-
1
-
-
0028352860
-
Tyrosine kinase-deficient mutant human insulin receptors (Met1153->lle) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4
-
Quon MJ, Guerre-Millo M, Zarnowski MJ, Butte AJ, Em M, Cushman SW, Taylor SI 1994 Tyrosine kinase-deficient mutant human insulin receptors (Met1153->lle) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4. Proc Natl Acad Sci USA 91:5587-5591
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 5587-5591
-
-
Quon, M.J.1
Guerre-Millo, M.2
Zarnowski, M.J.3
Butte, A.J.4
Em, M.5
Cushman, S.W.6
Taylor, S.I.7
-
2
-
-
0028132214
-
Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells
-
Quon MJ, Butte AJ, Zarnowski MJ, Sesti G, Cushman SW, Taylor SI 1994 Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells. J Biol Chem 269:27920-27924
-
(1994)
J Biol Chem
, vol.269
, pp. 27920-27924
-
-
Quon, M.J.1
Butte, A.J.2
Zarnowski, M.J.3
Sesti, G.4
Cushman, S.W.5
Taylor, S.I.6
-
3
-
-
0029120061
-
Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells
-
Quon MJ, Chen H, Ing BL, Liu ML, Zarnowski MJ, Yonezawa K, Kasuga M, Cushman SW, Taylor SI 1995 Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells. Mol Cell Biol 15:5403-5411
-
(1995)
Mol Cell Biol
, vol.15
, pp. 5403-5411
-
-
Quon, M.J.1
Chen, H.2
Ing, B.L.3
Liu, M.L.4
Zarnowski, M.J.5
Yonezawa, K.6
Kasuga, M.7
Cushman, S.W.8
Taylor, S.I.9
-
5
-
-
0028032894
-
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
-
Tamemoto H, Kadowaki T, Tobe K, Yagi T, Sakura H, Hayakawa T, Terauchi Y, Ueki K, Kaburagi Y, Satoh S, et al 1994 Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372:182-186
-
(1994)
Nature
, vol.372
, pp. 182-186
-
-
Tamemoto, H.1
Kadowaki, T.2
Tobe, K.3
Yagi, T.4
Sakura, H.5
Hayakawa, T.6
Terauchi, Y.7
Ueki, K.8
Kaburagi, Y.9
Satoh, S.10
-
6
-
-
0028032895
-
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
-
Araki E, Lipes MA, Patti ME, Bruning JC, Haag BR, Johnson RS, Kahn CR 1994 Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 372:186-190
-
(1994)
Nature
, vol.372
, pp. 186-190
-
-
Araki, E.1
Lipes, M.A.2
Patti, M.E.3
Bruning, J.C.4
Haag, B.R.5
Johnson, R.S.6
Kahn, C.R.7
-
7
-
-
0029795178
-
Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote Glut 4 translocation in adipocytes
-
Tanti JF, Gremeaux T, Grillo S, Calleja V, Klippel A, Williams LT, Van Obberghen E, Le Marchand-Brustel Y 1996 Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote Glut 4 translocation in adipocytes. J Biol Chem 271:25227-25232
-
(1996)
J Biol Chem
, vol.271
, pp. 25227-25232
-
-
Tanti, J.F.1
Gremeaux, T.2
Grillo, S.3
Calleja, V.4
Klippel, A.5
Williams, L.T.6
Van Obberghen, E.7
Le Marchand-Brustel, Y.8
-
8
-
-
0031022582
-
Differential effects of constitutively active phosphatidylinositol 3- Kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes
-
Frevert EU, Kahn BB 1997 Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes. Mol Cell Biol 17:190-198
-
(1997)
Mol Cell Biol
, vol.17
, pp. 190-198
-
-
Frevert, E.U.1
Kahn, B.B.2
-
9
-
-
0029113787
-
Molecular actions of insulin on glucose transport
-
Czech MP 1995 Molecular actions of insulin on glucose transport. Annu Rev Nutr 15:441-471
-
(1995)
Annu Rev Nutr
, vol.15
, pp. 441-471
-
-
Czech, M.P.1
-
10
-
-
0030907987
-
PI3K: Down-stream AKTion blocks apoptosis
-
Franke TF, Kaplan DR, Cantley LC 1997 PI3K: down-stream AKTion blocks apoptosis. Cell 88:435-437
-
(1997)
Cell
, vol.88
, pp. 435-437
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
-
11
-
-
0029891232
-
Expression of a constitutively activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation
-
Magun R, Burgering BM, Coffer PJ, Pardasani D, Lin Y, Chabot J, Sorisky A 1996 Expression of a constitutively activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation. Endocrinology 137:3590-3593
-
(1996)
Endocrinology
, vol.137
, pp. 3590-3593
-
-
Magun, R.1
Burgering, B.M.2
Coffer, P.J.3
Pardasani, D.4
Lin, Y.5
Chabot, J.6
Sorisky, A.7
-
12
-
-
0029908016
-
Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
-
Kohn AD, Summers SA, Birnbaum MJ, Roth RA 1996 Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem 271: 31372-31378
-
(1996)
J Biol Chem
, vol.271
, pp. 31372-31378
-
-
Kohn, A.D.1
Summers, S.A.2
Birnbaum, M.J.3
Roth, R.A.4
-
13
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
Cross DAE, Alessi DR, Cohen P, Andjelkovich M, Hammings BA 1995 Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785-789
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.E.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hammings, B.A.5
-
14
-
-
0029160069
-
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
-
Burgering BM, Coffer PJ 1995 Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376:599-602
-
(1995)
Nature
, vol.376
, pp. 599-602
-
-
Burgering, B.M.1
Coffer, P.J.2
-
15
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA 1996 Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15:6541-6551
-
(1996)
EMBO J
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
Hemmings, B.A.7
-
16
-
-
0031028730
-
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
-
Kauffmann-Zeh A, Rodriguez-Viciana P, Ulrich E, Gilbert C, Coffer P, Downward J, Evan G 1997 Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature 385:544-548
-
(1997)
Nature
, vol.385
, pp. 544-548
-
-
Kauffmann-Zeh, A.1
Rodriguez-Viciana, P.2
Ulrich, E.3
Gilbert, C.4
Coffer, P.5
Downward, J.6
Evan, G.7
-
17
-
-
0028170817
-
Receptor protein-tyrosine kinases and their signal transduction pathways
-
van der Geer P, Hunter T, Lindberg RA 1994 Receptor protein-tyrosine kinases and their signal transduction pathways. Annu Rev Cell Biol 10:251-337
-
(1994)
Annu Rev Cell Biol
, vol.10
, pp. 251-337
-
-
Van Der Geer, P.1
Hunter, T.2
Lindberg, R.A.3
-
19
-
-
0030600403
-
Effects of overexpressing wild-type and mutant PDGF receptors on translocation of GLUT4 in transfected rat adipose cells
-
Quon MJ, Chen H, Lin CH, Zhou L, Zarnowski MJ, Klinghoffer R, Kazlauskas A, Cushman SW, Taylor SI 1996 Effects of overexpressing wild-type and mutant PDGF receptors on translocation of GLUT4 in transfected rat adipose cells. Biochem Biophys Res Commun 226:587-594
-
(1996)
Biochem Biophys Res Commun
, vol.226
, pp. 587-594
-
-
Quon, M.J.1
Chen, H.2
Lin, C.H.3
Zhou, L.4
Zarnowski, M.J.5
Klinghoffer, R.6
Kazlauskas, A.7
Cushman, S.W.8
Taylor, S.I.9
-
20
-
-
0028865424
-
The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake
-
Isakoff SJ, Taha C, Rose E, Marcusohn J, Klip A, Skolnik EY 1995 The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake. Proc Natl Acad Sci USA 92:10247-10251
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 10247-10251
-
-
Isakoff, S.J.1
Taha, C.2
Rose, E.3
Marcusohn, J.4
Klip, A.5
Skolnik, E.Y.6
-
21
-
-
0029966086
-
Insulin-mediated targeting of phosphatidylinositol 3-kinase to GLUT4-containing vesicles
-
Heller-Harrison RA, Morin M, Guilherme A, Czech MP 1996 Insulin-mediated targeting of phosphatidylinositol 3-kinase to GLUT4-containing vesicles. J Biol Chem 271:10200-10204
-
(1996)
J Biol Chem
, vol.271
, pp. 10200-10204
-
-
Heller-Harrison, R.A.1
Morin, M.2
Guilherme, A.3
Czech, M.P.4
-
23
-
-
0031034574
-
Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
-
Kulik G, Klippel A, Weber MJ 1997 Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol Cell Biol 17: 1595-1606
-
(1997)
Mol Cell Biol
, vol.17
, pp. 1595-1606
-
-
Kulik, G.1
Klippel, A.2
Weber, M.J.3
-
24
-
-
0031053586
-
Regulation of neuronal survival by the serine-threonine protein kinase Akt
-
Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME 1997 Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275:661-665
-
(1997)
Science
, vol.275
, pp. 661-665
-
-
Dudek, H.1
Datta, S.R.2
Franke, T.F.3
Birnbaum, M.J.4
Yao, R.5
Cooper, G.M.6
Segal, R.A.7
Kaplan, D.R.8
Greenberg, M.E.9
-
25
-
-
0029079275
-
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
-
Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN 1995 The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81:727-736
-
(1995)
Cell
, vol.81
, pp. 727-736
-
-
Franke, T.F.1
Yang, S.I.2
Chan, T.O.3
Datta, K.4
Kazlauskas, A.5
Morrison, D.K.6
Kaplan, D.R.7
Tsichlis, P.N.8
-
26
-
-
0029143388
-
Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase
-
Kohn AD, Kovacina KS, Roth RA 1995 Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase. EMBO J 14:4288-4295
-
(1995)
EMBO J
, vol.14
, pp. 4288-4295
-
-
Kohn, A.D.1
Kovacina, K.S.2
Roth, R.A.3
-
27
-
-
0029807471
-
Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells
-
Datta K, Bellacosa A, Chan TO, Tsichlis PN 1996 Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells. J Biol Chem 271:30835-30839
-
(1996)
J Biol Chem
, vol.271
, pp. 30835-30839
-
-
Datta, K.1
Bellacosa, A.2
Chan, T.O.3
Tsichlis, P.N.4
-
28
-
-
0031015986
-
A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain
-
Klippel A, Kavanaugh WM, Pot D, Williams LT 1997 A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain. Mol Cell Biol 17:338-344
-
(1997)
Mol Cell Biol
, vol.17
, pp. 338-344
-
-
Klippel, A.1
Kavanaugh, W.M.2
Pot, D.3
Williams, L.T.4
-
29
-
-
0031039024
-
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
-
Franke TF, Kaplan DR, Cantley LC, Toker A 1997 Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275:665-668
-
(1997)
Science
, vol.275
, pp. 665-668
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
Toker, A.4
-
30
-
-
0027242129
-
The proteins encoded by c-akt and v-akt differ in post-translational modification, subcellular localization and oncogenic potential
-
Ahmed NN, Franke TF, Bellacosa A, Datta K, Gonzalez-Portal ME, Taguchi T, Testa JR, Tsichlis PN 1993 The proteins encoded by c-akt and v-akt differ in post-translational modification, subcellular localization and oncogenic potential. Oncogene 8:1957-1963
-
(1993)
Oncogene
, vol.8
, pp. 1957-1963
-
-
Ahmed, N.N.1
Franke, T.F.2
Bellacosa, A.3
Datta, K.4
Gonzalez-Portal, M.E.5
Taguchi, T.6
Testa, J.R.7
Tsichlis, P.N.8
-
31
-
-
0027465113
-
Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes
-
Spiegelman BM, Choy L, Hotamisligil GS, Graves RA, Tontonoz P 1993 Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes. J Biol Chem 268:6823-6826
-
(1993)
J Biol Chem
, vol.268
, pp. 6823-6826
-
-
Spiegelman, B.M.1
Choy, L.2
Hotamisligil, G.S.3
Graves, R.A.4
Tontonoz, P.5
-
32
-
-
0029062839
-
Transcriptional regulation of gene expression during adipocyte differentiation
-
MacDougald OA, Lane MD 1995 Transcriptional regulation of gene expression during adipocyte differentiation. Annu Rev Biochem 64:345-373
-
(1995)
Annu Rev Biochem
, vol.64
, pp. 345-373
-
-
MacDougald, O.A.1
Lane, M.D.2
-
33
-
-
0028641559
-
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
-
Tontonoz P, Hu E, Spiegelman BM 1994 Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 79:1147-1156
-
(1994)
Cell
, vol.79
, pp. 1147-1156
-
-
Tontonoz, P.1
Hu, E.2
Spiegelman, B.M.3
-
34
-
-
0030046879
-
Characterization of a mutant GLUT4 lacking the N-glycosylation site: Studies in transfected rat adipose cells
-
Ing BL, Chen H, Robinson KA, Buse MG, Quon MJ 1996 Characterization of a mutant GLUT4 lacking the N-glycosylation site: studies in transfected rat adipose cells. Biochem Biophys Res Commun 218:76-82
-
(1996)
Biochem Biophys Res Commun
, vol.218
, pp. 76-82
-
-
Ing, B.L.1
Chen, H.2
Robinson, K.A.3
Buse, M.G.4
Quon, M.J.5
-
35
-
-
0030961536
-
Protein-tyrosine phosphatases PTP1B and Syp are modulators of insulin-stimulated translocation of GLUT4 in transfected rat adipose cells
-
Chen H, Wertheimer SJ, Lin CH, Katz SL, Amrein KE, Burn P, Quon MJ 1997 Protein-tyrosine phosphatases PTP1B and Syp are modulators of insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. J Biol Chem 272:8026-8031
-
(1997)
J Biol Chem
, vol.272
, pp. 8026-8031
-
-
Chen, H.1
Wertheimer, S.J.2
Lin, C.H.3
Katz, S.L.4
Amrein, K.E.5
Burn, P.6
Quon, M.J.7
-
36
-
-
0029942186
-
Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors
-
Andjelkovic M, Jakubowicz T, Cron P, Ming XF, Han JW, Hemmings BA 1996 Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc Natl Acad Sci USA 93: 5699-5704
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 5699-5704
-
-
Andjelkovic, M.1
Jakubowicz, T.2
Cron, P.3
Ming, X.F.4
Han, J.W.5
Hemmings, B.A.6
-
37
-
-
0027284458
-
Transfection of DNA into isolated rat adipose cells by electroporation: Evaluation of promoter activity in transfected adipose cells which are highly responsive to insulin after one day in culture
-
Quon MJ, Zarnowski MJ, Guerre-Millo M, de la Luz Sierra M, Taylor SI, Cushman SW 1993 Transfection of DNA into isolated rat adipose cells by electroporation: evaluation of promoter activity in transfected adipose cells which are highly responsive to insulin after one day in culture. Biochem Biophys Res Commun 194:338-346
-
(1993)
Biochem Biophys Res Commun
, vol.194
, pp. 338-346
-
-
Quon, M.J.1
Zarnowski, M.J.2
Guerre-Millo, M.3
De La Luz Sierra, M.4
Taylor, S.I.5
Cushman, S.W.6
-
38
-
-
0029943605
-
Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
-
Klippel A, Reinhard C, Kavanaugh WM, Apell G, Escobedo MA, Williams LT 1996 Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol Cell Biol 16:4117-4127
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4117-4127
-
-
Klippel, A.1
Reinhard, C.2
Kavanaugh, W.M.3
Apell, G.4
Escobedo, M.A.5
Williams, L.T.6
-
39
-
-
0019861360
-
Insulin- Stimulated translocation of glucose transport systems in the isolated rat adipose cell. Time course, reversal, insulin concentration dependency, and relationship to glucose transport activity
-
Karnieli E, Zarnowski MJ, Hissin PJ, Simpson IA, Salans LB, Cushman SW 1981 Insulin-stimulated translocation of glucose transport systems in the isolated rat adipose cell. Time course, reversal, insulin concentration dependency, and relationship to glucose transport activity. J Biol Chem 256:4772-4777
-
(1981)
J Biol Chem
, vol.256
, pp. 4772-4777
-
-
Karnieli, E.1
Zarnowski, M.J.2
Hissin, P.J.3
Simpson, I.A.4
Salans, L.B.5
Cushman, S.W.6
-
40
-
-
0017904216
-
Determinations of adipose cell size and number in suspensions of isolated rat and human adipose cells
-
Cushman SW, Salans LB 1978 Determinations of adipose cell size and number in suspensions of isolated rat and human adipose cells. J Lipid Res 19:269-273
-
(1978)
J Lipid Res
, vol.19
, pp. 269-273
-
-
Cushman, S.W.1
Salans, L.B.2
|