Defects in insulin secretion and insulin action in non-insulin-dependent diabetes mellitus are inherited. Metabolic studies on offspring of diabetic probands

Journal of Clinical Investigation

Volumn 101, Issue 1, 1998, Pages 86-96

  Vauhkonen, Ilkka ^a   Niskanen, Leo ^a   Vanninen, Esko ^a   Kainulainen, Sakari ^a   Uusitupa, Matti ^a   Laakso, Markku ^a,b  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Fat distribution; Glucose tolerance; Insulin secretion; Insulin sensitivity; Maximal oxygen uptake

Indexed keywords

C PEPTIDE; GLUCOSE; INSULIN; NEUTRAL INSULIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RELEASE; INSULIN RESPONSE; LEAN BODY WEIGHT; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL;

EID: 0031963964     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI716     Document Type: Article

References (61)

1. Defronzo, R.M. 1988. The triumvirate: β-cell, muscle and liver: a collusion responsible for NIDDM. Diabetes. 37:667-687.
2. Barnett, A.H., C. Eff, and D.A. Pyke. 1981. Diabetes in identical twins: a study of 200 pairs. Diabetes. 20:87-93.
3. Newman, B., J.V. Selby, M.C. King, C. Slemenda, R. Fabsitz, and G.D. Friedman. 1987. Concordance for type II (non-insulin dependent) diabetes mellitus in male twins. Diabetologia. 30:763-768.
4. Froguel P., H. Zouali, N. Vionnet, G. Velho, M. Vaxillaire, F. Sun, S. Lesage, M. Stoffel, J. Takeda, P. Passa, et al. 1993. Familial hyperglycemia due to mutations in glucokinase. Definition of subtype of diabetes mellitus. N. Engl. J. Med. 328:697-702.
5. (UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness. Nat. Genet. 1: 368-371.
6. Arner, P., T. Pollare, and H. Lithell. 1995. Different aetiologies of type 2 (non-insulin dependent) diabetes mellitus in obese and non-obese subjects. Diabetologia. 34:483-487.
7. Rossetti, L., A. Giaccari, and R.A. DeFronzo. 1990. Glucose toxicity. Diabetes Care. 13:610-630.
8. Eriksson, J., A. Franssila-Kallunki, A. Ekstrand, C. Saloranta, E. Widen, C. Schalin, and L. Groop. 1989. Early metabolic defects in persons at increased risk for non-insulin dependent diabetes mellitus. N. Engl. J. Med. 321:337-343.
9. Gulli, G., E. Ferrannini, M. Stern, S. Haffner, and R.A. DeFronzo. 1992. The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents. Diabetes. 41:1575-1586.
10. Warram, J., B. Martin, A. Krolewski, S. Soellener, and C. Kahn. 1990. Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann. Intern. Med. 113:909-915.
11. Haffner, S., M. Stern, H. Hazuda, J. Pugh, and J. Patterson. 1986. Hyperinsulinemia in a population at high risk for non-insulin dependent diabetes mellitus. N. Eng. J. Med. 315:220-224.
12. Haffner, S.M., M.P. Stern, B.D. Mitchell, H.P. Hazuda, and J.K. Patterson. 1980. Incidence of type II diabetes mellitus in Mexican Americans predicted by fasting insulin and glucose levels, obesity and body fat distribution. Diabetes. 39:283-288.
13. Knowler, W.C., D.J. Pettitt, P.J. Savage, and P.H. Bennett. 1981. Diabetes incidence in Pima Indians: contributions of obesity and parental diabetes. Am. J. Epidemiol. 113:144-151.
14. Migdalis, I.N., D. Zachariadis, K. Kalogeropoulou, C. Nounopoulos, A. Bouloukos, and M. Samartzis. 1996. Metabolic abnormalities in offspring of NIDDM patients with a family history of diabetes mellitus. Diabet. Med. 13: 434-440.
15. O'Rahilly, S., R. Turner, and D. Matthews. 1988. Impaired pulsatile secretion of insulin in relatives of patients with non-insulin dependent diabetes. N. Engl. J. Med. 18:1225-1230.
16. Pimenta, W., M. Korytkowski, A. Mitrakou, T. Jenssen, H. Yki-Järvinen, W. Evron, G. Dailey, and J. Gerich. 1995. Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM: evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative. JAMA (J. Am. Med. Assoc). 273:1855-1861.
17. Uusitupa, M., O. Siitonen, A. Aro, and K. Pyörälä. 1985. Prevalence of coronary heart disease, left ventricular failure and hypertension in middle-aged, newly diagnosed type 2 (non-insulin dependent) diabetic subjects. Diabetologia. 28:22-27.
18. Niskanen, L.K., M.I. Uusitupa, H. Sarlund, O. Siitonen, and K. Pyörälä. 1990. Five-year follow-up study on plasma insulin levels in newly diagnosed NIDDM patients and nondiabetic subjects. Diabetes Care. 13:41-48.
19. Uusitupa, M.I.J., L.K. Niskanen, O. Siitonen, E. Voutilainen, and K. Pyörälä. 1993. Ten-year cardiovascular mortality in relation to risk factors and abnormalities in lipoprotein composition in type 2 (non-insulin dependent) diabetic and nondiabetic subjects. Diabetologia. 36:1175-1184.
20. Niskanen, L., J. Karjalainen, O. Siitonen, and M. Uusitupa. 1994. Metabolic evolution of type 2 diabetes: a 10-year follow-up from the time of diagnosis. J. Intern. Med. 236:263-270.
21. Niskanen, L.K., T. Tuomi, J. Karjalainen, L.C. Groop, and M.I.J. Uusitupa. 1995. GAD antibodies in NIDDM. Ten-year follow-up from the diagnosis. Diabetes Care. 18:1557-1565.
22. Niskanen, L.K., J. Karjalainen, H. Sarlund, O. Siitonen, and M.I.J. Uusitupa. 1991. Five-year follow-up of islet cell antibodies in Type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia. 34:402-108.
23. World Health Organization Study Group. 1985. Diabetes Mellitus. WHO Tech. Rep. Ser. 727.
24. DeFronzo, R.A., J.E. Tobin, and R. Andres. 1979. Glucose clamp techniques: a method for quantifying insulin secretion and resistance. Am. J. Physiol. 237:E214-E223.
25. Laakso, M., M. Uusitupa, J. Takala, H. Majander, T. Reijonen, and I. Penttilä. 1988. Effects of hypocaloric diet and insulin therapy on metabolic control and mechanisms of hyperglycemia in obese non-insulin dependent diabetic subjects. Metabolism. 37:1092-1100.
26. Ferrannini, E. 1988. The theoretical bases of indirect calorimetry. Metabolism. 37:287-301.
27. Fuller, N.J., and M. Elia. 1989. Potential use of bioelectrical impedance of the "whole body" and of body segments for assessment of body composition: comparison with densitometry and anthropometry. Eur. J. Clin. Nutr. 43:779-791.
28. 40K, and tritium. Am. J. Physiol. 250:E736-E745.
29. Kvist, H., U. Tylen, and L. Sjöström. 1986. Adipose tissue volume determinations in women by computed tomography: technical considerations. Int. J. Obes. 10:53-67.
30. Whipp, B.J., J.A. Davis, F. Torres, and K. Wasserman. 1981. A test to determine parameters for aerobic function during exercise. J. Appl. Physiol. 50: 217-221.
31. Penttilä, I.M., E. Voutilainen, P. Laitinen, and P. Juutilainen. 1984. Comparison of different analytical and precipitation methods for the direct estimation of serum high-density lipoprotein cholesterol. Scand. J. Clin. Lab. Invest. 41:353-360.
32. Laakso, M., H. Sarlund, and L. Mykkänen. 1990. Insulin resistance is associated with lipid and lipoprotein abnormalities in subjects with varying degrees of glucose tolerance. Arteriosclerosis. 10:223-231.
33. Hawk, P.B., B.L. Oser, and W.H. Summerson. 1947. In Practical Physiological Chemistry. 12th ed. Blakiston. Toronto. 814-822.
34. Larsson, H., and B. Ahrén. 1996. Failure to adequately adapt reduced insulin sensitivity with increased insulin secretion in women with impaired glucose tolerance. Diabetologia. 39:1099-1107.
35. Henriksen, J.E., F. Alford, A. Hanberg, A. Vaag, G.M. Ward, A. Kalfas, and H. Beck-Nielsen. 1994. Increased glucose effectiveness in normoglycemic but insulin resistant relatives of patients with non-insulin-dependent diabetes mellitus. A novel compensatory mechanism. J. Clin. Invest. 94:1196-1204.
36. Vaag, A., J.E. Henriksen, S. Madsbad, N. Holm, and H. Beck-Nielsen. 1995. Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin-dependent diabetes mellitus. J. Clin. Invest. 95:690-698.
37. Turner, R.C., S.T. McCarthy, R.R. Holman, and E. Harris. 1976. Beta-cell function improved by supplementing basal insulin secretion in mild diabetes. Br. Med. J. 1:1252-1254.
38. Leahy, J.L., H.E. Cooper, and G.C. Weir. 1987. Impaired insulin secretion associated with near normoglycemia. Diabetes. 36:459-464.
39. McLean, N., and R.F. Ogilve. 1955. Quantitative estimation of the pancreatic islet tissue in diabetic subjects. Diabetes. 4:367-376.
40. Klöppel, G., M. Löhr, K. Habich, M. Oberholzer, and P.U. Heitz. 1985. Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv. Synth. Pathol. Res. 4:110-125.
41. Ward, W.K., D.C. Bolgiano, B. McKnight, J.B. Halter, and D. Porte, Jr. 1984. Diminished β cell secretory capacity in patients with non-insulin-dependent diabetes mellitus. J. Clin. Invest. 74:1318-1328.
42. Hosker, J., A. Rudenski, M. Burnett, D. Matthews, and R. Turner. 1989. Similar reduction of first- and second phase β-cell responses at three different glucose levels in type II diabetes and the effect of gliclazide therapy. Metabolism. 38:767-772.
43. Bonadonna, R.C., L. Groop, N. Kraemer, E. Ferrannini, S. Del-Prato, and R. DeFronzo. 1990. Obesity and insulin resistance in humans: a dose-response study. Metabolism. 39:452-459.
44. Kissebah, H. 1991. Insulin resistance in visceral obesity. Int. J. Obes. 15: 109-115.
45. Walker, M. 1995. Obesity, insulin resistance, and its link to non-insulin-dependent diabetes mellitus. Metabolism. 44:18-20.
46. Firth, R., P. Bell, and R. Rizza. 1987. Insulin action in non-insulin-dependent diabetes mellitus: the relationship between hepatic and extrahepatic insulin resistance and obesity. Metab. Clin. Exp. 36:1091-1095.
47. Campell, P.J., and M.G. Carlson. 1993. Impact of obesity in insulin action in NIDDM. Diabetes. 42:405-410.
48. Abate, N., A. Garg, R.M. Peshock, J. Stray-Gundersen, and S.M. Grundy. 1995. Relationships of generalized and regional adiposity to insulin sensitivity. J. Clin. Invest. 96:88-98.
49. Abate, N., A. Garg, R.M. Peshock, J. Stray-Gundersen, B. Adams-Huet, and S.M. Grundy. 1996. Relationships of generalized and regional adiposity to insulin sensitivity in men with NIDDM. Diabetes. 45:1684-1693.
50. Nyholm, B., A. Mengel, S. Nielsen, C. Skaærbæk, N. Møller, K.G. Alberti, and O. Schmitz. 1996. Insulin resistance in relatives of NIDDM patients: the role of physical fitness and muscle metabolism. Diabetologia. 39:813-822.
51. Laws, A., M.L. Stefanik, and G.M. Reaven. 1989. Insulin resistance and hypertriglyceridemia in nondiabetic relatives of patients with non-insulin-dependent diabetes mellitus. J. Clin Endocrinol. Metab. 69:343-347.
52. Lillioja, S., A.A. Young, C.L. Culter, et al. 1987. Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man. J. Clin. Invest. 80:415-424.
53. Matsuda, A., and T. Kuzuya. 1996. The prevalence of low insulin responders to oral glucose load among groups with various patterns of family history of diabetes. Diabet. Med. 13:S59-S62
54. Lindsten, J., E. Cerasi, R. Luft, N. Morton, and N. Ryman. 1976. Significance of genetic factors for the plasma insulin response to glucose in healthy subjects. Clin. Genet. 10:125-134.
55. Ward, W.K., J.B. Halter, J.D. Best, J.C. Beard, and D. Porte, Jr. 1983. Hyperglycemia and β-cell adaptation during prolonged somatostatin infusion with glucagon replacement in man. Diabetes. 32:943-947.
56. ATP: an inward rectifier subunit plus the sulphonylurea receptor. Science. 270:1166-1169.
57. Yamagata, K., N. Oda, P.J. Kaisaki, S. Menzel, H. Furuta, M. Vaxillaire, L. Southam, R.D. Cox, G.M. Lathrop, V.V. Boriraj, et al. 1996. Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3). Nature. 384:455-458.
58. Yamagata, K., H. Furuta, N. Oda, P.J. Kaisaki, S. Menzel, N.J. Cox, S.S. Fajans, S. Signorini, M. Stoffel, and G.I. Bell. 1996. Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1). Science. 384:458-460.
59. Schalin-Jäntti, C., M. Härkönen, and L.C. Groop. 1992. Impaired activation of glycogen synthase in people at increased risk for developing NIDDM. Diabetes. 41:598-604.
60. Freymond, D., C. Bogardus, M. Okubo, K. Stone, and D. Mott. 1988. Impaired insulin-stimulated muscle glycogen synthase phosphatase activity. J. Clin. Invest. 82:1503-1509.
61. Kahn, C.R., D. Vicent, and A. Doria. 1996. Genetics of non-insulin-dependent (type-II) diabetes mellitus. Annu. Rev. Med. 47:509-531.