Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance

Journal of Biological Chemistry

Volumn 274, Issue 20, 1999, Pages 14306-14314

  Egawa, Katsuya ^a   Sharma, Prem M ^a   Nakashima, Naoki ^a   Huang, Yi ^a   Huver, Evana ^b   Boss, Gerry R ^b   Olefsky, Jerrold M ^a,b,c  

^a Whittier Institute for Diabetes   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYGLUCOSE; INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE;

ADENOVIRUS; ADIPOCYTE; ANIMAL CELL; ARTICLE; CATALYSIS; DESENSITIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; IMMUNOPRECIPITATION; INSULIN RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; RECEPTOR BINDING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ANIMALS; BIOLOGICAL TRANSPORT; CATALYTIC DOMAIN; GLUCOSE; GLYCOGEN SYNTHASE; INSULIN; INSULIN RESISTANCE; MICE; MOLECULAR MIMICRY; MONOSACCHARIDE TRANSPORT PROTEINS; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS P21(RAS); RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; SWINE;

ADENOVIRIDAE; ANIMALIA;

EID: 0033553415     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.20.14306     Document Type: Article

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