The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians

Diabetes

Volumn 49, Issue 9, 2000, Pages 1608-1611

  Rasmussen, S K ^a   Urhammer, S A ^a   Pizzuti, A ^a   Echwald, S M ^a   Ekstrom, C T ^a   Hansen, L ^a   Hansen, T ^a   Borch Johnsen, K ^a   Frittitta, L ^a   Trischitta, V ^a   Pedersen, O ^a  

^a STENO DIABETES CENTER   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

ADULT; ARTICLE; DIABETES MELLITUS; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAVENOUS GLUCOSE TOLERANCE TEST; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL;

EID: 0033850381     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.9.1608     Document Type: Article

References (17)

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5. Insulin receptor kinase defects in insulin-resistant tissues and their role in the pathogenesis of NIDDM
6. Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus
7. Identification of nucleotide pyrophosphatase/alkaline phosphodiesterase I activity associated with the mouse plasma cell differentiation antigen PC-1
8. Overexpression of membrane glycoprotein PC-1 in MDA-MB231 breast cancer cells is associated with inhibition of insulin receptor tyrosine kinase activity
9. No correlation of plasma cell 1 overexpression with insulin resistance in diabetic rats and 3T3-L1 adipocytes
10. PC-1 content in skeletal muscle of non-obese, non-diabetic subjects: Relation to insulin receptor tyrosine kinase and whole body insulin sensitivity
11. Increased adipose tissue PC-1 content but not tumor necrosis factor-alpha gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity
12. Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: Evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling
13. A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance
14. Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
15. Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp
16. Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians
17. The Ala/Val98 polymorphism of the hepatocyte nuclear factor-1α gene contributes to the interindividual variation in serum C-peptide response during an oral glucose tolerance test: Evidence from studies of 231 glucose-tolerant first-degree relatives of type 2 diabetic probands