A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter

Journal of Clinical Investigation

Volumn 102, Issue 4, 1998, Pages 704-709

  Ghosh, Soumitra ^a   Hauser, Elizabeth R ^b,f   Magnuson, Victoria L ^a   Valle, Timo ^c   Ally, Delphine S ^a   Karanjawala, Zarir E ^a   Rayman, Joseph B ^a   Knapp, Julie I ^a   Musick, Anjene ^a   Tannenbaum, Joyce ^a   Te, Catherine ^a   Eldridge, William ^a   Shapiro, Shane ^a   Musick, Tiffany ^a   Martin, Colin ^a   So, Alistair ^a   Witt, Alyson ^a   Harvan, Julian Blaschak ^b   Watanabe, Richard M ^b   Hagopian, William ^d   Eriksson, Johan ^c   Nylund, Stella J ^c   Kohtamaki, Kimmo ^c   Tuomilehto Wolf, Eva ^c   Toivanen, Liisa ^c   Vidgren, Gabriele ^c   Ehnholm, Christian ^c   Bergman, Richard N ^e   Tuomilehto, Jaakko ^c   Collins, Francis S ^a   Boehnke, Michael ^b   more..

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d UNIVERSITY OF WASHINGTON   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Affected sib pairs; Fluorescent genotyping; Gene mapping; Linkage analysis; Non insulin dependent diabetes mellitus

Indexed keywords

ADULT; AGED; ARTICLE; CHROMOSOME 2Q; FEMALE; GENE FREQUENCY; GENE LOCUS; GENE MAPPING; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MARKER GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL;

EID: 17644441297     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI2512     Document Type: Article

References (34)

1. Bennett, P.H., C. Bogardus, J. Tuomilehto, and P. Zimmett. 1992. Epidemiology and natural history of NIDDM: non-obese and obese. In International Textbook of Diabetes Mellitus. K.G.M.M. Alberti, R.A. DeFronzo, H. Keen, and P. Zimmett, editors. John Wiley & Sons, New York. 147-176.
2. Tuomilehto, J., H.J. Korhonen, L. Kartovaara, V. Salomaa, J.H. Stengard, M. Pitkanen, A. Aro, K. Javela, M. Uusitupa, and J. Pitkaniemi. 1991. Prevalence of diabetes mellitus and impaired glucose tolerance in the middle-aged population of three areas in Finland. Int. J. Epidemiol. 20:1010-1017.
3. Valle, T., J. Tuomilehto, and J. Eriksson. 1997. Epidemiology of NIDDM in Europids. In Internalional Textbook of Diabetes Mellitus. K.G.M.M. Alberti, P. Zimmet, R.A. DeFronzo, and H. Keen, editors. John Wiley & Sons, New York. 125-142.
4. Ghosh, S., and N.J. Schork. 1996. Genetic analysis of NIDDM. The study of quantitative traits. Diabetes. 45:1-14.
5. Hanis, C., E. Boerwinkle, R. Chakraborty, D. Ellsworth, P. Concannon, B. Stirling, V.A. Morrison, B. Wapelhorst, R. Spielman, K.J. Gogolin-Ewens, et al. 1996. A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a susceptibility locus on chromosome 2. Nat. Genet. 13:161-166.
6. Mahtani, M.M., E. Widen, M. Lehto, J. Thomas, M. McCarthy, J. Brayer, B. Bryant, G. Chan, M. Daly, C. Forsblom, et al. 1996. Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nat. Genet. 14:90-94.
7. Kaprio, J., J. Tuomilehto, M. Koskenvuo, K. Romanov, A. Reunanen, J. Eriksson, J. Stengård, and Y.A. Kesäniemi. 1992. Concordance for Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia. 35:1060-1067.
8. Lander, E.S., and L. Kruglyak. 1995. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat. Genet. 11:241-249.
9. Valle, T., J. Tuomilehto, R.N. Bergman, S. Ghosh, E.R. Hauser, J. Eriksson, S.J. Nylund, K. Kohtamaki, E. Tuomilehto-Wolf, L. Toivanen, et al. 1998. Mapping genes for non-insulin dependent diabetes mellitus: design of the Finland-United States Investigation of NIDDM genetics (FUSION) study. Diabetes Care. 21:949-958.
10. World Health Organization. 1980. World Health Organization: WHO expert committee on diabetes mellitus. Second Report. Technical Report Series, no. 646. Geneva, Switzerland. 7-80.
11. Boehnke, M., and N.J. Cox. 1997. Accurate inference of relationships in sibling pair linkage studies. Am. J. Hum. Genet. 61:423-429.
12. Ghosh, S., Z. Karanjawala, E.R. Hauser, D. Ally, J.I. Knapp, J.B. Rayman, A. Musick, J. Tannenbaum, C. Te, S. Shapiro, et al. 1997. Methods for precise sizing, automatic binning of alleles and reduction of error rates in large-scale genotyping using fluorescently-labeled dinucleotide markers. Genome Res. 7:165-178.
13. Magnuson, V., D. Ally, S. Nylund, Z. Karanjawala, J. Rayman, J. Knapp, A. Lowe, S. Ghosh, and F.S. Collins. 1996. Substrate nucleotide-determined non-templated addition of adenine by Taq DNA polymerase: implications for PCR-based genotyping and cloning. BioTechniques. 21:700-709.
14. Boehnke, M. 1991. Allele frequency estimation from data on relatives. Am. J. Hum. Genet. 48:22-25.
15. Lange, K., D. Weeks, and M. Boehnke. 1988. Programs for pedigree analysis: MENDEL, FISHER and dGENE. Genet. Epidemiol. 5:471-472.
16. Lander, E.S., and P. Green. 1987. Construction of multilocus genetic linkage maps in humans. Proc. Natl. Acatl. Sci. USA. 84:2363-2367.
17. Dausset, J., H. Cann, D. Cohen, M. Lathrop, J.-M. Lalouel, and R. White. 1990. Centre d'Étude du Polymorphisme Humain (CEPH): Collaborative genetic mapping of the human genome. Genomics. 6:575-577.
18. Dib, C. S. Faure, C. Fizames, D. Samson, N. Drouot, A. Vignal, P. Millasseau, S. Marc, J. Hazan, E. Seboun, et al. 1996. A comprehensive genetic map of the human genome based on 5,264 microsatellite. Nature. 380:152-154.
19. Bishop, D.T., and J.A. Williamson. 1990. The power of identity-by-state methods for linkage analysis. Am. J. Hum. Genet. 46:254-265.
20. Hauser, E.R., M. Boehnke, S.-W. Guo, and N. Risch. 1996. Affected-sib pair interval mapping and exclusion for complex genetic traits: sampling considerations. Genet. Epidemiol. 13:117-137.
21. Risch, N. 1990. Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am. J. Hum. Genet. 46:229-241.
22. Risch, N. 1993. Exclusion mapping for complex disease. Am. J. Hum. Genet. 53:A185. (Abstr.)
23. Kruglyak, L., M.J. Daly, M.P. Reeve-Daly, and E.S. Lander. 1996. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am. J. Hum. Genet. 58:1347-1363.
24. Holmans, P. 1993. Asymptotic properties of affected-sib pair linkage analysis. Am. J. Hum. Genet. 52:362-374.
25. Suarez, B.K., and S.E. Hodge. 1979. A simple method to detect linkage for rare recessive diseases: an application to juvenile diabetes. Clin. Genet. 15: 126-136.
26. National Diabetes Data Group. 1979. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 28:1039-1057.
27. Haffner, S.M., H. Miettinen, and M.P. Stern. 1996. Insulin secretion and resistance in non-diabetic Mexican-Americans and non-hispanic whites with a parental history of diabetes. J. Clin. Endocrinol. Metab. 81:1846-1851.
28. Cerasi, E., S. Efendic, and R. Luft. 1973. Dose-response relation between plasma-insulin and blood-glucose levels during oral glucose loads in prediabetic and diabetic subjects. Lancet. 1:794-797.
29. Eriksson, J., A. Franssila-Kallunki, A. Ekstrand, C. Saloranta, E. Widen, C. Schalin, and L. Groop. 1989. Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N. Engl. J. Med. 321: 337-343.
30. Risch, N., and L. Giuffra. 1992. Model misspecification and multipoint linkage analysis. Hum. Hered. 42:77-92.
31. Bell, G.I., N.J. Cox, T. Lindner, P. Concannon, R.S. Spielman, E. Boerwinkle, and C.L. Hanis. 1997. Genetics of NIDDM in Mexican-Americans of Starr County, Texas: an update. Diabetic Rev. 5:277-283.
32. Stern, M.P., R. Duggirala, B.D. Mitchell, L.J. Reinhart, S. Shivakumar, P.A. Shipman, O.C. Uresandi, E. Benavides, J. Blangero, and P. O'Connell. 1996. Evidence for linkage of regions on chromosome 6 and 11 to plasma glucose concentrations in Mexican Americans. Genome Res. 6:724-734.
33. Hani, E.H., J. Hager, A. Phillipi, F. Demenais, P. Froguel, and N. Vionnet. 1997. Mapping NIDDM susceptibility loci in French families: studies with markers in the region of NIDDM1 on chromosome 2q. Diabetes. 46:1225-1226.
34. McCarthy, M., P. Cassell, P. Saker, M. Armstrong, R. Turner, S. O'Rahilly, M. Walker, A. Hattersley, and G. Hitman. 1997. No excess allele-sharing on chromosome 2q (region of NIDDM1) in a large European sibship collection. Diabetes. 46:0201. (Abstr.)