Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3

Molecular and Cellular Biology

Volumn 20, Issue 12, 2000, Pages 4445-4454

  Jacquemin, Patrick ^a   Durviaux, Serge M ^a   Jensen, Jan ^b   Godfraind, Catherine ^c   Gradwohl, Gerard ^d   Guillemot, François ^d   Madsen, Ole D ^b   Carmeliet, Peter ^e   Dewerchin, Mieke ^e   Collen, Désiré ^e   Rousseau, Guy G ^a   Lemaigre, Frédéric P ^a,f  

^a DE DUVE INSTITUTE   (Belgium)

^b HAGEDORN RESEARCH INSTITUTE   (Denmark)

^c UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^d INSERM   (France)

^e DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^f Box 7529 ^*  (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROGENIN 3; NUCLEAR FACTOR; NUCLEAR FACTOR 6; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DIABETES MELLITUS; GENE EXPRESSION REGULATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; HEPATOCYTE NUCLEAR FACTOR 6; HOMEODOMAIN PROTEINS; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; PANCREAS; TRANS-ACTIVATORS;

ANIMALIA; MAMMALIA;

EID: 19244372001     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.12.4445-4454.2000     Document Type: Article

References (36)

1. Ahlgren, U., S. L. Pfaff, T. M. Jessell, T. Edlund, and H. Edlund. 1997. Independent requirement for Isl1 in formation of pancreatic mesenchyme and islet cells. Nature 385:257-260.
2. Ahlgren, U., J. Jonsson, L. Jonsson, K. Simu, and H. Edlund. 1998. β-Cell-specific inactivation of the mouse Ipf1/PdxI gene results in loss of the β-cell phenotype and maturity onset diabetes. Genes Dev. 12:1673-1768.
3. Apelqvist, A., H. Li, L. Sommer, P. Beatus, D. J. Anderson, T. Honjo, M. Hrabe de Angelis, U. Lendahl, and H. Edlund. 1999. Notch signalling controls pancreatic cell differentiation. Nature 400:877-881.
4. Bonner-Weir, S., L. A. Baxter, G. T. Schuppin, and F. E. Smith. 1993. A second pathway for regeneration of adult exocrine and endocrine pancreas. Diabetes 42:1715-1720.
5. Boyd, K. E., and P. J. Farnham. 1999. Coexamination of site-specific transcription factor binding and promoter activity in living cells. Mol. Cell. Biol. 19:8393-8399.
6. Carmeliet, P., V. Ferreira, G. Breier, S. Pollefeyt, L. Kieckens, M. Gertsenstein, M. Fahrig, A. Vandenhoeck, K. Harpal, C. Eberhardt, C. Declercq, J. Pawling, L. Moons, D. Collen, W. Risau, and A. Nagy. 1996. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380:435-439.
7. Cau, E., G. Gradwohl, C. Fode, and F. Guillemot. 1997. Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors. Development 124:1611-1621.
8. Edlund, H. 1998. Transcribing pancreas. Diabetes 47:1817-1823.
9. Fode, C., Q. Ma, S. Casarosa, S.-L. Ang, D. J. Anderson, and F. Guillemot. 2000. A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons. Genes Dev. 14:67-80.
10. Gradwohl, G., A. Dierich, M. LeMeur, and F. Guillemot. 2000. Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc. Natl. Acad. Sci. USA 97:1607-1611.
11. Groop, L., and M. Lehto. 1999. Molecular and physiological basis for maturity onset diabetes of youth. Curr. Opin. Endocrinol. Diabetes 6:157-162.
12. Guillam, M. T., E. Hümmler, E. Schaerer, J.-Y. Wu, M. J. Birnbaum, F. Beermann, A. Schmidt, N. Dériaz, and B. Thorens. 1997. Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2. Nat. Genet. 17:327-330.
13. Harrison, K. A., J. Thaler, S. L. Pfaff, H. Gu, and J. H. Kehrl. 1999. Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. Nat. Genet. 23:71-75.
14. Jacquemin, P., V. J. Lannoy, G. G. Rousseau, and F. P. Lemaigre. 1999. OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of HNF-6. J. Biol. Chem. 274:2665-2671.
15. Jensen, J., P. Serup, C. Karlsen, T. Funder Neilsen, and O. D. Madsen. 1996. mRNA profiling of rat islet tumors reveals Nkx6.1 as a β-cell-specific homeodomain transcription factor. J. Biol. Chem. 271:18749-18758.
16. Jensen, J., R. S. Heller, T. Funder-Nielsen, E. E. Pedersen, C. Lindsell, G. Weinmaster, O. D. Madsen, and P. Serup. 2000 Independent development of pancreatic α- and β-cells from neurogenin3-expressing precursors. A role for the Notch pathway in repression of premature differentiation. Diabetes 49:163-176.
17. Jensen, J., E. E. Pedersen, P. Galante, J. Hald, R. S. Heller, M. Ishibashi, R. Kageyama, F. Guillemot, P. Serup, and O. D. Madsen. 2000. Control of endodermal endocrine development by hes-1. Nat. Genet. 24:36-44.
18. Jonsson, J., L. Carlsson, T. Edlund, and H. Edlund. 1994. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371:606-609.
19. Krapp, A., M. Knöfler, B. Ledermann, K. Bürki, C. Berney, N. Zoerkler, O. Hagenbüchle, and P. Wellauer. 1998. The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev. 12:3752-3763.
20. Landry, C., F. Clotman, T. Hioki, H. Oda, J. J. Picard, F. P. Lemaigre, and G. G. Rousseau. 1997. HNF-6 is expressed in endoderm derivatives and nervous system of the mouse embryo and participates to the cross-regulatory network of liver-enriched transcription factors. Dev. Biol. 192:247-257.
21. Lannoy, V. J., T. R. Bürglin, G. G. Rousseau, and F. P. Lemaigre. 1998. Isoforms of HNF-6 differ in DNA-binding properties, contain a bifunctional homeodomain and define the new ONECUT class of homeodomain proteins. J. Biol. Chem. 273:13552-13562.
22. Lemaigre, F. P., S. M. Durviaux, O. Truong, V. J. Lannoy, J. J. Hsuan, and G. G. Rousseau. 1996. Hepatocyte nuclear factor-6, a transcription factor that contains a novel type of homeodomain and a single cut domain. Proc. Natl. Acad. Sci. USA 93:9460-9464.
23. Li, H., T. M. Jessell, and H. Edlund. 1999. Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. Nat. Genet. 23:67-70.
24. Naya, F. J., H. P. Huang, Y., Qiu, H. Mutoh, F. J. DeMayo, A. B. Leiter, and M.-J. Tsai. 1997. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice. Genes Dev. 11:2323-2334.
25. Nielsen, J. H., and P. Serup. 1998. Molecular basis for islet development, growth, and regeneration. Curr. Opin. Endocrinol. Diabetes 5:97-107.
26. Offield, M. F., T. L. Jetton, P. A. Labosky, M. Ray, R. W. Stein, M. A. Magnuson, B. L. M. Hogan, and C. V. E. Wright. 1996. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122:983-995.
27. Øster, A., J. Jensen, P. Serup, P. Galante, O. D. Madsen, and L.-I. Larsson. 1998. Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx1 and Nkx6.1). J. Histochem. Cytochem. 46:707-715.
28. Pang, K., C. Mukonoweshuro, and G. G. Wong. 1994. Beta cells arise from glucose transporter type 2 (Glut2)-expressing epithelial cells of the developing rat pancreas. Proc. Natl. Acad. Sci. USA 91:9559-9563.
29. Pictet, R. L., and W. J. Rutter. 1972. Development of the endocrine pancreas, p. 25-66. In D. Steiner and N. Freinkel (ed.), Handbook of physiology: the endocrine pancreas. Williams & Wilkins, Baltimore, Md.
30. Rausa, F., U. Samadani, H. Ye, L. Lim, C. F. Fletcher, N. A. Jenkins, N. G. Copeland, and R. H. Costa. 1997. The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3β in the developing murine liver and pancreas. Dev. Biol. 192:228-246.
31. Sander, M., A. Neubüser, J. Kalamaras, H. C. Ee, G. R. Martin, and M. S. German. 1997. Genetic analysis reveals that Pax6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev. 11:1662-1673.
32. Slack, J. M. W. 1995. Developmental biology of the pancreas. Development 121:1569-1580.
33. Sosa-Pineda, B., K. Chowdury, M. Torres, G. Oliver, and P. Gruss. 1997. The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas. Nature 386:399-402.
34. St-Onge, L., B. Sosa-Pineda, K. Chowdury, and P. Gruss. 1997. Pax6 is required for the differentiation of glucagon-producing α-cells in mouse pancreas. Nature 387:406-409.
35. Sussel, L., J. Kalamaras, D. J. Hartigan-O'Connor, J. J. Meneses, R. A. Pedersen, J. L. R. Pedersen, and M. S. German. 1998. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cells. Development 125:2213-2221.
36. Wu, K. L., M. Gannon, M. Peshavaria, M. F. Offield, E. Henderson, M. Ray, A. Marks, L. W. Gamer, C. V. E. Wright, and R. Stein. 1997. Hepatocyte nuclear factor 3β is involved in pancreatic β-cell-specific transcription of the pdx1 gene. Mol. Cell. Biol. 17:6002-6013.