Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ)

Science

Volumn 292, Issue 5522, 2001, Pages 1728-1731

  Cho, Han ^a   Mu, James ^b,c   Kim, Jason K ^c   Thorvaldsen, Joanne L ^b,c   Chu, Qingwei ^b,c   Crenshaw, E Bryan ^b   Kaestner, Klaus H ^b   Bartolomei, Marisa S ^b,c   Shulman, Gerald I ^c   Birnbaum, Morris J ^b,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; GENES; GLUCOSE; MUSCLE; PROTEINS;

INSULIN RESISTANCE;

INSULIN;

PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; FEMALE; GLUCOSE HOMEOSTASIS; INSULIN METABOLISM; INSULIN RESISTANCE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0035368548     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.292.5522.1728     Document Type: Article

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36. We thank J. Richa (Transgenic and Chimeric Mouse Facility, University of Pennsylvania) for the generation of chimeric mice and W. Ewens and B. Wolf (University of Pennsylvania) for advice on statistical analyses. The histological procedures were performed by the Center for Molecular Studies in Digestive and Liver Diseases (supported by NIH grant P30 DK50306). Serum insulin was assayed by the Radio-immunoassay Core Facility at the Penn Center for Diabetes (NIH grant P30 19525). H.C. is a recipient of the National Research Service Award for Training in Cell and Molecular Biology (GM07229). Supported in part by NIH grant RO1 DK56886 (to M.J.B.).