메뉴 건너뛰기




Volumn 408, Issue 6815, 2000, Pages 994-997

Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE;

EID: 0034700456     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35050135     Document Type: Article
Times cited : (393)

References (32)
  • 1
    • 0032489358 scopus 로고    scopus 로고
    • Type 2 diabetes: When insulin secretion fails to compensate for insulin resistance
    • (1998) Cell , vol.92 , pp. 593-596
    • Kahn, B.B.1
  • 3
    • 0033524937 scopus 로고    scopus 로고
    • Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
    • (1999) Cell , vol.96 , pp. 329-339
    • Kulkarni, R.N.1
  • 4
    • 0028032894 scopus 로고
    • Insulin resistance and growth retardation in mice lacking insulin receptor substrate-l
    • (1994) Nature , vol.372 , pp. 182-186
    • Tamemoto, H.1
  • 5
    • 0028032895 scopus 로고
    • Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
    • (1994) Nature , vol.372 , pp. 186-190
    • Araki, E.1
  • 6
    • 0032567937 scopus 로고    scopus 로고
    • Disruption of IRS-2 causes type 2 diabetes in mice
    • (1998) Nature , vol.391 , pp. 900-904
    • Withers, D.J.1
  • 7
    • 0032841435 scopus 로고    scopus 로고
    • Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling
    • (1999) Nature Genet. , vol.23 , pp. 32-40
    • Withers, D.J.1
  • 8
    • 0033379267 scopus 로고    scopus 로고
    • Altered function of insulin receptor substrate-l-deficient mouse islets and cultured beta-cell lines
    • (1999) J. Clin. Invest. , vol.104
    • Kulkarni, R.N.1
  • 12
    • 0030724591 scopus 로고    scopus 로고
    • Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes
    • (1997) Diabetes Rev. , vol.5 , pp. 177-269
    • Defronzo, R.A.1
  • 13
    • 0029791898 scopus 로고    scopus 로고
    • Insulin resistance as a programmed response to fetal undernutrition
    • (1996) Diabetologia , vol.39 , pp. 1119-1122
    • Phillips, D.I.1
  • 14
    • 0032486268 scopus 로고    scopus 로고
    • Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
    • (1998) J. Biol. Chem. , vol.273 , pp. 14484-14494
    • Hara, K.1
  • 17
    • 0032504211 scopus 로고    scopus 로고
    • Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells
    • (1998) J. Biol. Chem. , vol.273 , pp. 17771-17779
    • Hugl, S.R.1    White, M.F.2    Rhodes, C.J.3
  • 18
    • 0032538890 scopus 로고    scopus 로고
    • s6k gene reveals a small mouse phenotype and a new functional S6 kinase
    • (1998) EMBO J. , vol.17 , pp. 6649-6659
    • Shima, H.1
  • 19
    • 0029911864 scopus 로고    scopus 로고
    • Diverse effects of Glut 4 ablation on glucose uptake and glycogen synthesis in red and white skeletal muscle
    • (1996) J. Clin. Invest. , vol.98 , pp. 629-634
    • Stenbit, A.E.1
  • 21
    • 0031767702 scopus 로고    scopus 로고
    • Insulin, but not glucose lowering corrects the hyperglucagonemia and increased proglucagon messenger ribonucleic acid levels observed in insulinopenic diabetes
    • (1998) Endocrinology , vol.139 , pp. 4540-4546
    • Dumonteil, E.1
  • 22
    • 0032843917 scopus 로고    scopus 로고
    • Drosophila S6 kinase: A regulator of cell size
    • (1999) Science , vol.285 , pp. 2126-2129
    • Montagne, J.1
  • 24
    • 0023742627 scopus 로고
    • Intermittent protein-calorie malnutrition in the young rat causes long- term impairment of the insulin secretory response to glucose in vitro
    • (1988) J. Endocrinol , vol.118 , pp. 295-302
    • Swenne, I.1    Crace, C.J.2    Jansson, L.3
  • 27
  • 28
    • 0030707689 scopus 로고    scopus 로고
    • Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2
    • (1997) Nature Genet. , vol.17 , pp. 327-330
    • Guillam, M.T.1
  • 29
    • 0030662371 scopus 로고    scopus 로고
    • Errata: Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2
    • (1997) Nature Genet. , vol.17 , pp. 503
    • Guillam, M.T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.