Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

Nature Genetics

Volumn 15, Issue 4, 1997, Pages 356-362

  Steck, Peter A ^a   Pershouse, Mark A ^a   Jasser, Samar A ^a   Yung, W K Alfred ^a   Lin, Huai ^a   Ligon, Azra H ^a   Langford, Lauren A ^a   Baumgard, Michelle L ^b   Hattier, Thomas ^b   Davis, Thaylon ^b   Frye, Cheryl ^b   Hu, Rong ^b   Swedlund, Bradley ^b   Teng, David H F ^b   Tavtigian, Scan V ^b  

^a UNIVERSITY OF TEXAS   (United States)

^b Myriad Genetics Laboratories Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSKELETON PROTEIN; PHOSPHOPROTEIN PHOSPHATASE;

ARTICLE; BREAST CARCINOMA; CARCINOGENESIS; CHROMOSOME 10Q; CONTROLLED STUDY; GENE EXPRESSION; GENE ISOLATION; GENE MUTATION; GLIOMA; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROSTATE CARCINOMA; SEQUENCE HOMOLOGY; TUMOR SUPPRESSOR GENE;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; CHROMOSOMES, HUMAN, PAIR 10; DNA MUTATIONAL ANALYSIS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; GLIOBLASTOMA; HUMANS; MALE; MICE; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASMS; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN-TYROSINE-PHOSPHATASE; PTEN PHOSPHOHYDROLASE; RNA, MESSENGER; RNA, NEOPLASM; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 17144436629     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng0497-356     Document Type: Article

References (30)

1. Louis, D.N. & Gusella, J.F. A tiger behind many doors: multiple genetic pathways to malignant glioma. Trends. Genet 11, 412-415 (1995).
2. Fults, D., Pedone, C.A., Thomas, G.A. & White, R. Allelotype of human malignant astrocytoma. Cancer Res. 50, 5784-5789 (1990).
3. Rahseed, B.K., Fuller, G.N., Friedman, A.M., Bigner, D.D. & Bigner, S.H. Loss of heterozygosity for 10q loci in human gliomas. Genes Chromosome Cancer 5, 75-82 (1992).
4. Herbst, R.A., Weiss, J., Ehnis, A., Cavenee, W.K. & Arden, K.C. Loss of heterozygosity for 10q22-qter in malignant melanoma progression. Cancer Res. 54, 3111-3114 (1994).
5. Rempel, S.A., Schwechheimer, K., Davis, R.L., Cavenee, W.K. & Rosenblum, M.L. Loss of heterozygosity for loci on chromosome 10 is associated with morphologically malignant meningioma progression. Cancer Res. 53, 2386-2392 (1993).
6. Morita, R. et al. Common regions of deletion on chromosomes 5q, 6q, and 10q in renal cell carcinoma. Cancer Res. 51, 5817-5820 (1991).
7. Eagle, L.R. et al. Mutation of the MXI1 gene in prostate cancer. Nature Genet. 9, 249-255 (1995).
8. Peterson, I. et al. Small-cell lung cancer is characterized by a high incidence of deletions on chromosomes 3p, 4q, 5q, 10q, 13q, and 17p. Brit. J. Cancer 75, 79-86 (1997).
9. Peiffer, S.L. et al. Allelic loss of sequences from the long arm of chromosome 10 and replication errors in endometrial cancers. Cancer Res. 55, 1922-1926 (1995).
10. Gray, I.C. et al. Loss of chromosomal region 10q23-25 in prostate cancer. Cancer Res. 55, 4800-4803 (1995).
11. Trybus, T.M., Burgress, A.C., Wojno, K.J., Glover, T.W. & Macoska, J.A. Distinct areas of allelic loss on chromosomal regions 10p and 10q in human prostate cancer. Cancer Res. 56, 2263-2267 (1996).
12. Ransom, D.T. et al. Correlation of cytogenetic analysis and loss of heterozygosity studies in diffuse astrocytomas and mixed oligo-astrocytomas. Genes Chromosome. Cancer 5, 357-374 (1992).
13. Pershouse, M.A. et al. Analysis of the functional role of chromosome 10 loss in human glioblastomas. Cancer Res. 53, 5043-5050 (1993).
14. Steck, P.A., Hadi, A., Cheong, H.C., Yung, W.K.A., & Pershouse, M.A. Evidence for two tumour suppressive loci on chromosome 10 involved in glioblastomas. Genes Chromosome. Cancer 12, 255-261 (1995).
15. Church, D.M. et al. Isolation of genes from complex sources of mammalian genomic DNA using exon amplification. Nature Genet 6, 98-105 (1994).
16. Tavtigian, S.V. et al. The complete BCRA2 gene and mutations in chromosome 13q-linked kindreds. Nature Genet. 12, 333-337 (1996).
17. Kozak, M. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15, 8125-8148 (1987).
18. Denu, J., Stuckey, J.A., Saper D. & Dixon, J.E. Form and function in protein dephosphorylation. Cell 87, 361-364 (1996).
19. Denu, J.M. & Dixon, J.E. A catalytic mechanism for the dual-specific phosphatase. Proc. Natl. Acad. Sci. USA 92, 5910-5914 (1995).
20. Spruck, C.H. et al. p16 gene in uncultured tumours. Nature 370, 183-184 (1994).
21. Herman, J.G. et al. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res. 55, 4520-4530 (1995).
22. Chou, P.Y. & Fassman-Fasman, G.D. Conformational parameters for amino acids in helical, beta-sheet, and random coil regions calculated from protein. Biochemistry 13, 211-222 (1974).
23. von Diemling, A. et al. Association of epidermal growth factor receptor gene amplification with loss of chromosome 10 in human glioblastoma multiforme. J. Neurosurg. 77, 295-301 (1992).
24. Tokiyoshi, K., Yoshimine, T., Maruno, M., Muhammad, A.K.M.G. & Hayakawa, T. Accumulation of allelic losses on chromosome 10 in human gliomas at recurrence. J. Clin. Pathol: Mol. Pathol. 49, 218-222 (1996).
25. Nihei, N. et al. Localization of a metastasis suppressor gene(s) for rat prostatic cancer to the long arm of human chromosome 10. Genes Chromosome. Cancer 14, 112-119 (1995).
26. Albarosa, A., DiDonato, S. & Finocchiaro, G. Redefinition of the coding sequence of the MXI-1 gene and identification of a polymorphic repeat in the 3′ noncoding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas. Hum. Genet. 95, 709-711 (1995).
27. Nelen, M.R. et al. Localization of the gene for Cowdens disease to 10q22-23. Nature Genet. 13, 114-116 (1996).
28. Eng, C. et al. Cowden syndrome and Lhermitte-Duclos disease in a family: a single genetic syndrome with pleiotropy? J. Med. Genet. 31, 458-461 (1994).
29. Teng, D.H.-F. et al. Low incidence of BRCA2 mutation in breast carcinoma and other cancers. Nature Genet. 13, 241-248 (1996).
30. Barford, D., Flint, A.J. & Tonks, N.K. Crystal structure of human protein tyrosine phosphatase 1b. Science 263, 1397-1404 (1994).