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Volumn 21, Issue 2, 1999, Pages 230-235

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3-kinase

(30)  Terauchi, Yasuo a   Tsuji, Youki a   Satoh, Shinobu c   Minoura, Hideaki a   Murakami, Koji a   Okuno, Akira a   Inukai, Kouichi a   Asano, Tomoichiro a   Kaburagi, Yasushi a   Ueki, Kohjiro a   Nakajima, Hiromu d   Hanafusa, Toshiaki d   Matsuzawa, Yuji d   Sekihara, Hisahiko c   Yin, Yuxin h   Barrett, J Carl h   Oda, Hideaki a   Ishikawa, Takatoshi a   Akanuma, Yasuo e   Komuro, Issei a   more..

h NONE

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE;

EID: 0032909703     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/6023     Document Type: Article
Times cited : (362)

References (28)
  • 2
    • 0030867766 scopus 로고    scopus 로고
    • From receptor to transporter: Insulin signalling to glucose transport
    • Holman, G.D. & Kasaga, M. From receptor to transporter: insulin signalling to glucose transport. Diabetologia 40, 991-1003 (1997).
    • (1997) Diabetologia , vol.40 , pp. 991-1003
    • Holman, G.D.1    Kasaga, M.2
  • 3
    • 0025727594 scopus 로고
    • cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of P13-kinase to the PDGF β-receptor
    • Escobedo, J.A. et al. cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of P13-kinase to the PDGF β-receptor. Cell 65, 75-82 (1991)
    • (1991) Cell , vol.65 , pp. 75-82
    • Escobedo, J.A.1
  • 4
    • 0025755422 scopus 로고
    • c-src complexs, and P13-kinase
    • c-src complexs, and P13-kinase. Cell 65, 91-104 (1991).
    • (1991) Cell , vol.65 , pp. 91-104
    • Otsu, M.1
  • 5
    • 0025921611 scopus 로고
    • Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases
    • Skolnik, E.Y. et al. Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell 65, 83-90 (1991).
    • (1991) Cell , vol.65 , pp. 83-90
    • Skolnik, E.Y.1
  • 6
    • 0030271565 scopus 로고    scopus 로고
    • Structual organization and alternative splicing of the murine phosphoinositide 3-kinase p85α gene
    • Fruman, D.A., Cantley, L.C. & Carpenter, C.L. Structual organization and alternative splicing of the murine phosphoinositide 3-kinase p85α gene Genomics 37, 113-121 (1996).
    • (1996) Genomics , vol.37 , pp. 113-121
    • Fruman, D.A.1    Cantley, L.C.2    Carpenter, C.L.3
  • 7
    • 0030615068 scopus 로고    scopus 로고
    • p85α gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-kinase), p50α, p55α, and p85α, with different PI 3-kinase activity elevating responses to insulin
    • Inukai, K. et al. p85α gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-kinase), p50α, p55α, and p85α, with different PI 3-kinase activity elevating responses to insulin. J. Biol. Chem. 272, 7873-7882 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 7873-7882
    • Inukai, K.1
  • 8
    • 0025201426 scopus 로고
    • Purification and characterization of phosphoinositide 3-kinase from rat liver
    • Carpenter, C.L. et al. Purification and characterization of phosphoinositide 3-kinase from rat liver. J. Biol. Chem. 265, 19704-19711 (1990).
    • (1990) J. Biol. Chem. , vol.265 , pp. 19704-19711
    • Carpenter, C.L.1
  • 9
    • 0029913340 scopus 로고    scopus 로고
    • Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunits of phosphatidylinositol 3-kinase in muscle and brain
    • Antonetti, D.A., Algenstaedt, P. & Kahn, C.R. Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunits of phosphatidylinositol 3-kinase in muscle and brain. Mol. Cell. Biol. 16, 2195-2203 (1996).
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2195-2203
    • Antonetti, D.A.1    Algenstaedt, P.2    Kahn, C.R.3
  • 10
    • 0029920935 scopus 로고    scopus 로고
    • A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structually similar to p55PIK is generated by alternative splicing of the p85α gene
    • Inukai, K. et al. A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structually similar to p55PIK is generated by alternative splicing of the p85α gene. J. Biol. Chem. 271, 5317-5320 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 5317-5320
    • Inukai, K.1
  • 11
    • 0028982198 scopus 로고
    • PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase
    • PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Mol. Cell. Biol. 15, 4453-4465 (1995).
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 4453-4465
    • Pons, S.1
  • 12
    • 0025813375 scopus 로고
    • The structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
    • Sun, X.J. et al. The structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352, 73-77 (1991).
    • (1991) Nature , vol.352 , pp. 73-77
    • Sun, X.J.1
  • 13
    • 0029148591 scopus 로고
    • Role of IRS-2 in insulin and cytokine signalling
    • Sun, X.J et al. Role of IRS-2 in insulin and cytokine signalling. Nature 377, 173-177 (1995).
    • (1995) Nature , vol.377 , pp. 173-177
    • Sun, X.J.1
  • 14
    • 0030443613 scopus 로고    scopus 로고
    • Signal transduction mechanism of insulin and insulin-like growth factor-1
    • Kadowaki, T. et al. Signal transduction mechanism of insulin and insulin-like growth factor-1. Endocrine J. 43, S33-41 (1996).
    • (1996) Endocrine J. , vol.43
    • Kadowaki, T.1
  • 15
    • 0030995946 scopus 로고    scopus 로고
    • The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family
    • Lavan, B.E., Lane, W.S. & Lienhard, G.E. The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family. J. Biol. Chem. 272, 11439-11443 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 11439-11443
    • Lavan, B.E.1    Lane, W.S.2    Lienhard, G.E.3
  • 16
    • 0030992837 scopus 로고    scopus 로고
    • Signalling through the lipid products of phosphoinositide-3-OH kinase
    • Toker, A. & Cantley, L.C. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387, 673-676 (1997).
    • (1997) Nature , vol.387 , pp. 673-676
    • Toker, A.1    Cantley, L.C.2
  • 17
    • 0019736918 scopus 로고
    • Clinical significance of altered insulin sensitivity in diabetes mellitus assessed by glucose, insulin, and somatostatin infusion
    • Harano, Y et al. Clinical significance of altered insulin sensitivity in diabetes mellitus assessed by glucose, insulin, and somatostatin infusion. J. Clin. Endocrinol. Metab 52, 982-987 (1981).
    • (1981) J. Clin. Endocrinol. Metab , vol.52 , pp. 982-987
    • Harano, Y.1
  • 18
    • 0027290847 scopus 로고
    • Use of bismannose photolabel to elucidate insulin-regulated GLUT4 subcellular trafficking kinetics in rat adipose cells
    • Satoh, S. et al. Use of bismannose photolabel to elucidate insulin-regulated GLUT4 subcellular trafficking kinetics in rat adipose cells. J. Biol. Chem. 268, 17820-17829 (1993).
    • (1993) J. Biol. Chem. , vol.268 , pp. 17820-17829
    • Satoh, S.1
  • 19
    • 0029811141 scopus 로고    scopus 로고
    • Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes
    • Nave, B.T., Haigh, R.J., Hayward, A.C., Siddle, K. & Shepherd, P.R. Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes. Biochem. J. 318, 55-60 (1996).
    • (1996) Biochem. J. , vol.318 , pp. 55-60
    • Nave, B.T.1    Haigh, R.J.2    Hayward, A.C.3    Siddle, K.4    Shepherd, P.R.5
  • 20
    • 0030015109 scopus 로고    scopus 로고
    • Different effects of insulin and platelet-derived growth factor on phosphatidylinositol 3-kinase at the subcellular level in 3T3-L1 adipocytes
    • Ricort, J.-M., Tanti, J.-F., Van Obberghen, E. & Le Marchand-Brustel, Y. Different effects of insulin and platelet-derived growth factor on phosphatidylinositol 3-kinase at the subcellular level in 3T3-L1 adipocytes. Eur J. Biochem. 239, 17-22 (1996).
    • (1996) Eur J. Biochem. , vol.239 , pp. 17-22
    • Ricort, J.-M.1    Tanti, J.-F.2    Van Obberghen, E.3    Le Marchand-Brustel, Y.4
  • 21
    • 0027753184 scopus 로고
    • A role for Fyn tyrosine kinase in the suckling behaviour of neonatal mice
    • Yagi, T. et al. A role for Fyn tyrosine kinase in the suckling behaviour of neonatal mice. Nature 366, 742-745 (1993).
    • (1993) Nature , vol.366 , pp. 742-745
    • Yagi, T.1
  • 22
    • 0028032894 scopus 로고
    • Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
    • Tamemoto, H. et al. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372, 182-186 (1994).
    • (1994) Nature , vol.372 , pp. 182-186
    • Tamemoto, H.1
  • 23
    • 0027440811 scopus 로고
    • A novel E5 cell line, TT2, with high germline-differentialing potency
    • Yagi, T. et al. A novel E5 cell line, TT2, with high germline-differentialing potency. Anal. Biochem. 214, 70-76 (1993).
    • (1993) Anal. Biochem. , vol.214 , pp. 70-76
    • Yagi, T.1
  • 24
    • 0029897280 scopus 로고    scopus 로고
    • Insulin signalling and insulin action in the muscles and livers of insulin-resistant, insulin receptor substrate-1 deficient mice
    • Yamauchi, T. et al. Insulin signalling and insulin action in the muscles and livers of insulin-resistant, insulin receptor substrate-1 deficient mice. Mol. Cell. Biol. 16, 3074-3084 (1996).
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3074-3084
    • Yamauchi, T.1
  • 25
    • 0027412618 scopus 로고
    • Insulin-stimulated phosphatidylinositol 3-kinase
    • Kelly, K.L. & Ruderman, N.B. Insulin-stimulated phosphatidylinositol 3-kinase. J. Biol. Chem. 268, 4391-4398 (1993).
    • (1993) J. Biol. Chem. , vol.268 , pp. 4391-4398
    • Kelly, K.L.1    Ruderman, N.B.2
  • 26
    • 0021016035 scopus 로고
    • Insulin-stimulated translocalion of glucose transporters in the isolated rat adipose cells
    • Simpson, I.A. et al. Insulin-stimulated translocalion of glucose transporters in the isolated rat adipose cells. Biochim. Biophys. Acta 763, 393-407 (1983).
    • (1983) Biochim. Biophys. Acta , vol.763 , pp. 393-407
    • Simpson, I.A.1
  • 27
    • 0030848724 scopus 로고    scopus 로고
    • Role of insulin receptor substrate-1 and pp60 in the regulation of insulin induced glucose transport and GLUT4 translocation in primary adipocytes
    • Kaburagi, Y. et al. Role of insulin receptor substrate-1 and pp60 in the regulation of insulin induced glucose transport and GLUT4 translocation in primary adipocytes. J. Biol. Chem. 272, 25839-25844 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 25839-25844
    • Kaburagi, Y.1
  • 28
    • 0028242353 scopus 로고
    • Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase
    • Kimura, K. et al. Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase. J. Biol. Chem. 269, 18961-18967 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 18961-18967
    • Kimura, K.1


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