Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice

Genes and Development

Volumn 11, Issue 18, 1997, Pages 2323-2334

  Naya, Francisco J ^a,c   Huang, Hsiang Po ^a   Qiu, Yuhong ^a   Mutoh, Hiroyuki ^b   DeMayo, Francesco J ^a   Leiter, Andrew B ^b   Tsai, Ming Jer ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

BETA2; Diabetes; Enteroendocrine development; Insulin gene regulation; Mice; NeuroD; Pancreatic endocrine development

Indexed keywords

CHOLECYSTOKININ; GENE PRODUCT; HELIX LOOP HELIX PROTEIN; SECRETIN; TRANSCRIPTION FACTOR;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL POLARITY; CONTROLLED STUDY; DIABETES MELLITUS; EXOCRINE CELL; GENE CONTROL; GLUCOSE HOMEOSTASIS; INSULIN RELEASE; MORPHOGENESIS; MOUSE; NEUROSECRETORY CELL; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN ISOLATION;

ANIMALIA;

EID: 0030886674     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.18.2323     Document Type: Article

References (57)

1. Ahlgren, U., S.L. Pfaff, T.M. Jessell, T. Edlund, and H. Edlund. 1997. Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. Nature. 385: 257-260.
2. Alpert, S., D. Hanahan, and G. Teitelman. 1988. Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cell and imply a relationship with neurons. Cell 53: 295-308.
3. Bain, G., E.C.R. Maandag, D.J. Izon, D. Amsen, A.M. Kruisbeek, B.C. Weintraub, I. Krop, M.S. Schlissel, A.J. Feenyey, and M.V. Roon. 1994. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 79: 885-892.
4. Bartholoma, A., and K. A. Nave. 1994. NEX-1: A novel brain specific helix loop helix protein with autoregulation and sustained expression in mature cortical neurons. Mech. Dev. 48: 217-228.
5. Bonner-Weir, S., D. Trent, and G.C. Weir. 1983. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin secretion. J. Clin. Invest. 71: 1544-1553.
6. Bukovsky, A., M.R. Caudle, J.A. Keenan, J. Wimalasena, J.S. Foster, and S.E. Van Meter. 1995. Quantative evaluation of the cell cycle-related retinoblastoma protein and location of Thy-1 differentiation protein and macrophage during follicular development and atresia, and in human corpora lutea. Biol. Reprod. 52: 776-792.
7. Chen, Z.-F. and R.R. Behringer. 1995. twist is required in head mesenchyme for cranial neural tube morphogenesis. Genes & Dev. 9: 686-699.
8. Cirulli, V., D. Baetens, U. Rutishauser, P.A. Halban, L. Orci, and D.G. Rouiller. 1994. Expression of neural cell adhesion molecule (N-CAM) in rat islets and its role in islet cell type segregation. J. Cell Sci. 107: 1429-1436.
9. Copeman J.B., F. Cucca, C.M. Hearne, R.J. Cornall, P.W. Reed, K.S. Ronningen, D.E. Undlien, L. Nistico, R. Briggeti, R. Tosi et al. 1995. Linkage disequilibrium mapping of a type I diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33. Nature Genet. 9: 80-85.
10. Cordle, S.R., E. Henderson, H. Masucha, P.A. Weil, and R. Stein. 1991. Pancreatic β-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins. Mol. Cell. Biol. 11: 1734-1738.
11. Dahl, U., A. Sjodin, and H. Semb. 1996. Cadherins regulate aggregation of pancreatic β cells in vivo. Development 122: 2895-2902.
12. Gavrieli, Y., T. Sherman, and S.A. Ben-Sasson. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragment. J. Cell Biol. 119:493-501.
13. Gepts, W. and P.M. Lecompte. 1981. The pancreatic islets in diabetes. Am. J. Med. 70: 105-115.
14. German, M. S., M. A. Blanar, C. Nelson, L. G. Moss, and W. J. Rutter. 1991. Two related helix-loop-helix proteins participate in separate cell-specific complexes that bind the insulin enhancer. Mol. Endocrinol. 5: 292-299.
15. Gittes, G.K. and W.J. Rutter. 1992. Onset of cell-specific gene expression in the developing mouse pancreas. Proc. Natl. Acad. Sci. 89: 1128-1132.
16. Gomez Dumm, C.L.A., M.C. Semino, and J.J. Gagliardino. 1990. Sequential morphological changes in pancreatic islets of spontaneously diabetic rats. Pancreas 5: 533-539.
17. Guillemot, F., L.C. Lo, J.E. Johnson, A. Auerbach, D.J. Anderson and A.L. Joyner. 1993. Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell 75: 463-476.
18. Guz, Y., M.R. Montminy, R. Stein, J. Leonard, L.W. Gamer, C.V.E. Wright, and G. Teitelman. 1995. Expression of murine STF-1, a putative insulin gene transcription factor in b cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 121: 11-18.
19. Halban, P., C. Wollheim, B. Blondel, P. Meda, E.N. Niesor, and D.H. Mintz. 1982. The importance of contact between pancreatic islets cells for the control of insulin release. Endocrinology 111: 86-94.
20. Haun, R.S. and Dixon, J.E. 1990. A transcriptional enhancer essential for the rat cholecystokinin gene contains a sequence identical to the -296 element of the human c-fos gene. J. Biol. Chem. 265: 15455-15463.
21. Herrera, P.L., J. Huarte, F. Sanvito, P. Meda, L. Orci, and J.-D. Vassalli. 1991. Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene. Development 113: 1257-1265.
22. Hutton, J.C., G. Christofori, W.Y. Chin, U. Edman, P.C. Guest, D. Hanahan, and R.B. Kelly. 1993. Molecular cloning of mouse pancreatic R-cadherin: Differential expression in endocrine and exocrine tissue. Mol. Endocrinol. 7: 1151-1160.
23. Jan, Y.N. and L.Y. Jan. 1993. HLH proteins, fly neurogenesis, and vertebrate myogenesis. Cell 75: 827-830.
24. Jonsson, J., L. Carlsson, T. Edlund, and H. Edlund. 1994. Insulin promoter factor 1 is required for pancreas development in mice. Nature 371: 606-609.
25. Joyner, A.L. 1995. Gene targeting: A practical approach. Oxford University Press, Oxford, UK.
26. Kume, H.K., T. Maruyama, T. Tomita, T. Iwatsubo, T.C. Saido, and K. Obata. 1996. Molecular cloning of a novel basic helix loop helix protein from the rat brain. Biochem. Biophys. Res. Commun. 219: 526-530.
27. Lee, J.L., S.M. Hollenberg, L. Snider, D.L. Turner, N. Lipnick, and H. Weintraub. 1995. Conversion of Xenopus ectoderm into neurons by neuroD, a basic helix loop helix transcription factor. Science 268: 836-844.
28. Lopez, M.J., B.H. Upchurch, G. Rindi, and A.B. Leiter. 1995. Studies in transgenic mice reveal potential relationships between secretin producing cells and other endocrine cell types. J. Biol. Chem. 270: 885-891.
29. Lucas-Clerc, C., C. Massart, J.P. Campion, B. Launois, and M. Nicol. 1993. Long-term culture of human pancreatic islets in an extracellular matrix; morphological and metabolic effects. Mol. Cell. Endocrinol. 94: 9-20.
30. McCormick, M.B., R.A. Tamimi, L. Snider, A. Asakura, D. Bergstrom and S.J. Tapscott. 1996. Neurod2 and neurod3: Distinct expression patterns and transcriptional activation potentials within the neurod gene family. Mol. Cell. Biol. 16: 5792-5800.
31. Moller, C.J., S. Christgau, M.R. Williamson, O.D. Madsen, N. Zhan-Po, E. Bock, and S. Baekkeskov. 1992. Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas. Mol. Endocrinol. 6: 1332-1342.
32. Mutoh, H., B.P. Fung, F.J. Naya, M.J. Tsai, J. Nishitani, and A.B. Leiter. 1997. The basic helix loop helix transcription factor BETA2/NeuroD is expressed in enteroendocrine cells and activates secretin gene expression. Proc. Natl. Acad. Sci. 94: 3560-3564.
33. Naya, F.J., C.M.M. Stellrecht, and M.-J. Tsai. 1995. Tissue specific regulation of the insulin gene by a novel basic helix loop helix transcription factor. Genes & Dev. 9: 1009-1019.
34. Nelson, C., L.-P. Shen, A. Meister, E. Fodor, and W. J. Rutter. 1990. Pan: A transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs. Genes & Dev. 4: 1035-1043.
35. Offield, M.F., T.L. Jetton, P.A. Labosky, M. Ray, R.W. Stein, M.A. Magnuson, B.L.M. Hogan, and C.V.E. Wright. 1996. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122: 983-995.
36. Olson, E.N. and W.H. Klein. 1994. bHLH factors in muscle development: Dead lines and commitments, what to leave in and what to leave out. Genes & Dev. 8: 1-8.
37. Orci, L. 1982. Macro- and micro-domains in the nedocrine pancreas. Diabetes 31: 538-565.
38. Peyton, M., L.G. Moss, and M.-J. Tsai. 1994. Two distinct class A helix-loop-helix transcription factors, E2A and BETA1, form separate DNA binding complexes on the insulin gene E box. J. Biol. Chem. 269: 25936-25941.
39. Pictet, R.L. and W. J.. Rutter. 1972. Development of the embryonic endocrine pancreas. In Handbook of physiology, American Physiology Society (ed. D.F. Steiner and N. Frenkel), vol 1, section 7, Williams and Wilkins, Washington, DC.
40. Pipeleers, D.P., P. In'T Veld, E. Macs, and M. Van De Winkel. 1982. Glucose-induced insulin release depends on functional cooperation between islet cells. Proc. Natl. Acad. Sci. 79: 7322-7325.
41. Rouiller, D.G., V. Cirulli, and P.A. Halban. 1991. Uvomorulin mediates calcium dependent aggregation of islet cells, whereas calcium independent cell adhesion molecules distinguish between islet cell types. Dev. Biol. 148: 233-242.
42. Sharma, S., U.S. Jhala, T. Johnson, K. Ferreri, J. Leonard, and M. Montminy. 1997. Hormonal regulation of an islet-specific enhancer in the pancreatic homeobox gene STF-1. Mol. Cell. Biol. 17: 2598-2604.
43. Shieh, S.-Y. and M.-J. Tsai. 1991. Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene. J. Biol. Chem. 266: 16707-16714.
44. Shimizu, C., C. Akazawa, S. Nakanishi, and R. Kageyama. 1995. MATH-2 a mammalian helix loop helix factor structurally related to the product of Drosophila proneural gene atonal is specifically expressed in the nervous system. Eur. J. Biochem. 229: 239-248.
45. Shivdasani, R.A., E.L. Mayer, and S.H. Orkin. 1995. Absence of blood formation in mice lacking the T-cell leukemia oncoprotein tal-1/SCL-1. Nature 373: 432-434.
46. Sommer, L., Q. Ma, and D.J. Anderson. 1996. Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Mol. Cell. Neurobiol. 8: 221-241.
47. Sosa-Pineda, B., K. Chowdury, M. Torres, G. Oliver, and P. Gruss. 1997. The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas. Nature 386: 399-402.
48. Tamimi, R., E. Steingrimsson, N. G. Copeland, K. Dyer-Montgomery, J.E. Lee, R. Hernandez, N.A. Jenkins, and S.J. Tapscott. 1996. The NEUROD gene maps to human chromosome 2q32 and mouse chromosome 2. Genomics 34: 418-421.
49. Teitelman, G., S. Alpert, J.M. Polak, A. Martinez, and D. Hanahan. 1993. Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. Development 118: 1031-1039.
50. Tokuyama, Y., J. Stuns, A.M. DePaoli, J. Takeda, M. Stoffel, J. Tang, X. Sun, K.S. Polonsky, and G.I. Bell. 1995. Evolution of β cell dysfunction in the male Zucker diabetic fatty rat. Diabetes 44: 1447-1457.
51. Upchurch, B.H., G. W. Aponte, and A.B. Leiter. 1994. Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY producing progenitor. Development 120: 245-252.
52. Walker, M. D., C. W. Park, A. Rosen, and A. Aronheim. 1990. A cDNA from a mouse pancreatic β-cell encoding a putative transcription factor of the insulin gene. Nucleic Acids Res. 18: 1159-1166.
53. Weintraub, H. 1993. The MyoD family and myogenesis: Redundancy, networks, and thresholds. Cell 75: 1241-1244.
54. Wheeler, M.B., J. Nishitani, A. J. Buchan, A.S. Kopin, W.Y. Chey, T.-A. Chang, and A.B. Leiter. 1992. Identification of a transcriptional enhancer important for enteroendocrine and pancreatic islet cell specific expression of the secretin gene. Mol. Cell. Biol. 12: 3531-3539.
55. Williams, J.A. and I.D. Goldfine. 1985. The insulin-pancreatic acinar axis. Diabetes 34: 980-986.
56. Yasunami, M., K. Suzuki, H. Maruyama, H. Kawakami, Y. Nagai, M. Hagiwara, and H. Okubo. 1996. Molecular cloning and characterization of a cDNA encoding a novel basic helix loop helix protein structurally related to neuroD/BHF1. Biochem. Biophys. Res. Commun. 220: 754-758.
57. Zhuang, Y., P. Soriano, and H. Weintraub. 1994. The helix loop helix gene E2A is required for B cell formation. Cell 79: 875-884.