Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis

Nature

Volumn 402, Issue 6762, 1999, Pages 685-689

  Maechler, Pierre ^a   Wollhelm, Claes B ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; GLUTAMIC ACID; INSULIN;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; EXOCYTOSIS; GLUCOSE METABOLISM; INSULIN RELEASE; MITOCHONDRIAL RESPIRATION; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; SECOND MESSENGER; SECRETORY GRANULE;

ADENOSINE TRIPHOSPHATE; ANIMALS; EXOCYTOSIS; GLUCOSE; GLUTAMIC ACID; HUMANS; INSULIN; INTRACELLULAR MEMBRANES; ISLETS OF LANGERHANS; MEMBRANE POTENTIALS; MITOCHONDRIA; RATS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0033540037     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/45280     Document Type: Article

References (29)

1. 2+ and G-proteins. Diabetes Rev. 4, 276-297 (1996).
2. Matschinsky, F. M. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. Diabetes 45, 223-241 (1996).
3. Ashcroft, F. M. et al. Stimulus-secretion coupling in pancreatic beta cells. J. Cell Biochem. 55, 54-65 (1994).
4. Lang, J. Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion. Eur. J. Biochem. 259, 3-17 (1999).
5. + channels in mouse B cells. J. Clin. Invest. 89, 1288-1295 (1992).
6. 2+ influx in rat pancreatic B-cell. Diabetes 41, 438-443 (1992).
7. Maechler, P., Kennedy, E. D., Pozzan, T. & Wollheim, C. B. Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic β-cells. EMBO J. 16, 3833-3841 (1997).
8. 2+ and insulin secretion responses in the beta cell. J. Biol. Chem. 273, 20770-20778 (1998).
9. 2+ in aequorin-expressing INS-1 cells. J. Clin. Invest. 98, 2524-2538 (1996).
10. Duchen, M. R. Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death. J. Physiol. (Lond.) 516, 1-17 (1999).
11. Fisher, H. F. L-glutamate dehydrogenase from bovine liver. Meth. Enzymol. 113, 16-27 (1985).
12. Janjic, D. et al. Improved insulin secretion of cryopreserved human islets by antioxidant treatment. Pancreas 13, 166-172 (1996).
13. Sener, A. et al. Insulinotropic action of glutamic acid dimethyl ester. Am. J. Physiol. 267, E573-E584 (1994).
14. Eto, K. et al. Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science 283, 981-985 (1999).
15. Maechler, P., Wang, H. & Wollheim, C. B. Continuous monitoring of ATP levels in living insulin secreting cells expressing cytosolic firefly luciferase. FEBS Lett. 422, 328-332 (1998).
16. Johnson, R. G. Jr Proton pumps and chemiosmotic coupling as a generalized mechanism for neurotransmitter and hormone transport. Ann. N. Y. Acad. Sci. 493, 162-177 (1987).
17. Maycox, P. R., Deckwerth, T., Hell, J. W. & Jahn, R. Glutamate uptake by brain synaptic vesicles. Energy dependence of transport reconstitution in proteoliposomes. J. Biol. Chem. 263, 15423-15428 (1988).
18. Hutton, J. C. The internal pH and membrane potential of the insulin-secretory granule. Biochem. J. 204, 171-178 (1982).
19. Orci, L. et al. Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles. J. Cell Biol. 103, 2273-2281 (1986).
20. Breckenridge, L. J. & Almers, W. Currents through the fusion pore that forms during exocytosis of a secretory vesicle. Nature 328, 814-817 (1987).
21. Ozkan, E. D. & Ueda, T. Glutamate transport and storage in synaptic vesicles. Jpn. J. Pharmacol. 77, 1-10 (1998).
22. Roisin, M. P., Scherman, D. & Henry, J. P. Synthesis of ATP by an artificially imposed electrochemical proton gradient in chromaffin granule ghosts. FEBS Lett. 115, 143-147 (1980).
23. Roseth, S., Fykse, E. M. & Fonnum, F. Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transporter. J. Neurochem. 65, 96-103 (1995).
24. 2+ depletion from granules inhibits exocytosis. A study with insulin-secreting cells. J. Biol. Chem. 273, 19002-19008 (1998).
25. Churcher, Y. & Gomperts, B. D. ATP-dependent and ATP-independent pathways of exocytosis revealed by interchanging glutamate and chloride as the major anion in permeabilized mast cells. Cell Regul. 1, 337-346 (1990).
26. i regulation of secretory vesicle swelling examined by atomic force microscopy. Proc. Natl Acad. Sci. USA 94, 13317-13322 (1997).
27. 13C]NMR. Proc. Natl Acad. Sci. USA 93, 7612-7617 (1996).
28. Stanley, C. A. et al. Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. N. Engl. J. Med. 338, 1352-1357 (1998).
29. Cho, S. W., Lee, J. & Choi, S. Y. Two soluble forms of glutamate dehydrogenase isoproteins from bovine brain. Eur. J. Biochem. 233, 340-346 (1995).