Regulation of insulin gene transcription

Seminars in Cell and Developmental Biology

Volumn 11, Issue 4, 2000, Pages 227-233

  Ohneda, Kinuko ^a,b   Ee, Hooi ^a   German, Michael ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c PATHWEST LABORATORY MEDICINE   (Australia)

Author keywords

BETA2; Glucose; Insulin gene; NeuroD1; Transcription

Indexed keywords

GLUCOSE; INSULIN; TRANSCRIPTION FACTOR;

GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE SEQUENCE; GENETIC TRANSCRIPTION; INSULIN RELEASE; INSULIN SYNTHESIS; PANCREAS ISLET BETA CELL; PROMOTER REGION; PROTEIN BINDING; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0034507714     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1006/scdb.2000.0171     Document Type: Article

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10. Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic β-cells and lymphocytes
11. Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene
12. Two related helix-loop-helix proteins participate in separate cell-specific complexes that bind to the insulin enhancer
13. Pancreatic β-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins
14. Two distinct class A helix-loop-helix transcription factors, E2A and BETA1, form separate DNA binding complexes on the insulin gene E box
15. Tissue-specific regulation of the insulin gene by a basic helix-loop-helix transcription factor
16. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein
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21. Pancreatic beta cells express a diverse set of homeobox genes
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24. Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1
25. Functional characterization of the transactivation properties of the PDX-1 homeodomain protein
26. The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin gene promoter
27. Higher-order nucleoprotein complexes in transcription: Analogies with site-specific recombination
28. The enhanceosome and transcriptional synergy
29. The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells
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31. p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene
32. Regulation of insulin gene expression by glucose and calcium in transfected primary islet cultures
33. Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters
34. The insulin gene contains multiple transcriptional elements that respond to glucose
35. Glucose-induced transcription of the insulin gene is mediated by factors required for beta-cell-type-specific expression
36. Function of the human insulin promoter in primary cultured islet cells
37. A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured islets
38. The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells
39. Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells
40. Glucose-dependent translocation of insulin promoter factor-1 (IPF-1) between the nuclear periphery and the nucleoplasm of single MIN6 beta-cells
41. Glucose stimulates the activation domain potential of the PDX-1 homeodomain transcription factor
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43. Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: The LIM2 domain determines specificity
44. Insulin-promoter-factor 1 is required for pancreas development in mice
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46. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
47. Beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes
48. Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells
49. A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues
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53. The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: Importance of the FPWMK motif and of the homedomain
54. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells