Association of polymorphism in the neuroD/BETA2 gene with type 1 diabetes in the Japanese

Diabetes

Volumn 48, Issue 2, 1999, Pages 416-419

  Iwata, Isao ^a,g   Nagafuchi, Seiho ^a,g   Nakashima, Hitoshi ^a   Kondo, Shiori ^a   Koga, Tatsuhiko ^b   Yokogawa, Yasushi ^c   Akashi, Tomoyuki ^c   Shibuya, Tsunefumi ^c   Umeno, Yoshikazu ^d   Okeda, Toshimitsu ^e   Shibata, Shoichiro ^a   Kono, Suminori ^a   Yasunami, Michio ^f   Ohkubo, Hiroaki ^f   Niho, Yoshiyuki ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b YAMAGUCHI RED CROSS HOSPITAL   (Japan)

^c HAMANOMACHI HOSPITAL   (Japan)

^d Saga Prefectural Hospital   (Japan)

^e OITA UNIVERSITY   (Japan)

^f KUMAMOTO UNIVERSITY   (Japan)

^g KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; CHROMOSOME 2Q; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENE MAPPING; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; JAPAN; MAJOR CLINICAL STUDY; MALE; PANCREAS ISLET BETA CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM;

ADULT; AMINO ACID SEQUENCE; ASIAN CONTINENTAL ANCESTRY GROUP; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DNA; DNA-BINDING PROTEINS; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; JAPAN; MALE; POLYMORPHISM, GENETIC; TRANS-ACTIVATORS;

EID: 0033047379     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.2.416     Document Type: Article

References (24)

1. Atkinson MA, Maclaren NK: The pathogenesis of insulin-dependent diabetes mellitus. N Engl J Med 331:1428-1436, 1994
2. Tisch R, McDevitt H: Insulin-dependent diabetes mellitus. Cell 85:291-297, 1996
3. Tood JA, Farrall M: Panning for gold: genome-wide scanning for linkage in type 1 diabetes (Review). Hum Mol Genet 5 (spec. no.):1443-1448, 1996
4. Copeman JB, Cucca F, Hearne CM, Cornall RJ, Reed PW, Ronningen KS, Undlien DE, Nistico L, Buzzetti R, Tosi R: Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33. Nat Genet 9:80-85, 1995
5. Tamimi R, Steingrimsson E, Copeland NG, Dyer-Montgomery K, Lee JE, Hernandez R, Jenkins NA, Tapscott SJ: The NEUROD gene maps to human chromosome 2q32 and mouse chromosome 2. Genomics 34:418-421, 1990
6. Lee JE, Hollenberg SM, Snider L, Turner DL, Lipnick N, Weintraub H: Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science 268:836-844, 1995
7. Ma Q, Kintner C, Anderson DJ: Identification of neurogenin, a vertebrate neuronal determination gene. Cell 87:43-52, 1996
8. Yasunami M, Suzuki K, Maruyama H, Kawakami H, Nagai Y, Hagiwara M, Ohkubo H: Molecular cloning and characterization of a cDNA encoding a novel basic helix-loop-helix protein structurally related to Neuro-D/BHF1. Biochem Biophys Res Commun 220:754-758, 1996
9. Roztocil T, Mattersadzinski L, Alliod C, Ballivet M, Matter JM: NeuroM, a neural helix-loop-helix transcription factor, defines a new transition stage in neurogenesis. Development 124:3263-3272, 1997
10. Lee JE: NeuroD and neurogenesis. Dev Neurosci 19:27-32, 1997
11. Naya FJ, Stellrecht CM, Tsai MJ: Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev 9:1009-1019, 1895
12. Mutoh H, Fung BP, Naya FJ, Tsai MJ, Nishitani J, Leiter AB: The basic helix-loop-helix transcription factor BETA2/NeuroD is expressed in mammalian enteroendocrine cells and activates secretin gene expression. Proc Natl Acad Sci U S A 94:3560-3564, 1907
13. Madsen OD, Jensen J, Potersen HV, Pedersen EE, Oster A, Andersen FG, Jorgensen MC, Jensen PB, Larsson LI, Serup P: Transcription factors contributing to the pancreatic β-cell phenotype. Horm Metab Res 29:265-270, 1997
14. Naya FJ, Huang HP, Qiu YH, Mutoh H, Demayo FJ, Leiter AB, Tsai MJ: Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice. Genes Dev 11:2323-2334, 1997
15. Yoon Y-S, Noma T, Yamashiro Y, Ito H, Nakazawa A: Molecular cloning and characterization of the gene encoding human NeuroD. Neurosci Lett 251:17-20, 1998
16. Oakley BR, Kirsch DR, Morris NR: A simplified ultrasensitive silver stain for detecting proteins in polyacrylamide gels. Anal Biochem 105:361-363, 1980
17. Hingorani AD, Brown MJ: A simple molecular assay for the C1166 valiant of the angiotensin II type 1 receptor gone. Biochem Biophys Res Commun 213:725-729, 1995 (Erratum published in Biochem Biophys Res Commun 218:420, 1996.)
18. 125I-labelled recombinant GAD65 produced in yeast. Clin Chim Acta 250:175-188, 1996
19. Ohta M, Obayashi H, Takahashi K, Kitagawa Y, Nakano K, Matsuo S, Nishimura M, Itoh N, Ohta K: Radioimmunoprecipitation assay for glutamic acid decarboxylase antibodies evaluated clinically with sera from patients with insulin-dependent diabetes mellitus. Clin Chem 42:1975-1978, 1996
20. Owerbach D, Naya FJ, Tsai MJ, Allander SV, Powell DR, Gabbay KH: Analysis of candidate genes for susceptibility to type 1 diabetes: a case-control and family-association study of genes on chromosome 2q31-35. Diabetes 46:1069-1074, 1997
21. Furuta H, Horikawa Y, Iwasaki N, Hara M, Sussel L, Le Beau MM, Davis EM, Ogata M, Iwamoto Y, German MS, Bell GI: Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1(NEUROD1) and Nkx2.2(NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese. Diabetes 47:1356-1358, 1998
22. Dumonteil E, Philippe J: Insulin gene: organisation, expression and regulation. Diabete Metab 22:164-173, 1996
23. Ptashne M: How eukaryotic transcriptional activators work. Nature 335:683-689, 1988
24. Patrick SL, Moy CS, LaPorte RE: The world of insulin-dependent diabetes mellitus: what international epidemiologic studies reveal about the etiology and natural history of IDDM. Diabetes Metab Rev 5:571-578, 1989