Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice

Nature Genetics

Volumn 23, Issue 1, 1999, Pages 71-75

  Harrison, Kathleen A ^a   Thaler, Joshua ^b   Pfaff, Samuel L ^b   Gu, Hua ^c   Kehrl, John H ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER; HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR;

AGENESIS; ARTICLE; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; GENE SEQUENCE; GENE TARGETING; HOMEOBOX; HUMAN; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGANOGENESIS; PANCREAS; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; DNA-BINDING PROTEINS; EYE PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; GENOTYPE; GLUCAGON; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN; ISLETS OF LANGERHANS; MICE; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MOTOR NEURONS; NERVE TISSUE PROTEINS; PAIRED BOX TRANSCRIPTION FACTORS; PANCREAS; PANCREATIC POLYPEPTIDE; REPRESSOR PROTEINS; SOMATOSTATIN; TIME FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

MAMMALIA; RODENTIA;

EID: 0032860478     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/12674     Document Type: Article

References (26)

1. Githens, S. Differentiation and development of the pancreas in animals. in The Pancreas: Biology, Pathobiology, and Disease (ed. Go, V.L.W.) 21-55 (Raven Press, New York, 1993).
2. Slack, J.M. Developmental biology of the pancreas. Development 121, 1569-80 (1995).
3. Jonsson, J., Carlsson, L., Edlund, T. & Edlund, H. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371, 606-609 (1994).
4. Ahlgren, U., Jonsson, J. & Edlund, H. The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development 122, 1409-1416 (1996).
5. Offield, M.F. et al. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122, 983-995 (1996).
6. Ahlgren, U., Pfaff, S.L., Jessell, T.M., Edlund, T. & Edlund, H. Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. Nature 385, 257-260 (1997).
7. Sosa-Pineda, B., Chowdhury, K., Torres, M., Oliver, G. & Gruss, P. The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas. Nature 386, 399-402 (1997).
8. St-Onge, L., Sosa-Pineda, B., Chowdhury, K., Mansouri, A. & Gruss, P. Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas. Nature 387, 406-409 (1997).
9. Sander, M. et al. Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev. 11, 1662-1673 (1997).
10. Sussel, L. et al. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cells. Development 125, 2213-2221 (1998).
11. Harrison, K.A., Druey, K.M., Deguchi, Y., Tuscano, J.M. & Kehrl, J.H. A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues. J. Biol. Chem. 269, 19968-19975 (1994).
12. Baubonis, W. & Sauer, B. Genomic targeting with purified Cre recombinase. Nucleic Acids Res. 21, 2025-2029 (1993).
13. Gu, H., Zou, Y.R. & Rajewsky, K. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 73, 1155-1164 (1993).
14. Thaler, J. et al. Active suppression of interneuron programs within developing motor neurons revealed by the analysis of homeodomain factor HB9. Neuron (in press).
15. Ross, A.J. et al. A homeobox gene, HLXB9, is the major locus for dominantly inherited sacral agenesis. Nature Genet. 20, 358-361 (1998).
16. Wu, K.L. et al. Hepatocyte nuclear factor 3β is involved in pancreatic β-cell-specific transcription of the pdx-1 gene. Mol. Cell. Biol. 17, 6002-6013 (1997).
17. Thorens, B., Sarkar, H.K., Kaback, H.R. & Lodish, H.F. Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and β-pancreatic islet cells. Cell 55, 281-290 (1988).
18. Jensen, J., Serup, P., Karlsen, C., Nielsen, T.F. & Madsen, O.D. mRNA profiling of rat islet tumors reveals Nkx 6.1 as a β-cell-specific homeodomain transcription factor. J. Biol. Chem. 271, 18749-18758 (1996).
19. Ahlgren, U., Jonsson, J., Jonsson, L., Simu, K. & Edlund, H. β-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes. Genes Dev. 12, 1763-1768 (1998).
20. Kim, S.K., Hebrok, M. & Melton, D.A. Notochord to endoderm signaling is required for pancreas development. Development 124, 4243-4252 (1997).
21. Hebrok, M., Kim, S.K. & Melton, D.A. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev. 12, 1705-1713 (1998).
22. Apelqvist, A., Ahlgren, U. & Edlund, H. Sonic hedgehog directs specialized mesoderm differentiation in the intestine and pancreas. Curr. Biol. 7, 801-804 (1997).
23. Rudnick, A., Ling, T.Y., Odagiri, H., Rutter, W.J. & German, M.S. Pancreatic β cells express a diverse set of homeobox genes. Proc. Natl Acad. Sci. USA 91, 12203-12207 (1994).
24. Sander, M. & German, M.S. The β-cell transcription factors and development of the pancreas. J. Mol. Med. 75, 327-340 (1997).
25. Thor, S., Andersson, S.G., Tomlinson, A. & Thomas, J.B. A LIM-homeodomain combinatorial code for motor-neuron pathway selection. Nature 397, 76-80 (1999).
26. Pfaff, S.L., Mendelsohn, M., Stewart, C.L., Edlund, T. & Jessell, T.M. Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. Cell 84, 309-320 (1996).