Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: Evaluation of their relation with alterations in insulin secretion and insulin sensitivity

Diabetologia

Volumn 42, Issue 10, 1999, Pages 1244-1249

  Almind, K ^a   Frederiksen, S K ^a   Bernal, D ^c   Hansen, T ^a   Ambye, L ^a   Urhammer, S ^a   Ekstrom C T ^a   Berglund, L ^c   Reneland, R ^c   Lithell, H ^c   White, M F ^b   Van Obberghen, E ^c   Pedersen, O ^a  

^a STENO DIABETES CENTER   (Denmark)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Steno Diabetes Centre ^*

Author keywords

Insulin receptor substrate 2; Insulin secretion; Insulin sensitivity; Mutations; Type II diabetes

Indexed keywords

INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 2; MUTANT PROTEIN; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; CODON; DENMARK; DNA POLYMORPHISM; FEMALE; GENE SEQUENCE; GENETIC VARIABILITY; HUMAN; INSULIN RELEASE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SINGLE STRAND CONFORMATION POLYMORPHISM; SWEDEN;

ADOLESCENT; ADULT; AGED; AMINO ACID SUBSTITUTION; BASE SEQUENCE; DIABETES MELLITUS, TYPE 2; GENE FREQUENCY; GENETIC SCREENING; GLUCOSE TOLERANCE TEST; HETEROZYGOTE DETECTION; HUMANS; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PEDIGREE; PHOSPHOPROTEINS; PHOSPHOTYROSINE; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROMOTER REGIONS (GENETICS); PROSPECTIVE STUDIES; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 0032822218     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051299     Document Type: Article

References (10)

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