Two Splice Variants of Protein Kinase Bγ Have Different Regulatory Capacity Depending on the Presence or Absence of the Regulatory Phosphorylation Site Serine 472 in the Carboxyl-terminal Hydrophobic Domain

Journal of Biological Chemistry

Volumn 276, Issue 31, 2001, Pages 29550-29558

  Brodbeck, Daniela ^a   Hill, Michelle M ^a   Hemmings, Brian A ^a  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; CLONING; CYTOLOGY; HYDROPHOBICITY; INSULIN; PEROXIDES;

PHOSPHORYLATION; PLASMA MEMBRANES;

PROTEINS;

INSULIN; OKADAIC ACID; PEROXIDE; PERVANADATE; PHOSPHATIDYLINOSITIDE; PROTEIN KINASE B; PROTEIN KINASE B GAMMA; PROTEIN KINASE B GAMMA1; PROTEIN SERINE THREONINE KINASE; SERINE; UNCLASSIFIED DRUG; AKT3 PROTEIN, HUMAN; AKT3 PROTEIN, MOUSE; AKT3 PROTEIN, RAT; OLIGOPEPTIDE; ONCOPROTEIN; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ISOLATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN TRANSPORT; RAT; SECOND MESSENGER; ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL; ANTIBODY SPECIFICITY; BRAIN; CHEMISTRY; COMPARATIVE STUDY; EMBRYO; ENZYME SPECIFICITY; ENZYMOLOGY; EXON; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENETICS; KINETICS; MALE; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

ANIMALIA;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BRAIN; CLONING, MOLECULAR; CONSERVED SEQUENCE; EMBRYO; ENZYME ACTIVATION; EXONS; HUMANS; KINETICS; MALE; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OLIGOPEPTIDES; ONCOGENE PROTEINS; ORGAN SPECIFICITY; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; SUBSTRATE SPECIFICITY; TRANSCRIPTION, GENETIC; VARIATION (GENETICS);

EID: 0035800763     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M104633200     Document Type: Article

References (67)

1. Galetic, I., Andjelkovic, M., Meier, R., Brodbeck, D., Park, J., and Hemmings, B. A. (1999) Pharmacol. Ther. 82, 409-425
2. Chan, T. O., Rittenhouse, S. E., and Tsichlis, P. N. (1999) Annu. Rev. Biochem. 68, 965-1014
3. Jones, P. F., Jakubowicz, T., and Hemmings, B. A. (1991) Cell Regul. 2, 1001-1009
4. Jones, P. F., Jakubowicz, T., Pitossi, F. J., Maurer, F., and Hemmings, B. A. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 4171-4175
5. Cheng, J. Q., Godwin, A. K., Bellacosa, A., Taguchi, T., Franke, T. F., Hamilton, T. C., Tsichlis, P. N., and Testa, J. N. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 9267-9271
6. Konishi, H., Kuroda, S., Tanaka, M., Matsuzaki, H., Ono, Y., Kameyama, K., Haga, T., and Kikkawa, U. (1995) Biochem. Biophys. Res. Commun. 216, 526-534
7. Brodbeck, D., Cron, P., and Hemmings, B. A. (1999) J. Biol. Chem. 274, 9133-9136
8. Nakatani, K., Sakaue, H., Thompson, D. A., Weigel, R. J., and Roth, R. A. (1999) Biochem. Biophys. Res. Commun. 257, 906-910
9. Masure, S., Haefner, B., Wesselink, J. J., Hoefnagel, E., Mortier, E., Verhasselt, P., Tuytelaars, A., Gordon, R., and Richardson, A. (1999) Eur. J. Biochem. 265, 353-360
10. Burgering, B. M. T., and Coffer, P. J. (1995) Nature 376, 599-602
11. Kohn, A. D., Summers, S. A., Birnbaum, M. J., and Roth, R. A. (1996) J. Biol. Chem. 271, 31372-31378
12. Andjelkovic, M., Jakubowicz, T., Cron, P., Ming, X.-F., Han, J.-W., and Hemmings, B. A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 5699-5704
13. Franke, T. F., Kaplan, D. R., Cantley, L. C., and Toker, A. (1997) Science 275, 665-668
14. Toker, A., and Cantley, L. C. (1997) Nature 387, 673-676
15. Hemmings, B. A. (1997) Science 275, 628-630
16. Hemmings, B. A. (1997) Science 277, 534
17. Downward, J. (1998) Science 279, 673-674
18. James, S. R., Downes, C. P., Gigg, R., Grove, S. J. A., Holmes, A. B., and Alessi, D. R. (1996) Biochem. J. 315, 709-713
19. Frech, M., Andjelkovic, M., Ingley, E., Reddy, K. K., Falck, J. R., and Hemmings, B. A. (1997) J. Biol. Chem. 272, 8474-8481
20. Kohn, A. D., Takeuchi, F., and Roth, R. A. (1996) J. Biol. Chem. 271, 21920-21926
21. Andjelkovic, M., Alessi, D. R., Meier, R., Fernandez, A., Lamb, N. J. C., Frech, M., Cron, P., Cohen, P., Lucocq, J. M., and Hemmings, B. A. (1997) J. Biol. Chem. 272, 31515-31524
22. Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P., and Hemmings, B. A. (1996) EMBO J. 15, 6541-6551
23. Meier, R., Alessi, D. R., Cron, P., Andjelkovic, M., and Hemmings, B. A. (1997) J. Biol. Chem. 272, 30491-30497
24. Alessi, D. R., Deak, M., Casamayor, A., Caudwell, F. B., Morrice, N., Norman, D. G., Gaffney, P., Reese, C. B., MacDougall, C. N., Harbison, D., Ashworth, A., and Bownes, M. (1997) Curr. Biol. 7, 776-789
25. Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., and Cohen, P. (1997) Curr. Biol. 7, 261-269
26. Stokoe, D., Stephens, L. R., Copeland, T., Gaffney, P. R. J., Reese, C. B., Painter, G. F., Holmes, A. B., McCormick, F., and Hawkins, P. T. (1997) Science 277, 567-570
27. Stephens, L., Anderson, K., Stokoe, D., Erdjument-Bromage, H., Painter, G. F., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., McCormick, F., Tempst, P., Coadwell, J., and Hawkins, P. T. (1998) Science 279, 710-714
28. Alessi, D. R., Kozlowski, M. T., Weng, Q.-P., Morrice, N., and Avruch, J. (1997) Curr. Biol. 8, 69-81
29. Pullen, N., Dennis, P. B., Andjelkovic, M., Dufner, A., Kozma, S. C., Hemmings, B. A., and Thomas, G. (1998) Science 279, 707-710
30. Cheng, X., Ma, Y., Moore, M., Hemmings, B. A., and Taylor, S. S. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 9849-9854
31. Le Good, J. A., Ziegler, W. H., Parekh, D. B., Alessi, D. R., Cohen, P., and Parker, P. J. (1998) Science 281, 2042-2045
32. Park, J., Leong, M. L., Buse, P., Maiyar, A. C., Firestone, G. L., and Hemmings, B. A. (1999) EMBO J. 18, 3024-3033
33. Kobayashi, T., and Cohen, P. (1999) Biochem. J. 339, 319-328
34. Jensen, C. J., Buch, M. B., Krag, T. O., Hemmings, B. A., Gammeltoft, S., and Frodin, M. (1999) J. Biol. Chem. 274, 27168-27176
35. Delcommenne, M., Tan, C., Gray, V., Rue, L., Woodgett, J., and Dedhar, S. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 11211-11216
36. Balendran, A., Casamayor, A., Deak, M., Paterson, A., Gaffney, P., Currie, R., Downes, C. P., and Alessi, D. R. (1999) Curr. Biol. 9, 393-404
37. Toker A., and Newton, A. C. (2000) J. Biol. Chem. 275, 8271-8274
38. Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovic, M., and Hemmings, B. A. (1995) Nature 378, 785-789
39. Scott, P. H., Brunn, G. J., Kohn, A. D., Roth, R. A., and Lawrence, J. C. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 7772-7777
40. Gingras, A. C., Kennedy, S. G., O'Leary, M. A., Sonenberg, N., and Hay, N. (1998) Genes Dev. 12, 502-513
41. Deprez, J., Vertommen, D., Alessi, D. R., Hue, L., and Rider, M. H. (1997) J. Biol. Chem. 272, 17269-17275
42. Fulton, D., Gratton, J.-P., McCabe, T. J., Fontana, J., Fujio, Y., Walsh, K., Franke, T. F., Papapetropoulos, A., and Sessa, W. C. (1999) Nature 399, 597-601
43. Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., and Zeiher, A. M. (1999) Nature 399, 601-605
44. Du, K., and Montminy, M. (1998) J. Biol. Chem. 273, 32377-32379
45. Cichy, S. B., Uddin, S., Danilkovich, A., Guo, S., Klippel, A., and Unterman, T. G. (1998) J. Biol. Chem. 273, 6482-6487
46. Datta, S. R., Brunet, A., and Greenberg, M. E. (1999) Genes Dev. 13, 2905-2927
47. Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., and Greenberg, M. E. (1997) Cell 91, 231-241
48. del Peso, L., Gonzalez-Garcia, M., Page, C., Herrera, R., and Nuñez, G. (1997) Science 278, 687-689
49. Cardone, M. H., Roy, N., Stennicke, H. R., Salvesen, G. S., Franke, T. F., Stanbridge, E., Frisch, S., and Reed, J. C. (1998) Science 282, 1318-1321
50. Zundel, W., and Giaccia, A. (1998) Genes Dev. 12, 1941-1946
51. Galili, N., Davis, R. J., Fredericks, W. J., Mukhopadhyay, S., Rauscher, F. J. D., Emanuel, B. S., Rovera, G., and Barr, F. G. (1993) Nat. Genet. 5, 230-235
52. Hillion, J., Le Coniat, M., Jonveaux, P., Berger, R., and Bernard, O. A. (1997) Blood 90, 3714-3719
53. Anderson, M. J., Viars, C. S., Czekay, S., Cavenee, W. K., and Arden, K. C. (1998) Genomics 47, 187-199
54. Borkhardt, A., Repp, R., Haas, O. A., Leis, T., Harbott, J., Kreuder, J., Hammermann, J., Henn, T., and Lampert, F. (1997) Oncogene 14, 195-202
55. Alessi, D. R., Caudwell, F. B., Andjelkovic, M., Hemmings, B. A., and Cohen, P. (1996) FEBS Lett. 399, 333-338
56. Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., and Greenberg, M. E. (1999) Cell 96, 857-868
57. Biggs, W. H., Meisenhelder, J., Hunter, T., Cavenee, W. K., and Arden, K. C. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 7421-7426
58. Tang, E. D., Nuñez, G., Barr, F. G., and Guan, K.-L. (1999) J. Biol. Chem. 274, 16741-16746
59. Guo, S., Rena, G., Cichy, S., He, X., Cohen, P., and Unterman, T. (1999) J. Biol. Chem. 274, 17184-17192
60. Andersson, S., Davie, D. N., Dahlback, H., Jornwall, H., and Russell, D. W. (1989) J. Biol. Chem. 264, 8222-8229
61. Bellacosa, A., Franke, T. F., Gonzalez-Portal, M. E., Datta, K., Taguchi, T., Gardner, J., Cheng, J. Q., Testa, J. R., and Tsichlis, P. N. (1993) Oncogene 8, 745-754
62. Schubert, K. M., Scheid, M. P., and Duronio, V. (2000) J. Biol. Chem. 275, 13330-13335
63. Walker, K. S., Deak, M., Paterson, A., Hudson, K., Cohen, P., and Alessi, D. R. (1998) Biochem. J. 331, 299-308
64. Groenen, P. J. T. A., Wansink, D. G., Coerwinkel, M., van den Broek, W., Jansen, G., and Wieringa, B. (2000) Hum. Mol. Genet. 9, 605-616
65. Chalfant, C. E., Watson, J. E., Bisnauth, L. D., Kang, J. B., Patel, N., Obeid, L. M., Eichler, D. C., and Cooper, D. R. (1998) J. Biol. Chem. 273, 910-916
66. Blobe, G. C., Stribling, D. S., Fabbro, D., Stabel, S., and Hannun, Y. A. (1996) J. Biol. Chem. 271, 15823-15830
67. Andjelkovic, M., Maira, S.-M., Cron, P., Parker, P. J., and Hemmings, B. A. (1999) Mol. Cell. Biol. 19, 5061-5072