Analysis of candidate genes for susceptibility to type I diabetes: A case-control and family-association study of genes on chromosome 2q31-35

Diabetes

Volumn 46, Issue 6, 1997, Pages 1069-1074

  Owerbach, David ^a   Naya, Francisco J ^a   Tsai, Ming Jer ^a   Allander, Susanne V ^b   Powell, David R ^a   Gabbay, Kenneth H ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY CHILDREN S HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CASE CONTROL STUDY; CHROMOSOME 2Q; CONTROLLED STUDY; FAMILY STUDY; FEMALE; GENE CLUSTER; GENE ISOLATION; GENE LOCUS; GENETIC SUSCEPTIBILITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 0030952822     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.6.1069     Document Type: Article

References (35)

1. Owerbach D, Gabbay KH: The search for type I diabetes susceptibility genes: the next generation. Diabetes 45:544-551, 1996
2. Field LL, Tobias R, Magnus T: A locus on chromosome 15q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus. Nature Genet 8:189-194, 1994
3. Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE, Reed PW, Gough SCL, Jenkins SC, Palmer SM, Balfour KM, Rowe BR, Farrall M, Barnett AH, Bain SC, Todd JA- A genome-wide search for human type 1 diabetes susceptibility genes. Nature 371:130-136, 1994
4. Hashimoto L, Habita C, Beressi JP, Delepine M, Besse C, Cambon-Thomsen A, Deschamps I, Rotter JI, Djoulah S, James MR, Froguel P, Weiseenbach J, Lathrop GM, Julier C: Genetic mapping of a susceptibility locus for insulindependent diabetes mellitus on chromosome l1q. Nature 371:161-164, 1994
5. Owerbach D, Gabbay KH: The HOXD8 locus (2q31) is linked to type I diabetes mellitus: interaction with chromosome 6 and 11 disease susceptibility genes. Diabetes 44:132-136, 1995
6. Copeman JB, Cucca F, Hearne CM, Cornall RJ, Reed PW, Rønnigen KS, Undlien DE, Nistico L, Buzzetti R, Tosi R, Pociot F, Nerup J, Cornelis F, Barnett AH, Bain SC, Todd JA: Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33, Nature Genet 9:80-85, 1995
7. Luo D-F, Bui MM, Muir A, Maclaren NK, Thomson G, She J-X: Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-27. Am J Hum Genet 57:911-919, 1995
8. Davies JL, Cucca F, Goy JV, Atta ZA, Merriman ME, Wilson A, Barnett AH, Bain SC, Todd JA: Saturation multipoint linkage mapping of chromosome 6q in type I diabetes. Hum Mol Genet. In press
9. Field LL, Tobias R, Thomson G, Pion S: Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM11) on human chromosome 14q24.3-q31. Genomics 33:1-8, 1996
10. Buzzetti R, Pritchard LE, Van der Auwera B, Giovannini C, Bosi E, Larrad MTM, Rios MS, Chow CC, Cockram CS, Jacobs K, Mijovic C, Bain SC, Barnett AH, Vandewalle CL, Schuit F, Gorus FK, Belgian Diabetes Registry, Tosi R, Pozzili P, Todd JA: The CTLA-4 gene region is linked to, and associated with, type I diabetes. Hum Mol Genet. In press
11. Morahan G, Huang D, Tait BD, Colman PG, Harrison LC: Markers on distal chrosome 2q linked to insulin-dependent diabetes melutus. Science 272:1811-1813, 1996
12. Rowe RE, Wapelhorst B, Bell GI, Risch N, Spielman RS, Concannon P: Linkage and association between insulin-dependent diabetes mellitus (IDDM) susceptibility and markers near the glucokinase gene on chromosome 7. Nature Genet 10:240-242, 1995
13. Lander E, Kruglyak L: Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet 11:241-247, 1995
14. Olson JM, Wijsman EM: Design and sample-size considerations in the detection of linkage disequilibrium with a disease locus. Am J Hum Genet 55:574-580, 1994
15. Jorde LB: Linkage disequilibrium mapping as a gene-mapping tool. Am J Hum Genet 56:11-14, 1995
16. Dib C, Faure S, Fizames C, Samson D, Drouot N, Vignal A, Millasseau P, Marc S, Kazan J, Seboun E, Lathrop M, Gyapay G, Morissette J, Weissenbach J: A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature 380:152-154, 1996
17. D'Esposito M, Morelli F, Acampora D, Migliaccio E, Simeone A, Boncinelli E: EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is located at the 5′ end of HOX4 locus on chromosome 2. Genomics 10:43-50, 1991
18. Levine M, Hoey T: Homeobox proteins as sequence-specific transcription factors. Cell 55:537-540, 1988
19. Naya FJ, Stellrecht CMM, Tsai MJ: Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev 9:1009-1019, 1995
20. Balzano C, Buonavista N, Rouvier E, Goldstein P: CTLA-4 and CD28: similar proteins, neighboring genes. Int J Cancer 7:28-32, 1992
21. Allander SV, Larsson C, Ehrenborg E, Suwanichkul A, Weber G, Morris SL, Bajalica S, Kiefer MC, Luthman H, Powell DR: Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5. J Biol Chem 269:10891-10898, 1994
22. Owerbach D, Gunn S, TV G, Wible L, Gabbay KH: Oligonucleotide probes for HLA-DQA and DQB genes define susceptibility to type I (insulin-dependent) diabetes mellitus. Diabetologia 31:751-757, 1988
23. Owerbach D, Gabbay KH: Localization of a type I diabetes susceptibility locus to the VNTR region flanking the insulin gene. Diabetes 42:1708-1714, 1993
24. Carrington M, Miller T, White M, Gerrard B, Stewart C, Dean M, Mann D: Typing of HLA-DQA1 and DQB1 using DNA single-stranded conformational polymorphism. Hum Immun 33:208-212, 1992
25. Redline RW, Williams AJ, Patterson P, Collins T: Human HOX4E: a gene strongly expressed in adult male and female urogenital tracts. Genomics 13:425-430, 1992
26. Spielman RS, McGinnis RE, Ewens WJ: Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM), Am J Hum Genet 52:506-516, 1993
27. Tamimi R, Steingrimsson E, Copeland NG, Dyer-Montgomery K, Lee JE, Hernandez R, Jenkins NA, Tapscott SJ: The neurod gene maps to human chromomome 2q32 and mouse chromosome 2. Genomics. In press
28. Platz P, Jakobsen BK, Morling N, Ryder LP, Sveygaard A, Thomsen M, Christy M, Kromann H, Benn J, Nerup J, Green A, Hauge M: HLA-D and HLA-DR antigens in genetic analysis of insulin-dependent diabetes mellitus. Diabetologia 21:1108-1115, 1981
29. Bennett ST, Lucassen AM, Gough SCL, Powell EE, Undlien DE, Pritchard LE, Merriman ME, Kawaguchi Y, Dronsfield MJ, Pociot F, Nerup J, Bouzekri N, Cambon-Thomsen A, Ronnigen KS, Barnett AH, Bain SC, Todd JA: Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nature Genet 9:284-292, 1995
30. Yanaqawa T, Hidaka Y, Guimaraes V, Soliman M, DeGroot LJ: CTLA4 gene polymorphism associated with Grave's Disease in a Caucasian population. J Clin Endocrinol Metab 80:41-45, 1995
31. Rosen DR, Brown RH: Dinucleotide repeat polymorphism in the HOX4E locus. Hum Mol Genet 2:617, 1993
32. Pozzilli P, Buzzetti R, Bottazzo GF, Tosi R: The selection of control subjects for case/control analysis of susceptibility to type I (insulin-dependent) diabetes mellitus. Diabetologia 36:1208-1209, 1993
33. Petrovsky N, Harrison LC: HLA-matched control subjects are essential in studies of susceptibility to IDDM. Diabetologia 38:125, 1995
34. Caillat-Zucman S, Garchon HJ, Timsit J, Assan R, Boitard C, Idriss O-S, Bougneres P, Bach J-F: Age-dependent HLA genetic heterogeneity of type I insulin-dependent diabetes mellitus. J Clin Invest 90:2242-2250, 1992
35. Van der Auwera B, Schuit F, Lyaruu I, Falorni A Svanhom S, Vandewalle CL, Gorus FK, Belgian Diabetes Registry: Genetic susceptibility for insulin-dependent diabetes mellitus in Caucasians revisited: the importance of diabetes registries in disclosing interactions between HLA-DQ- and insulin gene-linked risk J Clin Endocrinol Metab 80:2567-2573, 1995