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Volumn 26, Issue 3, 2000, Pages 379-382

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE;

EID: 0033757592     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/81715     Document Type: Article
Times cited : (259)

References (28)
  • 3
    • 0032909703 scopus 로고    scopus 로고
    • Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 α subunit of phosphoinositide 3-kinase
    • (1999) Nature Genet. , vol.21 , pp. 230-235
    • Terauchi, Y.1
  • 6
    • 0030615068 scopus 로고    scopus 로고
    • p85α gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-kinase), p50α, p55α, and p85α, with different PI 3-kinase activity elevating responses to insulin
    • (1997) J. Biol. Chem. , vol.272 , pp. 7873-7882
    • Inukai, K.1
  • 7
    • 0033556333 scopus 로고    scopus 로고
    • Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α
    • (1999) Science , vol.283 , pp. 393-397
    • Fruman, D.A.1
  • 10
    • 0030756571 scopus 로고    scopus 로고
    • Regulation of endocytic-transcytotic pathways and bile secretion by phosphatidylinositol 3-kinase in rats
    • (1997) Gastroenterology , vol.113 , pp. 954-965
    • Folli, F.1
  • 15
    • 0034213075 scopus 로고    scopus 로고
    • The conserved phosphoinositide 3-kinase pathway determines heart size in mice
    • (2000) EMBO J. , vol.19 , pp. 2537-2548
    • Shioi, T.1
  • 17
    • 0026660653 scopus 로고
    • Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation
    • (1992) EMBO J. , vol.11 , pp. 3469-3479
    • Backer, J.M.1
  • 18
    • 0030854777 scopus 로고    scopus 로고
    • Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle
    • (1997) J. Biol. Chem. , vol.272 , pp. 19000-19007
    • Shepherd, P.R.1
  • 19
    • 2642683510 scopus 로고    scopus 로고
    • Differential regulation of insulin receptor substrates-1 and -2 (IR5-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob)mouse
    • (1997) J. Clin. Invest. , vol.100 , pp. 3164-3172
    • Kerouz, N.J.1    Horsch, D.2    Pons, S.3    Kahn, C.R.4
  • 20
    • 0031887249 scopus 로고    scopus 로고
    • Regulation of the p85/p110 phosphatidylinositol 3'-kinase: Stabilization and inhibition of the p110α catalytic subunit by the p85 regulatory subunit
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1379-1387
    • Yu, J.1
  • 21
    • 0028982198 scopus 로고
    • The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 4453-4465
    • Pons, S.1
  • 24
    • 0033046582 scopus 로고    scopus 로고
    • Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle
    • (1999) Diabetes , vol.48 , pp. 310-320
    • Kim, Y.B.1
  • 25
    • 13344277357 scopus 로고    scopus 로고
    • Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
    • (1996) Nature Genet. , vol.12 , pp. 106-109
    • Accili, D.1
  • 26
    • 0032567937 scopus 로고    scopus 로고
    • Disruption of IRS-2 causes type 2 diabetes in mice
    • (1998) Nature , vol.391 , pp. 900-904
    • Withers, D.J.1
  • 27
    • 0033553415 scopus 로고    scopus 로고
    • Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance
    • (1999) J. Biol. Chem. , vol.274 , pp. 14306-14314
    • Egawa, K.1
  • 28


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.