Disruption of IRS-2 causes type 2 diabetes in mice

Nature

Volumn 391, Issue 6670, 1998, Pages 900-904

  Withers, D J ^a   Gutierrez, J S ^a   Towery, H ^a   Burks, D J ^a   Ren, J M ^a   Previs, S ^a   Zhang, Y ^a   Bernal, D ^a   Pons, S ^a   Shulman, G I ^a   Bonner Weir, S ^a   White, M F ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HORMONE RECEPTOR STIMULATING AGENT; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE DISRUPTION; GLUCOSE HOMEOSTASIS; INSULIN RELEASE; INSULIN RESISTANCE; LIVER; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SKELETAL MUSCLE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOOD GLUCOSE; CLONING, MOLECULAR; DIABETES MELLITUS, TYPE 2; FEMALE; GENE TARGETING; HUMANS; INSULIN; INSULIN RESISTANCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISLETS OF LANGERHANS; LIVER; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; PHOSPHOPROTEINS; PHOSPHORYLATION; RECEPTOR, INSULIN; RECOMBINATION, GENETIC; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0032567937     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/36116     Document Type: Article

References (22)