In vitro and in vivo studies of a naturally occurring variant of the human p85α regulatory subunit of the phosphoinositide 3-kinase: Inhibition of protein kinase B and relationships with type 2 diabetes, insulin secretion, glucose disappearance constant, and insulin sensitivity

Diabetes

Volumn 50, Issue 3, 2001, Pages 690-693

  Hansen, Lars ^a   Zethelius, Björn ^b   Berglund, Lars ^b   Reneland, Richard ^b   Hansen, Torben ^a   Berne, Christian ^b   Lithell, Hans ^b   Hemmings, Brian A ^c   Pedersen, Oluf ^a  

^a STENO DIABETES CENTER   (Denmark)

^b UPPSALA UNIVERSITY   (Sweden)

^c FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

HEMAGGLUTININ; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85;

AGED; ARTICLE; BODY MASS; CARBOXY TERMINAL SEQUENCE; CARDIOVASCULAR DISEASE; CAUCASIAN; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBUNIT; FOLLOW UP; GENOTYPE; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; INSULIN RESPONSE; INSULIN SENSITIVITY; MISSENSE MUTATION; ORAL GLUCOSE TOLERANCE TEST; PHENOTYPE; PRIORITY JOURNAL;

EID: 0035095168     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.3.690     Document Type: Article

References (20)

1. Metabolic and genetic characterization of prediabetic states
2. Insulin action and the insulin signaling network
3. Mutational analysis of the coding regions of the genes encoding protein kinase B-α and -β, phosphoinositide-dependent protein kinase-1 phosphatase targeting to glycogen, protein phosphatase inhibitor-1 and glycogenin: Lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients
4. Genetics of insulin resistance
5. Amino acid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus
6. A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes
7. A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin
8. Insulin resistance: Interactions between a common variant of the insulin receptor substrate-1
9. Phosphoinositide 3-kinase, the key switch mechanism in insulin signalling
10. Identification of a common amino acid polymorphism in the p85α regulatory subunit of phosphatidylinositol 3-kinase
11. Variant in the regulatory subunit of phosphatidylinositol 3-kinase (p85α): Preliminary evidence indicates a potential role of this variant in the acute insulin response and type 2 diabetes in Pima Women
12. Prevalence of a polymorphism of the phosphatidylinositol 3-kinase p85α regulatory subunit (codon 326 Met→Ile) in Japanese NIDDM patients
13. A study of middle-aged men with particular reference to risk factors for cardiovascular disease
14. Natural variants of human p85α phosphoinositide-3 kinase in severe insulin resistance: A novel variant with impaired insulin-stimulated lipid kinase activity
15. PI3-kinase: Structural and functional analysis of intersubunit interactions
16. Role of translocation in the activation and function of protein kinase B
17. AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide dependent phosphorylation
18. Increased insulin sensitivity and hypoglycemia in mice lacking the p85α subunit of phosphoinositide 3-kinase
19. Glucose tolerance and resistance to insulin-stimulated glucose uptake in men aged 70 years in relation to size at birth
20. Lipoprotein lipase activity in skeletal muscle is related to insulin sensitivity