Promoter variation in the liver glucokinase is a risk factor for non-insulin-dependent diabetes mellitus

Biochemical and Biophysical Research Communications

Volumn 221, Issue 3, 1996, Pages 614-618

  Chiu, Ken C ^a   McCarthy, Jennifer E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOKINASE; INSULIN; LIVER ENZYME;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; DNA TRANSFECTION; FEMALE; GENOTYPE; HORMONAL REGULATION; HORMONE RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; ORAL GLUCOSE TOLERANCE TEST; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; RISK FACTOR; TRANSCRIPTION REGULATION;

EID: 0029882911     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.1996.0644     Document Type: Article

References (17)

1. Martin, B. C., Warram, J. H., Krolewski, A. S., Bergman, R. N., Soeldner, J. S., and Kahn, C. R. (1992) Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of a 25-year follow-up study. Lancet 340, 925-929.
2. Borgardus, C., Lillioja, S., Howard, B. V., Reaven, G., and Mott, D. (1984) Relationship between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects. J Clinical Investigation 74, 1238-1246.
3. Defronzo, R. A., Bonadonna, R. C., and Ferranini, E. (1992) Pathogenesis of NIDDM: A balanced overview. Diabetes Care 15, 318-368.
4. Matschinsky, F. M. (1990) Glucokinase as glucose sensor and metabolic signal generator in pancreatic β-cells and hepatocytes. Diabetes 39, 647-652.
5. Forguel, P., Zouali, H., and Vionnet, N., et al. (1993) Familial hyperglycemia due to mutations in glucokinase. New England J Medicine 328, 697-702.
6. Matschinsky, F., Liang, Y., Kesavan, P., and Wang, L., et al. (1993) Glucokinase as pancreatic β-cell glucose sensor and diabetes gene. J. Clinical Investigation 92, 2092-2098.
7. Chiu, K. C., Tanizawa, Y., and Permutt, M. A. (1993) Glucokinase gene variations in the common form of NIDDM. Diabetes 42, 579-582.
8. Chiu, K. C., Go, R. P. C., Aoki, M., Riggs, A. C., Tanizawa, Y., Acton, R. T., Bell, D. S. H., Goldenberg, R. L., Roseman, J. M., and Permutt, M. A. (1994) Glucokinase gene in gestational diabetes mellitus: population association study and molecular scanning. Diabetologia 37, 104-110.
9. Towler, D. A., Havlin, C. E., Craft, S., and Cryer, P. E. (1993) Mechanism of awareness of hypoglycemia, perception of neurogenic (predominately cholinergic) rather than neuroglycopenic symptoms. Diabetes 42, 1791-1798.
10. Ausubel, I. and Frederick, M. (Eds.) Current Protocols in Molecular Biology, unit 9.1 Calcium Phosphate Transfection, Alternate Protocol: High Efficiency Transfection Using Calcium Phosphate-DNA Precipitate Formed in BES, John Wiley and Sons, Inc. New York, New York.
11. Brasier, A. R., Tate, J. E., and Habener, J. F. (1989) Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines. Biotechniques 4, 99-111.
12. Jain, V., and Magrath, I. (1991) A chemiluminescent assay for quantitation of β-galactosidase in the femtogram range: Application to quantitation of β-galactosidase in lacZ-transfected cells. Anal. Biochem. 199, 119-124.
13. Tanizawa, Y., Matsutani, A., Chiu, K. C., and Permutt, M. A. (1992) Human glucokinase gene: Isolation, structural characterization, and identification of a microsatellite repeat polymorphism. Molecular Endrocrinology 6, 1070-1071.
14. Magnuson, M. A., Andreone, T. L., Printz, R. L., Koch, S., and Granner, D. K. (1989) Rat glucokinase gene: structure and regulation by insulin. Proc Natl Acda Sci USA 86, 4838-4842.
15. O'Brien, R. M., Bonovich, M. T., Forest, C. D., and Granner, D. K. (1991) Signal transduction convergence: Phorbol esters and insulin inhibit phosphoenolpyruvate carboxykinase gene transcription through the same 10-base-pare sequence. Proc Natl Acda Sci USA 88, 6580-6584.
16. Granner, D., and Pilkis, S. (1990) The genes of hepatic glucose metabolism. J Biol Chem 265, 10173-10176.
17. Valera, A., Pujol, A., Pelegrin, M., and Bosch, F. (1994) Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus. Pro Natl Acad Sci 91, 9151-9154.