Regulation by insulin of gene expression in human skeletal muscle and adipose tissue: Evidence for specific defects in type 2 diabetes

Diabetes

Volumn 50, Issue 5, 2001, Pages 1134-1142

  Ducluzeau, Pierre Henri ^a   Perretti, Noël ^a   Laville, Martine ^a,b,c   Andreelli, Fabrizio ^a,c   Vega, Nathalie ^a   Riou, Jean Paul ^a,b,c   Vidal, Hubert ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ LYON 1   (France)

^c EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 4; GLYCOGEN SYNTHASE; HEXOKINASE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE CONTROL; GENE EXPRESSION; GLUCOSE CLAMP TECHNIQUE; HORMONAL REGULATION; HORMONE ACTION; HUMAN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE;

EID: 0035029812     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.5.1134     Document Type: Article

References (45)

1. Pathogenesis of NIDDM: A balanced overview
2. Role of insulin resistance in the pathogenesis of NIDDM
3. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of a 25-year follow-up study
4. Insulin action, diabetogenes, and the cause of type II diabetes
5. The role of phosphoinositide 3-kinase in insulin signalling
6. Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and type 2 (non-insulin-dependent) diabetes mellitus
7. Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation
8. Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle
9. Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients
10. Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from non-insulin-dependent diabetic subjects
11. Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus
12. Regulation of gene expression by insulin
13. Human diabetes associated with defects in nuclear regulatory proteins for the insulin receptor gene
14. Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension
15. Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients
16. Regulation of gene expression during severe caloric restriction: Lack of induction of p85α phosphatidylinositol 3-kinase mRNA in skeletal muscle of patients with type II (non-insulin-dependent) diabetes mellitus
17. Glycogen synthase and phosphofructokinase protein and mRNA levels in skeletal muscle from insulin-resistant patients with non-insulin-dependent diabetes mellitus
18. Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity
19. Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus
20. Expression of the major insulin regulatable glucose transporter (Glut 4) in skeletal muscle of non insulin dependent diabetic patients and healthy subjects before and after insulin infusion
21. Effect of insulin on Glut 4 mRNA and protein concentrations in skeletal muscle of patients with NIDDM and their first-degree relatives
22. Insulin-induced hexokinase II expression is reduced in obesity and NIDDM
23. Defective regulation of phosphatidylinositol 3-kinase gene expression in skeletal muscle and adipose tissue of non-insulin-dependent diabetes mellitus patients
24. Acute regulation by insulin of phosphatidylinositol-3-kinase, Rad, Glut 4 and lipoprotein lipase mRNA levels in human muscle
25. Respective role of plasma non esterified fatty acid oxidation and total lipid oxidation in lipid-induced insulin resistance
26. Defect in insulin action on expression of the muscle/adipose tissue glucose transporter gene in skeletal muscle of type 1 diabetic patients
27. The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue
28. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
29. The use of the reverse transcription-competitive polymerase chain reaction to investigate the in vivo regulation of gene expression in small tissue samples
30. Nutritional and insulin regulation of fatty acid synthase and leptin gene expression through ADD1/SREBP-1
31. ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose
32. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
33. Muscle Rad expression and human metabolism: Potential role of the novel Ras-related GTPase in energy expenditure and body composition
34. Leptin-specific patterns of gene expression in white adipose tissue
35. The expression of adipogenic genes is decreased in obesity and diabetes mellitus
36. Regulation of hexokinase II and glycogen synthase mRNA, protein activity in human muscle
37. Insulin resistance is a prominent feature of insulin-dependent diabetes
38. Enhanced hepatic insulin sensitivity, but peripheral insulin resistance in patients with type 1 (insulin-dependent) diabetes
39. Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)
40. Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1)
41. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: Model for congenital generalized lipodystrophy
42. Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes
43. Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes
44. Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulin
45. A phosphatidylinositol 3-kinase/p70 ribosomal S6 protein kinase pathway is required for the regulation by insulin of the p85α regulatory subunit of phosphatidylinositol 3-kinase gene expression in human muscle cells