Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects

Diabetes

Volumn 47, Issue 8, 1998, Pages 1281-1286

  Krook, Anna ^a   Roth, Richard A ^b   Jiang, Xin Jian ^a   Zierath, Juleen R ^a   Wallberg Henriksson, Harriet ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PROTEIN SERINE KINASE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; GLUCOSE TRANSPORT SYSTEM; GLUCOSE UTILIZATION; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

EID: 0031852665     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.47.8.1281     Document Type: Article

References (45)

1. Kahn CR: Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 43:1066-1084, 1994
2. Warram JH, Rich SS, Krolewski AS: Epidemiology and genetics of diabetes mellitus. In Joslin's Diabetes Mellitus. Kahn CR, Weir GC, Eds. Philadelphia, Lea and Febiger, 1995, p. 206-216, 1995
3. Galuska D, Zierath JR, Thörne A, Sonnenfeld T, Wallberg-Henriksson H: Metformin increases insulin-stimulated glucose transport in insulin-resistant human skeletal muscle. Diabete Metab 17:159-163, 1991
4. DeFronzo RA, Bonadonna RC, Ferranini E: Pathogenesis of NIDDM, a balanced overview. Diabetes Care 15:318-316, 1992
5. Dohm GL, Tapscott EB, Pories WJ, Dabbs DJ, Flickinger EG, Meelhein D, Fushiki T, Atkinson SM, Elton CW, Caro JF: An in vitro human skeletal muscle preparation suitable for metabolic studies: decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects. J Clin Invest 82:486-494, 1988
6. Andreasson K, Galuska D, Thörne A, Sonnenfeld T, Wallberg-Henriksson H: Decreased insulin-stimulated 3-O-methyl glucose transport in in vitro incubated skeletal muscle from type II diabetic subjects. Acta Physiol Scand 142:255-260, 1991
7. Zierath JR, Galuska D, Nolte LA, Thörne A, Smedegaard-Kristensen J, Wallberg-Henriksson H: Effects of glycemia on glucose transport in isolated skeletal muscle from patients with NIDDM: in vitro reversal of muscular insulin resistance. Diabetologia 37:270-277, 1994
8. Nolan JJ, Freidenberg G, Henery R, Reichart D, Olefsky JM: Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of non-insulin-dependent diabetes mellitus and obesity. J Clin Endocrinol Metab 78:471-477, 1994
9. Björnholm M, Kawano Y, Lehtihet M, Zierath JR: Insulin receptor substrate1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation. Diabetes 46:524-427, 1997
10. Goodyear LJ, Giorgino F, Sherman LA, Carey J, Smith RJ, Dohm GL: Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J Clin Invest 95:2195-2204, 1995
11. Kohn AD, Kovacina KS, Roth RA: Insulin stimulates the kinase activity of RAKPK, a pleckstrin homology domain containing ser/thr kinase. EMBO J 14:4288-4295, 1995
12. Burgering BMT, Coffer PJ: Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376:599-602, 1995
13. Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN: The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF activated phosphatidylinositol 3-kinase. Cell 81:727-736, 1995
14. phox by a membrane-targeted phosphoinositide 3-kinase. Curr Biol 6:1271-1278, 1996
15. Klippel A, Reinhard C, Kavanaugh M, Apell G, Escobedo MA, Williams TL: Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transduction kinase pathways. Mol Cell Biol 16:4117-4127, 1996
16. Datta K, Bellacusa A, Chun TO, Tsiclulis PN: Akt is a direct target of the phosphatidylinositol 3-kinase: activation by growth factors, v-src, v-Ha-ras in Sf9 and mammalian calls. J Biol Chem 271:30835-30839, 1996
17. Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PRJ, Reese CB, Cohen P: Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Ba. Curr Biol 7:261-269, 1997
18. Yao R, Cooper GM: Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267:2003-2006, 1995
19. Kulik G, Klippel A, Weber MJ: Antiapoptotic signalling by the insulin-like growth factor I receptor phosphatidylinositol 3-kinase, and Akt. Mol Cell Biol 17:1595-1606, 1997
20. Peso LD, González-García M, Page C, Herrera R, Nuñez G: Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278:687-689, 1997
21. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME: Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275:661-665, 1997
22. Kohn AD, Summers SA, Birnbaum MJ, Roth RA: Expression of a constitutively active Akt Ser/Thr kinase in 3T3-Li adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem 271:31372-31378, 1996
23. Tanti J-F, Grillo S, Grémeaux T, Coffer PJ, Van Obberghen E, Le Marchand-Brustel Y: Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes. Endocrinology 138:2005-2010, 1997
24. Krook A, Kawano Y, Song XM, Efendic S, Roth RA, Wallberg-Henriksson H, Zierath JR: Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki (GK) rats. Diabetes 36:2110-2114, 1997
25. DeFronzo RA, Tobin JC, Andres R: Glucose clamp technique: a method for quantifying insulin secretion and resistance. A m J Physiol 6:E214-E223, 1979
26. Zierath JR, He L, Gumá A, Odegaard-Wahlström E, Klip A, Wallberg-Henriksson H: Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM. Diabetologia 39:1180-1189, 1996
27. Zierath JR: In vitro studies of human skeletal muscle: hormonal and metabolic regulation of glucose transport. Acta Physiol Scand 155 (Suppl. 626):1-96, 1995
28. Wallberg-Henriksson H, Zetan N, Henriksson J: Reversibility of decreased insulin-stimulated glucose transport capacity in diabetic muscle with in vitro incubation: insulin is not required. J Biol Chem 262:7665-7671, 1987
29. Cross AU, Alessi DAE, Cohen DR, Andjelkovich P, Hemmings BA: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785-789, 1995
30. Barthel A, Nakatani K, Dandekar AA, Roth RA: Protein kinase C modulates the insulin-stimulated increase in Akt1 and Akt3 activity in 3T3-L1 adipocytes. Biochem Biophys Res Commun 243:509-513, 1998
31. Shepherd PR, Nave BT, Rincon J, Haigh RJ, Foulstone E, Proud C, Zierath JR, Siddle K, Wallberg-Henriksson H: Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: implications for glucose metabolism. Diabetologia 40:1172-1177, 1997
32. Rossetti L, Smith D, Schulman GI, Papachristou D, DeFronzo RA: Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest 79:1510-1515, 1987
33. Yki-Järvinen H, Helve E, Koivisto V: Hyperglycemia decreases glucose uptake in type I diabetes. Diabetes 36:892-896, 1987
34. Richter EA, Hansen BF, Hansen SA: Glucose-induced insulin resistance of skeletal muscle glucose transport and uptake. Biochem J 252:733-737, 1988
35. Kahn BB, Schulman GI, DeFronzo RA, Cushman SW, Rossetti L: Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression. J Clin Invest 87:561-570, 1991
36. Marshall S, Bacote V, Traxinger RR: Discovery of a metabolic pathway mediating desensitization of the glucose transport system: role of hexosamine biosynthesis in the induction of insulin resistance. J Biol Chem 266:4706-4712, 1992
37. Pillay TS, Xiao S, Olefsky JM: Glucose-induced phosphorylation on the insulin receptor. J Clin Invest 97:613-620, 1996
38. Rossetti L, Hawkins M, Chen W, Gindi J, Barzilai N: In vivo glucosamine infusion induces insulin resistance in normoglycemic but not hyperglycemic conscious rats. J Clin Invest 96:132-140, 1997
39. Wijkander, J, Stenson-Holst L, Rahn T, Resjö S, Castan I, Manganiello V, Belfrage P, Degerman E: Regulation of protein kinase B in rat adipocytes by insulin, vanadate, and peroxovanadate: membrane localisation in response to peroxovanadate. J Biol Chem 272:21520-21526, 1997.
40. Cross DAE, Watt PW, Shaw M, van der Kaay J, Downes CP, Holder JC, Cohen P: Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue. FEES Lett 406:211-215, 1997
41. 3 production in rat skeletal muscle in vivo. J Biol Chem 272:5477-5481, 1997
42. Jullien D, Tanti JF, Heydrick SJ, Gautier N, Grémeaux T, van Obberghen E, Le Marchand-Brustel Y: Differential effects of okadaic acid on insulin stimulated glucose and amino acid uptake and phosphatidylinositol 3-kinase activity. J Biol Chem 268:15246-15251, 1993
43. Marte P, Rodriguez-Viciana BM, Wennström S, Warne PH, Downward J: R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways. Curr Biol 7:63-70, 1997
44. Konishi H, Matsuzaki H, Tanaka M, Ono Y, Tokunaga C, Kuroda S, Kikkawa U: Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A 93:7639-7643, 1996
45. Chen D, Elmendorf JS, Olson AL, Li X, Earp HS, Pessin JE: Osmotic shock stimulates GLUT4 translocation in 3T3L1 adipocytes by a novel tyrosine kinase pathway. J Biol Chem 272:27401-27410, 1997