Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia

Nature Genetics

Volumn 22, Issue 1, 1999, Pages 44-54

  Rane, Sushil G ^a   Dubus, Pierre ^b   Mettus, Richard V ^a   Galbreath, Elizabeth J ^c   Boden, Guenther ^a   Reddy, E Premkumar ^a   Barbacid, Mariano ^d  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c ELI LILLY AND COMPANY   (United States)

^d Invest Oncol Carlos III Ctr Nac   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL HYPERPLASIA; FEMALE; FEMALE INFERTILITY; FIBROBLAST; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; IMMUNOBLOTTING; INSULIN DEFICIENCY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPERMATOGENESIS;

ANIMALS; CELL LINE; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; DIABETES MELLITUS; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION; HYPERPLASIA; INFERTILITY, FEMALE; INFERTILITY, MALE; INSULIN; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED STRAINS; MUTAGENESIS, SITE-DIRECTED; PROTO-ONCOGENE PROTEINS; SPERMATOGENESIS;

EID: 0032937751     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/8751     Document Type: Article

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