Asp905tyr polymorphism of the gene for the skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in NIDDM

Diabetes Care

Volumn 21, Issue 7, 1998, Pages 1086-1089

  Shen, Gong Qing ^a   Ikegami, Hiroshi ^a,b   Kawaguchi, Yoshihiko ^a   Fujisawa, Tomomi ^a   Hamada, Yoichi ^a   Ueda, Hironori ^a   Shintani, Maki ^a   Nojima, Koji ^a   Kawabata, Yumiko ^a   Yamada, Kazunori ^a   Babaya, Naru ^a   Ogihara, Toshio ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

ADULT; AGED; ARTICLE; BODY MASS; CLINICAL TRIAL; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC RISK; GENOTYPE; HUMAN; INSULIN RESISTANCE; INSULIN TREATMENT; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN EXPRESSION;

ADULT; AGED; ALLELES; AMINO ACID SUBSTITUTION; ASPARTIC ACID; BODY MASS INDEX; DATA INTERPRETATION, STATISTICAL; DIABETES MELLITUS, TYPE 2; FEMALE; GENE FREQUENCY; GENES; GENOTYPE; GLYCOGEN; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MIDDLE AGED; MUSCLE, SKELETAL; PHOSPHOPROTEIN PHOSPHATASE; POLYMORPHISM, GENETIC; TYROSINE;

EID: 0031819689     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.21.7.1086     Document Type: Article

References (16)

1. Hamman RF: Genetic and environmental determinants of non-insulin-dependent diabetes mellitus (NIDDM). Diabetes Metab Rev 8:287-338, 1992
2. Yki-Jarvinen H: Role of insulin resistance in the pathogenesis of NIDDM. Diabetologia 38:1378-1388, 1995
3. Reaven GM: Banting Lecture 1988: role of insulin resistance in human disease. Diabetes 37:1595-1607, 1988
4. Reaven GM: Insulin resistance, hyperinsulinemia, hypertriglyceridemia, and hypertension: parallels between human disease and rodent models. Diabetes Care 14:195-202, 1991
5. DeFronzo RA, Ferrannini E: Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:173-194, 1991
6. Kida Y, Esposito-Del P, Bogardus C, Mott DM: Insulin resistance is associated with reduced fasting and insulin-stimulated glycogen synthase phosphatase activity in human skeletal muscle. J Clin Invest 85:476-481, 1990
7. Hubbard MJ, Cohen P: On target with a new mechanism for the regulation of protein phosphatase. TIBS 18:172-177, 1993
8. Kahn CR: Banting Lecture: insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 43:1066-1084, 1994
9. Kida Y, Raz I, Maeda R, Nyomba BL, Stone K, Bogardus C, Sommercorn J, Mott DM: Defective insulin response of phosphorylase phosphatase in insulin-resistant humans. J Clin Invest 89:610-617, 1992
10. Stråfors P, Hiraga A, Cohen P: The protein phosphatases involved in cellular regulation: purification and characterisation of the glycogen-bound form of protein phosphatase-1 from rabbit skeletal muscle. Eur J Biochem 149:295-303, 1985
11. Tang PM, Bondor EJA, Swiderek KM, DePaoli-Roach AA: Molecular cloning and expression of the regulatory R (G1) subunit of the glycogen-associated protein phosphatase. J Biol Chem 266:15782-15789, 1991
12. Hansen L, Hansen T, Vestergaard H, Bjørbæk C, Echwald SM, Clausen JO, Chen YH, Chen MX, Cohen PTW, Pederson OA: Widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin. Hum Mol Genet 4:1313-1320, 1995
13. Shen GQ, Ikegami H, Fujisawa T, Hamada Y, Kamide K, Rakugi H, Higaki J, Murakami H, Shimamoto K, Ogihara T: Asp905Tyr polymorphism of protein phosphatase 1 G-subunit gene in hypertension. Hypertension 30:236-239, 1997
14. Kuroyama H, Sanke T, Ohagi S, Furuta M, Furuta H, Nanjo K: Simple tandem repeat DNA polymorphism in the human glycogen synthase gene is associated with NIDDM in Japanese subjects. Diabetologia 37:536-539, 1994
15. Fujisawa T, Ikegami H, Yamato E, Takekawa K, Nakagawa Y, Hamada Y, Ueda H, Fukuda M, Ogihara T: A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus. Diabetologia 38:983-985, 1995
16. Dent P, Lavoinne A, Nakielny S, Caudwell FB, Watt P, Cohen P: The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle. Nature 348:302-308, 1990