Targeted overactivity of β cell K(ATP) channels induces profound neonatal diabetes

Cell

Volumn 100, Issue 6, 2000, Pages 645-654

  Koster, J C ^a   Marshall, B A ^b   Ensor, N ^b   Corbett, J A ^c   Nichols, C G ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST LOUIS CHILDREN S HOSPITAL   (United States)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; GLUCOSE; INSULIN; POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DEPOLARIZATION; DIABETES MELLITUS; GLUCOSE METABOLISM; HYPERGLYCEMIA; HYPOINSULINEMIA; INSULIN DEFICIENCY; INSULIN RELEASE; KETOACIDOSIS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PATCH CLAMP; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

EID: 0034677634     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80701-1     Document Type: Article

References (72)

1. The b cell high affinity sulfonylurea receptor: A regulator of insulin secretion
2. Glucose action 'beyond ionic events' in the pancreatic beta cell
3. Epigenetic control of transgene expression and imprinting by genotype-specific modifiers
4. Adenosine 5'-triphosphate-sensitive potassium channels
5. ATP-sensitive K+ channels: A link between beta-cell metabolism and insulin secretion
6. Nesidioblastosis of the pancreas: Definition of the syndrome and the management of the severe neonatal hyperinsulinaemic hypoglycaemia
7. The N-terminus of KIR6.2 limits spontaneous bursting and modulates the ATP-inhibition of K(ATP) channels
8. Alteration of islet cell populations in spontaneously diabetic mice
9. PIP2 and PIP as determinants for ATP inhibition of K(ATP) channels
10. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release
11. Transgenic mice in the analysis of metabolic regulation
12. Evidence for a unique long chain acyl-CoA ester binding site on the ATP-regulated potassium channel in mouse pancreatic beta cells
13. Long chain coenzyme A esters activate the pore-forming subunit (Kir6. 2) of the ATP-regulated potassium channel
14. Quantitative immuncytochemical study of islet cell populations in diabetic calmodulin-transgenic mice
15. Association and stoichiometry of K(ATP) channel subunits
16. ATP-sensitive K+ channels in pancreatic β-cells: The spare channels hypothesis
17. Regulatory regions of rat insulin I gene necessary for expression in transgenic mice
18. Variegated transgene expression in mouse mammary gland is determined by the transgenic integration locus
19. K-ATP channel inhibition by ATP requires distinct functional domains of the cytoplasmic C-terminus of the pore-forming subunit
20. Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice
21. Familial persistent hyperinsulinemic hypoglycemia of infancy and mutations in the sulfonylurea receptor
22. A strain-specific modifier on mouse chromosome 4 controls the methylation of independent transgene loci
23. Calmodulin-induced early-onset diabetes in transgenic mice
24. Anionic phospholipids activate ATP-sensitive potassium channels
25. Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus
26. The interaction of nucleotides with tolbutamide block of cloned ATP-sensitive K channel currents expressed in Xenopus oocytes - A reinterpretation
27. The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide
28. Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA
29. Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KiR6.2/BIR): A meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians
30. Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1
31. Linkage of type 2 diabetes to the glucokinase gene
32. 2+ exchange and K(ATP) potassium channels by PIP2
33. Reconstitution of IK(ATP): An inward rectifier subunit plus the sulfonylurea receptor
34. + channels
35. + channel
36. A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel
37. Loss of functional K(ATP) channels in pancreatic beta-cells causes persistent hyperinsulinemic hypoglycemia of infancy
38. Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathway
39. Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells
40. ATP inhibition of K(ATP) channels: Control of nucleotide sensitivity by the N-terminal domain of the Kir6.2 subunit
41. Sulfonylurea and K+-channel opener sensitivity of K-ATP channels: Functional coupling of Kit6.2 and SUR1 subunits
42. Suppression of K(ATP) currents by gene transfer of a dominant negative Kir6.2 construct
43. Differential effects of GLUT1 and GLUT4 overexpression on insulin responsiveness in transgenic mice
44. Germline manipulation of glucose homeostasis via alteration of glucose transporter levels in skeletal muscle
45. Abnormalities of pancreatic islets by targeted expression of a dominant-negative K(ATP) channel
46. Electrophysiology of stimulus-secretion coupling in human β-cells
47. Mutations in the sulfonylurea receptor gene are associated with familial hyperinsulinism in Ashkenazi Jews
48. A nonsense mutation in the inward rectifier potassium channel gene, Kit6.2, is associated with familial hyperinsulinism
49. Adenosine diphosphate as an intracellular regulator of insulin secretion
50. + channel overexpression in transgenic islets and β-cells associated with impaired glucose responsiveness
51. Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice
52. Timing of paternal Pgk-1 expression in embryos of transgenic mice
53. Involvement of the N-terminus of Kir6.2 in the inhibition of the K(ATP) channel by ATP
54. Cellular composition of the human diabetic pancreas
55. Involvement of the N-terminus of Kir6.2 in coupling to the sulphonylurea receptor
56. Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice
57. Potassium channel openers require ATP to bind to and act through sulphonylurea receptors
58. Octameric stoichiometry of the K(ATP) channel complex
59. Membrane phospholipid control of nucleotide sensitivity of K(ATP) channels
60. Regulation of K(ATP) channel activity by diazoxide and MgADP: Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor
61. Control of rectification and gating of cloned K(ATP) channels by the Kit6.2 subunit
62. Functional analyses of novel mutations in the sulfonylurea receptor I associated with persistent hyperinsulinemic hypoglycemia of infancy
63. Direct photoaffinity labeling of the Kit6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP
64. Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose
65. Mutations in the sulfonylurea receptor gane in familial persistent hyperinsulinemic hypoglycemia of infancy
66. + channels in the absence of the sulphonylurea receptor
67. Molecular determinants of K-ATP channel inhibition by ATP
68. Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus
69. Deficiency of pyruvate dehydrogenase activity in pancreatic islets of diabetic GK rats