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Volumn 13, Issue 2, 1996, Pages 161-166

A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2

(33)  Hanis, C L a   Boerwinkle, E a   Chakraborty, R a   Ellsworth, D L a   Concannon, P b,c   Stirling, B b,c   Morrison, V A b,c   Wapelhorst, B b,c   Spielman, R S d   Gogolin Ewens, K J d   Shephard, J M d   Williams, S R d   Risch, N e   Hinds, D e   Iwasaki, N f   Ogata, M f   Omori, Y f   Petzold, C g   Rietzsch, H g   Schroder H E g   more..


Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME 2; DISEASE PREDISPOSITION; GENE LOCUS; GENETIC LINKAGE; GENOME; HUMAN; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RISK ASSESSMENT;

EID: 9044243415     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng0696-161     Document Type: Article
Times cited : (557)

References (44)
  • 2
    • 0027532914 scopus 로고
    • Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults
    • King, H. & Rewers, M. Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults. Diabetes Care 16, 157-177 (1993).
    • (1993) Diabetes Care , vol.16 , pp. 157-177
    • King, H.1    Rewers, M.2
  • 4
    • 0001094428 scopus 로고
    • Diabetes mellitus
    • (eds King, R.A., Rotter, J.I. & Motulsky, A.G.) Oxford University Press, New York
    • Rotter J.I., Vadheim, C.M. & Rimoin, D.L. Diabetes mellitus. in The Genetic Basis of Common Diseases. (eds King, R.A., Rotter, J.I. & Motulsky, A.G.) 413-481 (Oxford University Press, New York, 1992).
    • (1992) The Genetic Basis of Common Diseases , pp. 413-481
    • Rotter, J.I.1    Vadheim, C.M.2    Rimoin, D.L.3
  • 5
    • 0028817665 scopus 로고
    • Type II diabetes: Clinical aspects of molecular biological studies
    • Turner, R.C., Hattersley, A.T., Shaw, J.T.E. & Levy, J.C. Type II diabetes: clinical aspects of molecular biological studies. Diabetes 44, 1-10 (1995).
    • (1995) Diabetes , vol.44 , pp. 1-10
    • Turner, R.C.1    Hattersley, A.T.2    Shaw, J.T.E.3    Levy, J.C.4
  • 6
    • 0024425880 scopus 로고
    • Maturity-onset diabetes of the young
    • Fajans, S.S. Maturity-onset diabetes of the young. Diabetes/Metab. Rev. 5, 579-606 (1989).
    • (1989) Diabetes/Metab. Rev. , vol.5 , pp. 579-606
    • Fajans, S.S.1
  • 7
    • 0028907342 scopus 로고
    • A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q
    • Vaxillaire, M, et al. A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q. Nature Genet. 9, 418-423 (1995).
    • (1995) Nature Genet. , vol.9 , pp. 418-423
    • Vaxillaire, M.1
  • 8
    • 0029002588 scopus 로고
    • Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20
    • Byrne, M.M. et al. Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20. Diabetes 44, 699-704 (1995).
    • (1995) Diabetes , vol.44 , pp. 699-704
    • Byrne, M.M.1
  • 9
    • 0027472126 scopus 로고
    • Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus
    • Froguel, P. et al. Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus. N. Engl. J. Med. 328, 697-702, 1993.
    • (1993) N. Engl. J. Med. , vol.328 , pp. 697-702
    • Froguel, P.1
  • 10
    • 0028826361 scopus 로고
    • Transgenic knockouts reveal a critical requirement for pancreatic β cell glucokinase in maintaining glucose homeostasis
    • Grupe, A. et al. Transgenic knockouts reveal a critical requirement for pancreatic β cell glucokinase in maintaining glucose homeostasis. Cell 83, 69-78 (1995).
    • (1995) Cell , vol.83 , pp. 69-78
    • Grupe, A.1
  • 11
    • 0026849690 scopus 로고
    • Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion
    • Ballinger, S.W. et al. Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion. Nature Genet. 1, 11-15 (1992).
    • (1992) Nature Genet. , vol.1 , pp. 11-15
    • Ballinger, S.W.1
  • 12
    • 0026906885 scopus 로고
    • Leu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness
    • Leu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness. Nature Genet. 1, 368-371 (1992).
    • (1992) Nature Genet. , vol.1 , pp. 368-371
    • Van Den Ouweland, J.M.V.1
  • 13
    • 0000689386 scopus 로고
    • Familial syndromes of hyperproinsulinemia and hyperinsulinemia with mild diabetes
    • (eds Scriver, C.R., Beaudet, A.L., Sly, W.S. & Valle, D.) McGraw-Hill, Inc., New York
    • Steiner, D.F., Tager, H.S., Nanjo, K., Chan, S.J. & Rubenstein, A.H. Familial syndromes of hyperproinsulinemia and hyperinsulinemia with mild diabetes. In The Metabolic and Molecular Bases of Inherited Disease. (eds Scriver, C.R., Beaudet, A.L., Sly, W.S. & Valle, D.) 897-904 (McGraw-Hill, Inc., New York, 1995).
    • (1995) The Metabolic and Molecular Bases of Inherited Disease , pp. 897-904
    • Steiner, D.F.1    Tager, H.S.2    Nanjo, K.3    Chan, S.J.4    Rubenstein, A.H.5
  • 14
    • 0000743525 scopus 로고
    • Diabetes mellitus
    • (eds Scriver, C.R., Beaudet, A.L., Sly, W.S. & Valle, D.) McGraw-Hill, Inc., New York
    • Taylor, S.I. Diabetes mellitus. in The Metabolic ana Molecular Bases of Inherited Disease. (eds Scriver, C.R., Beaudet, A.L., Sly, W.S. & Valle, D.) 843-896 (McGraw-Hill, Inc., New York, 1995).
    • (1995) The Metabolic Ana Molecular Bases of Inherited Disease , pp. 843-896
    • Taylor, S.I.1
  • 15
    • 0026969347 scopus 로고
    • Genetic and environmental determinants of non-insulin-dependent diabetes mellitus (NIDDM)
    • Hamman, R.F. Genetic and environmental determinants of non-insulin-dependent diabetes mellitus (NIDDM). Diabetes Metab. Rev. 8, 287-338 (1992).
    • (1992) Diabetes Metab. Rev. , vol.8 , pp. 287-338
    • Hamman, R.F.1
  • 16
    • 0028877463 scopus 로고
    • Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
    • Lander, E. & Kruglyak, L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet. 11, 241-247 (1995).
    • (1995) Nature Genet. , vol.11 , pp. 241-247
    • Lander, E.1    Kruglyak, L.2
  • 17
    • 0027393068 scopus 로고
    • Mortality of Mexican Americans with NIDDM: Retinopathy and other predictors in Starr County, Texas
    • Hanis, C.L. et al. Mortality of Mexican Americans with NIDDM: retinopathy and other predictors in Starr County, Texas. Diabetes Care 16, 82-89 (1993).
    • (1993) Diabetes Care , vol.16 , pp. 82-89
    • Hanis, C.L.1
  • 19
    • 0027529253 scopus 로고
    • Asymptotic properties of affected-sib-pair linkage analysis
    • Holmans, P. Asymptotic properties of affected-sib-pair linkage analysis. Am. J. Hum. Genet. 52, 362-374 (1993).
    • (1993) Am. J. Hum. Genet. , vol.52 , pp. 362-374
    • Holmans, P.1
  • 20
    • 0028832203 scopus 로고
    • Efficiency of typing unaffected relatives in an affected-sib-pair linkage study with single-locus and multiple tightly linked markers
    • Holmans, P. & Clayton, D. Efficiency of typing unaffected relatives in an affected-sib-pair linkage study with single-locus and multiple tightly linked markers. Am. J. Hum. Genet. 57, 1221-1232 (1995).
    • (1995) Am. J. Hum. Genet. , vol.57 , pp. 1221-1232
    • Holmans, P.1    Clayton, D.2
  • 21
    • 0025093523 scopus 로고
    • The power of identity-by-state methods for linkage analysis
    • Bishop, D.T. & Williamson, J.A. The power of identity-by-state methods for linkage analysis. Am. J. Hum. Genet. 46, 254-265 (1990).
    • (1990) Am. J. Hum. Genet. , vol.46 , pp. 254-265
    • Bishop, D.T.1    Williamson, J.A.2
  • 22
    • 0011077658 scopus 로고
    • Exclusion mapping for complex diseases
    • Risch, N. Exclusion mapping for complex diseases. Am. J. Hum. Genet. 53, A185 (1993).
    • (1993) Am. J. Hum. Genet. , vol.53
    • Risch, N.1
  • 23
    • 0018378456 scopus 로고
    • A simple method to detect linkage for rare recessive diseases: An application to juvenile diabetes
    • Suarez, B.K. & Hodge, S.E. A simple method to detect linkage for rare recessive diseases: an application to juvenile diabetes. Clin. Genet. 15, 126-136 (1979).
    • (1979) Clin. Genet. , vol.15 , pp. 126-136
    • Suarez, B.K.1    Hodge, S.E.2
  • 24
    • 0028029930 scopus 로고
    • Lods, wrods, and mods: The interpretation of lod scores calculated under different models
    • Hodge, S.E. & Elston, R.C. Lods, wrods, and mods: the interpretation of lod scores calculated under different models. Genet. Epidemiol. 11, 329-342 (1994)
    • (1994) Genet. Epidemiol. , vol.11 , pp. 329-342
    • Hodge, S.E.1    Elston, R.C.2
  • 25
    • 0029096538 scopus 로고
    • Model-free linkage analysis using likelihoods
    • Curtis, D. & Sham, P.C. Model-free linkage analysis using likelihoods. Am. J. Hum. Genet. 57, 703-716 (1995).
    • (1995) Am. J. Hum. Genet. , vol.57 , pp. 703-716
    • Curtis, D.1    Sham, P.C.2
  • 26
    • 0025008677 scopus 로고
    • Linkage strategies for genetically complex traits. II. the power of affected relative pairs
    • Risch, N. Linkage strategies for genetically complex traits. II. the power of affected relative pairs. Am. J. Hum. Genet. 46, 229-241 (1990).
    • (1990) Am. J. Hum. Genet. , vol.46 , pp. 229-241
    • Risch, N.1
  • 27
    • 0028231090 scopus 로고
    • The 1993-94 Généthon human genetic linkage map
    • Gyapay, G. et al. The 1993-94 Généthon human genetic linkage map. Mature Genet. 7, 246-339 (1994).
    • (1994) Mature Genet. , vol.7 , pp. 246-339
    • Gyapay, G.1
  • 28
    • 13344259999 scopus 로고    scopus 로고
    • A comprehensive genetic map of the human genome based on 5,264 microsatellites
    • Dib, C. et al. A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature 380, 152-154 (1996).
    • (1996) Nature , vol.380 , pp. 152-154
    • Dib, C.1
  • 29
    • 0029145667 scopus 로고
    • Linkage between obesity and a marker near the tumor necrosis factor-α locus in Pima Indians
    • Norman, R.A., Bogardus, C. & Ravussin, E. Linkage between obesity and a marker near the tumor necrosis factor-α locus in Pima Indians. J. Clin. Invest. 96, 158-162 (1995).
    • (1995) J. Clin. Invest. , vol.96 , pp. 158-162
    • Norman, R.A.1    Bogardus, C.2    Ravussin, E.3
  • 30
    • 0029084088 scopus 로고
    • 3-adrenergic-receptor gene
    • 3-adrenergic-receptor gene. N. Engl. J. Med. 333, 342-347 (1995).
    • (1995) N. Engl. J. Med. , vol.333 , pp. 342-347
    • Walston, J.1
  • 31
    • 0028978913 scopus 로고
    • 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns
    • 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns. N. Engl. J. Med. 333, 348-351 (1995).
    • (1995) N. Engl. J. Med. , vol.333 , pp. 348-351
    • Widén, E.1
  • 32
    • 0028978910 scopus 로고
    • 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity
    • 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N. Engl. J. Med. 333, 352-354 (1995).
    • (1995) N. Engl. J. Med. , vol.333 , pp. 352-354
    • Clément, K.1
  • 33
    • 0027933734 scopus 로고
    • A genome-wide screen for human type 1 diabetes susceptibility genes
    • Davies, J.L. et al. A genome-wide screen for human type 1 diabetes susceptibility genes. Nature 371, 130-136 (1994).
    • (1994) Nature , vol.371 , pp. 130-136
    • Davies, J.L.1
  • 34
    • 0028070552 scopus 로고
    • Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q
    • Hashimoto, L. et al. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q. Nature 371, 161-164 (1994).
    • (1994) Nature , vol.371 , pp. 161-164
    • Hashimoto, L.1
  • 35
    • 0029022917 scopus 로고
    • Genetic analysis of type 1 diabetes using whole genome approaches
    • Todd, J.A. Genetic analysis of type 1 diabetes using whole genome approaches. Proc. Natl. Acad. Sci. USA 92, 8560-8565 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 8560-8565
    • Todd, J.A.1
  • 36
    • 0028848010 scopus 로고
    • A missense mutation in the glucagon receptor gene is associated with non-insulin dependent diabetes mellitus
    • Hager, J. et al. A missense mutation in the glucagon receptor gene is associated with non-insulin dependent diabetes mellitus. Nature Genet. 9, 299-304 (1995).
    • (1995) Nature Genet. , vol.9 , pp. 299-304
    • Hager, J.1
  • 37
    • 0028947513 scopus 로고
    • Evidence for linkage between a region on chromosome 1p and the acute insulin response in Pima Indians
    • Thompson, D.B. et al. Evidence for linkage between a region on chromosome 1p and the acute insulin response in Pima Indians. Diabetes 44, 478-481 (1995).
    • (1995) Diabetes , vol.44 , pp. 478-481
    • Thompson, D.B.1
  • 38
    • 0027468540 scopus 로고
    • Linkage of chromosomal markers on 4q with a putative gene determining maximal insulin action in Pima Indians
    • Prochazka, M. et al. Linkage of chromosomal markers on 4q with a putative gene determining maximal insulin action in Pima Indians. Diabetes 42, 514-519 (1993).
    • (1993) Diabetes , vol.42 , pp. 514-519
    • Prochazka, M.1
  • 39
    • 13344259308 scopus 로고    scopus 로고
    • + channel and linkage studies with NIDDM in Japanese
    • + channel and linkage studies with NIDDM in Japanese. Diabetes 45, 267-269 (1996).
    • (1996) Diabetes , vol.45 , pp. 267-269
    • Iwasaki, N.1
  • 40
    • 0029416826 scopus 로고
    • An STS-based map of the human genome
    • Hudson, T.J. et al. An STS-based map of the human genome. Science 270, 1945-1954 (1995).
    • (1995) Science , vol.270 , pp. 1945-1954
    • Hudson, T.J.1
  • 41
    • 0002681091 scopus 로고
    • Classification, diagnostic criteria, and screening for diabetes
    • NIH Publication No. 95-1468
    • Harris, M.I. Classification, diagnostic criteria, and screening for diabetes, in Diabetes in America, 2nd edn. 15-36 (NIH Publication No. 95-1468, 1995).
    • (1995) Diabetes in America, 2nd Edn. , pp. 15-36
    • Harris, M.I.1
  • 43
    • 0021850103 scopus 로고
    • Multilocus linkage analysis in humans: Detection of linkage and estimation of recombination
    • Lathrop, G.M., Lalouel, JM, Julier, C. & Ott, J. Multilocus linkage analysis in humans: detection of linkage and estimation of recombination. Am. J. Hum. Genet. 37, 482-498 (1985).
    • (1985) Am. J. Hum. Genet. , vol.37 , pp. 482-498
    • Lathrop, G.M.1    Lalouel, J.M.2    Julier, C.3    Ott, J.4
  • 44
    • 0029665285 scopus 로고    scopus 로고
    • Searching for NIDDM susceptibility genes: Studies of genes with triplet repeats expressed in skeletal muscle
    • in the press
    • Yamagata, K. et al. Searching for NIDDM susceptibility genes: studies of genes with triplet repeats expressed in skeletal muscle. Diabetologia (in the press).
    • Diabetologia
    • Yamagata, K.1


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