Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Nature

Volumn 411, Issue 6837, 2001, Pages 599-603

  Hugot, Jean Pierre ^a,b,c   Chamaillard, Mathias ^a,b   Zouali, Habib ^a   Lesage, Suzanne ^a   Cézard, Jean Pierre ^c   Belaiche, Jacques ^d   Almer, Sven ^e   Tysk, Curt ^f   O'morain, Colm A ^g   Gassull, Miquel ^h   Binder, Vibeke ⁱ   Finkel, Yigael ^j   Cortot, Antoine ^k   Modigliani, Robert ^l   Laurent Puig, Pierre ^b   Gower Rousseau, Corine ^k   Macry, Jeanne ^c   Colombel, Jean Frédéric ^k   Sahbatou, Mourad ^a   Thomas, Gilles ^a,b,m  

^a FONDATION JEAN DAUSSET CEPH   (France)

^b INSERM   (France)

^c HÔPITAL ROBERT DEBRÉ   (France)

^d UNIVERSITY OF LIÈGE   (Belgium)

^e LINKÖPING UNIVERSITY   (Sweden)

^f ÖREBRO MEDICAL CENTRE HOSPITAL   (Sweden)

^g ADELAIDE AND MEATH HOSPITAL   (Ireland)

^h HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

ⁱ GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^j KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^k LILLE UNIVERSITY HOSPITAL   (France)

^l SAINT LOUIS HOSPITAL   (France)

^m HÔPITAL SAINT ANTOINE   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CLONING; DISEASES; PROTEINS;

ULCERATIVE COLITIS;

CHROMOSOMES;

CASPASE RECRUITMENT DOMAIN PROTEIN 15; GENE PRODUCT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUCINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHROMOSOME 16; CROHN DISEASE; FRAMESHIFT MUTATION; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HUMAN; MISSENSE MUTATION; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; ULCERATIVE COLITIS;

ALLELES; CARRIER PROTEINS; CHROMOSOMES, HUMAN, PAIR 16; CLONING, MOLECULAR; COLITIS, ULCERATIVE; CROHN DISEASE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUCINE; LINKAGE (GENETICS); NF-KAPPA B; NOD2 SIGNALING ADAPTOR PROTEIN; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS; REPETITIVE SEQUENCES, AMINO ACID; SIGNAL TRANSDUCTION; VARIATION (GENETICS);

EID: 0035978651     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35079107     Document Type: Article

References (30)

1. Etiology of the inflammatory bowel diseases
2. Mapping of a susceptibility locus for Crohn's disease on chromosome 16
3. Analysis of single-nucleotide polymorphisms in the interleukin-4 receptor gene for association with inflammatory bowel disease
4. Mutation screening in the CD19 and CD43 (sialophorin) genes in Crohn Disease patients
5. Refined mapping of the inflammatory bowel disease 1 gene
6. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
7. A test for linkage and association in general pedigrees: The pedigree disequilibrium test
8. The genetics of Crohn's disease: Complex segregation analysis of a family study with 265 patients with Crohn's disease and 5387 relatives
9. Evidence for a recessive gene in Crohn's disease
10. Investigation of inheritance of chronic inflammatory bowel disease by complex segregation analysis
11. Clinical characteristics of Crohn's disease in 72 families
12. International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16
13. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB
14. Human Nod1 confers responsiveness to bacterial lipopolysaccharides
15. Nod 1, an Apaf-1-like activator of caspase-9 and nuclear factor κB
16. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-κB
17. An induced proximity model for NF-κB activation in the Nod1/RICK and RIP signaling pathways
18. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
19. Spontaneous, heritable colitis in a new substrain of C3H/HeJ mice
20. Intestinal inflammation and the gut microflora
21. Activation of nuclear factor κB in inflammatory bowel disease
22. Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of 1κB synthesis
23. Sulfasalazine: A potent and specific inhibitor of nuclear factor κB
24. Two stage genome wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosome 3, 7 and 12
25. Linkage of inflammatory bowel disease to Human chromosome 6p
26. Linkage and linkage disequilibrium in chromosome band 1p36 in American Chaldeans with inflammatory bowel disease
27. High-density genome scan in Crohn disease shows confirmed linkage to chromosome 14q11-12
28. Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci
29. Classification of inflammatory bowel disease