Y, Esposito-Del Puente A, Bogardus C, Mott DM: Insulin resistance is associated with reduced fasting and insulin-stimulated glycogen synthase phosphatase activity in human skeletal muscle. J Clin Invest 85: 476-481, 1990.
    • (1990) J Clin Invest , vol.85 , pp. 476-481
    • Kida, Y.1    Esposito-Del Puente, A.2    Bogardus, C.3    Mott, D.M.4
  • 188
    • 0033966768 scopus 로고    scopus 로고
    • Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
    • Kido Y, Burks DJ, Withers D, Brüning JC, kahn CR, White MF, Accili D: Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest 105: 199-205, 2000.
    • (2000) J Clin Invest , vol.105 , pp. 199-205
    • Kido, Y.1    Burks, D.J.2    Withers, D.3    Brüning, J.C.4    Kahn, C.R.5    White, M.F.6    Accili, D.7
  • 189
    • 0035006359 scopus 로고    scopus 로고
    • Mutation screening of the neurogenin-3 gene in autosomal dominant diabetes
    • Kim SH, Warram JH, Krolewski AS, Doria A: Mutation screening of the neurogenin-3 gene in autosomal dominant diabetes. J Clin Endocrinol Metab 86: 2320-22, 2001.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2320-2322
    • Kim, S.H.1    Warram, J.H.2    Krolewski, A.S.3    Doria, A.4
  • 190
    • 0034085886 scopus 로고    scopus 로고
    • Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats
    • Kim Y-B, Peroni OD, Franke TF, Kahn BB: Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats. Diabetes 49: 847-856, 2000.
    • (2000) Diabetes , vol.49 , pp. 847-856
    • Kim, Y.-B.1    Peroni, O.D.2    Franke, T.F.3    Kahn, B.B.4
  • 192
    • 0028881784 scopus 로고
    • Elevation of serum insulin concentration during euglycemic hyperinsulinemic clamp studies leads to similar activation of insulin receptor kinase in skeletal muscle of subjects with and without NIDDM
    • Klein HH, Vestergaard H, Kotzke G, Pedersen O: Elevation of serum insulin concentration during euglycemic hyperinsulinemic clamp studies leads to similar activation of insulin receptor kinase in skeletal muscle of subjects with and without NIDDM. Diabetes 44: 1310-17, 1995.
    • (1995) Diabetes , vol.44 , pp. 1310-1317
    • Klein, H.H.1    Vestergaard, H.2    Kotzke, G.3    Pedersen, O.4
  • 193
    • 0029908016 scopus 로고    scopus 로고
    • Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
    • Kohn AD, Summers SA, Birnbaum MJ, Roth RA: Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem 271: 31271-8, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 31271-31278
    • Kohn, A.D.1    Summers, S.A.2    Birnbaum, M.J.3    Roth, R.A.4
  • 194
    • 0033815162 scopus 로고    scopus 로고
    • Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: Cloning, genomic structure, and screening for variants in patients with type 2 diabetes
    • Kossila M, Sinkovic M, Karkkainen P, Laukkanen MO, Miettinen R, Rissanen J, Kekalainen P, Kuusisto J, Yla-Herttuala S, Laakso M: Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes. Diabetes 49: 1740-43, 2000.
    • (2000) Diabetes , vol.49 , pp. 1740-1743
    • Kossila, M.1    Sinkovic, M.2    Karkkainen, P.3    Laukkanen, M.O.4    Miettinen, R.5    Rissanen, J.6    Kekalainen, P.7    Kuusisto, J.8    Yla-Herttuala, S.9    Laakso, M.10
  • 195
    • 0033558098 scopus 로고    scopus 로고
    • ATP channels: Control of nucleotide sensitivity by the N-terminal domain of the Kir6.2 subunit
    • ATP channels: control of nucleotide sensitivity by the N-terminal domain of the Kir6.2 subunit. J Physiol 515: 19-30, 1999.
    • (1999) J Physiol , vol.515 , pp. 19-30
    • Koster, J.C.1    Sha, Q.2    Shyng, S.-L.3    Nichols, C.G.4
  • 197
  • 199
    • 0034146742 scopus 로고    scopus 로고
    • Extended transmission disequilibrium testing reveals linkage of IDDM7 on 2q31 to insulin-dependent diabetes mellitus in Danish multiplex families but linkage is not explained by novel polymorphisms in the candidate gene GALNT3
    • Kristiansen OP, Pociot F, Bennett EP, Clausen H, Johannesen J, Nerup J, Mandrup-Poulsen T: Extended transmission disequilibrium testing reveals linkage of IDDM7 on 2q31 to insulin-dependent diabetes mellitus in Danish multiplex families but linkage is not explained by novel polymorphisms in the candidate gene GALNT3. Human Mutation 15: 295-96, 2000.
    • (2000) Human Mutation , vol.15 , pp. 295-296
    • Kristiansen, O.P.1    Pociot, F.2    Bennett, E.P.3    Clausen, H.4    Johannesen, J.5    Nerup, J.6    Mandrup-Poulsen, T.7
  • 200
    • 0028047457 scopus 로고
    • Molecular scanning of the insulin receptor gene in syndromes of insulin resistance
    • Krook A, Kumar S, Laing I, Boulton AJM, Wass JAH, O'Rahilly: Molecular scanning of the insulin receptor gene in syndromes of insulin resistance. Diabetes 43: 357-68, 1994.
    • (1994) Diabetes , vol.43 , pp. 357-368
    • Krook, A.1    Kumar, S.2    Laing, I.3    Boulton, A.J.M.4    Wass, J.A.H.5    O'Rahilly6
  • 201
    • 0031852665 scopus 로고    scopus 로고
    • Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects
    • Krook A, Roth RA, Jiang XJ, Zierath JR, Wallberg-Henriksson H: Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects. Diabetes 47: 1281-86, 1998.
    • (1998) Diabetes , vol.47 , pp. 1281-1286
    • Krook, A.1    Roth, R.A.2    Jiang, X.J.3    Zierath, J.R.4    Wallberg-Henriksson, H.5
  • 203
    • 0030999123 scopus 로고    scopus 로고
    • Are animal models of diabetes relevant to the study of the genetics of non-insulin-dependent diabetes in humans?
    • Ktorza A, Bernard C, Parent V, Penicaud L, Froguel P, Lathrop M, Gaugier D: Are animal models of diabetes relevant to the study of the genetics of non-insulin-dependent diabetes in humans? Diabetes Metab 23 suppl 2: 38-46, 1997.
    • (1997) Diabetes Metab , vol.23 , Issue.SUPPL. 2 , pp. 38-46
    • Ktorza, A.1    Bernard, C.2    Parent, V.3    Penicaud, L.4    Froguel, P.5    Lathrop, M.6    Gaugier, D.7
  • 204
    • 0033524937 scopus 로고    scopus 로고
    • Tissue-specific knockout of the insulin receptor in pancreatic β-cells creates an insulin secretory defect similar to that in type 2 diabetes
    • Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR: Tissue-specific knockout of the insulin receptor in pancreatic β-cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96: 329-39, 1999a.
    • (1999) Cell , vol.96 , pp. 329-339
    • Kulkarni, R.N.1    Brüning, J.C.2    Winnay, J.N.3    Postic, C.4    Magnuson, M.A.5    Kahn, C.R.6
  • 206
    • 0034976644 scopus 로고    scopus 로고
    • Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas
    • Kurose K, Zhou XP, Araki T, Cannistra SA, Maher ER, Eng C: Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas. Am J Pathol 158: 2097-106, 2001.
    • (2001) Am J Pathol , vol.158 , pp. 2097-2106
    • Kurose, K.1    Zhou, X.P.2    Araki, T.3    Cannistra, S.A.4    Maher, E.R.5    Eng, C.6
  • 207
    • 0002872316 scopus 로고
    • Empirical risk figures for first-degree relatives of noninsulin dependent diabetics
    • Köbberling J, Tattersall R (eds). Academic Press, London, New York
    • Köbberling J, Tillil H: Empirical risk figures for first-degree relatives of noninsulin dependent diabetics. In: Köbberling J, Tattersall R (eds) Sereno Symposium No 47. The Genetics of Diabetes Mellitus. Academic Press, London, New York, pp 201-9, 1982.
    • (1982) Sereno Symposium No 47. The Genetics of Diabetes Mellitus , pp. 201-209
    • Köbberling, J.1    Tillil, H.2
  • 208
    • 0028914027 scopus 로고
    • Amino acid substututions in hexokinase II among patients with NIDDM
    • Laakso M, Malkki M, Deeb SS: Amino acid substututions in hexokinase II among patients with NIDDM. Diabetes 44: 330-334, 1995.
    • (1995) Diabetes , vol.44 , pp. 330-334
    • Laakso, M.1    Malkki, M.2    Deeb, S.S.3
  • 210
    • 0023808322 scopus 로고
    • Effect of acute administration of insulin-like growth factor 1 in patients with Laron-type dwarfism
    • Laron Z, Klinger B, Erster B, Anin S: Effect of acute administration of insulin-like growth factor 1 in patients with Laron-type dwarfism. Lancet 8621: 1170-72, 1988.
    • (1988) Lancet , vol.8621 , pp. 1170-1172
    • Laron, Z.1    Klinger, B.2    Erster, B.3    Anin, S.4
  • 211
    • 0031792118 scopus 로고    scopus 로고
    • Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue
    • Lauro D, Kido Y, castle AL, Zamowski MJ, Hayashi H, Ebina Y, Accili D: Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue. Nature Genetics 20, 294-98, 1998.
    • (1998) Nature Genetics , vol.20 , pp. 294-298
    • Lauro, D.1    Kido, Y.2    Castle, A.L.3    Zamowski, M.J.4    Hayashi, H.5    Ebina, Y.6    Accili, D.7
  • 212
    • 0030984321 scopus 로고    scopus 로고
    • New insights into the role and mechanism of glycogen synthase activation by insulin
    • Lawrence JC, Roach PJ: New insights into the role and mechanism of glycogen synthase activation by insulin. Diabetes 46: 541-547, 1997.
    • (1997) Diabetes , vol.46 , pp. 541-547
    • Lawrence, J.C.1    Roach, P.J.2
  • 213
    • 0031944313 scopus 로고    scopus 로고
    • Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse
    • Lee YH, Sauer B, Gonzalez FJ: Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. Mol Cell Biol 18: 3059-68, 1998.
    • (1998) Mol Cell Biol , vol.18 , pp. 3059-3068
    • Lee, Y.H.1    Sauer, B.2    Gonzalez, F.J.3
  • 215
    • 0032061042 scopus 로고    scopus 로고
    • Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways
    • Leibiger IB, Leibiger B, Moede T, Berggren P-O: Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways. Moll Cell 1: 933-38, 1998.
    • (1998) Moll Cell , vol.1 , pp. 933-938
    • Leibiger, I.B.1    Leibiger, B.2    Moede, T.3    Berggren, P.-O.4
  • 217
    • 0034704166 scopus 로고    scopus 로고
    • Overexpression of protein targeting to glycogen in cultured human muscle cells stimulates glycogen synthesis independent of glycogen and glucose 6-phosphate levels
    • Lerin C, Montell E, Berman HK, Newgard CB, Gomez-Foix AM: Overexpression of protein targeting to glycogen in cultured human muscle cells stimulates glycogen synthesis independent of glycogen and glucose 6-phosphate levels. J Biol Chem 275: 39991-95, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 39991-39995
    • Lerin, C.1    Montell, E.2    Berman, H.K.3    Newgard, C.B.4    Gomez-Foix, A.M.5
  • 218
    • 0033662314 scopus 로고    scopus 로고
    • The insulin gene VNTR is associated with fasting insulin levels and the development of juvenile obesity
    • Le Stunff C, Fallin D, Schork NJ, Bougnères P: The insulin gene VNTR is associated with fasting insulin levels and the development of juvenile obesity. Nat Genet 26: 444-446, 2000.
    • (2000) Nat Genet , vol.26 , pp. 444-446
    • Le Stunff, C.1    Fallin, D.2    Schork, N.J.3    Bougnères, P.4
  • 219
    • 0032844643 scopus 로고    scopus 로고
    • Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9
    • Li H, Arber S, Jessell TM, Edlund H: Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. Nature Genetics 23: 67-70, 1999.
    • (1999) Nature Genetics , vol.23 , pp. 67-70
    • Li, H.1    Arber, S.2    Jessell, T.M.3    Edlund, H.4
  • 221
    • 0030980371 scopus 로고    scopus 로고
    • The 31-cM region of chromosome 11 including the obesity gene tubby and ATP-sensitive potassium channel genes, SUR1 and Kir6.2, does not contain a major susceptibility locus for NIDDM in 127 nonHispanic white affected sibships
    • Lindner T, Cragnoli C, Schulze J, Rietzsch H, Petzold C, Schroder HE, Cox NJ, Bell GI: The 31-cM region of chromosome 11 including the obesity gene tubby and ATP-sensitive potassium channel genes, SUR1 and Kir6.2, does not contain a major susceptibility locus for NIDDM in 127 nonHispanic white affected sibships. Diabetes 46: 1227-1229, 1997.
    • (1997) Diabetes , vol.46 , pp. 1227-1229
    • Lindner, T.1    Cragnoli, C.2    Schulze, J.3    Rietzsch, H.4    Petzold, C.5    Schroder, H.E.6    Cox, N.J.7    Bell, G.I.8
  • 222
    • 0030056272 scopus 로고    scopus 로고
    • Relation of size at birth to non-insulin dependent diabetes and insulin concentrations in men aged 50-60 years
    • Lithell HO, McKeigue PM, Berglund L, Mohsen R, Lithell U-B: Relation of size at birth to non-insulin dependent diabetes and insulin concentrations in men aged 50-60 years. BMJ 312: 406-10, 1996.
    • (1996) BMJ , vol.312 , pp. 406-410
    • Lithell, H.O.1    McKeigue, P.M.2    Berglund, L.3    Mohsen, R.4    Lithell, U.-B.5
  • 223
    • 0027496895 scopus 로고
    • Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
    • Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A: Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75: 59-72, 1993.
    • (1993) Cell , vol.75 , pp. 59-72
    • Liu, J.P.1    Baker, J.2    Perkins, A.S.3    Robertson, E.J.4    Efstratiadis, A.5
  • 225
    • 0035041250 scopus 로고    scopus 로고
    • Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats
    • Lynn FC, Pamir N, Ng EH, McIntosh CH, Kieffer TJ, Pederson RA: Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes 50: 1004-11, 2001.
    • (2001) Diabetes , vol.50 , pp. 1004-1011
    • Lynn, F.C.1    Pamir, N.2    Ng, E.H.3    McIntosh, C.H.4    Kieffer, T.J.5    Pederson, R.A.6
  • 227
    • 0033540037 scopus 로고    scopus 로고
    • Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis
    • Maechler P, Wollheim CB: Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis. Nature 402: 685-9, 1999.
    • (1999) Nature , vol.402 , pp. 685-689
    • Maechler, P.1    Wollheim, C.B.2
  • 228
  • 229
    • 16044374799 scopus 로고    scopus 로고
    • Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families
    • Mahtani MM, Widén E, Lehto M et al.: Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nature Gen. 14; 1: 90-94, 1996.
    • (1996) Nature Gen , vol.14 , Issue.1 , pp. 90-94
    • Mahtani, M.M.1    Widén, E.2    Lehto, M.3
  • 232
    • 0033060302 scopus 로고    scopus 로고
    • Pro12Ala substitution in the peroxisome proliferator-activated receptor-γ is not associated with type 2 diabetes
    • Mancini FP, Vaccaro O, Sabatino L, Tufano A, Rivellese AA, Riccardi G, Colantuoni V: Pro12Ala substitution in the peroxisome proliferator-activated receptor-γ is not associated with type 2 diabetes. Diabetes 48: 1466-8, 1999.
    • (1999) Diabetes , vol.48 , pp. 1466-1468
    • Mancini, F.P.1    Vaccaro, O.2    Sabatino, L.3    Tufano, A.4    Rivellese, A.A.5    Riccardi, G.6    Colantuoni, V.7
  • 233
    • 17444444715 scopus 로고
    • Abnormal coupling of the insulin receptor binding in non-insulin-dependent diabetes
    • Mandarino LJ, Cambell PJ, Gottesman IS, Gerich JE: Abnormal coupling of the insulin receptor binding in non-insulin-dependent diabetes. Am J Physiol 247: E688-92, 1984.
    • (1984) Am J Physiol , vol.247
    • Mandarino, L.J.1    Cambell, P.J.2    Gottesman, I.S.3    Gerich, J.E.4
  • 234
    • 0026793446 scopus 로고
    • Role of glucose and insulin resistance in the development of type 2 diabetes mellitus: Results of a 25 year follow-up study
    • Martin BC, Warran JH, Krolewski AS, Bergman RN, Soeldner J, Kahn CR: Role of glucose and insulin resistance in the development of type 2 diabetes mellitus: results of a 25 year follow-up study. Lancet 340: 925-929, 1992.
    • (1992) Lancet , vol.340 , pp. 925-929
    • Martin, B.C.1    Warran, J.H.2    Krolewski, A.S.3    Bergman, R.N.4    Soeldner, J.5    Kahn, C.R.6
  • 235
    • 0034931529 scopus 로고    scopus 로고
    • Isolation and characterisation of the human akt1 gene, identification of 13 single nucleotide polymorphism (SNPs) and lack of association with type II (non-insulin dependent) diabetes mellitus
    • Matsubara A, Wasson JC, Donelan SS, Welling CM, Glaser B, Permutt MA: Isolation and characterisation of the human akt1 gene, identification of 13 single nucleotide polymorphism (SNPs) and lack of association with type II (non-insulin dependent) diabetes mellitus. Diabetologia 44: 910-13, 2001.
    • (2001) Diabetologia , vol.44 , pp. 910-913
    • Matsubara, A.1    Wasson, J.C.2    Donelan, S.S.3    Welling, C.M.4    Glaser, B.5    Permutt, M.A.6
  • 236
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudensji AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-19, 1985.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudensji, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 237
    • 0006151390 scopus 로고    scopus 로고
    • Specific inhibition of PTEN expression with antisense oligonucleotide normalizes plasma glucose in db/db mice
    • Mckay RA, Butler M, Popoff IJ et al. (2000) Specific inhibition of PTEN expression with antisense oligonucleotide normalizes plasma glucose in db/db mice. Diabetes supplement 1; 207-OR.
    • (2000) Diabetes , Issue.SUPPL. 1
    • Mckay, R.A.1    Butler, M.2    Popoff, I.J.3
  • 238
    • 0031783161 scopus 로고    scopus 로고
    • Glucose tolerance and resistance to insulin-stimulated glucose uptake in men aged 70 years in relation to size at birth
    • McKeigue PM, Lithell H, Leon DA: Glucose tolerance and resistance to insulin-stimulated glucose uptake in men aged 70 years in relation to size at birth. Diabetologia 41: 1133-1138, 1998.
    • (1998) Diabetologia , vol.41 , pp. 1133-1138
    • McKeigue, P.M.1    Lithell, H.2    Leon, D.A.3
  • 239
  • 240
    • 0032739288 scopus 로고    scopus 로고
    • Identifcation of a nuclear localization signal, RRMKWKK, in the homeodomain trasncription factor PDX-1
    • Moede T, Leibiger B, Pour HG, Berggren P Leibiger IB: Identifcation of a nuclear localization signal, RRMKWKK, in the homeodomain trasncription factor PDX-1. FEBS Lett 461: 229-34, 1999.
    • (1999) FEBS Lett , vol.461 , pp. 229-234
    • Moede, T.1    Leibiger, B.2    Pour, H.G.3    Berggren, P.4    Leibiger, I.B.5
  • 241
    • 0032567331 scopus 로고    scopus 로고
    • Characterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen meatbolism
    • Mu J, Roach PJ: Characterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen meatbolism. J Biol Chem 273: 34850-6, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 34850-34856
    • Mu, J.1    Roach, P.J.2
  • 242
    • 0031793698 scopus 로고    scopus 로고
    • Mutations in the hepatocyte nuclear factor-1alpha gene in Caucasian families originally classified as having Type I diabetes
    • Møller AM, Dalgaard LT, Pociot F, Nerup J, Hansen T, Pedersen O: Mutations in the hepatocyte nuclear factor-1alpha gene in Caucasian families originally classified as having Type I diabetes. Diabetologia 41: 1528-1531, 1998.
    • (1998) Diabetologia , vol.41 , pp. 1528-1531
    • Møller, A.M.1    Dalgaard, L.T.2    Pociot, F.3    Nerup, J.4    Hansen, T.5    Pedersen, O.6
  • 243
    • 0030886674 scopus 로고    scopus 로고
    • Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in Beta2/NeuroD-deficient mice
    • Naya FJ, Huang H-P, Qiu Y, Mutoh H, DeMayo FJ, Leiter AB, Tsai M-J: Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in Beta2/NeuroD-deficient mice. Genes and Development 11, 18: 2323-2334, 1997.
    • (1997) Genes and Development , vol.11-18 , pp. 2323-2334
    • Naya, F.J.1    Huang, H.-P.2    Qiu, Y.3    Mutoh, H.4    DeMayo, F.J.5    Leiter, A.B.6    Tsai, M.-J.7
  • 247
    • 0031716242 scopus 로고    scopus 로고
    • Determinants for the progression from impaired glucose tolerance to non-insulin-dependent diabetes mellitus
    • Nijpels G: Determinants for the progression from impaired glucose tolerance to non-insulin-dependent diabetes mellitus. Eur J Clin Invest Suppl 2: 8-13, 1998.
    • (1998) Eur J Clin Invest Suppl , vol.2 , pp. 8-13
    • Nijpels, G.1
  • 248
    • 0030905313 scopus 로고    scopus 로고
    • Regulation of glycogen synthase activity in cultured skeletal muscle cells from subjects with type II diabetes
    • Nikoulina SE, Ciaralda TP, Abrams-Carter L, Mudulair S, Park KS, Henry RR: Regulation of glycogen synthase activity in cultured skeletal muscle cells from subjects with type II diabetes. Diabetes 46: 1017-1024, 1997.
    • (1997) Diabetes , vol.46 , pp. 1017-1024
    • Nikoulina, S.E.1    Ciaralda, T.P.2    Abrams-Carter, L.3    Mudulair, S.4    Park, K.S.5    Henry, R.R.6
  • 249
    • 0033958644 scopus 로고    scopus 로고
    • Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes
    • Nikoulina SE, Ciaraldi TP, Mudaliar S, Mohideen P, Carter L, Henry RR: Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes. Diabetes 49: 263-71, 2000.
    • (2000) Diabetes , vol.49 , pp. 263-271
    • Nikoulina, S.E.1    Ciaraldi, T.P.2    Mudaliar, S.3    Mohideen, P.4    Carter, L.5    Henry, R.R.6
  • 250
    • 0033995047 scopus 로고    scopus 로고
    • Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen
    • O'Doherty RM, Jensen PB, Anderson P, Jones JG, Berman HK, Kearney D, Newgard CB: Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen. J Clin Invest 105: 479-488, 2000.
    • (2000) J Clin Invest , vol.105 , pp. 479-488
    • O'Doherty, R.M.1    Jensen, P.B.2    Anderson, P.3    Jones, J.G.4    Berman, H.K.5    Kearney, D.6    Newgard, C.B.7
  • 251
    • 0034507714 scopus 로고    scopus 로고
    • Regulation of insulin gene transcription
    • Ohneda K, Ee H, German M: Regulation of insulin gene transcription. Semin Cell Dev Biol 11: 227-33, 2000.
    • (2000) Semin Cell Dev Biol , vol.11 , pp. 227-233
    • Ohneda, K.1    Ee, H.2    German, M.3
  • 253
    • 0035135375 scopus 로고    scopus 로고
    • Variants of neurogenin 3 gene are not associated with type II diabetes in Japanese subjects
    • Okada T, Tobe K, Hara K, Kawaguchi Y, Ikegami H, Ito C, Kadowaki T: Variants of neurogenin 3 gene are not associated with type II diabetes in Japanese subjects. Diabetologia 44: 241-244, 2001.
    • (2001) Diabetologia , vol.44 , pp. 241-244
    • Okada, T.1    Tobe, K.2    Hara, K.3    Kawaguchi, Y.4    Ikegami, H.5    Ito, C.6    Kadowaki, T.7
  • 255
    • 0023951171 scopus 로고
    • Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes
    • O'Rahilly S, Turne RC, Matthews DR: Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes. N Engl J Med 318: 1225-30, 1988.
    • (1988) N Engl J Med , vol.318 , pp. 1225-1230
    • O'Rahilly, S.1    Turne, R.C.2    Matthews, D.R.3
  • 256
    • 0025896884 scopus 로고
    • Detection of mutations in the insulin receptor gene in non-insulin dependent diabetic patients by analysis of single-stranded conformation polymorphisms
    • O'Rahilly S, Choi WH, Patel P, Turner RC, Flier JS, Moller DE: Detection of mutations in the insulin receptor gene in non-insulin dependent diabetic patients by analysis of single-stranded conformation polymorphisms. Diabetes 40: 777-782, 1991.
    • (1991) Diabetes , vol.40 , pp. 777-782
    • O'Rahilly, S.1    Choi, W.H.2    Patel, P.3    Turner, R.C.4    Flier, J.S.5    Moller, D.E.6
  • 257
    • 0026578215 scopus 로고
    • Insulin receptor and insulin-responsive glusose transporter (GLUT4) mutations and polymorphisms in a Welsh non-insulin dependent diabetic population
    • O'Rahilly S, Krook A, Bishop A, Rees A, Flier JS, Moller DE: Insulin receptor and insulin-responsive glusose transporter (GLUT4) mutations and polymorphisms in a Welsh non-insulin dependent diabetic population. Diabetologia 35: 486-489, 1992.
    • (1992) Diabetologia , vol.35 , pp. 486-489
    • O'Rahilly, S.1    Krook, A.2    Bishop, A.3    Rees, A.4    Flier, J.S.5    Moller, D.E.6
  • 260
    • 0032868004 scopus 로고    scopus 로고
    • A paired-sibling analysis of the XbaI polymorphism in the muscle glycoden synthase gene
    • Orho-Melander M, Almgren P, Kanninnen T, Forsblom C, Groop LC: A paired-sibling analysis of the XbaI polymorphism in the muscle glycoden synthase gene. Diabetologia 42: 1138-1145, 1999b.
    • (1999) Diabetologia , vol.42 , pp. 1138-1145
    • Orho-Melander, M.1    Almgren, P.2    Kanninnen, T.3    Forsblom, C.4    Groop, L.C.5
  • 262
    • 0032976998 scopus 로고    scopus 로고
    • Functional and morphological abnormalities of mitochondria harbouring the tRNA(Leu)(UUR) mutation in mitochondrial DNA derived from patients with maternally inherited diabetes and deafness (MIDD) and progressive kidney disease
    • van den Ouweland JM, Maechler P, Wollheim CB, Attardi G, Maassen JA: Functional and morphological abnormalities of mitochondria harbouring the tRNA(Leu)(UUR) mutation in mitochondrial DNA derived from patients with maternally inherited diabetes and deafness (MIDD) and progressive kidney disease. Diabetologia 42: 482-495, 1999.
    • (1999) Diabetologia , vol.42 , pp. 482-495
    • Van Den Ouweland, J.M.1    Maechler, P.2    Wollheim, C.B.3    Attardi, G.4    Maassen, J.A.5
  • 263
    • 0030952822 scopus 로고    scopus 로고
    • Analysis of candidate genes for susceptibility to type I diabetes: A case-control and a family-association study of genes on chromosome 2q31-35
    • Owerbach D, Naya F J, Tsai M-J, Allander SV, Powell DR, Gabbay KH: Analysis of candidate genes for susceptibility to type I diabetes: a case-control and a family-association study of genes on chromosome 2q31-35. Diabetes 46: 1069-1074, 1997.
    • (1997) Diabetes , vol.46 , pp. 1069-1074
    • Owerbach, D.1    Naya, F.J.2    Tsai, M.-J.3    Allander, S.V.4    Powell, D.R.5    Gabbay, K.H.6
  • 266
    • 0033614439 scopus 로고    scopus 로고
    • Protein targeting to glycogen/PPP1R5: Screening of coding and flanking genomic regions for polymorphisms and association analysis with insulin action in Pima Indians
    • Permana PA, Luczy-Bachman G, Bogardus C: Protein targeting to glycogen/PPP1R5: screening of coding and flanking genomic regions for polymorphisms and association analysis with insulin action in Pima Indians. Biochem Biophys Res Commun 258: 184-186, 1999.
    • (1999) Biochem Biophys Res Commun , vol.258 , pp. 184-186
    • Permana, P.A.1    Luczy-Bachman, G.2    Bogardus, C.3
  • 267
    • 0033910405 scopus 로고    scopus 로고
    • Functional analyses of amino acid substitutions Arg883Ser and Asp905Tyr of protein phosphatase-1 G-subunit
    • Permana PA, Kahn BB, Huppertz C, Mott DM: Functional analyses of amino acid substitutions Arg883Ser and Asp905Tyr of protein phosphatase-1 G-subunit. Mol Genet Metab 79: 151-158, 2000.
    • (2000) Mol Genet Metab , vol.79 , pp. 151-158
    • Permana, P.A.1    Kahn, B.B.2    Huppertz, C.3    Mott, D.M.4
  • 269
    • 0030941820 scopus 로고    scopus 로고
    • Metabolic defects in lean nondiabetic offspring of NIDDM patients
    • Perseghin G, Ghosh S, Gerow K, Shulman GI: Metabolic defects in lean nondiabetic offspring of NIDDM patients. Diabetes 46: 1001-1009, 1997.
    • (1997) Diabetes , vol.46 , pp. 1001-1009
    • Perseghin, G.1    Ghosh, S.2    Gerow, K.3    Shulman, G.I.4
  • 273
    • 0030980023 scopus 로고    scopus 로고
    • Low birth-weight is associated with NIDDM in discordant monozygotic and dizygotic twin pairs
    • Poulsen P, Vaag A, Kyvik K, Møller Jensen D, Beck-Nielsen H: Low birth-weight is associated with NIDDM in discordant monozygotic and dizygotic twin pairs. Diabetologia 40: 439-44, 1997.
    • (1997) Diabetologia , vol.40 , pp. 439-444
    • Poulsen, P.1    Vaag, A.2    Kyvik, K.3    Møller Jensen, D.4    Beck-Nielsen, H.5
  • 274
    • 0032953097 scopus 로고    scopus 로고
    • Heritability of type II (noninsulin-dependent) diabetes mellitus and abnormal glucose-tolerance: A population-based twin study
    • Poulsen P, Kyvik KO, Vaag A, Beck-Nielsen H: Heritability of type II (noninsulin-dependent) diabetes mellitus and abnormal glucose-tolerance: a population-based twin study. Diabetologia 42: 139-45, 1999.
    • (1999) Diabetologia , vol.42 , pp. 139-145
    • Poulsen, P.1    Kyvik, K.O.2    Vaag, A.3    Beck-Nielsen, H.4
  • 275
    • 0030614364 scopus 로고    scopus 로고
    • PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism
    • Printen JA, Brady M J, Saltiel AR: PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism. Science 275: 1475-1478, 1997.
    • (1997) Science , vol.275 , pp. 1475-1478
    • Printen, J.A.1    Brady, M.J.2    Saltiel, A.R.3
  • 276
    • 0028927487 scopus 로고
    • Molecular and linkage analysis of type-I protein phosphatase catalytic beta-subunit gene: Lack of evidence for its major role in insulin resistance in Pima Indians
    • Prochazka M, Mochizuki H, Baier LJ, Cohen PT, Bogardus C: Molecular and linkage analysis of type-I protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima Indians. Diabetologia 38: 461-66, 1995.
    • (1995) Diabetologia , vol.38 , pp. 461-466
    • Prochazka, M.1    Mochizuki, H.2    Baier, L.J.3    Cohen, P.T.4    Bogardus, C.5
  • 277
    • 0033304957 scopus 로고    scopus 로고
    • Effect of an Asp905Tyr mutation of the glycogen-associated regulatory subunit of protein phosphatase-1 on the regulation of glycogen synthesis by insulin and cyclic adenosine 3′, 5′-monophosphate agonists
    • Ragolia L, Duddy N, Begum N: Effect of an Asp905Tyr mutation of the glycogen-associated regulatory subunit of protein phosphatase-1 on the regulation of glycogen synthesis by insulin and cyclic adenosine 3′, 5′-monophosphate agonists. Mol Endocrinol 13: 1773-83, 1999.
    • (1999) Mol Endocrinol , vol.13 , pp. 1773-1783
    • Ragolia, L.1    Duddy, N.2    Begum, N.3
  • 278
    • 0013844340 scopus 로고
    • The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus
    • Randle PJ, Garland PB, Newsholme EA, Hales CN: The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus. Ann NY Acad Sci 131: 324-333, 1965.
    • (1965) Ann NY Acad Sci , vol.131 , pp. 324-333
    • Randle, P.J.1    Garland, P.B.2    Newsholme, E.A.3    Hales, C.N.4
  • 279
    • 0032452225 scopus 로고    scopus 로고
    • Regulatory interactions between lipids and carbohydrates: The glucose fatty acid cycle after 35 years
    • Randle PJ: Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diabetes Metab Rev 14: 263-83, 1998.
    • (1998) Diabetes Metab Rev , vol.14 , pp. 263-283
    • Randle, P.J.1
  • 280
    • 0032937751 scopus 로고    scopus 로고
    • Loss of Cdk4 expression causes insulin deficient diabetes and Cdk4 activation results in β-cell hyperplasia
    • Rane SG, Dubus P, Mettus RV, Galbreath EJ, Boden G, Reddy EP, Barbacid M: Loss of Cdk4 expression causes insulin deficient diabetes and Cdk4 activation results in β-cell hyperplasia. Nature Genetics 22: 44-52, 1999.
    • (1999) Nature Genetics , vol.22 , pp. 44-52
    • Rane, S.G.1    Dubus, P.2    Mettus, R.V.3    Galbreath, E.J.4    Boden, G.5    Reddy, E.P.6    Barbacid, M.7
  • 281
    • 0034089587 scopus 로고    scopus 로고
    • Adenovirus-mediated expression of a naturally occurring Asp905Tyr variant of the glycogen-associated regulatory subunit of protein phosphatase-1 in L6 myotubes
    • Rasmussen SK, Hansen L, Frevert EU, Cohen PT, Kahn BB, Pedersen O: Adenovirus-mediated expression of a naturally occurring Asp905Tyr variant of the glycogen-associated regulatory subunit of protein phosphatase-1 in L6 myotubes. Diabetologia 43: 718-22, 2000a.
    • (2000) Diabetologia , vol.43 , pp. 718-722
    • Rasmussen, S.K.1    Hansen, L.2    Frevert, E.U.3    Cohen, P.T.4    Kahn, B.B.5    Pedersen, O.6
  • 284
    • 0025094344 scopus 로고
    • Mapping genes in Diabetes
    • Rich SS: Mapping genes in Diabetes. Diabetes 39: 1319-1323, 1990.
    • (1990) Diabetes , vol.39 , pp. 1319-1323
    • Rich, S.S.1
  • 287
    • 0027138261 scopus 로고
    • Skeletal muscle glycogenolysis is more sensitive to insulin than is glucose transport/phosphorylation
    • Rosetti L, and Hu M: Skeletal muscle glycogenolysis is more sensitive to insulin than is glucose transport/phosphorylation. J Clin Invest 92: 2963-2974, 1993.
    • (1993) J Clin Invest , vol.92 , pp. 2963-2974
    • Rosetti, L.1    Hu, M.2
  • 288
    • 0028809238 scopus 로고
    • Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin dependent diabetes mellitus
    • Rothman DL, Magnusson I, Cline G, Gerard D, Kahn CR, Shulman RG, Shulman GI: Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin dependent diabetes mellitus. Proc. Natl. Acad. Sci. 92: 983-987, 1995.
    • (1995) Proc Natl Acad Sci , vol.92 , pp. 983-987
    • Rothman, D.L.1    Magnusson, I.2    Cline, G.3    Gerard, D.4    Kahn, C.R.5    Shulman, R.G.6    Shulman, G.I.7
  • 289
    • 0030914931 scopus 로고    scopus 로고
    • Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas
    • St-Onge L, Sosa-Pineda B, Chowdhury K, Mansouri A, Gruss P: Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas. Nature 387: 406-9, 1997.
    • (1997) Nature , vol.387 , pp. 406-409
    • St-Onge, L.1    Sosa-Pineda, B.2    Chowdhury, K.3    Mansouri, A.4    Gruss, P.5
  • 291
    • 0029561629 scopus 로고
    • Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic β-cells, brain, heart and skeletal muscle
    • Sakura H, Ämmälä C, Smith PA, Gribble FM, Ashcroft FM: Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic β-cells, brain, heart and skeletal muscle. FEBS Lett 377: 338-344. 1995.
    • (1995) FEBS Lett , vol.377 , pp. 338-344
    • Sakura, H.1    Ämmälä, C.2    Smith, P.A.3    Gribble, F.M.4    Ashcroft, F.M.5
  • 292
    • 0029066625 scopus 로고
    • Characterization and variation of a human inwardly-rectifying K-channel gene (KCNJ6): A putative ATP-sensitive K-channel subunit
    • Sakura H, Bond C, Warren-Perry M et al: Characterization and variation of a human inwardly-rectifying K-channel gene (KCNJ6): A putative ATP-sensitive K-channel subunit. FEBS Lett 367: 193-197, 1995.
    • (1995) FEBS Lett , vol.367 , pp. 193-197
    • Sakura, H.1    Bond, C.2    Warren-Perry, M.3
  • 293
    • 0029740428 scopus 로고    scopus 로고
    • Sequence variations in th human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: No association with NIDDM in white Caucasian subjects or evidence of of abnormal function when expressed in vitro
    • Sakura H, Wat N, Horton V, Millns H, Turner RC, Aschcroft FM: Sequence variations in th human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in white Caucasian subjects or evidence of of abnormal function when expressed in vitro. Diabetologia 39: 1233-6,1996.
    • (1996) Diabetologia , vol.39 , pp. 1233-1236
    • Sakura, H.1    Wat, N.2    Horton, V.3    Millns, H.4    Turner, R.C.5    Aschcroft, F.M.6
  • 294
    • 0026636946 scopus 로고
    • Impaired activation of glycogen synthase in people at risk for developing NIDDM
    • Schalin-Jantti C, Harkonen M, Groop LC: Impaired activation of glycogen synthase in people at risk for developing NIDDM. Diabetes 41: 598-604, 1992.
    • (1992) Diabetes , vol.41 , pp. 598-604
    • Schalin-Jantti, C.1    Harkonen, M.2    Groop, L.C.3
  • 296
    • 0025067390 scopus 로고
    • Human insulin receptor gene: Partial sequence and amplifications of exons by the polymerase chain reaction
    • Seino S, Seino M, Bell GI: Human insulin receptor gene: partial sequence and amplifications of exons by the polymerase chain reaction. Diabetes 39: 123-128, 1990.
    • (1990) Diabetes , vol.39 , pp. 123-128
    • Seino, S.1    Seino, M.2    Bell, G.I.3
  • 297
    • 0028981182 scopus 로고
    • An extended transmission/disequilibrium test (TDT) for multi-allele marker loci
    • Sham PC, Curtis D: An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. Am. J. Hum. Genet. 59: 323-336, 1995.
    • (1995) Am J Hum Genet , vol.59 , pp. 323-336
    • Sham, P.C.1    Curtis, D.2
  • 298
    • 0032540944 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action
    • Sharma PM, Egawa K, Huang Y, Martin JL, Huvar I, Boss GR, Olefsky JM: Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action. J Biol Chem 273: 18528-37, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 18528-18537
    • Sharma, P.M.1    Egawa, K.2    Huang, Y.3    Martin, J.L.4    Huvar, I.5    Boss, G.R.6    Olefsky, J.M.7
  • 302
    • 0029348806 scopus 로고
    • Protein phosphatase regulation by endogenous inhibitors
    • Shenolikar S: Protein phosphatase regulation by endogenous inhibitors. Semin. Cancer Biol. 6: 219-227, 1995.
    • (1995) Semin Cancer Biol , vol.6 , pp. 219-227
    • Shenolikar, S.1
  • 303
    • 0032143284 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase, the key switch mechanism in insulin signalling
    • Shepherd PR, Withers D J, Siddle K: Phosphoinositide 3-kinase, the key switch mechanism in insulin signalling. Biochem. J. 333 (Pt3): 471-490, 1998.
    • (1998) Biochem J , vol.333 , Issue.PART 3 , pp. 471-490
    • Shepherd, P.R.1    Withers, D.J.2    Siddle, K.3
  • 304
    • 0030798067 scopus 로고    scopus 로고
    • A missense mutation of the muscle glycogen synthase gene (M41 6V) is associated with insulin resistance in the Japanese population
    • Shimomura H, sanke T, Ueda K, Hanabusa T, Sakagashira S, nanjo K: A missense mutation of the muscle glycogen synthase gene (M41 6V) is associated with insulin resistance in the Japanese population. Diabetologia 40: 947-52, 1997.
    • (1997) Diabetologia , vol.40 , pp. 947-952
    • Shimomura, H.1    Sanke, T.2    Ueda, K.3    Hanabusa, T.4    Sakagashira, S.5    Nanjo, K.6
  • 305
    • 0033856122 scopus 로고    scopus 로고
    • Nonsense mutation of islet-1 gene (Q310X) in a type 2 diabetic patient with strong family history
    • Shimomura H, sanke T, Hanabusa T, Tsunoda K, Furuta H, Nanjo K: Nonsense mutation of islet-1 gene (Q310X) in a type 2 diabetic patient with strong family history. Diabetes 49: 1597-1600, 2000.
    • (2000) Diabetes , vol.49 , pp. 1597-1600
    • Shimomura, H.1    Sanke, T.2    Hanabusa, T.3    Tsunoda, K.4    Furuta, H.5    Nanjo, K.6
  • 308
    • 0033499662 scopus 로고    scopus 로고
    • Paired-homeobox transcription factor pax4 acts as a transcriptional repressor in early pancreatic development
    • Smith SB, Ee HC, Conners JR, German MS: Paired-homeobox transcription factor pax4 acts as a transcriptional repressor in early pancreatic development. Moll Cell Biol 19: 8272-80, 1999.
    • (1999) Moll Cell Biol , vol.19 , pp. 8272-8280
    • Smith, S.B.1    Ee, H.C.2    Conners, J.R.3    German, M.S.4
  • 309
    • 0034711279 scopus 로고    scopus 로고
    • Autoregulation and maturity onset diabetes of the young transcription factors control the human Pax4 promoter
    • Smith SB, Watada H, Scheel DW, Mrejen C, German MS: Autoregulation and maturity onset diabetes of the young transcription factors control the human Pax4 promoter. J Biol Chem 275: 36910-19, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 36910-36919
    • Smith, S.B.1    Watada, H.2    Scheel, D.W.3    Mrejen, C.4    German, M.S.5
  • 310
    • 0030026603 scopus 로고    scopus 로고
    • Growth and endocrine function after near total pancreatectomy for hyperinsulinaemic hypoglycaemia
    • Soliman AT, Alsalmi I, Darwish A, Asfour MG: Growth and endocrine function after near total pancreatectomy for hyperinsulinaemic hypoglycaemia. Arch Dis Child 74: 379-385, 1996.
    • (1996) Arch Dis Child , vol.74 , pp. 379-385
    • Soliman, A.T.1    Alsalmi, I.2    Darwish, A.3    Asfour, M.G.4
  • 311
    • 0027377799 scopus 로고
    • Transmission test for linkage disequilibrium: The insulin gene region and insulin dependent diabetes mellitus (IDDM)
    • Spielman RS, McGinnis RE, Ewens WJ: Transmission test for linkage disequilibrium: the insulin gene region and insulin dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. 52: 506-516, 1993.
    • (1993) Am J Hum Genet , vol.52 , pp. 506-516
    • Spielman, R.S.1    McGinnis, R.E.2    Ewens, W.J.3
  • 312
    • 0027960448 scopus 로고
    • Mitogen inactivation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylation
    • Stambolic V, Woodgett JR: Mitogen inactivation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylation. Biochem J. 303: 701-704, 1994.
    • (1994) Biochem J , vol.303 , pp. 701-704
    • Stambolic, V.1    Woodgett, J.R.2
  • 313
    • 0032475861 scopus 로고    scopus 로고
    • Negative regulation of pkb/akt-dependent cell-survival by the tumor-suppressor pten
    • Stambolic V, Suzuki A, Delapompa JL et al: Negative regulation of pkb/akt-dependent cell-survival by the tumor-suppressor pten. Cell 95: 29-39, 1998.
    • (1998) Cell , vol.95 , pp. 29-39
    • Stambolic, V.1    Suzuki, A.2    Delapompa, J.L.3
  • 315
    • 17144436629 scopus 로고    scopus 로고
    • Identification of a candidate tumor-suppressor gene, mmac1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    • Steck PA, Pershouse MA, Jasser SA et al. Identification of a candidate tumor-suppressor gene, mmac1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15: 356-362, 1997.
    • (1997) Nat Genet , vol.15 , pp. 356-362
    • Steck, P.A.1    Pershouse, M.A.2    Jasser, S.A.3
  • 317
    • 0030695445 scopus 로고    scopus 로고
    • The maturity-onset diabetes of the young (MODY1) transcription factor HNF 4alpha regulates expression of genes required for glucose transport and metabolism
    • Stoffel M, Duncan SA: The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism. Proc Natl Acad Sci 94: 13209-14, 1997.
    • (1997) Proc Natl Acad Sci , vol.94 , pp. 13209-13214
    • Stoffel, M.1    Duncan, S.A.2
  • 318
    • 0031031571 scopus 로고    scopus 로고
    • Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence
    • Stoffers DA, Zinkin NT, Stanojevic V, Clarke WL, Habener JF: Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nature Genetics 15: 106-110, 1997a.
    • (1997) Nature Genetics , vol.15 , pp. 106-110
    • Stoffers, D.A.1    Zinkin, N.T.2    Stanojevic, V.3    Clarke, W.L.4    Habener, J.F.5
  • 320
    • 0032128288 scopus 로고    scopus 로고
    • Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein
    • Stoffers DA, Stanojevic V, Habener JF: Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein. J Clin Invest 102: 232-241, 1998.
    • (1998) J Clin Invest , vol.102 , pp. 232-241
    • Stoffers, D.A.1    Stanojevic, V.2    Habener, J.F.3
  • 321
    • 0029933511 scopus 로고    scopus 로고
    • A variation at position -30 of the β-cell glucokinase promotor is associated with reduced β-cell function in middle-aged Japanese-American men
    • Stone LM, Kahn SE, Fujimoto WY, Deeb SS, Porte D Jr: A variation at position -30 of the β-cell glucokinase promotor is associated with reduced β-cell function in middle-aged Japanese-American men. Diabetes 46: 422-28, 1996.
    • (1996) Diabetes , vol.46 , pp. 422-428
    • Stone, L.M.1    Kahn, S.E.2    Fujimoto, W.Y.3    Deeb, S.S.4    Porte Jr., D.5
  • 322
    • 0035078748 scopus 로고    scopus 로고
    • The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans
    • Stumvoll M, Fritsche A, Volk A, Stefan N, Madaus A, Maerker E, Teigeler A, Koch M, Machicao F, Haring H: The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans. Diabetes 50: 882-885, 2001.
    • (2001) Diabetes , vol.50 , pp. 882-885
    • Stumvoll, M.1    Fritsche, A.2    Volk, A.3    Stefan, N.4    Madaus, A.5    Maerker, E.6    Teigeler, A.7    Koch, M.8    Machicao, F.9    Haring, H.10
  • 323
    • 0032699475 scopus 로고    scopus 로고
    • Identification of novel non-insulin-dependent diabetes mellitus susceptibility loci in the Otsuka Long-Evans Tokoshima fatty rat by MQM-mapping method
    • Sugiura K, Miyake T, Taniguchi Y, Yamada T, Moralejo DH, Wei S, Wei K, Sasaki Y, Matsumoto K: Identification of novel non-insulin-dependent diabetes mellitus susceptibility loci in the Otsuka Long-Evans Tokoshima fatty rat by MQM-mapping method. Mamm Genome 12: 1126-31, 1999.
    • (1999) Mamm Genome , vol.12 , pp. 1126-1131
    • Sugiura, K.1    Miyake, T.2    Taniguchi, Y.3    Yamada, T.4    Moralejo, D.H.5    Wei, S.6    Wei, K.7    Sasaki, Y.8    Matsumoto, K.9
  • 325
    • 0021214244 scopus 로고
    • Chronic hyperinsulinemia in the fetal rhesus monkey. Effects of physiological hyperinsulinemia on fetal growth and composition
    • Susa JB, Neave C, Sehgal P, Singer DB, Zeller WP, Schwartz R: Chronic hyperinsulinemia in the fetal rhesus monkey. Effects of physiological hyperinsulinemia on fetal growth and composition. Diabetes 33: 656-660, 1984.
    • (1984) Diabetes , vol.33 , pp. 656-660
    • Susa, J.B.1    Neave, C.2    Sehgal, P.3    Singer, D.B.4    Zeller, W.P.5    Schwartz, R.6
  • 327
    • 0027515127 scopus 로고
    • Inactivation of glycogen synthase kinase 3b by phosphorylation: New kinase connections in insulin and growth factor signaling
    • Sutherland C, Leighton IA, Cohen P: Inactivation of glycogen synthase kinase 3b by phosphorylation: New kinase connections in insulin and growth factor signaling. Biochem J 296: 15-19, 1993.
    • (1993) Biochem J , vol.296 , pp. 15-19
    • Sutherland, C.1    Leighton, I.A.2    Cohen, P.3
  • 328
    • 0032898857 scopus 로고    scopus 로고
    • The insulin signaling pathway
    • Taha C, Klip A: The insulin signaling pathway. J Membr Biol; 169(1): 1-12, 1999
    • (1999) J Membr Biol , vol.169 , Issue.1 , pp. 1-12
    • Taha, C.1    Klip, A.2
  • 330
    • 0029981205 scopus 로고    scopus 로고
    • A pancreatic islet inwardly rectifying potassium channel: cDNA cloning, determination of the genomic structure and genetic variations in Japanese NIDDM patients
    • Tanizawa Y, Matsubara A, Ueda K, Katagiri H, Kuwano A, Ferrer J, Permutt MA, Oka Y: A pancreatic islet inwardly rectifying potassium channel: cDNA cloning, determination of the genomic structure and genetic variations in Japanese NIDDM patients. Diabetologia 39: 447-452, 1996.
    • (1996) Diabetologia , vol.39 , pp. 447-452
    • Tanizawa, Y.1    Matsubara, A.2    Ueda, K.3    Katagiri, H.4    Kuwano, A.5    Ferrer, J.6    Permutt, M.A.7    Oka, Y.8
  • 331
    • 0016641270 scopus 로고
    • A difference between the inheritance of classical juvenile-onset and maturity-onset type diabetes of young people
    • Tattersall RB, Fajans SS: A difference between the inheritance of classical juvenile-onset and maturity-onset type diabetes of young people. Diabetes 24: 44-55, 1975.
    • (1975) Diabetes , vol.24 , pp. 44-55
    • Tattersall, R.B.1    Fajans, S.S.2
  • 332
    • 0032469940 scopus 로고    scopus 로고
    • Syndromes associated with insulin resistance and acanthosis nigricans
    • Taylor SI and Arioglu E: Syndromes associated with insulin resistance and acanthosis nigricans. J Basic Clin Physiol Pharmacol 9: 419-439, 1998.
    • (1998) J Basic Clin Physiol Pharmacol , vol.9 , pp. 419-439
    • Taylor, S.I.1    Arioglu, E.2
  • 333
    • 0030961962 scopus 로고    scopus 로고
    • Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease
    • Terauchi Y, Iwamoto K, Tamemoto H, Komeda K, Ishii C, Kanazawa Y, Asanuma N, Aizawa T, Akanuma Y, Yasuda K, Kodama T, Tobe K, Yazaki Y, Kadowaki T: Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease. J Clin Invest 99: 861-866, 1997.
    • (1997) J Clin Invest , vol.99 , pp. 861-866
    • Terauchi, Y.1    Iwamoto, K.2    Tamemoto, H.3    Komeda, K.4    Ishii, C.5    Kanazawa, Y.6    Asanuma, N.7    Aizawa, T.8    Akanuma, Y.9    Yasuda, K.10    Kodama, T.11    Tobe, K.12    Yazaki, Y.13    Kadowaki, T.14
  • 335
    • 0033970635 scopus 로고    scopus 로고
    • Insulin effect during embryo genesis determines fetal growth: A possible molecular link between birth weight and susceptibility to type 2 diabetes
    • Terauchi Y, Kubota N, Tamemoto H, Sakura H, Nagai R, Akanuma Y, Kimura S, Kadowaki T: Insulin effect during embryogenesis determines fetal growth: a possible molecular link between birth weight and susceptibility to type 2 diabetes. Diabetes 49: 82-86, 2000.
    • (2000) Diabetes , vol.49 , pp. 82-86
    • Terauchi, Y.1    Kubota, N.2    Tamemoto, H.3    Sakura, H.4    Nagai, R.5    Akanuma, Y.6    Kimura, S.7    Kadowaki, T.8
  • 336
    • 0035220163 scopus 로고    scopus 로고
    • On the resolution and feasibility of genome scanning approaches
    • Terwilliger JD: On the resolution and feasibility of genome scanning approaches. Adv Genet 42: 351-91, 2001.
    • (2001) Adv Genet , vol.42 , pp. 351-391
    • Terwilliger, J.D.1
  • 337
    • 0345421089 scopus 로고
    • The AKT1 gene, the human homologue of a retroviral oncogene, is located on chromosome 14 at band q32
    • Testa JR, Huebner K, Croce CM, Staal S: The AKT1 gene, the human homologue of a retroviral oncogene, is located on chromosome 14 at band q32. Cytogenet Cell Genet 40: 761, 1985.
    • (1985) Cytogenet Cell Genet , vol.40 , pp. 761
    • Testa, J.R.1    Huebner, K.2    Croce, C.M.3    Staal, S.4
  • 339
    • 0031438446 scopus 로고    scopus 로고
    • Genetic linkage study of a major susceptibility locus (D2S125) in a British population of non-insulin dependent diabetic sib-pairs using a simple nonisotopic screening method
    • Thomas AW, Sherrat EJ, Gagg JW, Davies SA, Majid A, Alcolado JC: Genetic linkage study of a major susceptibility locus (D2S125) in a British population of non-insulin dependent diabetic sib-pairs using a simple nonisotopic screening method. Hum Genet 101: 212-13, 1997.
    • (1997) Hum Genet , vol.101 , pp. 212-213
    • Thomas, A.W.1    Sherrat, E.J.2    Gagg, J.W.3    Davies, S.A.4    Majid, A.5    Alcolado, J.C.6
  • 340
    • 0029807640 scopus 로고    scopus 로고
    • Human primary myoblast cell cultures from non-diabetic insulin resistant subjects retain defects in insulin action
    • Thompson BD, Pratley R, Ossowski V: Human primary myoblast cell cultures from non-diabetic insulin resistant subjects retain defects in insulin action. J. Clin. Invest. 98; 10: 2346-2350, 1996.
    • (1996) J Clin Invest , vol.98 , Issue.10 , pp. 2346-2350
    • Thompson, B.D.1    Pratley, R.2    Ossowski, V.3
  • 343
    • 0030943465 scopus 로고    scopus 로고
    • A prevalent amin oacid polymorphism at codon 98 in the hepatocyte nuclear factor-1a is associated with reduced serum C-peptide and insulin responses to an oral glucose challenge
    • Urhammer SA, Fridberg M, Hansen T, Rasmussen SK, Moller AM, Clausen JO, Pedersen O: A prevalent amin oacid polymorphism at codon 98 in the hepatocyte nuclear factor-1a is associated with reduced serum C-peptide and insulin responses to an oral glucose challenge. Diabetes 46: 912-916, 1997.
    • (1997) Diabetes , vol.46 , pp. 912-916
    • Urhammer, S.A.1    Fridberg, M.2    Hansen, T.3    Rasmussen, S.K.4    Moller, A.M.5    Clausen, J.O.6    Pedersen, O.7
  • 345
    • 0031852907 scopus 로고    scopus 로고
    • The g/a nucleotide variant at position -30 in the beta-cell-specific glucokinase gene promoter has no impact on the beta-cell function in Danish Caucasians
    • Urhammer SA, Hansen T, Clausen JO, Eiberg H, Pedersen O: The g/a nucleotide variant at position -30 in the beta-cell-specific glucokinase gene promoter has no impact on the beta-cell function in Danish Caucasians. Diabetes 47: 1359-61, 1998.
    • (1998) Diabetes , vol.47 , pp. 1359-1361
    • Urhammer, S.A.1    Hansen, T.2    Clausen, J.O.3    Eiberg, H.4    Pedersen, O.5
  • 346
    • 0026575758 scopus 로고
    • Decreased activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin dependent diabetes mellitus
    • Vaag A, Henriksen JE, Beck-Nielsen: Decreased activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin dependent diabetes mellitus. J. Clin. Invest. 89: 782-788, 1992.
    • (1992) J Clin Invest , vol.89 , pp. 782-788
    • Vaag, A.1    Henriksen, J.E.2    Beck-Nielsen3
  • 347
    • 0033063033 scopus 로고    scopus 로고
    • On the pathophysiology of late onset non-insulin dependent diabetes mellitus. Current controversies and new insights
    • Vaag A: On the pathophysiology of late onset non-insulin dependent diabetes mellitus. Current controversies and new insights. Dan Med Bull 46: 197-234, 1999.
    • (1999) Dan Med Bull , vol.46 , pp. 197-234
    • Vaag, A.1
  • 349
    • 0031436966 scopus 로고    scopus 로고
    • Human beta-2 receptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function
    • Valerie L, Hellström L, Reynisdottir S, Lönnqvist F, Eriksson P, Lannfelt L, Amer P: Human beta-2 receptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function. J Clin Invest 100: 3005-13, 1997.
    • (1997) J Clin Invest , vol.100 , pp. 3005-3013
    • Valerie, L.1    Hellström, L.2    Reynisdottir, S.3    Lönnqvist, F.4    Eriksson, P.5    Lannfelt, L.6    Amer, P.7
  • 350
    • 0031963964 scopus 로고    scopus 로고
    • Defects in insulin secretion and insulin action in non-insulin dependent diabetes mellitus are inherited
    • Vaukhonen I, Niskanen L, Vanninen E, Uusitupa M, Laakso M: Defects in insulin secretion and insulin action in non-insulin dependent diabetes mellitus are inherited. J Clin Invest 101: 86-96, 1997.
    • (1997) J Clin Invest , vol.101 , pp. 86-96
    • Vaukhonen, I.1    Niskanen, L.2    Vanninen, E.3    Uusitupa, M.4    Laakso, M.5
  • 351
    • 0033842777 scopus 로고    scopus 로고
    • Maternel diabetes alters birth weight in glucokinase-deficient (MODY2) kindred but has no influence on adult weight, height, insulin secretion or insulin sensitivity
    • Velho G, Hattersley AT, froguel P: Maternel diabetes alters birth weight in glucokinase-deficient (MODY2) kindred but has no influence on adult weight, height, insulin secretion or insulin sensitivity. Diabetologia 43: 1060-63, 2000.
    • (2000) Diabetologia , vol.43 , pp. 1060-1063
    • Velho, G.1    Hattersley, A.T.2    Froguel, P.3
  • 353
    • 0026315717 scopus 로고
    • Impaired expression of glycogen synthase mRNA in skeletal muscle of NIDDM patients
    • Vestergaard H, Bjørbæk C, Andersen PH, Bak JF, Pedersen O: Impaired expression of glycogen synthase mRNA in skeletal muscle of NIDDM patients. Diabetes 40: 1740-1745, 1991.
    • (1991) Diabetes , vol.40 , pp. 1740-1745
    • Vestergaard, H.1    Bjørbæk, C.2    Andersen, P.H.3    Bak, J.F.4    Pedersen, O.5
  • 354
    • 0028842531 scopus 로고
    • Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients
    • Vestergaard H, Bjorbaek C, Hansen T, Larsen FS, Granner DK, Pedersen O: Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients. J Clin Invest 96: 2639-45, 1995.
    • (1995) J Clin Invest , vol.96 , pp. 2639-2645
    • Vestergaard, H.1    Bjorbaek, C.2    Hansen, T.3    Larsen, F.S.4    Granner, D.K.5    Pedersen, O.6
  • 355
    • 0032993608 scopus 로고    scopus 로고
    • Studies of gene expression and activity of hexokinase, phosphofructokinase and glycogen synthase in human skeletal muscle in states of altered insulin-stimulated glucose metabolism
    • Vestergaard H: Studies of gene expression and activity of hexokinase, phosphofructokinase and glycogen synthase in human skeletal muscle in states of altered insulin-stimulated glucose metabolism. Dan Med Bull 46: 13-34, 1999.
    • (1999) Dan Med Bull , vol.46 , pp. 13-34
    • Vestergaard, H.1
  • 356
    • 0028902091 scopus 로고
    • Analysis of the hexokinase II gene in subjects with insulin resistance and NIDDM and detection of a Gln142→His substitution
    • Vidal-Pluig A, Printz RL, Stratton IM, Granner DK, Moller DE: Analysis of the hexokinase II gene in subjects with insulin resistance and NIDDM and detection of a Gln142→His substitution. Diabetes 44: 340-346, 1995.
    • (1995) Diabetes , vol.44 , pp. 340-346
    • Vidal-Pluig, A.1    Printz, R.L.2    Stratton, I.M.3    Granner, D.K.4    Moller, D.E.5
  • 357
    • 0042570843 scopus 로고    scopus 로고
    • Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
    • Virkamaki A, Ueki K, Kahn CR: Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest 103: 931-43, 1999.
    • (1999) J Clin Invest , vol.103 , pp. 931-943
    • Virkamaki, A.1    Ueki, K.2    Kahn, C.R.3
  • 359
    • 0032980306 scopus 로고    scopus 로고
    • Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus
    • Finland-United States Investigation of NIDDM Genetics (FUSION) Study investigators
    • Watanabe RM, Valle T, Hauser ER, Ghosh S, Eriksson J, Kohtamaki K, Ehnholm C, Tuomilehto J, Collins FS, Bergman RN, Boehnke M: Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus. Finland-United States Investigation of NIDDM Genetics (FUSION) Study investigators. Hum Hered 49: 159-68, 1999.
    • (1999) Hum Hered , vol.49 , pp. 159-168
    • Watanabe, R.M.1    Valle, T.2    Hauser, E.R.3    Ghosh, S.4    Eriksson, J.5    Kohtamaki, K.6    Ehnholm, C.7    Tuomilehto, J.8    Collins, F.S.9    Bergman, R.N.10    Boehnke, M.11
  • 361
    • 0027457357 scopus 로고
    • Abnormal activation of glycogen synthesis in fibroblasts from NIDDM subjects: Evidence for an abnormality specific to glucose metabolism
    • Wells AM, Sutcliffe IC, Johnson AB, Taylor R: Abnormal activation of glycogen synthesis in fibroblasts from NIDDM subjects: Evidence for an abnormality specific to glucose metabolism. Diabetes 42: 583-589, 1993.
    • (1993) Diabetes , vol.42 , pp. 583-589
    • Wells, A.M.1    Sutcliffe, I.C.2    Johnson, A.B.3    Taylor, R.4
  • 364
    • 0028978913 scopus 로고
    • Association of a polymorphism in the β3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns
    • Widen E, Lehto M, Kanninen T, Walstron J, Shuldiner AR, Groop LC: Association of a polymorphism in the β3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns. N Engl J Med 333: 348-51, 1995.
    • (1995) N Engl J Med , vol.333 , pp. 348-351
    • Widen, E.1    Lehto, M.2    Kanninen, T.3    Walstron, J.4    Shuldiner, A.R.5    Groop, L.C.6
  • 367
    • 0025286104 scopus 로고
    • Molecular cloning and expression of glycogen synthase kinase-3/Factor A
    • Woodgett JR: Molecular cloning and expression of glycogen synthase kinase-3/Factor A. EMBO J. 9: 8: 2431-2438, 1990.
    • (1990) EMBO J , vol.9 , Issue.8 , pp. 2431-2438
    • Woodgett, J.R.1
  • 368
    • 0025761472 scopus 로고
    • A common denominator linking glycogen metabolism, nuclear oncogenes and development
    • Woodgett JR: A common denominator linking glycogen metabolism, nuclear oncogenes and development. TIBS 16: 177-181, 1991.
    • (1991) TIBS , vol.16 , pp. 177-181
    • Woodgett, J.R.1
  • 379
    • 0029857775 scopus 로고    scopus 로고
    • UKPDS19: Heterogeneity in NIDDM: Separate contributions of IRS-1 and Beta 3-adrenergic receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations. UK Prospective Diabetes Study
    • Zhang Y, Wat N, Stratton IM, Warren-Perry MG, Orho M, Groop L, Turner RC:UKPDS19: heterogeneity in NIDDM: separate contributions of IRS-1 and Beta 3-adrenergic receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations. UK Prospective Diabetes Study. Diabetologia 39: 1505-11, 1996.
    • (1996) Diabetologia , vol.39 , pp. 1505-1511
    • Zhang, Y.1    Wat, N.2    Stratton, I.M.3    Warren-Perry, M.G.4    Orho, M.5    Groop, L.6    Turner, R.C.7
  • 380
    • 0030896748 scopus 로고    scopus 로고
    • The global epidemiology of noninsulin-dependent diabetes mellitus and the metabolic syndrome
    • Zimmet PZ, McCarty DJ, de Courten MP: The global epidemiology of noninsulin-dependent diabetes mellitus and the metabolic syndrome. J Diabetes Complications 11: 60-68, 1997.
    • (1997) J Diabetes Complications , vol.11 , pp. 60-68
    • Zimmet, P.Z.1    McCarty, D.J.2    De Courten, M.P.3
  • 381
    • 0027215282 scopus 로고
    • Polymorphism of the glycogen synthase gene and non-insulin dependent-diabetes mellitus
    • Zouali H, Velho G, Froguel P: Polymorphism of the glycogen synthase gene and non-insulin dependent-diabetes mellitus. N Engl J Med 328: 1568-69, 1993.
    • (1993) N Engl J Med , vol.328 , pp. 1568-1569
    • Zouali, H.1    Velho, G.2    Froguel, P.3
  • 382
    • 0030766446 scopus 로고    scopus 로고
    • A susceptibility locus for early-onset non-insulin dependent diabetes (type 2) mellitus maps to chromosome 20q, proximal to the phosphoenolpyrovate carboxylase gene
    • Zouali H, Hani EH, Philippi A, Vionnet N, Beckmann JS, Demenais F, Froguel: A susceptibility locus for early-onset non-insulin dependent diabetes (type 2) mellitus maps to chromosome 20q, proximal to the phosphoenolpyrovate carboxylase gene: J. Hum. Mol. Genet. 6: 1401-1408, 1997.
    • (1997) J Hum Mol Genet , vol.6 , pp. 1401-1408
    • Zouali, H.1    Hani, E.H.2    Philippi, A.3    Vionnet, N.4    Beckmann, J.S.5    Demenais, F.6    Froguel7


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