Homozygosity of the Pro12Ala variant of the peroxisome proliferation- activated receptor-γ2 (PPAR-γ2): Divergent modulating effects on body mass index in obese and lean Caucasian men

Diabetologia

Volumn 42, Issue 7, 1999, Pages 892-895

  Ek, J ^a   Urhammer, S A ^a   Sorensen T I A ^b   Andersen, T ^b   Auwerx, J ^c   Pedersen, O ^a  

^a STENO DIABETES CENTER   (Denmark)

^b DEPARTMENT OF EPIDEMIOLOGY RESEARCH   (Denmark)

^c INSTITUT PASTEUR DE LILLE   (France)

Author keywords

Body mass index changes; Epidemiology; Mutations; Obesity; PPAR 2

Indexed keywords

ALANINE; GLUTAMINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROLINE;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; BODY MASS; CAUCASIAN; CODON; CONTROLLED STUDY; DENMARK; GENE FREQUENCY; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; OBESITY; ONSET AGE; PRIORITY JOURNAL;

ADULT; BODY MASS INDEX; COHORT STUDIES; DENMARK; EUROPEAN CONTINENTAL ANCESTRY GROUP; HOMOZYGOTE; HUMANS; MALE; MICROBODIES; MIDDLE AGED; MUTATION; OBESITY; POLYMORPHISM, GENETIC; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; VARIATION (GENETICS);

EID: 0032781890     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051243     Document Type: Article

References (10)

1. 1. Fajas L, Auboeuf D, Raspé E et al. (1998) The organization, promoter analysis, and expression of the human PPARγ gene. J Biol Chem 272: 18779-18789
2. 2. Wu Z, Xie Y, Bucher NL, Farmer SR (1995) Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis. Genes Dev 9: 2350-2363
3. 3. Elbrecht A, Chen Y, Cullinan CA et al. (1996) Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2. Biochem Biophys Res Commun 224: 431-437
4. 4. Werman A, Wollenberg A, Solanes G, Bjørkbæk C, Vidal-Puig AJ, Flier JS (1997) Ligand independent activation domain in the N-terminus of peroxisome proliferator-γ (PPAR-γ) J Biol Chem 272: 20230-20235
5. 5. Vidal-Puig AJ, Considine RV, Jimenez-Linan M et al. (1997) Peroxisome proliferator-activated receptor gene expression in human tissues. J Clin Invest 99: 2416-2422
6. 6. Ristow M, Muller-Wieland D, Pfeiffer A, Krone W, Kahn CR (1998) Human obesity associated with a mutation in PPARγ2, a regulator of adipocyte differentiation. N Eng J Med 339: 953-959
7. 7. Yen CJ, Beamer BA, Negri C et al. (1997) Molecular scanning of the human peroxisome proliferator-activated receptor-γ (PPAR-γ) gene in diabetic Caucasians: identification of a Pro12Ala PPAR γ2 missense mutation. Biochem Biophys Res Commun 240: 270-274
8. 8. Deeb SS, Fajas L, Nemoto M et al. (1998) Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 20: 284-287
9. 9. Beamer BA, Yen CJ, Andersen RE et al. (1998) Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-γ2 gene with obesity in two Caucasian populations. Diabetes 47: 1806-1808
10. 10. Sonne-Holm S, Sørensen TIA, Jensen G, Schnohr P (1989) Longterm changes in body weight in adult obese and non-obese men. Int J Obes 14: 319-326