The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes

International Journal of Obesity

Volumn 24, Issue 3, 2000, Pages 391-393

  Clement, K ^a,b   Hercberg, S ^c   Passinge, B ^a,b   Galan, P ^c   Varroud Vial, M ^d   Shuldiner, A R ^e   Beamer, B A ^f   Charpentier, G ^d   Guy Grand, B ^a   Froguel, P ^a,b   Vaisse, C ^a,b,d,g  

^a Laboratoire de Nutrition   (France)

^b CNRS UPRESA 80 90 Inst de Biol L   (France)

^c École Supérieure d Ingénieurs Géomètres Topographes   (France)

^d CENTRE HOSPITALIER SUD FRANCILIEN   (France)

^e UNIVERSITY OF MARYLAND   (United States)

^f JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g VCSF   (United States)

Author keywords

Association study; Diabetes; Obesity; PPAR

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; FRANCE; GENE MUTATION; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHENOTYPE; POPULATION GENETICS; PRIORITY JOURNAL;

EID: 0004509649     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0801191     Document Type: Article

References (18)

1. 1 Spiegelman B. PPARγ: a adipogenic regulator and thiazolinedione receptor. Diabetes 1998; 47: 507-513.
2. 2 Lehmann J, Morre L, Smith-Olivier T, Wilkison W, Wilson T, Kliewer S. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ. Bio Chem 1995; 270: 12953-12956.
3. 12,14 prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 1995; 83: 803-812.
4. 4 Vidal-Puig A, Considine R, Jimenez-Linan M, Werman A, Pories W, Caro J, Flier J. Peroxisome proliferator-activated receptort gene expression in human tissues: effects of obesity, weight loss, and regulation by insulin and glucocorticoids. J Clin Invest 1997; 99: 2416-2422.
5. 5 Spiegelman B, Flier J. Adipogenesis: rounding out the big picture. Cell 1996; 87: 377-389.
6. 6 Latruffe N, Vamecq J. Peroxisome proliferator activated receptor (PPARs) as regulators of lipid metabolism. Biochimie 1997; 79: 81-94.
7. 7 Bloomgarden Z. Insulin resistance: current concepts. Clin Ther 1998; 20(2): 216-231.
8. 8 Neel J. Weder A, Julius S. Type II diabetes, essential hypertension, and obesity as "syndromes of impaired genetic homeostasis": the "thrifty genotype" hypothesis enters the 21st century. Perspect Biol Med 1998; 42(1): 44-74.
9. 9 Deeb S, Fajas L, Nemoto M, Pihlajamäki J, Mykkänen L, Kuusisto J, Laakso M, Fujimoto W, Auwerx J. A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nature Genet 1998; 20: 284-287.
10. 10 Ristow M, Muller-Wieland D, Pfeiffer A, Kahn C. Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. N Engl J Med. 1998; 339(14): 953-959.
11. 11 Yen C, Beamer B, Negri C, Silver K, Brown K, Yarnall D, Burns D, Roth J, Shuldiner A. Molecular scanning of the human peroxisome proliferator activated receptor γ (hPPAR γ) gene in diabetic Caucasians: identification of a Pro12Ala PPARγ2 missense mutation. Biochem Biophys Res Commun 1997; 24(2): 270-274.
12. 12 Mori Y, Kim-Motoyama H, Katakura T, Yasuda K, Kadowaki H, Beamer B, Shuldiner A, Akanuma Y, Yasaki Y, Kadowaki T. Effect of the Pro12Ala variant of the human peroxisome proliferator activated receptor γ gene on adiposity, fat distribution and insulin sensitivity in Japanese men. Biochem Biophys Res Commun 1998; 251: 195-198.
13. 13 Ringel J, Engeli S, Distler A, Sharma A. Pro12Ala PPARγ2 missense mutation of the peroxisome proliferator activated receptor γ and diabetes mellitus. Biochem Biophys Res Communun 1999; 254: 450-453.
14. 14 Mancini F, Vaccaro O, Sabatino L, Tufano A, Rivellese A, Riccardi G, Colantuoni V. Pro12Ala substitution in the peroxisome proliferator-activated receptor-γ2 is not associated with type 2 diabetes. Diabetes 1999; 48: 1466-1468.
15. 15 Beamer B, Yen C, Andersen R, Muller D, Elahi D, Cheskin L, Andres R, Roth J, Shuldiner A. Association of the Pro12Ala variant in the peroxisome proliferator activated receptor γ gene with obesity in two Caucasian populations. Diabetes 1998; 47: 1806-1808.
16. 16 Hercberg S, Preziosi P, Briançon S, Galan P, Triol I, Malvy D, Roussel A-M, Favier A. A primary prevention trial using nutritional doses of antioxidant vitamins and minerals in cardiovascular diseases and cancers in a general population: the SU-VI-MAX study-design, methods, and participants characteristics. Controlled Clin Trials 1998; 19: 336-351.
17. 17 Clément K, Lahlou N, Ruiz J, Hager J, Bougères P, Basdevant A, Guy-Grand B, Froguel P. Association of poorly controlled diabetes with low serum leptin in morbid obesity, Int J Obes 1997; 21: 556-561.
18. 18 Clément K, Dina C, Basdevant A, Chastang N, Pelloux V, Lahlou N, Berlan M, Langin D, Guy-Grand B, Froguel P. A sib-pair analysis study of 15 candidate genes in French families with morbid obesity. Indication for linkage with islet 1 locus on chromosome 5q. Diabetes 1999; 48: 398-402.