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Volumn 49, Issue 5, 2000, Pages 847-856

Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

EID: 0034085886     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.5.847     Document Type: Article
Times cited : (87)

References (64)
  • 1
    • 0020159899 scopus 로고
    • Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus
    • Olefsky JM, Kolterman OG, Scarlett JA: Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus. Am J Physiol 243:E15-E30, 1982
    • (1982) Am J Physiol , vol.243
    • Olefsky, J.M.1    Kolterman, O.G.2    Scarlett, J.A.3
  • 2
    • 0004278799 scopus 로고
    • Insulin resistance and its role in the pathogenesis of impaired glucose tolerance and non-insulin-dependent diabetes mellitus: Perspective gained from in vivo studies
    • Moller DE, Ed. Chichester, U.K., Wiley, 1993
    • Alzaid A, Rizza RA: Insulin resistance and its role in the pathogenesis of impaired glucose tolerance and non-insulin-dependent diabetes mellitus: perspective gained from in vivo studies. In Insulin Resistance. Moller DE, Ed. Chichester, U.K., Wiley, 1993, p. 143-186, 1993
    • (1993) Insulin Resistance , pp. 143-186
    • Alzaid, A.1    Rizza, R.A.2
  • 3
    • 0025138242 scopus 로고
    • Localization of rate-limiting defect for glucose disposal in skeletal muscle of insulin-resistant type I diabetic patients
    • Yki-Jarvinen H, Sahlin K, Ren JM, Koivisto VA: Localization of rate-limiting defect for glucose disposal in skeletal muscle of insulin-resistant type I diabetic patients. Diabetes 39:157-167, 1990
    • (1990) Diabetes , vol.39 , pp. 157-167
    • Yki-Jarvinen, H.1    Sahlin, K.2    Ren, J.M.3    Koivisto, V.A.4
  • 5
    • 0030748457 scopus 로고    scopus 로고
    • The insulin signalling system and the IRS proteins
    • White MF: The insulin signalling system and the IRS proteins. Diabetologia 40:S2-S17, 1997
    • (1997) Diabetologia , vol.40
    • White, M.F.1
  • 7
    • 0030995946 scopus 로고    scopus 로고
    • The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family
    • Lavan BE, Lane WS, Lienhard GE: The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family. J Biol Chem 272:11439-11443, 1997
    • (1997) J Biol Chem , vol.272 , pp. 11439-11443
    • Lavan, B.E.1    Lane, W.S.2    Lienhard, G.E.3
  • 8
    • 0030848782 scopus 로고    scopus 로고
    • A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family
    • Lavan BE, Fantin VR, Chang ET, Lane WS, Keller SR, Lienhard GE: A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family. J Biol Chem 272:21403-21407, 1997
    • (1997) J Biol Chem , vol.272 , pp. 21403-21407
    • Lavan, B.E.1    Fantin, V.R.2    Chang, E.T.3    Lane, W.S.4    Keller, S.R.5    Lienhard, G.E.6
  • 9
    • 0028308412 scopus 로고
    • Phosphatidylinositol 3-kinase is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation
    • Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Kahn CR: Phosphatidylinositol 3-kinase is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol Cell Biol 14:4902-4911, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 4902-4911
    • Cheatham, B.1    Vlahos, C.J.2    Cheatham, L.3    Wang, L.4    Blenis, J.5    Kahn, C.R.6
  • 10
    • 0028124189 scopus 로고
    • Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes: Studies with a selective inhibitor wortmannin
    • Okada T, Kawano Y, Sakakibara T, Hazeki O, Ui M: Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes: studies with a selective inhibitor wortmannin. J Biol Chem 269:3568-3573, 1994
    • (1994) J Biol Chem , vol.269 , pp. 3568-3573
    • Okada, T.1    Kawano, Y.2    Sakakibara, T.3    Hazeki, O.4    Ui, M.5
  • 11
    • 0029149712 scopus 로고
    • Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: Comparison with fat cells
    • Le-Marchand-Brustel Y, Gautier N, Cormant M, Van Obberghen E: Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: comparison with fat cells. Endocrinology 136:3564-3570, 1995
    • (1995) Endocrinology , vol.136 , pp. 3564-3570
    • Le-Marchand-Brustel, Y.1    Gautier, N.2    Cormant, M.3    Van Obberghen, E.4
  • 13
    • 0033613830 scopus 로고    scopus 로고
    • Molecular basis of insulin-stimulated GLUT4 vesicle trafficking: Location! location! location!
    • Pessin JE, Thurmond DC, Elmendorf JS, Coker KJ, Okada S: Molecular basis of insulin-stimulated GLUT4 vesicle trafficking: Location! Location! Location! J Biol Chem 274:2593-2596, 1999
    • (1999) J Biol Chem , vol.274 , pp. 2593-2596
    • Pessin, J.E.1    Thurmond, D.C.2    Elmendorf, J.S.3    Coker, K.J.4    Okada, S.5
  • 14
    • 0029160069 scopus 로고
    • Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
    • Burgering BM, Coffer PJ: Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376:599-602, 1995
    • (1995) Nature , vol.376 , pp. 599-602
    • Burgering, B.M.1    Coffer, P.J.2
  • 15
    • 0029143388 scopus 로고
    • Insulin stimulated the kinase activity of RAC-PK, a pleckstrin homology by domain containing ser/thr kinase
    • Kohn AD, Kovacina KS, Roth RA: Insulin stimulated the kinase activity of RAC-PK, a pleckstrin homology by domain containing ser/thr kinase. EMBO J 14:4288-4295, 1995
    • (1995) EMBO J , vol.14 , pp. 4288-4295
    • Kohn, A.D.1    Kovacina, K.S.2    Roth, R.A.3
  • 16
  • 17
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha
    • Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P: Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha. Curr Biol 7:261-269, 1997
    • (1997) Curr Biol , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3    Holmes, A.B.4    Gaffney, P.R.5    Reese, C.B.6    Cohen, P.7
  • 19
    • 0030951346 scopus 로고    scopus 로고
    • Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue
    • Cross DA, Watt PW, Shaw M, van der Kaay J, Downes CP, Holder JC, Cohen P: Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue. FEBS Lett 406:211-215, 1997
    • (1997) FEBS Lett , vol.406 , pp. 211-215
    • Cross, D.A.1    Watt, P.W.2    Shaw, M.3    Van Der Kaay, J.4    Downes, C.P.5    Holder, J.C.6    Cohen, P.7
  • 20
    • 0032698470 scopus 로고    scopus 로고
    • Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
    • Kim Y-B, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn BB: Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J Clin Invest 104:733-741, 1999
    • (1999) J Clin Invest , vol.104 , pp. 733-741
    • Kim, Y.-B.1    Nikoulina, S.E.2    Ciaraldi, T.P.3    Henry, R.R.4    Kahn, B.B.5
  • 21
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross DA, Alessi DR, Cohen P Andjelkovich M, Hemmings BA: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785-789, 1995
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 22
    • 0030748651 scopus 로고    scopus 로고
    • Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades
    • Deprez J, Vertommen D, Alessi DR, Hue L, Rider MH: Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades. J Biol Chem 272:17269-17275, 1997
    • (1997) J Biol Chem , vol.272 , pp. 17269-17275
    • Deprez, J.1    Vertommen, D.2    Alessi, D.R.3    Hue, L.4    Rider, M.H.5
  • 23
    • 0029908016 scopus 로고    scopus 로고
    • Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
    • Kohn AD, Summers SA, Birnbaum MJ, Roth RA: Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem 271:31372-31378, 1996
    • (1996) J Biol Chem , vol.271 , pp. 31372-31378
    • Kohn, A.D.1    Summers, S.A.2    Birnbaum, M.J.3    Roth, R.A.4
  • 25
    • 0031806103 scopus 로고    scopus 로고
    • Requirement for activation of the serine-threonine kinase akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport
    • Kitamura T, Ogawa W, Sakaue H, Hino Y, Kuroda S, Takata M, Matsumoto M, Maeda T, Konishi H, Kikkawa U, Kasuga M: Requirement for activation of the serine-threonine kinase akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport. Mol Cell Biol 18:3708-3717, 1998
    • (1998) Mol Cell Biol , vol.18 , pp. 3708-3717
    • Kitamura, T.1    Ogawa, W.2    Sakaue, H.3    Hino, Y.4    Kuroda, S.5    Takata, M.6    Matsumoto, M.7    Maeda, T.8    Konishi, H.9    Kikkawa, U.10    Kasuga, M.11
  • 26
    • 0033049422 scopus 로고    scopus 로고
    • Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts
    • Wang Q, Somwar R, Bilan PJ, Liu Z, Jin J, Woodgett JR, Klip A: Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Mol Cell Biol 19:4008-4018, 1999
    • (1999) Mol Cell Biol , vol.19 , pp. 4008-4018
    • Wang, Q.1    Somwar, R.2    Bilan, P.J.3    Liu, Z.4    Jin, J.5    Woodgett, J.R.6    Klip, A.7
  • 27
    • 0032055131 scopus 로고    scopus 로고
    • Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: Comparison with protein kinase B alpha
    • Walker KS, Deak M, Paterson A, Hudson K, Cohen P, Alessi DR: Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha. Biochem J 331:299-308, 1998
    • (1998) Biochem J , vol.331 , pp. 299-308
    • Walker, K.S.1    Deak, M.2    Paterson, A.3    Hudson, K.4    Cohen, P.5    Alessi, D.R.6
  • 28
    • 0032765342 scopus 로고    scopus 로고
    • Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with type II diabetes mellitus
    • Rondinone CM, Carvalho E, Wesslau C, Smith UP: Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with type II diabetes mellitus. Diabetologia 42:819-825, 1999
    • (1999) Diabetologia , vol.42 , pp. 819-825
    • Rondinone, C.M.1    Carvalho, E.2    Wesslau, C.3    Smith, U.P.4
  • 31
    • 0026438979 scopus 로고
    • Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance
    • Saad MJ, Araki E, Miralpeix M, Rothenberg PL, White MF, Kahn CR: Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance. J Clin Invest 90:1839-1849, 1992
    • (1992) J Clin Invest , vol.90 , pp. 1839-1849
    • Saad, M.J.1    Araki, E.2    Miralpeix, M.3    Rothenberg, P.L.4    White, M.F.5    Kahn, C.R.6
  • 32
    • 0027484001 scopus 로고
    • Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus
    • Folli F, Saad MJ, Backer JM, Kahn CR: Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus. J Clin Invest 92:1787-1794, 1993
    • (1993) J Clin Invest , vol.92 , pp. 1787-1794
    • Folli, F.1    Saad, M.J.2    Backer, J.M.3    Kahn, C.R.4
  • 33
    • 0028903232 scopus 로고
    • Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects
    • Goodyear LJ, Giorgino F, Sherman LA, Carey J, Smith RJ, Dohm GL: Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J Clin Invest 95:2195-2204, 1995
    • (1995) J Clin Invest , vol.95 , pp. 2195-2204
    • Goodyear, L.J.1    Giorgino, F.2    Sherman, L.A.3    Carey, J.4    Smith, R.J.5    Dohm, G.L.6
  • 34
    • 0025115342 scopus 로고
    • Insulin-receptor autophosphorylation and endogenous substrate phosphorylation in human adipocytes from control, obese, and NIDDM subjects
    • Thies RS, Molina JM, Ciaraldi TP, Freidenberg GR, Olefsky JM: Insulin-receptor autophosphorylation and endogenous substrate phosphorylation in human adipocytes from control, obese, and NIDDM subjects. Diabetes 39:250-259, 1990
    • (1990) Diabetes , vol.39 , pp. 250-259
    • Thies, R.S.1    Molina, J.M.2    Ciaraldi, T.P.3    Freidenberg, G.R.4    Olefsky, J.M.5
  • 35
    • 0030890580 scopus 로고    scopus 로고
    • Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus
    • Rondinone CM, Wang LM, Lonnroth P, Wesslau C, Pierce JH, Smith U: Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A 94:4171-4175, 1997
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 4171-4175
    • Rondinone, C.M.1    Wang, L.M.2    Lonnroth, P.3    Wesslau, C.4    Pierce, J.H.5    Smith, U.6
  • 36
    • 0031984952 scopus 로고    scopus 로고
    • Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats
    • Anai M, Funaki M, Ogihara T, Terasaki J, Inukai K, Katagiri H, Fukushima Y, Yazaki Y, Kikuchi M, Oka Y, Asano T: Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats. Diabetes 47:13-23, 1998
    • (1998) Diabetes , vol.47 , pp. 13-23
    • Anai, M.1    Funaki, M.2    Ogihara, T.3    Terasaki, J.4    Inukai, K.5    Katagiri, H.6    Fukushima, Y.7    Yazaki, Y.8    Kikuchi, M.9    Oka, Y.10    Asano, T.11
  • 37
    • 0030815973 scopus 로고    scopus 로고
    • Molecular analysis of insulin resistance in isolated ventricular cardiomyocytes of obese Zucker rats
    • Kolter T, Uphues I, Eckel J: Molecular analysis of insulin resistance in isolated ventricular cardiomyocytes of obese Zucker rats. Am J Physiol 273:E59-E67, 1997
    • (1997) Am J Physiol , vol.273
    • Kolter, T.1    Uphues, I.2    Eckel, J.3
  • 38
    • 0031852665 scopus 로고    scopus 로고
    • Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects
    • Krook A, Roth RA, Jiang XJ, Zierath JR, Wallberg-Henriksson H: Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects. Diabetes 47:1281-1286, 1998
    • (1998) Diabetes , vol.47 , pp. 1281-1286
    • Krook, A.1    Roth, R.A.2    Jiang, X.J.3    Zierath, J.R.4    Wallberg-Henriksson, H.5
  • 40
    • 0033009465 scopus 로고    scopus 로고
    • Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle
    • Kurowski TG, Lin Y, Luo Z, Tsichlis PN, Buse MG, Heydrick SJ, Ruderman NB: Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle. Diabetes 48:658-663, 1999
    • (1999) Diabetes , vol.48 , pp. 658-663
    • Kurowski, T.G.1    Lin, Y.2    Luo, Z.3    Tsichlis, P.N.4    Buse, M.G.5    Heydrick, S.J.6    Ruderman, N.B.7
  • 42
    • 0033046582 scopus 로고    scopus 로고
    • Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle
    • Kim Y-B, Zhu J-S, Zierath JR, Shell H-Q, Baron AD, Kahn BB: Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle. Diabetes 48:310-320, 1999
    • (1999) Diabetes , vol.48 , pp. 310-320
    • Kim, Y.-B.1    Zhu, J.-S.2    Zierath, J.R.3    Shell, H.-Q.4    Baron, A.D.5    Kahn, B.B.6
  • 43
    • 78651166782 scopus 로고
    • Metabolism of isolated fat cells: Effects of hormones on glucose metabolism and lipolysis
    • Rodbell M: Metabolism of isolated fat cells: effects of hormones on glucose metabolism and lipolysis. J Biol Chem 239:375-380, 1964
    • (1964) J Biol Chem , vol.239 , pp. 375-380
    • Rodbell, M.1
  • 44
    • 0014830814 scopus 로고
    • Structure-function relationship in the adipose cell: Ultrastructure of the isolated adipose cell
    • Cushman SW: Structure-function relationship in the adipose cell: ultrastructure of the isolated adipose cell. J Cell Biol 46:326-341, 1970
    • (1970) J Cell Biol , vol.46 , pp. 326-341
    • Cushman, S.W.1
  • 45
    • 0020576117 scopus 로고
    • In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin dependent diabetes mellitus
    • Kashiwagi A, Antonio-Verso M, Andrew J, Vasquez B, Reaven G: In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin dependent diabetes mellitus. J Clin Invest 72:1246-1254, 1983
    • (1983) J Clin Invest , vol.72 , pp. 1246-1254
    • Kashiwagi, A.1    Antonio-Verso, M.2    Andrew, J.3    Vasquez, B.4    Reaven, G.5
  • 46
    • 0017904216 scopus 로고
    • Determinations of adipose cell size and number in suspension of isolated rat and human adipose cells
    • Cushman SW, Salans LB: Determinations of adipose cell size and number in suspension of isolated rat and human adipose cells. J Lipid Res 19:269-273, 1978
    • (1978) J Lipid Res , vol.19 , pp. 269-273
    • Cushman, S.W.1    Salans, L.B.2
  • 47
    • 0027453501 scopus 로고
    • Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue
    • Shepherd PR, Gnudi L, Tozzo E, Yang H, Leach F, Kahn BB: Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. J Biol Chem 268:22243-22246, 1993
    • (1993) J Biol Chem , vol.268 , pp. 22243-22246
    • Shepherd, P.R.1    Gnudi, L.2    Tozzo, E.3    Yang, H.4    Leach, F.5    Kahn, B.B.6
  • 48
    • 0028799420 scopus 로고
    • Molecular cloning and characterization of a new member of the RAC protein kinase family: Association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins
    • Konishi H, Kuroda S, Tanaka M, Matsuzaki H, Ono Y, Kameyama K, Haga T, Kikkawa U: Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins. Biochem Biophys Res Commun 216:526-534, 1995
    • (1995) Biochem Biophys Res Commun , vol.216 , pp. 526-534
    • Konishi, H.1    Kuroda, S.2    Tanaka, M.3    Matsuzaki, H.4    Ono, Y.5    Kameyama, K.6    Haga, T.7    Kikkawa, U.8
  • 51
    • 0026681195 scopus 로고
    • Divergent regulation of the Glut 1 and Glut 4 glucose transporters in isolated adipocytes from Zucker rats
    • Pedersen O, Kahn CR, Kahn BB: Divergent regulation of the Glut 1 and Glut 4 glucose transporters in isolated adipocytes from Zucker rats. J Clin Invest 89:1964-1973, 1992
    • (1992) J Clin Invest , vol.89 , pp. 1964-1973
    • Pedersen, O.1    Kahn, C.R.2    Kahn, B.B.3
  • 52
    • 0018237942 scopus 로고
    • Insulin resistance, insulin insensitivity, and insulin unresponsiveness: A necessary distinction
    • Kahn CR: Insulin resistance, insulin insensitivity, and insulin unresponsiveness: a necessary distinction. Metabolism 27:1893-1902, 1978
    • (1978) Metabolism , vol.27 , pp. 1893-1902
    • Kahn, C.R.1
  • 53
    • 0018355898 scopus 로고
    • Developmental changes in thymidine kinase, DNA, and fat cellularity in Zucker rats
    • Cleary MP, Brasel JA, Greenwood MR: Developmental changes in thymidine kinase, DNA, and fat cellularity in Zucker rats. Am J Physiol 236:E508-E513, 1979
    • (1979) Am J Physiol , vol.236
    • Cleary, M.P.1    Brasel, J.A.2    Greenwood, M.R.3
  • 54
    • 0022378235 scopus 로고
    • Adipose tissue: Cellular morphology and development
    • Greenwood MR: Adipose tissue: cellular morphology and development. Ann Intern Med 103:996-999, 1985
    • (1985) Ann Intern Med , vol.103 , pp. 996-999
    • Greenwood, M.R.1
  • 55
    • 8544234984 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase is required for insulin-induced but not for growth hormone- or hyperosmolarity-induced glucose uptake in 3T3-L1 adipocytes
    • Sakaue H, Ogawa W, Takata M, Kuroda S, Kotani K, Matsumoto M, Sakaue M, Nishio S, Ueno H, Kasuga M: Phosphoinositide 3-kinase is required for insulin-induced but not for growth hormone- or hyperosmolarity-induced glucose uptake in 3T3-L1 adipocytes. Mol Endocrinol 11:1552-1562, 1997
    • (1997) Mol Endocrinol , vol.11 , pp. 1552-1562
    • Sakaue, H.1    Ogawa, W.2    Takata, M.3    Kuroda, S.4    Kotani, K.5    Matsumoto, M.6    Sakaue, M.7    Nishio, S.8    Ueno, H.9    Kasuga, M.10
  • 56
    • 16944366762 scopus 로고    scopus 로고
    • Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal fat cells: Activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms
    • Moule SK, Welsh GI, Edgell NJ, Foulstone EJ, Proud CG, Denton RM: Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal fat cells: activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms. J Biol Chem 272:7713-7719, 1997
    • (1997) J Biol Chem , vol.272 , pp. 7713-7719
    • Moule, S.K.1    Welsh, G.I.2    Edgell, N.J.3    Foulstone, E.J.4    Proud, C.G.5    Denton, R.M.6
  • 57
    • 0029821721 scopus 로고    scopus 로고
    • Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase
    • Konishi H, Matsuzaki H, Tanaka M, Ono Y, Tokunaga C, Kuroda S, Kikkawa U: Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A 93:7639-7643, 1996
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 7639-7643
    • Konishi, H.1    Matsuzaki, H.2    Tanaka, M.3    Ono, Y.4    Tokunaga, C.5    Kuroda, S.6    Kikkawa, U.7
  • 58
    • 0032506514 scopus 로고    scopus 로고
    • Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway
    • Yano S, Tokumistu H, Soderling TR: Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Nature 396:584-587, 1998
    • (1998) Nature , vol.396 , pp. 584-587
    • Yano, S.1    Tokumistu, H.2    Soderling, T.R.3
  • 60
    • 0032238299 scopus 로고    scopus 로고
    • The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway
    • Ogg S, Ruvkun G: The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol Cell 2:887-893, 1998
    • (1998) Mol Cell , vol.2 , pp. 887-893
    • Ogg, S.1    Ruvkun, G.2
  • 62
    • 0033556016 scopus 로고    scopus 로고
    • Akt-2 binds to Glut4-containing vesicles and phosphorylates their component proteins in response to insulin
    • Kupriyanova TA, Kandror KV: Akt-2 binds to Glut4-containing vesicles and phosphorylates their component proteins in response to insulin. J Biol Chem 274:1458-1464, 1999
    • (1999) J Biol Chem , vol.274 , pp. 1458-1464
    • Kupriyanova, T.A.1    Kandror, K.V.2
  • 63
    • 0032578915 scopus 로고    scopus 로고
    • Induction of Akt-2 correlates with differentiation in Sol8 muscle cells
    • Calera MR, Pilch PF: Induction of Akt-2 correlates with differentiation in Sol8 muscle cells. Biochem Biophys Res Commun 251:835-841, 1998
    • (1998) Biochem Biophys Res Commun , vol.251 , pp. 835-841
    • Calera, M.R.1    Pilch, P.F.2
  • 64
    • 0032493105 scopus 로고    scopus 로고
    • Akt2 mRNA is highly expressed in embryonic brown fat and the Akt2 kinase is activated by insulin
    • Altomare DA, Lyons GE, Mitsuuchi Y, Cheng JQ, Testa JR: Akt2 mRNA is highly expressed in embryonic brown fat and the Akt2 kinase is activated by insulin. Oncogene 16:2407-2411, 1998
    • (1998) Oncogene , vol.16 , pp. 2407-2411
    • Altomare, D.A.1    Lyons, G.E.2    Mitsuuchi, Y.3    Cheng, J.Q.4    Testa, J.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.