A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling: Evidence from transfection studies

Journal of Clinical Investigation

Volumn 97, Issue 11, 1996, Pages 2569-2575

  Almind, Katrine ^c   Inoue, Gen ^a,b   Pedersen, Oluf ^c   Kahn, C Ronald ^a,b  

^a JOSLIN DIABETES CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c STENO DIABETES CENTER   (Denmark)

Author keywords

Diabetes mellitus; Genetics; Insulin resistance; IRS 1; PI 3 kinase

Indexed keywords

INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DNA SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INSULIN RELEASE; INSULIN RESISTANCE; PRIORITY JOURNAL; PROMYELOCYTE; PROTEIN PHOSPHORYLATION; PROTEIN POLYMORPHISM; SITE DIRECTED MUTAGENESIS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ARGININE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL LINE; DIABETES MELLITUS, TYPE 2; DNA; ENZYME ACTIVATION; GENE EXPRESSION; GLYCINE; HEMATOPOIETIC STEM CELLS; HUMANS; INSULIN; MUTAGENESIS, SITE-DIRECTED; PHOSPHOPROTEINS; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RECEPTOR, INSULIN; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; THYMIDINE; TRANSFECTION;

EID: 0029893417     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118705     Document Type: Article

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